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Protein

Phospholipid phosphatase 2

Gene

PLPP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

Enzyme regulationi

Inhibited by sphingosine, zinc ions and propanolol.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-HSA-1660661. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase 2Imported (EC:3.1.3.4)
Alternative name(s):
Lipid phosphate phosphohydrolase 2
PAP2-gamma
Short name:
PAP2-G
Phosphatidate phosphohydrolase type 2c
Phosphatidic acid phosphatase 2c
Short name:
PAP-2c
Short name:
PAP2c
Gene namesi
Name:PLPP2Imported
Synonyms:LPP2, PPAP2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9230. PLPP2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33554.

Polymorphism and mutation databases

BioMutaiPPAP2C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Phospholipid phosphatase 2PRO_0000220909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO43688.
PaxDbiO43688.
PeptideAtlasiO43688.
PRIDEiO43688.

PTM databases

DEPODiO43688.
iPTMnetiO43688.
PhosphoSiteiO43688.

Expressioni

Tissue specificityi

Found mainly in brain, pancreas and placenta.

Gene expression databases

BgeeiO43688.
CleanExiHS_PPAP2C.
ExpressionAtlasiO43688. baseline and differential.
GenevisibleiO43688. HS.

Organism-specific databases

HPAiHPA055540.

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NOTCH2NLQ7Z3S93EBI-722017,EBI-945833

Protein-protein interaction databases

BioGridi114170. 5 interactions.
IntActiO43688. 6 interactions.
MINTiMINT-1372912.
STRINGi9606.ENSP00000329697.

Structurei

3D structure databases

ProteinModelPortaliO43688.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3030. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000041307.
HOVERGENiHBG002048.
InParanoidiO43688.
KOiK01080.
OMAiNCSIYVQ.
OrthoDBiEOG7C5M9Q.
PhylomeDBiO43688.
TreeFamiTF316040.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028674. LPP2.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF25. PTHR10165:SF25. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43688-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRRWVFVLL DVLCLLVASL PFAILTLVNA PYKRGFYCGD DSIRYPYRPD
60 70 80 90 100
TITHGLMAGV TITATVILVS AGEAYLVYTD RLYSRSDFNN YVAAVYKVLG
110 120 130 140 150
TFLFGAAVSQ SLTDLAKYMI GRLRPNFLAV CDPDWSRVNC SVYVQLEKVC
160 170 180 190 200
RGNPADVTEA RLSFYSGHSS FGMYCMVFLA LYVQARLCWK WARLLRPTVQ
210 220 230 240 250
FFLVAFALYV GYTRVSDYKH HWSDVLVGLL QGALVAALTV CYISDFFKAR
260 270 280
PPQHCLKEEE LERKPSLSLT LTLGEADHNH YGYPHSSS
Length:288
Mass (Da):32,574
Last modified:June 1, 1998 - v1
Checksum:iF7C6A09A28DA9AC8
GO
Isoform 2 (identifier: O43688-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MQRRWVFVLLDVLCLLV → MGVARGPGSRGQHPPPRQQEVCAEGPRARLHPAPPGLG

Note: No experimental confirmation available.
Show »
Length:309
Mass (Da):34,393
Checksum:i18E2A8A78FEB815A
GO
Isoform 3 (identifier: O43688-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Note: Gene prediction based on EST data.
Show »
Length:232
Mass (Da):26,103
Checksum:i672A852905D493C5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti180 – 1801A → V.
Corresponds to variant rs1138439 [ dbSNP | Ensembl ].
VAR_061541

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5656Missing in isoform 3. CuratedVSP_047366Add
BLAST
Alternative sequencei1 – 1717MQRRW…LCLLV → MGVARGPGSRGQHPPPRQQE VCAEGPRARLHPAPPGLG in isoform 2. CuratedVSP_037765Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035959 mRNA. Translation: AAC15968.1.
AF047760 mRNA. Translation: AAC32104.1.
AF056083 mRNA. Translation: AAC25666.1.
BT007021 mRNA. Translation: AAP35667.1.
AC016588 Genomic DNA. No translation available.
BC002806 mRNA. Translation: AAH02806.1.
CCDSiCCDS12023.1. [O43688-1]
CCDS12024.1. [O43688-2]
CCDS45889.1. [O43688-3]
RefSeqiNP_003703.1. NM_003712.3. [O43688-1]
NP_803545.1. NM_177526.2. [O43688-3]
NP_808211.1. NM_177543.2. [O43688-2]
UniGeneiHs.465506.

Genome annotation databases

EnsembliENST00000269812; ENSP00000269812; ENSG00000141934. [O43688-3]
ENST00000327790; ENSP00000329697; ENSG00000141934. [O43688-2]
ENST00000434325; ENSP00000388565; ENSG00000141934. [O43688-1]
GeneIDi8612.
KEGGihsa:8612.
UCSCiuc002loh.5. human. [O43688-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035959 mRNA. Translation: AAC15968.1.
AF047760 mRNA. Translation: AAC32104.1.
AF056083 mRNA. Translation: AAC25666.1.
BT007021 mRNA. Translation: AAP35667.1.
AC016588 Genomic DNA. No translation available.
BC002806 mRNA. Translation: AAH02806.1.
CCDSiCCDS12023.1. [O43688-1]
CCDS12024.1. [O43688-2]
CCDS45889.1. [O43688-3]
RefSeqiNP_003703.1. NM_003712.3. [O43688-1]
NP_803545.1. NM_177526.2. [O43688-3]
NP_808211.1. NM_177543.2. [O43688-2]
UniGeneiHs.465506.

3D structure databases

ProteinModelPortaliO43688.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114170. 5 interactions.
IntActiO43688. 6 interactions.
MINTiMINT-1372912.
STRINGi9606.ENSP00000329697.

PTM databases

DEPODiO43688.
iPTMnetiO43688.
PhosphoSiteiO43688.

Polymorphism and mutation databases

BioMutaiPPAP2C.

Proteomic databases

MaxQBiO43688.
PaxDbiO43688.
PeptideAtlasiO43688.
PRIDEiO43688.

Protocols and materials databases

DNASUi8612.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269812; ENSP00000269812; ENSG00000141934. [O43688-3]
ENST00000327790; ENSP00000329697; ENSG00000141934. [O43688-2]
ENST00000434325; ENSP00000388565; ENSG00000141934. [O43688-1]
GeneIDi8612.
KEGGihsa:8612.
UCSCiuc002loh.5. human. [O43688-1]

Organism-specific databases

CTDi8612.
GeneCardsiPPAP2C.
HGNCiHGNC:9230. PLPP2.
HPAiHPA055540.
MIMi607126. gene.
neXtProtiNX_O43688.
PharmGKBiPA33554.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3030. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000041307.
HOVERGENiHBG002048.
InParanoidiO43688.
KOiK01080.
OMAiNCSIYVQ.
OrthoDBiEOG7C5M9Q.
PhylomeDBiO43688.
TreeFamiTF316040.

Enzyme and pathway databases

ReactomeiR-HSA-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

GeneWikiiPhosphatidic_acid_phosphatase_2c.
GenomeRNAii8612.
PROiO43688.
SOURCEiSearch...

Gene expression databases

BgeeiO43688.
CleanExiHS_PPAP2C.
ExpressionAtlasiO43688. baseline and differential.
GenevisibleiO43688. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028674. LPP2.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF25. PTHR10165:SF25. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells."
    Leung D.W., Tompkins C.K., White T.
    DNA Cell Biol. 17:377-385(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform."
    Roberts R., Sciorra V.A., Morris A.J.
    J. Biol. Chem. 273:22059-22067(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
  3. "Identification of a novel human phosphatidic acid phosphatase type 2 isoform."
    Hooks S.B., Ragan S.P., Lynch K.R.
    FEBS Lett. 427:188-192(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary.

Entry informationi

Entry nameiPLPP2_HUMAN
AccessioniPrimary (citable) accession number: O43688
Secondary accession number(s): A6NLV0, E9PAY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.