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Reviewed, UniProtKB/Swiss-Prot O43688 (LPP2_HUMAN)

Last modified October 13, 2009. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Lipid phosphate phosphohydrolase 2
    EC=3.1.3.4
Alternative name(s):
    Phosphatidic acid phosphatase 2c
      Short name=PAP-2c
      Short name=PAP2c
    Phosphatidate phosphohydrolase type 2c
    PAP2-gamma
      Short name=PAP2-G
Gene names
Name: PPAP2C
Synonyms: LPP2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.

Catalytic activity

A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

Enzyme regulation

Inhibited by sphingosine, zinc ions and propanolol.

Subunit structure

Homodimer By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Found mainly in brain, pancreas and placenta.

Sequence similarities

Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytosol

Inferred from Experiment. Source: Reactome

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionphosphatidate phosphatase activity Ref.2

Inferred from Experiment. Source: Reactome

phosphoprotein phosphatase activity Ref.3

Traceable author statement. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O43688-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O43688-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MQRRWVFVLLDVLCLLV → MGVARGPGSRGQHPPPRQQEVCAEGPRARLHPAPPGLG
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Lipid phosphate phosphohydrolase 2
PRO_0000220909

Regions

Transmembrane5 – 2521 Potential
Transmembrane52 – 7221 Potential
Transmembrane88 – 10821 Potential
Transmembrane163 – 18321 Potential
Transmembrane197 – 21721 Potential
Transmembrane227 – 24721 Potential

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 1717MQRRW…LCLLV → MGVARGPGSRGQHPPPRQQE VCAEGPRARLHPAPPGLG in isoform 2.
VSP_037765

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: F7C6A09A28DA9AC8

FASTA28832,574
        10         20         30         40         50         60 
MQRRWVFVLL DVLCLLVASL PFAILTLVNA PYKRGFYCGD DSIRYPYRPD TITHGLMAGV 

        70         80         90        100        110        120 
TITATVILVS AGEAYLVYTD RLYSRSDFNN YVAAVYKVLG TFLFGAAVSQ SLTDLAKYMI 

       130        140        150        160        170        180 
GRLRPNFLAV CDPDWSRVNC SVYVQLEKVC RGNPADVTEA RLSFYSGHSS FGMYCMVFLA 

       190        200        210        220        230        240 
LYVQARLCWK WARLLRPTVQ FFLVAFALYV GYTRVSDYKH HWSDVLVGLL QGALVAALTV 

       250        260        270        280 
CYISDFFKAR PPQHCLKEEE LERKPSLSLT LTLGEADHNH YGYPHSSS 

« Hide

Isoform 2.

Checksum: 18E2A8A78FEB815A
Show »

FASTA30934,393

References

« Hide 'large scale' references
[1]"Molecular cloning of two alternatively spliced forms of human phosphatidic acid phosphatase cDNAs that are differentially expressed in normal and tumor cells."
Leung D.W., Tompkins C.K., White T.
DNA Cell Biol. 17:377-385(1998) [PubMed: 9570154] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform."
Roberts R., Sciorra V.A., Morris A.J.
J. Biol. Chem. 273:22059-22067(1998) [PubMed: 9705349] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
[3]"Identification of a novel human phosphatidic acid phosphatase type 2 isoform."
Hooks S.B., Ragan S.P., Lynch K.R.
FEBS Lett. 427:188-192(1998) [PubMed: 9607309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed: 15057824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF035959 mRNA. Translation: AAC15968.1.
AF047760 mRNA. Translation: AAC32104.1.
AF056083 mRNA. Translation: AAC25666.1.
BT007021 mRNA. Translation: AAP35667.1.
AC016588 Genomic DNA. No translation available.
BC002806 mRNA. Translation: AAH02806.1.
IPIIPI00216620.
IPI00334058.
RefSeqNP_003703.1.
NP_803545.1.
NP_808211.1.
UniGeneHs.465506

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActO43688. 2 interactions.
STRINGO43688.

PTM databases

PhosphoSiteO43688.

Proteomic databases

PRIDEO43688.

Genome annotation databases

EnsemblENST00000269812; ENSP00000269812; ENSG00000141934; Homo sapiens. [Genome view]
ENST00000327790; ENSP00000329697; ENSG00000141934; Homo sapiens. [Genome view]
ENST00000434325; ENSP00000388565; ENSG00000141934; Homo sapiens. [Genome view]
GeneID8612.
KEGGhsa:8612.
UCSCuc002loh.1. human.
uc002loi.1. human.

Organism-specific databases

CTD8612.
GeneCardsGC19M000232.
H-InvDBHIX0014548.
HGNCHGNC:9230. PPAP2C.
MIM607126. gene.
PharmGKBPA33554.
GenAtlasSearch...

Phylogenomic databases

HOVERGENO43688.

Enzyme and pathway databases

BRENDA3.1.3.4. 247.
ReactomeREACT_602. Metabolism of lipids and lipoproteins.

Gene expression databases

ArrayExpressO43688.
BgeeO43688.
CleanExHS_PPAP2C.
GenevestigatorO43688.
GermOnlineENSG00000141934. Homo sapiens.

Family and domain databases

InterProIPR016118. P_Acid_Pase/Cl_peroxidase_N.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
Gene3DG3DSA:1.20.144.10. P_Acid_Pase/Cl_peroxidase_N. 1 hit.
PfamPF01569. PAP2. 1 hit.
[Graphical view]
SMARTSM00014. acidPPc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio32269.
SOURCESearch...

Entry information

Entry nameLPP2_HUMAN
AccessionPrimary (citable) accession number: O43688
Secondary accession number(s): A6NLV0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 1998
Last modified: October 13, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents