ID   AKA7A_HUMAN             Reviewed;         104 AA.
AC   O43687; Q5TBR9; Q5TBS0; Q9HCZ8; Q9P0G4;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 4.
DT   04-NOV-2008, entry version 65.
DE   RecName: Full=A-kinase anchor protein 7 isoforms alpha and beta;
DE   AltName: Full=Protein kinase A-anchoring protein 7 isoforms alpha/beta;
DE   AltName: Full=A-kinase anchor protein 18;
GN   Name=AKAP7; Synonyms=AKAP18;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), FUNCTION, SUBCELLULAR
RP   LOCATION, TISSUE SPECIFICITY, MYRISTOYLATION AT GLY-2, AND
RP   PALMITOYLATION AT CYS-5 AND CYS-6.
RC   TISSUE=Brain;
RX   MEDLINE=98211936; PubMed=9545239; DOI=10.1093/emboj/17.8.2261;
RA   Fraser I.D.C., Tavalin S.J., Lester L.B., Langeberg L.K.,
RA   Westphal A.M., Dean R.A., Marrion N.V., Scott J.D.;
RT   "A novel lipid-anchored A-kinase anchoring protein facilitates cAMP-
RT   responsive membrane events.";
RL   EMBO J. 17:2261-2272(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA), FUNCTION, AND SUBCELLULAR
RP   LOCATION.
RC   TISSUE=Lung;
RX   MEDLINE=20082886; PubMed=10613906; DOI=10.1083/jcb.147.7.1481;
RA   Trotter K.W., Fraser I.D.C., Scott G.K., Stutts M.J., Scott J.D.,
RA   Milgram S.L.;
RT   "Alternative splicing regulates the subcellular localization of A-
RT   kinase anchoring protein 18 isoforms.";
RL   J. Cell Biol. 147:1481-1492(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22935763; PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
RC   TISSUE=Adrenal cortex, Hippocampus, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Targets the cAMP-dependent protein kinase (PKA) to the
CC       plasma membrane, and permits functional coupling to the L-type
CC       calcium channel.
CC   -!- SUBUNIT: Binds cAMP-dependent protein kinase (PKA).
CC   -!- SUBCELLULAR LOCATION: Isoform Alpha: Lateral cell membrane; Lipid-
CC       anchor. Note=Targeted predominantly to the lateral membrane.
CC   -!- SUBCELLULAR LOCATION: Isoform Beta: Apical cell membrane; Lipid-
CC       anchor. Note=Targeted predominantly to the apical membrane.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC         Comment=Additional isoforms seem to exist;
CC       Name=Beta;
CC         IsoId=O43687-1; Sequence=Displayed;
CC       Name=Alpha;
CC         IsoId=O43687-2; Sequence=VSP_004101;
CC       Name=Gamma;
CC         IsoId=Q9P0M2-1; Sequence=External;
CC   -!- TISSUE SPECIFICITY: Expressed in brain, heart, lung, pancreas and
CC       skeletal muscle.
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DR   EMBL; AF047715; AAC39715.1; -; mRNA.
DR   EMBL; AF161075; AAF26676.1; -; mRNA.
DR   EMBL; AL136110; CAI21507.1; -; Genomic_DNA.
DR   EMBL; AL137063; CAI21507.1; JOINED; Genomic_DNA.
DR   EMBL; AL136110; CAI21508.1; -; Genomic_DNA.
DR   EMBL; AL137063; CAI21508.1; JOINED; Genomic_DNA.
DR   EMBL; AL137063; CAI19001.1; -; Genomic_DNA.
DR   EMBL; AL136110; CAI19001.1; JOINED; Genomic_DNA.
DR   EMBL; AL137063; CAI19002.1; -; Genomic_DNA.
DR   EMBL; AL136110; CAI19002.1; JOINED; Genomic_DNA.
DR   EMBL; BC016927; AAH16927.1; -; mRNA.
DR   EMBL; BC073847; AAH73847.1; -; mRNA.
DR   EMBL; BC094732; AAH94732.1; -; mRNA.
DR   RefSeq; NP_004833.1; -.
DR   RefSeq; NP_619539.1; -.
DR   UniGene; Hs.486483; -.
DR   Ensembl; ENSG00000118507; Homo sapiens.
DR   GeneID; 9465; -.
DR   KEGG; hsa:9465; -.
DR   HGNC; HGNC:377; AKAP7.
DR   MIM; 604693; gene.
DR   PharmGKB; PA24671; -.
DR   HOVERGEN; O43687; -.
DR   NextBio; 35464; -.
DR   ArrayExpress; O43687; -.
DR   CleanEx; HS_AKAP7; -.
DR   GermOnline; ENSG00000118507; Homo sapiens.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
DR   GO; GO:0016328; C:lateral plasma membrane; IDA:UniProtKB.
DR   GO; GO:0051018; F:protein kinase A binding; IDA:UniProtKB.
DR   GO; GO:0007242; P:intracellular signaling cascade; TAS:UniProtKB.
DR   GO; GO:0006811; P:ion transport; TAS:ProtInc.
DR   GO; GO:0008104; P:protein localization; IC:UniProtKB.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Lipoprotein; Membrane; Myristate;
KW   Palmitate.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    104       A-kinase anchor protein 7 isoforms alpha
FT                                and beta.
FT                                /FTId=PRO_0000064522.
FT   REGION        2     11       Required for membrane localization.
FT   REGION       18     40       Required for apical membrane
FT                                localization.
FT   REGION       52     65       RII-binding.
FT   LIPID         2      2       N-myristoyl glycine.
FT   LIPID         5      5       S-palmitoyl cysteine.
FT   LIPID         6      6       S-palmitoyl cysteine.
FT   VAR_SEQ      18     40       Missing (in isoform Alpha).
FT                                /FTId=VSP_004101.
SQ   SEQUENCE   104 AA;  11465 MW;  6F84ED8E032AF954 CRC64;
     MGQLCCFPFS RDEGKISELE SSSSAVLQRY SKDIPSWSSG EKNGGEPDDA ELVRLSKRLV
     ENAVLKAVQQ YLEETQNKNK PGEGSSVKTE AADQNGNDNE NNRK
//