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Protein

Transcription factor 21

Gene

TCF21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118526-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 21
Short name:
TCF-21
Alternative name(s):
Capsulin
Class A basic helix-loop-helix protein 23
Short name:
bHLHa23
Epicardin
Podocyte-expressed 1
Short name:
Pod-1
Gene namesi
Name:TCF21
Synonyms:BHLHA23, POD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:11632. TCF21.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6943.
OpenTargetsiENSG00000118526.
PharmGKBiPA36387.

Polymorphism and mutation databases

BioMutaiTCF21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274641 – 179Transcription factor 21Add BLAST179

Proteomic databases

PaxDbiO43680.
PeptideAtlasiO43680.
PRIDEiO43680.

PTM databases

iPTMnetiO43680.
PhosphoSitePlusiO43680.

Expressioni

Gene expression databases

BgeeiENSG00000118526.
CleanExiHS_TCF21.
GenevisibleiO43680. HS.

Organism-specific databases

HPAiHPA013189.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and binds the E box (5'-CANNTG-3').

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112803. 9 interactors.
IntActiO43680. 9 interactors.
MINTiMINT-1180543.
STRINGi9606.ENSP00000237316.

Structurei

3D structure databases

ProteinModelPortaliO43680.
SMRiO43680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 131bHLHPROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00710000106684.
HOGENOMiHOG000261670.
HOVERGENiHBG105298.
InParanoidiO43680.
OMAiNESTEEG.
OrthoDBiEOG091G0N6P.
PhylomeDBiO43680.
TreeFamiTF350742.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGSLSDVE DLQEVEMLEC DGLKMDSNKE FVTSNESTEE SSNCENGSPQ
60 70 80 90 100
KGRGGLGKRR KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS
110 120 130 140 150
RLKTTLPWVP PDTKLSKLDT LRLASSYIAH LRQILANDKY ENGYIHPVNL
160 170
TWPFMVAGKP ESDLKEVVTA SRLCGTTAS
Length:179
Mass (Da):19,715
Last modified:August 14, 2001 - v2
Checksum:iA26F496C536B6F04
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61K → R in AAC62514 (PubMed:10572052).Curated1
Sequence conflicti83A → T in AAC62532 (PubMed:9733105).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047419 mRNA. Translation: AAC62532.1.
AF035718 mRNA. Translation: AAC62514.1.
BT019660 mRNA. Translation: AAV38466.1.
CR450293 mRNA. Translation: CAG29289.1.
AL356109 Genomic DNA. Translation: CAC26822.1.
CH471051 Genomic DNA. Translation: EAW48000.1.
CH471051 Genomic DNA. Translation: EAW48001.1.
BC025697 mRNA. Translation: AAH25697.1.
CCDSiCCDS5167.1.
RefSeqiNP_003197.2. NM_003206.3.
NP_938206.1. NM_198392.2.
UniGeneiHs.78061.

Genome annotation databases

EnsembliENST00000237316; ENSP00000237316; ENSG00000118526.
ENST00000367882; ENSP00000356857; ENSG00000118526.
GeneIDi6943.
KEGGihsa:6943.
UCSCiuc003qei.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047419 mRNA. Translation: AAC62532.1.
AF035718 mRNA. Translation: AAC62514.1.
BT019660 mRNA. Translation: AAV38466.1.
CR450293 mRNA. Translation: CAG29289.1.
AL356109 Genomic DNA. Translation: CAC26822.1.
CH471051 Genomic DNA. Translation: EAW48000.1.
CH471051 Genomic DNA. Translation: EAW48001.1.
BC025697 mRNA. Translation: AAH25697.1.
CCDSiCCDS5167.1.
RefSeqiNP_003197.2. NM_003206.3.
NP_938206.1. NM_198392.2.
UniGeneiHs.78061.

3D structure databases

ProteinModelPortaliO43680.
SMRiO43680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112803. 9 interactors.
IntActiO43680. 9 interactors.
MINTiMINT-1180543.
STRINGi9606.ENSP00000237316.

PTM databases

iPTMnetiO43680.
PhosphoSitePlusiO43680.

Polymorphism and mutation databases

BioMutaiTCF21.

Proteomic databases

PaxDbiO43680.
PeptideAtlasiO43680.
PRIDEiO43680.

Protocols and materials databases

DNASUi6943.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237316; ENSP00000237316; ENSG00000118526.
ENST00000367882; ENSP00000356857; ENSG00000118526.
GeneIDi6943.
KEGGihsa:6943.
UCSCiuc003qei.5. human.

Organism-specific databases

CTDi6943.
DisGeNETi6943.
GeneCardsiTCF21.
HGNCiHGNC:11632. TCF21.
HPAiHPA013189.
MIMi603306. gene.
neXtProtiNX_O43680.
OpenTargetsiENSG00000118526.
PharmGKBiPA36387.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00710000106684.
HOGENOMiHOG000261670.
HOVERGENiHBG105298.
InParanoidiO43680.
OMAiNESTEEG.
OrthoDBiEOG091G0N6P.
PhylomeDBiO43680.
TreeFamiTF350742.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118526-MONOMER.

Miscellaneous databases

GeneWikiiTCF21_(gene).
GenomeRNAii6943.
PROiO43680.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118526.
CleanExiHS_TCF21.
GenevisibleiO43680. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCF21_HUMAN
AccessioniPrimary (citable) accession number: O43680
Secondary accession number(s): E1P581
, O43545, Q6ICV0, Q9BZ14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: November 30, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.