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O43680

- TCF21_HUMAN

UniProt

O43680 - TCF21_HUMAN

Protein

Transcription factor 21

Gene

TCF21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

    GO - Molecular functioni

    1. androgen receptor binding Source: BHF-UCL
    2. bHLH transcription factor binding Source: UniProtKB
    3. E-box binding Source: BHF-UCL
    4. protein dimerization activity Source: UniProtKB
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
    6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB

    GO - Biological processi

    1. branching involved in ureteric bud morphogenesis Source: BHF-UCL
    2. branchiomeric skeletal muscle development Source: UniProtKB
    3. bronchiole development Source: UniProtKB
    4. diaphragm development Source: UniProtKB
    5. embryonic digestive tract morphogenesis Source: UniProtKB
    6. epithelial cell differentiation Source: UniProtKB
    7. gland development Source: UniProtKB
    8. glomerulus development Source: UniProtKB
    9. kidney development Source: BHF-UCL
    10. lung alveolus development Source: UniProtKB
    11. lung morphogenesis Source: UniProtKB
    12. lung vasculature development Source: UniProtKB
    13. metanephric glomerular capillary formation Source: UniProtKB
    14. metanephric mesenchymal cell differentiation Source: UniProtKB
    15. morphogenesis of a branching structure Source: BHF-UCL
    16. negative regulation of androgen receptor signaling pathway Source: BHF-UCL
    17. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    18. palate development Source: UniProtKB
    19. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    20. reproductive structure development Source: UniProtKB
    21. respiratory system development Source: UniProtKB
    22. Sertoli cell differentiation Source: UniProtKB
    23. sex determination Source: UniProtKB
    24. spleen development Source: UniProtKB
    25. ureteric bud development Source: BHF-UCL
    26. vasculature development Source: BHF-UCL

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor 21
    Short name:
    TCF-21
    Alternative name(s):
    Capsulin
    Class A basic helix-loop-helix protein 23
    Short name:
    bHLHa23
    Epicardin
    Podocyte-expressed 1
    Short name:
    Pod-1
    Gene namesi
    Name:TCF21
    Synonyms:BHLHA23, POD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:11632. TCF21.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36387.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 179179Transcription factor 21PRO_0000127464Add
    BLAST

    Proteomic databases

    PaxDbiO43680.
    PRIDEiO43680.

    PTM databases

    PhosphoSiteiO43680.

    Expressioni

    Gene expression databases

    BgeeiO43680.
    CleanExiHS_TCF21.
    GenevestigatoriO43680.

    Organism-specific databases

    HPAiHPA013189.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and binds the E box (5'-CANNTG-3').

    Protein-protein interaction databases

    BioGridi112803. 9 interactions.
    IntActiO43680. 7 interactions.
    MINTiMINT-1180543.
    STRINGi9606.ENSP00000237316.

    Structurei

    3D structure databases

    ProteinModelPortaliO43680.
    SMRiO43680. Positions 80-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini79 – 13153bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG235686.
    HOGENOMiHOG000261670.
    HOVERGENiHBG105298.
    InParanoidiO43680.
    OMAiESSNCET.
    OrthoDBiEOG7J181B.
    PhylomeDBiO43680.
    TreeFamiTF350742.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43680-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTGSLSDVE DLQEVEMLEC DGLKMDSNKE FVTSNESTEE SSNCENGSPQ    50
    KGRGGLGKRR KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS 100
    RLKTTLPWVP PDTKLSKLDT LRLASSYIAH LRQILANDKY ENGYIHPVNL 150
    TWPFMVAGKP ESDLKEVVTA SRLCGTTAS 179
    Length:179
    Mass (Da):19,715
    Last modified:August 14, 2001 - v2
    Checksum:iA26F496C536B6F04
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611K → R in AAC62514. (PubMed:10572052)Curated
    Sequence conflicti83 – 831A → T in AAC62532. (PubMed:9733105)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047419 mRNA. Translation: AAC62532.1.
    AF035718 mRNA. Translation: AAC62514.1.
    BT019660 mRNA. Translation: AAV38466.1.
    CR450293 mRNA. Translation: CAG29289.1.
    AL356109 Genomic DNA. Translation: CAC26822.1.
    CH471051 Genomic DNA. Translation: EAW48000.1.
    CH471051 Genomic DNA. Translation: EAW48001.1.
    BC025697 mRNA. Translation: AAH25697.1.
    CCDSiCCDS5167.1.
    RefSeqiNP_003197.2. NM_003206.3.
    NP_938206.1. NM_198392.2.
    UniGeneiHs.78061.

    Genome annotation databases

    EnsembliENST00000237316; ENSP00000237316; ENSG00000118526.
    ENST00000367882; ENSP00000356857; ENSG00000118526.
    GeneIDi6943.
    KEGGihsa:6943.
    UCSCiuc003qei.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047419 mRNA. Translation: AAC62532.1 .
    AF035718 mRNA. Translation: AAC62514.1 .
    BT019660 mRNA. Translation: AAV38466.1 .
    CR450293 mRNA. Translation: CAG29289.1 .
    AL356109 Genomic DNA. Translation: CAC26822.1 .
    CH471051 Genomic DNA. Translation: EAW48000.1 .
    CH471051 Genomic DNA. Translation: EAW48001.1 .
    BC025697 mRNA. Translation: AAH25697.1 .
    CCDSi CCDS5167.1.
    RefSeqi NP_003197.2. NM_003206.3.
    NP_938206.1. NM_198392.2.
    UniGenei Hs.78061.

    3D structure databases

    ProteinModelPortali O43680.
    SMRi O43680. Positions 80-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112803. 9 interactions.
    IntActi O43680. 7 interactions.
    MINTi MINT-1180543.
    STRINGi 9606.ENSP00000237316.

    PTM databases

    PhosphoSitei O43680.

    Proteomic databases

    PaxDbi O43680.
    PRIDEi O43680.

    Protocols and materials databases

    DNASUi 6943.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000237316 ; ENSP00000237316 ; ENSG00000118526 .
    ENST00000367882 ; ENSP00000356857 ; ENSG00000118526 .
    GeneIDi 6943.
    KEGGi hsa:6943.
    UCSCi uc003qei.4. human.

    Organism-specific databases

    CTDi 6943.
    GeneCardsi GC06P134251.
    HGNCi HGNC:11632. TCF21.
    HPAi HPA013189.
    MIMi 603306. gene.
    neXtProti NX_O43680.
    PharmGKBi PA36387.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG235686.
    HOGENOMi HOG000261670.
    HOVERGENi HBG105298.
    InParanoidi O43680.
    OMAi ESSNCET.
    OrthoDBi EOG7J181B.
    PhylomeDBi O43680.
    TreeFami TF350742.

    Miscellaneous databases

    GeneWikii TCF21_(gene).
    GenomeRNAii 6943.
    NextBioi 27179.
    PROi O43680.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43680.
    CleanExi HS_TCF21.
    Genevestigatori O43680.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Epicardin: a novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads."
      Robb L., Mifsud L., Hartley L., Biben C., Copeland N.G., Gilbert D.J., Jenkins N.A., Harvey R.P.
      Dev. Dyn. 213:105-113(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis."
      Quaggin S.E., Schwartz L., Cui S., Igarashi P., Deimling J., Post M., Rossant J.
      Development 126:5771-5783(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiTCF21_HUMAN
    AccessioniPrimary (citable) accession number: O43680
    Secondary accession number(s): E1P581
    , O43545, Q6ICV0, Q9BZ14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3