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Protein

Transcription factor 21

Gene

TCF21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 21
Short name:
TCF-21
Alternative name(s):
Capsulin
Class A basic helix-loop-helix protein 23
Short name:
bHLHa23
Epicardin
Podocyte-expressed 1
Short name:
Pod-1
Gene namesi
Name:TCF21
Synonyms:BHLHA23, POD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000118526.6
HGNCiHGNC:11632 TCF21
MIMi603306 gene
neXtProtiNX_O43680

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6943
OpenTargetsiENSG00000118526
PharmGKBiPA36387

Polymorphism and mutation databases

BioMutaiTCF21

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274641 – 179Transcription factor 21Add BLAST179

Proteomic databases

PaxDbiO43680
PeptideAtlasiO43680
PRIDEiO43680

PTM databases

iPTMnetiO43680
PhosphoSitePlusiO43680

Expressioni

Gene expression databases

BgeeiENSG00000118526
CleanExiHS_TCF21
GenevisibleiO43680 HS

Organism-specific databases

HPAiHPA013189

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and binds the E box (5'-CANNTG-3').

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112803, 9 interactors
IntActiO43680, 10 interactors
MINTiO43680
STRINGi9606.ENSP00000237316

Structurei

3D structure databases

ProteinModelPortaliO43680
SMRiO43680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 131bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00710000106684
HOGENOMiHOG000261670
HOVERGENiHBG105298
InParanoidiO43680
OMAiSSNCEGA
OrthoDBiEOG091G0N6P
PhylomeDBiO43680
TreeFamiTF350742

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

O43680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGSLSDVE DLQEVEMLEC DGLKMDSNKE FVTSNESTEE SSNCENGSPQ
60 70 80 90 100
KGRGGLGKRR KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS
110 120 130 140 150
RLKTTLPWVP PDTKLSKLDT LRLASSYIAH LRQILANDKY ENGYIHPVNL
160 170
TWPFMVAGKP ESDLKEVVTA SRLCGTTAS
Length:179
Mass (Da):19,715
Last modified:August 14, 2001 - v2
Checksum:iA26F496C536B6F04
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61K → R in AAC62514 (PubMed:10572052).Curated1
Sequence conflicti83A → T in AAC62532 (PubMed:9733105).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047419 mRNA Translation: AAC62532.1
AF035718 mRNA Translation: AAC62514.1
BT019660 mRNA Translation: AAV38466.1
CR450293 mRNA Translation: CAG29289.1
AL356109 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48000.1
CH471051 Genomic DNA Translation: EAW48001.1
BC025697 mRNA Translation: AAH25697.1
CCDSiCCDS5167.1
RefSeqiNP_003197.2, NM_003206.3
NP_938206.1, NM_198392.2
UniGeneiHs.78061

Genome annotation databases

EnsembliENST00000237316; ENSP00000237316; ENSG00000118526
ENST00000367882; ENSP00000356857; ENSG00000118526
GeneIDi6943
KEGGihsa:6943
UCSCiuc003qei.5 human

Similar proteinsi

Entry informationi

Entry nameiTCF21_HUMAN
AccessioniPrimary (citable) accession number: O43680
Secondary accession number(s): E1P581
, O43545, Q6ICV0, Q9BZ14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: March 28, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health