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O43680

- TCF21_HUMAN

UniProt

O43680 - TCF21_HUMAN

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Protein

Transcription factor 21

Gene

TCF21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.

GO - Molecular functioni

  1. androgen receptor binding Source: BHF-UCL
  2. bHLH transcription factor binding Source: UniProtKB
  3. E-box binding Source: BHF-UCL
  4. protein dimerization activity Source: UniProtKB
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: UniProtKB
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: UniProtKB

GO - Biological processi

  1. branching involved in ureteric bud morphogenesis Source: BHF-UCL
  2. branchiomeric skeletal muscle development Source: UniProtKB
  3. bronchiole development Source: UniProtKB
  4. diaphragm development Source: UniProtKB
  5. embryonic digestive tract morphogenesis Source: UniProtKB
  6. epithelial cell differentiation Source: UniProtKB
  7. gland development Source: UniProtKB
  8. glomerulus development Source: UniProtKB
  9. kidney development Source: BHF-UCL
  10. lung alveolus development Source: UniProtKB
  11. lung morphogenesis Source: UniProtKB
  12. lung vasculature development Source: UniProtKB
  13. metanephric glomerular capillary formation Source: UniProtKB
  14. metanephric mesenchymal cell differentiation Source: UniProtKB
  15. morphogenesis of a branching structure Source: BHF-UCL
  16. negative regulation of androgen receptor signaling pathway Source: BHF-UCL
  17. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  18. palate development Source: UniProtKB
  19. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  20. reproductive structure development Source: UniProtKB
  21. respiratory system development Source: UniProtKB
  22. Sertoli cell differentiation Source: UniProtKB
  23. sex determination Source: UniProtKB
  24. spleen development Source: UniProtKB
  25. ureteric bud development Source: BHF-UCL
  26. vasculature development Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 21
Short name:
TCF-21
Alternative name(s):
Capsulin
Class A basic helix-loop-helix protein 23
Short name:
bHLHa23
Epicardin
Podocyte-expressed 1
Short name:
Pod-1
Gene namesi
Name:TCF21
Synonyms:BHLHA23, POD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:11632. TCF21.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 179179Transcription factor 21PRO_0000127464Add
BLAST

Proteomic databases

PaxDbiO43680.
PRIDEiO43680.

PTM databases

PhosphoSiteiO43680.

Expressioni

Gene expression databases

BgeeiO43680.
CleanExiHS_TCF21.
GenevestigatoriO43680.

Organism-specific databases

HPAiHPA013189.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and binds the E box (5'-CANNTG-3').

Protein-protein interaction databases

BioGridi112803. 9 interactions.
IntActiO43680. 7 interactions.
MINTiMINT-1180543.
STRINGi9606.ENSP00000237316.

Structurei

3D structure databases

ProteinModelPortaliO43680.
SMRiO43680. Positions 80-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 13153bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG235686.
GeneTreeiENSGT00710000106684.
HOGENOMiHOG000261670.
HOVERGENiHBG105298.
InParanoidiO43680.
OMAiESSNCET.
OrthoDBiEOG7J181B.
PhylomeDBiO43680.
TreeFamiTF350742.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43680-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTGSLSDVE DLQEVEMLEC DGLKMDSNKE FVTSNESTEE SSNCENGSPQ
60 70 80 90 100
KGRGGLGKRR KAPTKKSPLS GVSQEGKQVQ RNAANARERA RMRVLSKAFS
110 120 130 140 150
RLKTTLPWVP PDTKLSKLDT LRLASSYIAH LRQILANDKY ENGYIHPVNL
160 170
TWPFMVAGKP ESDLKEVVTA SRLCGTTAS
Length:179
Mass (Da):19,715
Last modified:August 14, 2001 - v2
Checksum:iA26F496C536B6F04
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611K → R in AAC62514. (PubMed:10572052)Curated
Sequence conflicti83 – 831A → T in AAC62532. (PubMed:9733105)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047419 mRNA. Translation: AAC62532.1.
AF035718 mRNA. Translation: AAC62514.1.
BT019660 mRNA. Translation: AAV38466.1.
CR450293 mRNA. Translation: CAG29289.1.
AL356109 Genomic DNA. Translation: CAC26822.1.
CH471051 Genomic DNA. Translation: EAW48000.1.
CH471051 Genomic DNA. Translation: EAW48001.1.
BC025697 mRNA. Translation: AAH25697.1.
CCDSiCCDS5167.1.
RefSeqiNP_003197.2. NM_003206.3.
NP_938206.1. NM_198392.2.
UniGeneiHs.78061.

Genome annotation databases

EnsembliENST00000237316; ENSP00000237316; ENSG00000118526.
ENST00000367882; ENSP00000356857; ENSG00000118526.
GeneIDi6943.
KEGGihsa:6943.
UCSCiuc003qei.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047419 mRNA. Translation: AAC62532.1 .
AF035718 mRNA. Translation: AAC62514.1 .
BT019660 mRNA. Translation: AAV38466.1 .
CR450293 mRNA. Translation: CAG29289.1 .
AL356109 Genomic DNA. Translation: CAC26822.1 .
CH471051 Genomic DNA. Translation: EAW48000.1 .
CH471051 Genomic DNA. Translation: EAW48001.1 .
BC025697 mRNA. Translation: AAH25697.1 .
CCDSi CCDS5167.1.
RefSeqi NP_003197.2. NM_003206.3.
NP_938206.1. NM_198392.2.
UniGenei Hs.78061.

3D structure databases

ProteinModelPortali O43680.
SMRi O43680. Positions 80-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112803. 9 interactions.
IntActi O43680. 7 interactions.
MINTi MINT-1180543.
STRINGi 9606.ENSP00000237316.

PTM databases

PhosphoSitei O43680.

Proteomic databases

PaxDbi O43680.
PRIDEi O43680.

Protocols and materials databases

DNASUi 6943.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000237316 ; ENSP00000237316 ; ENSG00000118526 .
ENST00000367882 ; ENSP00000356857 ; ENSG00000118526 .
GeneIDi 6943.
KEGGi hsa:6943.
UCSCi uc003qei.4. human.

Organism-specific databases

CTDi 6943.
GeneCardsi GC06P134251.
HGNCi HGNC:11632. TCF21.
HPAi HPA013189.
MIMi 603306. gene.
neXtProti NX_O43680.
PharmGKBi PA36387.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG235686.
GeneTreei ENSGT00710000106684.
HOGENOMi HOG000261670.
HOVERGENi HBG105298.
InParanoidi O43680.
OMAi ESSNCET.
OrthoDBi EOG7J181B.
PhylomeDBi O43680.
TreeFami TF350742.

Miscellaneous databases

GeneWikii TCF21_(gene).
GenomeRNAii 6943.
NextBioi 27179.
PROi O43680.
SOURCEi Search...

Gene expression databases

Bgeei O43680.
CleanExi HS_TCF21.
Genevestigatori O43680.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Epicardin: a novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads."
    Robb L., Mifsud L., Hartley L., Biben C., Copeland N.G., Gilbert D.J., Jenkins N.A., Harvey R.P.
    Dev. Dyn. 213:105-113(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis."
    Quaggin S.E., Schwartz L., Cui S., Igarashi P., Deimling J., Post M., Rossant J.
    Development 126:5771-5783(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiTCF21_HUMAN
AccessioniPrimary (citable) accession number: O43680
Secondary accession number(s): E1P581
, O43545, Q6ICV0, Q9BZ14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3