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O43677 (NDUC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Alternative name(s):
Complex I-KFYI
Short name=CI-KFYI
NADH-ubiquinone oxidoreductase KFYI subunit
Gene names
Name:NDUFC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length76 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subunit structure

Complex I is composed of 45 different subunits.

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Sequence similarities

Belongs to the complex I NDUFC1 subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2727Mitochondrion By similarity
Chain28 – 7649NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
PRO_0000020049

Regions

Transmembrane41 – 5919Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O43677 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 7EEDEDE477E12B5E

FASTA768,734
        10         20         30         40         50         60 
MAPSALLRPL SRLLAPARLP SGPSVRSKFY VREPPNAKPD WLKVGFTLGT TVFLWIYLIK 

        70 
QHNEDILEYK RRNGLE 

« Hide

References

« Hide 'large scale' references
[1]"Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits."
Ton C., Hwang D.M., Dempsey A.A., Liew C.-C.
Biochem. Biophys. Res. Commun. 241:589-594(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF047184 mRNA. Translation: AAC04269.1.
AF047435 mRNA. Translation: AAC39886.1.
AK291147 mRNA. Translation: BAF83836.1.
CH471056 Genomic DNA. Translation: EAX05121.1.
BC101798 mRNA. Translation: AAI01799.1.
BC107682 mRNA. Translation: AAI07683.1.
BC112061 mRNA. Translation: AAI12062.1.
PIRJC5823.
RefSeqNP_001171915.1. NM_001184986.1.
NP_001171916.1. NM_001184987.1.
NP_001171917.1. NM_001184988.1.
NP_001171918.1. NM_001184989.1.
NP_001171919.1. NM_001184990.1.
NP_001171920.1. NM_001184991.1.
NP_002485.1. NM_002494.3.
UniGeneHs.84549.

3D structure databases

ProteinModelPortalO43677.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000265500.

Chemistry

ChEMBLCHEMBL2363065.
DrugBankDB00157. NADH.

Proteomic databases

PaxDbO43677.
PRIDEO43677.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000265500; ENSP00000265500; ENSG00000109390.
ENST00000394223; ENSP00000377770; ENSG00000109390.
ENST00000394228; ENSP00000377775; ENSG00000109390.
ENST00000503997; ENSP00000425882; ENSG00000109390.
ENST00000505036; ENSP00000421195; ENSG00000109390.
ENST00000539002; ENSP00000440133; ENSG00000109390.
ENST00000539387; ENSP00000439882; ENSG00000109390.
ENST00000544855; ENSP00000441126; ENSG00000109390.
GeneID4717.
KEGGhsa:4717.
UCSCuc003ihs.3. human.

Organism-specific databases

CTD4717.
GeneCardsGC04M140212.
H-InvDBHIX0004505.
HGNCHGNC:7705. NDUFC1.
HPAHPA044556.
MIM603844. gene.
neXtProtNX_O43677.
PharmGKBPA31516.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43351.
HOGENOMHOG000013086.
HOVERGENHBG006500.
InParanoidO43677.
KOK03967.
OMAFLWIYLI.
OrthoDBEOG7T4MP8.
PhylomeDBO43677.
TreeFamTF338333.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressO43677.
BgeeO43677.
CleanExHS_NDUFC1.
GenevestigatorO43677.

Family and domain databases

InterProIPR026192. NDUFC1.
[Graphical view]
PANTHERPTHR17097. PTHR17097. 1 hit.
PfamPF15088. NADH_dh_m_C1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNDUFC1.
GenomeRNAi4717.
NextBio18194.
PROO43677.
SOURCESearch...

Entry information

Entry nameNDUC1_HUMAN
AccessionPrimary (citable) accession number: O43677
Secondary accession number(s): A8K532, Q3MIJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM