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O43677

- NDUC1_HUMAN

UniProt

O43677 - NDUC1_HUMAN

Protein

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Gene

NDUFC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
    3. respiratory electron transport chain Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
    Alternative name(s):
    Complex I-KFYI
    Short name:
    CI-KFYI
    NADH-ubiquinone oxidoreductase KFYI subunit
    Gene namesi
    Name:NDUFC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:7705. NDUFC1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Reactome
    3. mitochondrial respiratory chain complex I Source: UniProtKB
    4. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31516.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2727MitochondrionBy similarityAdd
    BLAST
    Chaini28 – 7649NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialPRO_0000020049Add
    BLAST

    Proteomic databases

    MaxQBiO43677.
    PaxDbiO43677.
    PRIDEiO43677.

    Expressioni

    Gene expression databases

    ArrayExpressiO43677.
    BgeeiO43677.
    CleanExiHS_NDUFC1.
    GenevestigatoriO43677.

    Organism-specific databases

    HPAiHPA044556.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000265500.

    Structurei

    3D structure databases

    ProteinModelPortaliO43677.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 5919HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I NDUFC1 subunit family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG43351.
    HOGENOMiHOG000013086.
    HOVERGENiHBG006500.
    InParanoidiO43677.
    KOiK03967.
    OMAiNAKPDWL.
    OrthoDBiEOG7T4MP8.
    PhylomeDBiO43677.
    TreeFamiTF338333.

    Family and domain databases

    InterProiIPR026192. NDUFC1.
    [Graphical view]
    PANTHERiPTHR17097. PTHR17097. 1 hit.
    PfamiPF15088. NADH_dh_m_C1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O43677-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPSALLRPL SRLLAPARLP SGPSVRSKFY VREPPNAKPD WLKVGFTLGT   50
    TVFLWIYLIK QHNEDILEYK RRNGLE 76
    Length:76
    Mass (Da):8,734
    Last modified:June 1, 1998 - v1
    Checksum:i7EEDEDE477E12B5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047184 mRNA. Translation: AAC04269.1.
    AF047435 mRNA. Translation: AAC39886.1.
    AK291147 mRNA. Translation: BAF83836.1.
    CH471056 Genomic DNA. Translation: EAX05121.1.
    BC101798 mRNA. Translation: AAI01799.1.
    BC107682 mRNA. Translation: AAI07683.1.
    BC112061 mRNA. Translation: AAI12062.1.
    CCDSiCCDS3746.1.
    PIRiJC5823.
    RefSeqiNP_001171915.1. NM_001184986.1.
    NP_001171916.1. NM_001184987.1.
    NP_001171917.1. NM_001184988.1.
    NP_001171918.1. NM_001184989.1.
    NP_001171919.1. NM_001184990.1.
    NP_001171920.1. NM_001184991.1.
    NP_002485.1. NM_002494.3.
    UniGeneiHs.84549.

    Genome annotation databases

    EnsembliENST00000394223; ENSP00000377770; ENSG00000109390.
    ENST00000394228; ENSP00000377775; ENSG00000109390.
    ENST00000503997; ENSP00000425882; ENSG00000109390.
    ENST00000505036; ENSP00000421195; ENSG00000109390.
    ENST00000539002; ENSP00000440133; ENSG00000109390.
    ENST00000539387; ENSP00000439882; ENSG00000109390.
    ENST00000544855; ENSP00000441126; ENSG00000109390.
    GeneIDi4717.
    KEGGihsa:4717.
    UCSCiuc003ihs.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047184 mRNA. Translation: AAC04269.1 .
    AF047435 mRNA. Translation: AAC39886.1 .
    AK291147 mRNA. Translation: BAF83836.1 .
    CH471056 Genomic DNA. Translation: EAX05121.1 .
    BC101798 mRNA. Translation: AAI01799.1 .
    BC107682 mRNA. Translation: AAI07683.1 .
    BC112061 mRNA. Translation: AAI12062.1 .
    CCDSi CCDS3746.1.
    PIRi JC5823.
    RefSeqi NP_001171915.1. NM_001184986.1.
    NP_001171916.1. NM_001184987.1.
    NP_001171917.1. NM_001184988.1.
    NP_001171918.1. NM_001184989.1.
    NP_001171919.1. NM_001184990.1.
    NP_001171920.1. NM_001184991.1.
    NP_002485.1. NM_002494.3.
    UniGenei Hs.84549.

    3D structure databases

    ProteinModelPortali O43677.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000265500.

    Chemistry

    ChEMBLi CHEMBL2363065.
    DrugBanki DB00157. NADH.

    Proteomic databases

    MaxQBi O43677.
    PaxDbi O43677.
    PRIDEi O43677.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394223 ; ENSP00000377770 ; ENSG00000109390 .
    ENST00000394228 ; ENSP00000377775 ; ENSG00000109390 .
    ENST00000503997 ; ENSP00000425882 ; ENSG00000109390 .
    ENST00000505036 ; ENSP00000421195 ; ENSG00000109390 .
    ENST00000539002 ; ENSP00000440133 ; ENSG00000109390 .
    ENST00000539387 ; ENSP00000439882 ; ENSG00000109390 .
    ENST00000544855 ; ENSP00000441126 ; ENSG00000109390 .
    GeneIDi 4717.
    KEGGi hsa:4717.
    UCSCi uc003ihs.3. human.

    Organism-specific databases

    CTDi 4717.
    GeneCardsi GC04M140212.
    H-InvDB HIX0004505.
    HGNCi HGNC:7705. NDUFC1.
    HPAi HPA044556.
    MIMi 603844. gene.
    neXtProti NX_O43677.
    PharmGKBi PA31516.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43351.
    HOGENOMi HOG000013086.
    HOVERGENi HBG006500.
    InParanoidi O43677.
    KOi K03967.
    OMAi NAKPDWL.
    OrthoDBi EOG7T4MP8.
    PhylomeDBi O43677.
    TreeFami TF338333.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    GeneWikii NDUFC1.
    GenomeRNAii 4717.
    NextBioi 18194.
    PROi O43677.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43677.
    Bgeei O43677.
    CleanExi HS_NDUFC1.
    Genevestigatori O43677.

    Family and domain databases

    InterProi IPR026192. NDUFC1.
    [Graphical view ]
    PANTHERi PTHR17097. PTHR17097. 1 hit.
    Pfami PF15088. NADH_dh_m_C1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits."
      Ton C., Hwang D.M., Dempsey A.A., Liew C.-C.
      Biochem. Biophys. Res. Commun. 241:589-594(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
      Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
      Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Skin.

    Entry informationi

    Entry nameiNDUC1_HUMAN
    AccessioniPrimary (citable) accession number: O43677
    Secondary accession number(s): A8K532, Q3MIJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3