SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O43677

- NDUC1_HUMAN

UniProt

O43677 - NDUC1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Gene
NDUFC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  3. respiratory electron transport chain Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Alternative name(s):
Complex I-KFYI
Short name:
CI-KFYI
NADH-ubiquinone oxidoreductase KFYI subunit
Gene namesi
Name:NDUFC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:7705. NDUFC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 5919Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrial respiratory chain complex I Source: UniProtKB
  4. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727Mitochondrion By similarity
Add
BLAST
Chaini28 – 7649NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
PRO_0000020049Add
BLAST

Proteomic databases

MaxQBiO43677.
PaxDbiO43677.
PRIDEiO43677.

Expressioni

Gene expression databases

ArrayExpressiO43677.
BgeeiO43677.
CleanExiHS_NDUFC1.
GenevestigatoriO43677.

Organism-specific databases

HPAiHPA044556.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.

Protein-protein interaction databases

STRINGi9606.ENSP00000265500.

Structurei

3D structure databases

ProteinModelPortaliO43677.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43351.
HOGENOMiHOG000013086.
HOVERGENiHBG006500.
InParanoidiO43677.
KOiK03967.
OMAiNAKPDWL.
OrthoDBiEOG7T4MP8.
PhylomeDBiO43677.
TreeFamiTF338333.

Family and domain databases

InterProiIPR026192. NDUFC1.
[Graphical view]
PANTHERiPTHR17097. PTHR17097. 1 hit.
PfamiPF15088. NADH_dh_m_C1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43677-1 [UniParc]FASTAAdd to Basket

« Hide

MAPSALLRPL SRLLAPARLP SGPSVRSKFY VREPPNAKPD WLKVGFTLGT   50
TVFLWIYLIK QHNEDILEYK RRNGLE 76
Length:76
Mass (Da):8,734
Last modified:June 1, 1998 - v1
Checksum:i7EEDEDE477E12B5E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047184 mRNA. Translation: AAC04269.1.
AF047435 mRNA. Translation: AAC39886.1.
AK291147 mRNA. Translation: BAF83836.1.
CH471056 Genomic DNA. Translation: EAX05121.1.
BC101798 mRNA. Translation: AAI01799.1.
BC107682 mRNA. Translation: AAI07683.1.
BC112061 mRNA. Translation: AAI12062.1.
CCDSiCCDS3746.1.
PIRiJC5823.
RefSeqiNP_001171915.1. NM_001184986.1.
NP_001171916.1. NM_001184987.1.
NP_001171917.1. NM_001184988.1.
NP_001171918.1. NM_001184989.1.
NP_001171919.1. NM_001184990.1.
NP_001171920.1. NM_001184991.1.
NP_002485.1. NM_002494.3.
UniGeneiHs.84549.

Genome annotation databases

EnsembliENST00000265500; ENSP00000265500; ENSG00000109390.
ENST00000394223; ENSP00000377770; ENSG00000109390.
ENST00000394228; ENSP00000377775; ENSG00000109390.
ENST00000503997; ENSP00000425882; ENSG00000109390.
ENST00000505036; ENSP00000421195; ENSG00000109390.
ENST00000539002; ENSP00000440133; ENSG00000109390.
ENST00000539387; ENSP00000439882; ENSG00000109390.
ENST00000544855; ENSP00000441126; ENSG00000109390.
GeneIDi4717.
KEGGihsa:4717.
UCSCiuc003ihs.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047184 mRNA. Translation: AAC04269.1 .
AF047435 mRNA. Translation: AAC39886.1 .
AK291147 mRNA. Translation: BAF83836.1 .
CH471056 Genomic DNA. Translation: EAX05121.1 .
BC101798 mRNA. Translation: AAI01799.1 .
BC107682 mRNA. Translation: AAI07683.1 .
BC112061 mRNA. Translation: AAI12062.1 .
CCDSi CCDS3746.1.
PIRi JC5823.
RefSeqi NP_001171915.1. NM_001184986.1.
NP_001171916.1. NM_001184987.1.
NP_001171917.1. NM_001184988.1.
NP_001171918.1. NM_001184989.1.
NP_001171919.1. NM_001184990.1.
NP_001171920.1. NM_001184991.1.
NP_002485.1. NM_002494.3.
UniGenei Hs.84549.

3D structure databases

ProteinModelPortali O43677.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000265500.

Chemistry

ChEMBLi CHEMBL2363065.
DrugBanki DB00157. NADH.

Proteomic databases

MaxQBi O43677.
PaxDbi O43677.
PRIDEi O43677.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265500 ; ENSP00000265500 ; ENSG00000109390 .
ENST00000394223 ; ENSP00000377770 ; ENSG00000109390 .
ENST00000394228 ; ENSP00000377775 ; ENSG00000109390 .
ENST00000503997 ; ENSP00000425882 ; ENSG00000109390 .
ENST00000505036 ; ENSP00000421195 ; ENSG00000109390 .
ENST00000539002 ; ENSP00000440133 ; ENSG00000109390 .
ENST00000539387 ; ENSP00000439882 ; ENSG00000109390 .
ENST00000544855 ; ENSP00000441126 ; ENSG00000109390 .
GeneIDi 4717.
KEGGi hsa:4717.
UCSCi uc003ihs.3. human.

Organism-specific databases

CTDi 4717.
GeneCardsi GC04M140212.
H-InvDB HIX0004505.
HGNCi HGNC:7705. NDUFC1.
HPAi HPA044556.
MIMi 603844. gene.
neXtProti NX_O43677.
PharmGKBi PA31516.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43351.
HOGENOMi HOG000013086.
HOVERGENi HBG006500.
InParanoidi O43677.
KOi K03967.
OMAi NAKPDWL.
OrthoDBi EOG7T4MP8.
PhylomeDBi O43677.
TreeFami TF338333.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

GeneWikii NDUFC1.
GenomeRNAii 4717.
NextBioi 18194.
PROi O43677.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43677.
Bgeei O43677.
CleanExi HS_NDUFC1.
Genevestigatori O43677.

Family and domain databases

InterProi IPR026192. NDUFC1.
[Graphical view ]
PANTHERi PTHR17097. PTHR17097. 1 hit.
Pfami PF15088. NADH_dh_m_C1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits."
    Ton C., Hwang D.M., Dempsey A.A., Liew C.-C.
    Biochem. Biophys. Res. Commun. 241:589-594(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
    Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
    Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.

Entry informationi

Entry nameiNDUC1_HUMAN
AccessioniPrimary (citable) accession number: O43677
Secondary accession number(s): A8K532, Q3MIJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi