Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Gene

NDUFC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: ProtInc

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: Reactome
  • mitochondrial respiratory chain complex I assembly Source: UniProtKB

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Alternative name(s):
Complex I-KFYI
Short name:
CI-KFYI
NADH-ubiquinone oxidoreductase KFYI subunit
Gene namesi
Name:NDUFC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109390.11.
HGNCiHGNC:7705. NDUFC1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 59HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109390.
PharmGKBiPA31516.

Chemistry databases

ChEMBLiCHEMBL2363065.
DrugBankiDB00157. NADH.

Polymorphism and mutation databases

BioMutaiNDUFC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionBy similarityAdd BLAST27
ChainiPRO_000002004928 – 76NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialAdd BLAST49

Proteomic databases

EPDiO43677.
MaxQBiO43677.
PaxDbiO43677.
PeptideAtlasiO43677.
PRIDEiO43677.
TopDownProteomicsiO43677.

Expressioni

Gene expression databases

BgeeiENSG00000109390.
CleanExiHS_NDUFC1.
GenevisibleiO43677. HS.

Organism-specific databases

HPAiHPA044556.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

CORUMiO43677.
STRINGi9606.ENSP00000265500.

Structurei

3D structure databases

ProteinModelPortaliO43677.
SMRiO43677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC1 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0MG. Eukaryota.
ENOG410XUGS. LUCA.
GeneTreeiENSGT00390000002565.
HOGENOMiHOG000013086.
HOVERGENiHBG006500.
InParanoidiO43677.
KOiK03967.
OMAiNAKPDWL.
OrthoDBiEOG091G14QE.
PhylomeDBiO43677.
TreeFamiTF338333.

Family and domain databases

InterProiView protein in InterPro
IPR026192. NDUFC1.
PANTHERiPTHR17097. PTHR17097. 1 hit.
PfamiView protein in Pfam
PF15088. NADH_dh_m_C1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSALLRPL SRLLAPARLP SGPSVRSKFY VREPPNAKPD WLKVGFTLGT
60 70
TVFLWIYLIK QHNEDILEYK RRNGLE
Length:76
Mass (Da):8,734
Last modified:June 1, 1998 - v1
Checksum:i7EEDEDE477E12B5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047184 mRNA. Translation: AAC04269.1.
AF047435 mRNA. Translation: AAC39886.1.
AK291147 mRNA. Translation: BAF83836.1.
CH471056 Genomic DNA. Translation: EAX05121.1.
BC101798 mRNA. Translation: AAI01799.1.
BC107682 mRNA. Translation: AAI07683.1.
BC112061 mRNA. Translation: AAI12062.1.
CCDSiCCDS3746.1.
PIRiJC5823.
RefSeqiNP_001171915.1. NM_001184986.1.
NP_001171916.1. NM_001184987.1.
NP_001171917.1. NM_001184988.1.
NP_001171918.1. NM_001184989.1.
NP_001171919.1. NM_001184990.1.
NP_001171920.1. NM_001184991.1.
NP_002485.1. NM_002494.3.
UniGeneiHs.84549.

Genome annotation databases

EnsembliENST00000394223; ENSP00000377770; ENSG00000109390.
ENST00000394228; ENSP00000377775; ENSG00000109390.
ENST00000503997; ENSP00000425882; ENSG00000109390.
ENST00000505036; ENSP00000421195; ENSG00000109390.
ENST00000539002; ENSP00000440133; ENSG00000109390.
ENST00000539387; ENSP00000439882; ENSG00000109390.
ENST00000544855; ENSP00000441126; ENSG00000109390.
GeneIDi4717.
KEGGihsa:4717.
UCSCiuc003ihs.3. human.

Similar proteinsi

Entry informationi

Entry nameiNDUC1_HUMAN
AccessioniPrimary (citable) accession number: O43677
Secondary accession number(s): A8K532, Q3MIJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: September 27, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families