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Protein

NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Gene

NDUFC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  3. respiratory electron transport chain Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Alternative name(s):
Complex I-KFYI
Short name:
CI-KFYI
NADH-ubiquinone oxidoreductase KFYI subunit
Gene namesi
Name:NDUFC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:7705. NDUFC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 5919HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrial respiratory chain complex I Source: UniProtKB
  4. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31516.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727MitochondrionBy similarityAdd
BLAST
Chaini28 – 7649NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialPRO_0000020049Add
BLAST

Proteomic databases

MaxQBiO43677.
PaxDbiO43677.
PRIDEiO43677.

Expressioni

Gene expression databases

BgeeiO43677.
CleanExiHS_NDUFC1.
ExpressionAtlasiO43677. baseline and differential.
GenevestigatoriO43677.

Organism-specific databases

HPAiHPA044556.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.

Protein-protein interaction databases

STRINGi9606.ENSP00000265500.

Structurei

3D structure databases

ProteinModelPortaliO43677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFC1 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG43351.
GeneTreeiENSGT00390000002565.
HOGENOMiHOG000013086.
HOVERGENiHBG006500.
InParanoidiO43677.
KOiK03967.
OMAiFLWIYLI.
OrthoDBiEOG7T4MP8.
PhylomeDBiO43677.
TreeFamiTF338333.

Family and domain databases

InterProiIPR026192. NDUFC1.
[Graphical view]
PANTHERiPTHR17097. PTHR17097. 1 hit.
PfamiPF15088. NADH_dh_m_C1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSALLRPL SRLLAPARLP SGPSVRSKFY VREPPNAKPD WLKVGFTLGT
60 70
TVFLWIYLIK QHNEDILEYK RRNGLE
Length:76
Mass (Da):8,734
Last modified:May 31, 1998 - v1
Checksum:i7EEDEDE477E12B5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047184 mRNA. Translation: AAC04269.1.
AF047435 mRNA. Translation: AAC39886.1.
AK291147 mRNA. Translation: BAF83836.1.
CH471056 Genomic DNA. Translation: EAX05121.1.
BC101798 mRNA. Translation: AAI01799.1.
BC107682 mRNA. Translation: AAI07683.1.
BC112061 mRNA. Translation: AAI12062.1.
CCDSiCCDS3746.1.
PIRiJC5823.
RefSeqiNP_001171915.1. NM_001184986.1.
NP_001171916.1. NM_001184987.1.
NP_001171917.1. NM_001184988.1.
NP_001171918.1. NM_001184989.1.
NP_001171919.1. NM_001184990.1.
NP_001171920.1. NM_001184991.1.
NP_002485.1. NM_002494.3.
UniGeneiHs.84549.

Genome annotation databases

EnsembliENST00000394223; ENSP00000377770; ENSG00000109390.
ENST00000394228; ENSP00000377775; ENSG00000109390.
ENST00000503997; ENSP00000425882; ENSG00000109390.
ENST00000505036; ENSP00000421195; ENSG00000109390.
ENST00000539002; ENSP00000440133; ENSG00000109390.
ENST00000539387; ENSP00000439882; ENSG00000109390.
ENST00000544855; ENSP00000441126; ENSG00000109390.
GeneIDi4717.
KEGGihsa:4717.
UCSCiuc003ihs.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047184 mRNA. Translation: AAC04269.1.
AF047435 mRNA. Translation: AAC39886.1.
AK291147 mRNA. Translation: BAF83836.1.
CH471056 Genomic DNA. Translation: EAX05121.1.
BC101798 mRNA. Translation: AAI01799.1.
BC107682 mRNA. Translation: AAI07683.1.
BC112061 mRNA. Translation: AAI12062.1.
CCDSiCCDS3746.1.
PIRiJC5823.
RefSeqiNP_001171915.1. NM_001184986.1.
NP_001171916.1. NM_001184987.1.
NP_001171917.1. NM_001184988.1.
NP_001171918.1. NM_001184989.1.
NP_001171919.1. NM_001184990.1.
NP_001171920.1. NM_001184991.1.
NP_002485.1. NM_002494.3.
UniGeneiHs.84549.

3D structure databases

ProteinModelPortaliO43677.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265500.

Chemistry

ChEMBLiCHEMBL2363065.

Proteomic databases

MaxQBiO43677.
PaxDbiO43677.
PRIDEiO43677.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394223; ENSP00000377770; ENSG00000109390.
ENST00000394228; ENSP00000377775; ENSG00000109390.
ENST00000503997; ENSP00000425882; ENSG00000109390.
ENST00000505036; ENSP00000421195; ENSG00000109390.
ENST00000539002; ENSP00000440133; ENSG00000109390.
ENST00000539387; ENSP00000439882; ENSG00000109390.
ENST00000544855; ENSP00000441126; ENSG00000109390.
GeneIDi4717.
KEGGihsa:4717.
UCSCiuc003ihs.3. human.

Organism-specific databases

CTDi4717.
GeneCardsiGC04M140212.
H-InvDBHIX0004505.
HGNCiHGNC:7705. NDUFC1.
HPAiHPA044556.
MIMi603844. gene.
neXtProtiNX_O43677.
PharmGKBiPA31516.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43351.
GeneTreeiENSGT00390000002565.
HOGENOMiHOG000013086.
HOVERGENiHBG006500.
InParanoidiO43677.
KOiK03967.
OMAiFLWIYLI.
OrthoDBiEOG7T4MP8.
PhylomeDBiO43677.
TreeFamiTF338333.

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Miscellaneous databases

GeneWikiiNDUFC1.
GenomeRNAii4717.
NextBioi18194.
PROiO43677.
SOURCEiSearch...

Gene expression databases

BgeeiO43677.
CleanExiHS_NDUFC1.
ExpressionAtlasiO43677. baseline and differential.
GenevestigatoriO43677.

Family and domain databases

InterProiIPR026192. NDUFC1.
[Graphical view]
PANTHERiPTHR17097. PTHR17097. 1 hit.
PfamiPF15088. NADH_dh_m_C1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits."
    Ton C., Hwang D.M., Dempsey A.A., Liew C.-C.
    Biochem. Biophys. Res. Commun. 241:589-594(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning."
    Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z.
    Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skin.

Entry informationi

Entry nameiNDUC1_HUMAN
AccessioniPrimary (citable) accession number: O43677
Secondary accession number(s): A8K532, Q3MIJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1999
Last sequence update: May 31, 1998
Last modified: January 6, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.