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O43676

- NDUB3_HUMAN

UniProt

O43676 - NDUB3_HUMAN

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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

Gene

NDUFB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  3. respiratory electron transport chain Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Alternative name(s):
Complex I-B12
Short name:
CI-B12
NADH-ubiquinone oxidoreductase B12 subunit
Gene namesi
Name:NDUFB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:7698. NDUFB3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial inner membrane Source: Reactome
  4. mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti2609. Isolated NADH-CoQ reductase deficiency.
PharmGKBiPA31504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 9897NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3PRO_0000118797Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei5 – 51MethylhistidineBy similarity
Modified residuei7 – 71MethylhistidineBy similarity
Modified residuei9 – 91MethylhistidineBy similarity
Modified residuei23 – 231N6-acetyllysine; alternateBy similarity
Modified residuei23 – 231N6-succinyllysine; alternateBy similarity
Modified residuei34 – 341N6-acetyllysine; alternateBy similarity
Modified residuei34 – 341N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiO43676.
PRIDEiO43676.

PTM databases

PhosphoSiteiO43676.

Expressioni

Gene expression databases

BgeeiO43676.
CleanExiHS_NDUFB3.
ExpressionAtlasiO43676. baseline and differential.
GenevestigatoriO43676.

Organism-specific databases

HPAiHPA034596.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

BioGridi110789. 9 interactions.
IntActiO43676. 2 interactions.
MINTiMINT-1416095.
STRINGi9606.ENSP00000237889.

Structurei

3D structure databases

ProteinModelPortaliO43676.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei66 – 8823HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB3 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272434.
GeneTreeiENSGT00390000010316.
HOGENOMiHOG000173088.
HOVERGENiHBG006448.
InParanoidiO43676.
KOiK03959.
OMAiNEAWRYS.
PhylomeDBiO43676.
TreeFamiTF319656.

Family and domain databases

InterProiIPR012576. NDUFB3.
[Graphical view]
PANTHERiPTHR15082. PTHR15082. 1 hit.
PfamiPF08122. NDUF_B12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43676-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHEHGHEHG HHKMELPDYR QWKIEGTPLE TIQKKLAAKG LRDPWGRNEA
60 70 80 90
WRYMGGFAKS VSFSDVFFKG FKWGFAAFVV AVGAEYYLES LNKDKKHH
Length:98
Mass (Da):11,402
Last modified:January 23, 2007 - v3
Checksum:i1C77F0C7A4DC757F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047183 mRNA. Translation: AAC04268.1.
AF035839 mRNA. Translation: AAC15590.1.
CR456924 mRNA. Translation: CAG33205.1.
AC007272 Genomic DNA. Translation: AAX88972.1.
CH471063 Genomic DNA. Translation: EAW70233.1.
BC018183 mRNA. Translation: AAH18183.1.
CCDSiCCDS2336.1.
PIRiJC5822.
RefSeqiNP_001244031.1. NM_001257102.1.
NP_002482.1. NM_002491.2.
XP_006712607.1. XM_006712544.1.
UniGeneiHs.109760.

Genome annotation databases

EnsembliENST00000237889; ENSP00000237889; ENSG00000119013.
ENST00000433898; ENSP00000410600; ENSG00000119013.
ENST00000454214; ENSP00000407336; ENSG00000119013.
GeneIDi4709.
KEGGihsa:4709.
UCSCiuc002uwx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF047183 mRNA. Translation: AAC04268.1 .
AF035839 mRNA. Translation: AAC15590.1 .
CR456924 mRNA. Translation: CAG33205.1 .
AC007272 Genomic DNA. Translation: AAX88972.1 .
CH471063 Genomic DNA. Translation: EAW70233.1 .
BC018183 mRNA. Translation: AAH18183.1 .
CCDSi CCDS2336.1.
PIRi JC5822.
RefSeqi NP_001244031.1. NM_001257102.1.
NP_002482.1. NM_002491.2.
XP_006712607.1. XM_006712544.1.
UniGenei Hs.109760.

3D structure databases

ProteinModelPortali O43676.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110789. 9 interactions.
IntActi O43676. 2 interactions.
MINTi MINT-1416095.
STRINGi 9606.ENSP00000237889.

Chemistry

ChEMBLi CHEMBL2363065.

PTM databases

PhosphoSitei O43676.

Proteomic databases

PaxDbi O43676.
PRIDEi O43676.

Protocols and materials databases

DNASUi 4709.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000237889 ; ENSP00000237889 ; ENSG00000119013 .
ENST00000433898 ; ENSP00000410600 ; ENSG00000119013 .
ENST00000454214 ; ENSP00000407336 ; ENSG00000119013 .
GeneIDi 4709.
KEGGi hsa:4709.
UCSCi uc002uwx.4. human.

Organism-specific databases

CTDi 4709.
GeneCardsi GC02P201936.
HGNCi HGNC:7698. NDUFB3.
HPAi HPA034596.
MIMi 603839. gene.
neXtProti NX_O43676.
Orphaneti 2609. Isolated NADH-CoQ reductase deficiency.
PharmGKBi PA31504.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272434.
GeneTreei ENSGT00390000010316.
HOGENOMi HOG000173088.
HOVERGENi HBG006448.
InParanoidi O43676.
KOi K03959.
OMAi NEAWRYS.
PhylomeDBi O43676.
TreeFami TF319656.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

GenomeRNAii 4709.
NextBioi 18160.
PROi O43676.
SOURCEi Search...

Gene expression databases

Bgeei O43676.
CleanExi HS_NDUFB3.
ExpressionAtlasi O43676. baseline and differential.
Genevestigatori O43676.

Family and domain databases

InterProi IPR012576. NDUFB3.
[Graphical view ]
PANTHERi PTHR15082. PTHR15082. 1 hit.
Pfami PF08122. NDUF_B12. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits."
    Ton C., Hwang D.M., Dempsey A.A., Liew C.-C.
    Biochem. Biophys. Res. Commun. 241:589-594(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed."
    Loeffen J.L.C.M., Triepels R.H., van den Heuvel L.P., Schuelke M., Buskens C.A.F., Smeets R.J.P., Trijbels J.M.F., Smeitink J.A.M.
    Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
    Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
    J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNDUB3_HUMAN
AccessioniPrimary (citable) accession number: O43676
Secondary accession number(s): Q6IB80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3