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O43676 (NDUB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
Alternative name(s):
Complex I-B12
Short name=CI-B12
NADH-ubiquinone oxidoreductase B12 subunit
Gene names
Name:NDUFB3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subunit structure

Complex I is composed of 45 different subunits. Ref.7

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Sequence similarities

Belongs to the complex I NDUFB3 subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 9897NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
PRO_0000118797

Regions

Transmembrane66 – 8823Helical; Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue51Methylhistidine By similarity
Modified residue71Methylhistidine By similarity
Modified residue91Methylhistidine By similarity
Modified residue231N6-acetyllysine; alternate By similarity
Modified residue231N6-succinyllysine; alternate By similarity
Modified residue341N6-acetyllysine; alternate By similarity
Modified residue341N6-succinyllysine; alternate By similarity

Sequences

Sequence LengthMass (Da)Tools
O43676 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 1C77F0C7A4DC757F

FASTA9811,402
        10         20         30         40         50         60 
MAHEHGHEHG HHKMELPDYR QWKIEGTPLE TIQKKLAAKG LRDPWGRNEA WRYMGGFAKS 

        70         80         90 
VSFSDVFFKG FKWGFAAFVV AVGAEYYLES LNKDKKHH 

« Hide

References

« Hide 'large scale' references
[1]"Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits."
Ton C., Hwang D.M., Dempsey A.A., Liew C.-C.
Biochem. Biophys. Res. Commun. 241:589-594(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]"cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed."
Loeffen J.L.C.M., Triepels R.H., van den Heuvel L.P., Schuelke M., Buskens C.A.F., Smeets R.J.P., Trijbels J.M.F., Smeitink J.A.M.
Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[7]"The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF047183 mRNA. Translation: AAC04268.1.
AF035839 mRNA. Translation: AAC15590.1.
CR456924 mRNA. Translation: CAG33205.1.
AC007272 Genomic DNA. Translation: AAX88972.1.
CH471063 Genomic DNA. Translation: EAW70233.1.
BC018183 mRNA. Translation: AAH18183.1.
CCDSCCDS2336.1.
PIRJC5822.
RefSeqNP_001244031.1. NM_001257102.1.
NP_002482.1. NM_002491.2.
XP_006712607.1. XM_006712544.1.
UniGeneHs.109760.

3D structure databases

ProteinModelPortalO43676.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110789. 3 interactions.
IntActO43676. 2 interactions.
MINTMINT-1416095.
STRING9606.ENSP00000237889.

Chemistry

ChEMBLCHEMBL2363065.
DrugBankDB00157. NADH.

PTM databases

PhosphoSiteO43676.

Proteomic databases

MaxQBO43676.
PaxDbO43676.
PRIDEO43676.

Protocols and materials databases

DNASU4709.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000237889; ENSP00000237889; ENSG00000119013.
ENST00000433898; ENSP00000410600; ENSG00000119013.
ENST00000454214; ENSP00000407336; ENSG00000119013.
GeneID4709.
KEGGhsa:4709.
UCSCuc002uwx.4. human.

Organism-specific databases

CTD4709.
GeneCardsGC02P201936.
HGNCHGNC:7698. NDUFB3.
HPAHPA034596.
MIM603839. gene.
neXtProtNX_O43676.
Orphanet2609. Isolated NADH-CoQ reductase deficiency.
PharmGKBPA31504.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG272434.
HOGENOMHOG000173088.
HOVERGENHBG006448.
InParanoidO43676.
KOK03959.
OMANEAWRYS.
PhylomeDBO43676.
TreeFamTF319656.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressO43676.
BgeeO43676.
CleanExHS_NDUFB3.
GenevestigatorO43676.

Family and domain databases

InterProIPR012576. NDUFB3.
[Graphical view]
PANTHERPTHR15082. PTHR15082. 1 hit.
PfamPF08122. NDUF_B12. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi4709.
NextBio18160.
PROO43676.
SOURCESearch...

Entry information

Entry nameNDUB3_HUMAN
AccessionPrimary (citable) accession number: O43676
Secondary accession number(s): Q6IB80
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM