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O43676

- NDUB3_HUMAN

UniProt

O43676 - NDUB3_HUMAN

Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

Gene

NDUFB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
    3. respiratory electron transport chain Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
    Alternative name(s):
    Complex I-B12
    Short name:
    CI-B12
    NADH-ubiquinone oxidoreductase B12 subunit
    Gene namesi
    Name:NDUFB3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:7698. NDUFB3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial inner membrane Source: Reactome
    4. mitochondrial respiratory chain complex I Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti2609. Isolated NADH-CoQ reductase deficiency.
    PharmGKBiPA31504.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 9897NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3PRO_0000118797Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei5 – 51MethylhistidineBy similarity
    Modified residuei7 – 71MethylhistidineBy similarity
    Modified residuei9 – 91MethylhistidineBy similarity
    Modified residuei23 – 231N6-acetyllysine; alternateBy similarity
    Modified residuei23 – 231N6-succinyllysine; alternateBy similarity
    Modified residuei34 – 341N6-acetyllysine; alternateBy similarity
    Modified residuei34 – 341N6-succinyllysine; alternateBy similarity

    Keywords - PTMi

    Acetylation, Methylation

    Proteomic databases

    MaxQBiO43676.
    PaxDbiO43676.
    PRIDEiO43676.

    PTM databases

    PhosphoSiteiO43676.

    Expressioni

    Gene expression databases

    ArrayExpressiO43676.
    BgeeiO43676.
    CleanExiHS_NDUFB3.
    GenevestigatoriO43676.

    Organism-specific databases

    HPAiHPA034596.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits.1 Publication

    Protein-protein interaction databases

    BioGridi110789. 5 interactions.
    IntActiO43676. 2 interactions.
    MINTiMINT-1416095.
    STRINGi9606.ENSP00000237889.

    Structurei

    3D structure databases

    ProteinModelPortaliO43676.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei66 – 8823HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I NDUFB3 subunit family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG272434.
    HOGENOMiHOG000173088.
    HOVERGENiHBG006448.
    InParanoidiO43676.
    KOiK03959.
    OMAiNEAWRYS.
    PhylomeDBiO43676.
    TreeFamiTF319656.

    Family and domain databases

    InterProiIPR012576. NDUFB3.
    [Graphical view]
    PANTHERiPTHR15082. PTHR15082. 1 hit.
    PfamiPF08122. NDUF_B12. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O43676-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHEHGHEHG HHKMELPDYR QWKIEGTPLE TIQKKLAAKG LRDPWGRNEA   50
    WRYMGGFAKS VSFSDVFFKG FKWGFAAFVV AVGAEYYLES LNKDKKHH 98
    Length:98
    Mass (Da):11,402
    Last modified:January 23, 2007 - v3
    Checksum:i1C77F0C7A4DC757F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047183 mRNA. Translation: AAC04268.1.
    AF035839 mRNA. Translation: AAC15590.1.
    CR456924 mRNA. Translation: CAG33205.1.
    AC007272 Genomic DNA. Translation: AAX88972.1.
    CH471063 Genomic DNA. Translation: EAW70233.1.
    BC018183 mRNA. Translation: AAH18183.1.
    CCDSiCCDS2336.1.
    PIRiJC5822.
    RefSeqiNP_001244031.1. NM_001257102.1.
    NP_002482.1. NM_002491.2.
    XP_006712607.1. XM_006712544.1.
    UniGeneiHs.109760.

    Genome annotation databases

    EnsembliENST00000237889; ENSP00000237889; ENSG00000119013.
    ENST00000433898; ENSP00000410600; ENSG00000119013.
    ENST00000454214; ENSP00000407336; ENSG00000119013.
    GeneIDi4709.
    KEGGihsa:4709.
    UCSCiuc002uwx.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047183 mRNA. Translation: AAC04268.1 .
    AF035839 mRNA. Translation: AAC15590.1 .
    CR456924 mRNA. Translation: CAG33205.1 .
    AC007272 Genomic DNA. Translation: AAX88972.1 .
    CH471063 Genomic DNA. Translation: EAW70233.1 .
    BC018183 mRNA. Translation: AAH18183.1 .
    CCDSi CCDS2336.1.
    PIRi JC5822.
    RefSeqi NP_001244031.1. NM_001257102.1.
    NP_002482.1. NM_002491.2.
    XP_006712607.1. XM_006712544.1.
    UniGenei Hs.109760.

    3D structure databases

    ProteinModelPortali O43676.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110789. 5 interactions.
    IntActi O43676. 2 interactions.
    MINTi MINT-1416095.
    STRINGi 9606.ENSP00000237889.

    Chemistry

    ChEMBLi CHEMBL2363065.
    DrugBanki DB00157. NADH.

    PTM databases

    PhosphoSitei O43676.

    Proteomic databases

    MaxQBi O43676.
    PaxDbi O43676.
    PRIDEi O43676.

    Protocols and materials databases

    DNASUi 4709.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000237889 ; ENSP00000237889 ; ENSG00000119013 .
    ENST00000433898 ; ENSP00000410600 ; ENSG00000119013 .
    ENST00000454214 ; ENSP00000407336 ; ENSG00000119013 .
    GeneIDi 4709.
    KEGGi hsa:4709.
    UCSCi uc002uwx.4. human.

    Organism-specific databases

    CTDi 4709.
    GeneCardsi GC02P201936.
    HGNCi HGNC:7698. NDUFB3.
    HPAi HPA034596.
    MIMi 603839. gene.
    neXtProti NX_O43676.
    Orphaneti 2609. Isolated NADH-CoQ reductase deficiency.
    PharmGKBi PA31504.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272434.
    HOGENOMi HOG000173088.
    HOVERGENi HBG006448.
    InParanoidi O43676.
    KOi K03959.
    OMAi NEAWRYS.
    PhylomeDBi O43676.
    TreeFami TF319656.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    GenomeRNAii 4709.
    NextBioi 18160.
    PROi O43676.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43676.
    Bgeei O43676.
    CleanExi HS_NDUFB3.
    Genevestigatori O43676.

    Family and domain databases

    InterProi IPR012576. NDUFB3.
    [Graphical view ]
    PANTHERi PTHR15082. PTHR15082. 1 hit.
    Pfami PF08122. NDUF_B12. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits."
      Ton C., Hwang D.M., Dempsey A.A., Liew C.-C.
      Biochem. Biophys. Res. Commun. 241:589-594(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart.
    2. "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed."
      Loeffen J.L.C.M., Triepels R.H., van den Heuvel L.P., Schuelke M., Buskens C.A.F., Smeets R.J.P., Trijbels J.M.F., Smeitink J.A.M.
      Biochem. Biophys. Res. Commun. 253:415-422(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    7. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
      Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
      J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNDUB3_HUMAN
    AccessioniPrimary (citable) accession number: O43676
    Secondary accession number(s): Q6IB80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3