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O43674

- NDUB5_HUMAN

UniProt

O43674 - NDUB5_HUMAN

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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

Gene

NDUFB5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  3. respiratory electron transport chain Source: Reactome
  4. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Alternative name(s):
Complex I-SGDH
Short name:
CI-SGDH
NADH-ubiquinone oxidoreductase SGDH subunit
Gene namesi
Name:NDUFB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:7700. NDUFB5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
  3. mitochondrial respiratory chain complex I Source: UniProtKB
  4. mitochondrion Source: HPA
  5. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4646MitochondrionBy similarityAdd
BLAST
Chaini47 – 189143NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialPRO_0000020052Add
BLAST

Proteomic databases

MaxQBiO43674.
PaxDbiO43674.
PRIDEiO43674.

PTM databases

PhosphoSiteiO43674.

Expressioni

Gene expression databases

BgeeiO43674.
CleanExiHS_NDUFB5.
ExpressionAtlasiO43674. baseline and differential.
GenevestigatoriO43674.

Organism-specific databases

HPAiHPA005640.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

BioGridi110791. 18 interactions.
IntActiO43674. 2 interactions.
STRINGi9606.ENSP00000259037.

Structurei

3D structure databases

ProteinModelPortaliO43674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB5 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297432.
GeneTreeiENSGT00390000009980.
HOGENOMiHOG000004849.
HOVERGENiHBG003008.
InParanoidiO43674.
KOiK03961.
OrthoDBiEOG7M98HQ.
PhylomeDBiO43674.
TreeFamiTF313997.

Family and domain databases

InterProiIPR019173. NADH_UbQ_OxRdtase_B5_su.
[Graphical view]
PANTHERiPTHR13178. PTHR13178. 1 hit.
PfamiPF09781. NDUF_B5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43674-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAMSLLRRV SVTAVAALSG RPLGTRLGFG GFLTRGFPKA AAPVRHSGDH
60 70 80 90 100
GKRLFVIRPS RFYDRRFLKL LRFYIALTGI PVAIFITLVN VFIGQAELAE
110 120 130 140 150
IPEGYVPEHW EYYKHPISRW IARNFYDSPE KIYERTMAVL QIEAEKAELR
160 170 180
VKELEVRKLM HVRGDGPWYY YETIDKELID HSPKATPDN
Length:189
Mass (Da):21,750
Last modified:June 1, 1998 - v1
Checksum:i66D288F7AB7FD5C5
GO
Isoform 2 (identifier: O43674-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-93: Missing.

Note: No experimental confirmation available.

Show »
Length:137
Mass (Da):15,667
Checksum:iCD8C5524D8116C46
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331Y → H.
Corresponds to variant rs4147793 [ dbSNP | Ensembl ].
VAR_050590

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei42 – 9352Missing in isoform 2. 1 PublicationVSP_042516Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047181 mRNA. Translation: AAC04266.1.
AC090425 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78393.1.
BC005271 mRNA. Translation: AAH05271.1.
BC093071 mRNA. Translation: AAH93071.1.
BC009796 mRNA. Translation: AAH09796.1.
CCDSiCCDS3234.1. [O43674-1]
CCDS56297.1. [O43674-2]
PIRiJC5820.
RefSeqiNP_001186886.1. NM_001199957.1. [O43674-2]
NP_001186887.1. NM_001199958.1.
NP_002483.1. NM_002492.3. [O43674-1]
UniGeneiHs.730674.

Genome annotation databases

EnsembliENST00000259037; ENSP00000259037; ENSG00000136521. [O43674-1]
ENST00000493866; ENSP00000419656; ENSG00000136521. [O43674-2]
GeneIDi4711.
KEGGihsa:4711.
UCSCiuc003fkc.3. human. [O43674-1]
uc003fke.3. human. [O43674-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047181 mRNA. Translation: AAC04266.1 .
AC090425 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78393.1 .
BC005271 mRNA. Translation: AAH05271.1 .
BC093071 mRNA. Translation: AAH93071.1 .
BC009796 mRNA. Translation: AAH09796.1 .
CCDSi CCDS3234.1. [O43674-1 ]
CCDS56297.1. [O43674-2 ]
PIRi JC5820.
RefSeqi NP_001186886.1. NM_001199957.1. [O43674-2 ]
NP_001186887.1. NM_001199958.1.
NP_002483.1. NM_002492.3. [O43674-1 ]
UniGenei Hs.730674.

3D structure databases

ProteinModelPortali O43674.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110791. 18 interactions.
IntActi O43674. 2 interactions.
STRINGi 9606.ENSP00000259037.

Chemistry

ChEMBLi CHEMBL2363065.

PTM databases

PhosphoSitei O43674.

Proteomic databases

MaxQBi O43674.
PaxDbi O43674.
PRIDEi O43674.

Protocols and materials databases

DNASUi 4711.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259037 ; ENSP00000259037 ; ENSG00000136521 . [O43674-1 ]
ENST00000493866 ; ENSP00000419656 ; ENSG00000136521 . [O43674-2 ]
GeneIDi 4711.
KEGGi hsa:4711.
UCSCi uc003fkc.3. human. [O43674-1 ]
uc003fke.3. human. [O43674-2 ]

Organism-specific databases

CTDi 4711.
GeneCardsi GC03P179322.
HGNCi HGNC:7700. NDUFB5.
HPAi HPA005640.
MIMi 603841. gene.
neXtProti NX_O43674.
PharmGKBi PA31511.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297432.
GeneTreei ENSGT00390000009980.
HOGENOMi HOG000004849.
HOVERGENi HBG003008.
InParanoidi O43674.
KOi K03961.
OrthoDBi EOG7M98HQ.
PhylomeDBi O43674.
TreeFami TF313997.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.

Miscellaneous databases

ChiTaRSi NDUFB5. human.
GenomeRNAii 4711.
NextBioi 18168.
PROi O43674.
SOURCEi Search...

Gene expression databases

Bgeei O43674.
CleanExi HS_NDUFB5.
ExpressionAtlasi O43674. baseline and differential.
Genevestigatori O43674.

Family and domain databases

InterProi IPR019173. NADH_UbQ_OxRdtase_B5_su.
[Graphical view ]
PANTHERi PTHR13178. PTHR13178. 1 hit.
Pfami PF09781. NDUF_B5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits."
    Ton C., Hwang D.M., Dempsey A.A., Liew C.-C.
    Biochem. Biophys. Res. Commun. 241:589-594(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Heart.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Skin and Urinary bladder.
  5. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
    Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
    J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNDUB5_HUMAN
AccessioniPrimary (citable) accession number: O43674
Secondary accession number(s): Q561V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3