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O43674

- NDUB5_HUMAN

UniProt

O43674 - NDUB5_HUMAN

Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

Gene

NDUFB5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

    GO - Biological processi

    1. cellular metabolic process Source: Reactome
    2. mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
    3. respiratory electron transport chain Source: Reactome
    4. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
    Alternative name(s):
    Complex I-SGDH
    Short name:
    CI-SGDH
    NADH-ubiquinone oxidoreductase SGDH subunit
    Gene namesi
    Name:NDUFB5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:7700. NDUFB5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Reactome
    3. mitochondrial respiratory chain complex I Source: UniProtKB
    4. mitochondrion Source: HPA
    5. nucleus Source: HPA

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31511.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4646MitochondrionBy similarityAdd
    BLAST
    Chaini47 – 189143NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialPRO_0000020052Add
    BLAST

    Proteomic databases

    MaxQBiO43674.
    PaxDbiO43674.
    PRIDEiO43674.

    PTM databases

    PhosphoSiteiO43674.

    Expressioni

    Gene expression databases

    ArrayExpressiO43674.
    BgeeiO43674.
    CleanExiHS_NDUFB5.
    GenevestigatoriO43674.

    Organism-specific databases

    HPAiHPA005640.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits.1 Publication

    Protein-protein interaction databases

    BioGridi110791. 14 interactions.
    IntActiO43674. 2 interactions.
    STRINGi9606.ENSP00000259037.

    Structurei

    3D structure databases

    ProteinModelPortaliO43674.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I NDUFB5 subunit family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG297432.
    HOGENOMiHOG000004849.
    HOVERGENiHBG003008.
    InParanoidiO43674.
    KOiK03961.
    OrthoDBiEOG7M98HQ.
    PhylomeDBiO43674.
    TreeFamiTF313997.

    Family and domain databases

    InterProiIPR019173. NADH_UbQ_OxRdtase_B5_su.
    [Graphical view]
    PANTHERiPTHR13178. PTHR13178. 1 hit.
    PfamiPF09781. NDUF_B5. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43674-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MAAMSLLRRV SVTAVAALSG RPLGTRLGFG GFLTRGFPKA AAPVRHSGDH    50
    GKRLFVIRPS RFYDRRFLKL LRFYIALTGI PVAIFITLVN VFIGQAELAE 100
    IPEGYVPEHW EYYKHPISRW IARNFYDSPE KIYERTMAVL QIEAEKAELR 150
    VKELEVRKLM HVRGDGPWYY YETIDKELID HSPKATPDN 189
    Length:189
    Mass (Da):21,750
    Last modified:June 1, 1998 - v1
    Checksum:i66D288F7AB7FD5C5
    GO
    Isoform 2 (identifier: O43674-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         42-93: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:137
    Mass (Da):15,667
    Checksum:iCD8C5524D8116C46
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti133 – 1331Y → H.
    Corresponds to variant rs4147793 [ dbSNP | Ensembl ].
    VAR_050590

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei42 – 9352Missing in isoform 2. 1 PublicationVSP_042516Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047181 mRNA. Translation: AAC04266.1.
    AC090425 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78393.1.
    BC005271 mRNA. Translation: AAH05271.1.
    BC093071 mRNA. Translation: AAH93071.1.
    BC009796 mRNA. Translation: AAH09796.1.
    CCDSiCCDS3234.1. [O43674-1]
    CCDS56297.1. [O43674-2]
    PIRiJC5820.
    RefSeqiNP_001186886.1. NM_001199957.1. [O43674-2]
    NP_001186887.1. NM_001199958.1.
    NP_002483.1. NM_002492.3. [O43674-1]
    UniGeneiHs.730674.

    Genome annotation databases

    EnsembliENST00000259037; ENSP00000259037; ENSG00000136521. [O43674-1]
    ENST00000493866; ENSP00000419656; ENSG00000136521. [O43674-2]
    GeneIDi4711.
    KEGGihsa:4711.
    UCSCiuc003fkc.3. human. [O43674-1]
    uc003fke.3. human. [O43674-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047181 mRNA. Translation: AAC04266.1 .
    AC090425 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78393.1 .
    BC005271 mRNA. Translation: AAH05271.1 .
    BC093071 mRNA. Translation: AAH93071.1 .
    BC009796 mRNA. Translation: AAH09796.1 .
    CCDSi CCDS3234.1. [O43674-1 ]
    CCDS56297.1. [O43674-2 ]
    PIRi JC5820.
    RefSeqi NP_001186886.1. NM_001199957.1. [O43674-2 ]
    NP_001186887.1. NM_001199958.1.
    NP_002483.1. NM_002492.3. [O43674-1 ]
    UniGenei Hs.730674.

    3D structure databases

    ProteinModelPortali O43674.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110791. 14 interactions.
    IntActi O43674. 2 interactions.
    STRINGi 9606.ENSP00000259037.

    Chemistry

    BindingDBi O43674.
    ChEMBLi CHEMBL2363065.
    DrugBanki DB00157. NADH.

    PTM databases

    PhosphoSitei O43674.

    Proteomic databases

    MaxQBi O43674.
    PaxDbi O43674.
    PRIDEi O43674.

    Protocols and materials databases

    DNASUi 4711.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259037 ; ENSP00000259037 ; ENSG00000136521 . [O43674-1 ]
    ENST00000493866 ; ENSP00000419656 ; ENSG00000136521 . [O43674-2 ]
    GeneIDi 4711.
    KEGGi hsa:4711.
    UCSCi uc003fkc.3. human. [O43674-1 ]
    uc003fke.3. human. [O43674-2 ]

    Organism-specific databases

    CTDi 4711.
    GeneCardsi GC03P179322.
    HGNCi HGNC:7700. NDUFB5.
    HPAi HPA005640.
    MIMi 603841. gene.
    neXtProti NX_O43674.
    PharmGKBi PA31511.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297432.
    HOGENOMi HOG000004849.
    HOVERGENi HBG003008.
    InParanoidi O43674.
    KOi K03961.
    OrthoDBi EOG7M98HQ.
    PhylomeDBi O43674.
    TreeFami TF313997.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    ChiTaRSi NDUFB5. human.
    GenomeRNAii 4711.
    NextBioi 18168.
    PROi O43674.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43674.
    Bgeei O43674.
    CleanExi HS_NDUFB5.
    Genevestigatori O43674.

    Family and domain databases

    InterProi IPR019173. NADH_UbQ_OxRdtase_B5_su.
    [Graphical view ]
    PANTHERi PTHR13178. PTHR13178. 1 hit.
    Pfami PF09781. NDUF_B5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits."
      Ton C., Hwang D.M., Dempsey A.A., Liew C.-C.
      Biochem. Biophys. Res. Commun. 241:589-594(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Heart.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Skin and Urinary bladder.
    5. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
      Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
      J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNDUB5_HUMAN
    AccessioniPrimary (citable) accession number: O43674
    Secondary accession number(s): Q561V6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3