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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

Gene

NDUFB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciZFISH:HS06175-MONOMER.
ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Alternative name(s):
Complex I-SGDH
Short name:
CI-SGDH
NADH-ubiquinone oxidoreductase SGDH subunit
Gene namesi
Name:NDUFB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:7700. NDUFB5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4711.
OpenTargetsiENSG00000136521.
PharmGKBiPA31511.

Chemistry databases

ChEMBLiCHEMBL2363065.

Polymorphism and mutation databases

BioMutaiNDUFB5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46MitochondrionBy similarityAdd BLAST46
ChainiPRO_000002005247 – 189NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialAdd BLAST143

Proteomic databases

EPDiO43674.
MaxQBiO43674.
PaxDbiO43674.
PeptideAtlasiO43674.
PRIDEiO43674.
TopDownProteomicsiO43674-1. [O43674-1]
O43674-2. [O43674-2]

PTM databases

iPTMnetiO43674.
PhosphoSitePlusiO43674.

Expressioni

Gene expression databases

BgeeiENSG00000136521.
CleanExiHS_NDUFB5.
ExpressionAtlasiO43674. baseline and differential.
GenevisibleiO43674. HS.

Organism-specific databases

HPAiHPA005640.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Protein-protein interaction databases

BioGridi110791. 60 interactors.
IntActiO43674. 14 interactors.
STRINGi9606.ENSP00000259037.

Structurei

3D structure databases

ProteinModelPortaliO43674.
SMRiO43674.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB5 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4632. Eukaryota.
ENOG4111HCK. LUCA.
GeneTreeiENSGT00390000009980.
HOGENOMiHOG000004849.
HOVERGENiHBG003008.
InParanoidiO43674.
KOiK03961.
PhylomeDBiO43674.
TreeFamiTF313997.

Family and domain databases

InterProiIPR019173. NADH_UbQ_OxRdtase_B5_su.
[Graphical view]
PANTHERiPTHR13178. PTHR13178. 1 hit.
PfamiPF09781. NDUF_B5. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAMSLLRRV SVTAVAALSG RPLGTRLGFG GFLTRGFPKA AAPVRHSGDH
60 70 80 90 100
GKRLFVIRPS RFYDRRFLKL LRFYIALTGI PVAIFITLVN VFIGQAELAE
110 120 130 140 150
IPEGYVPEHW EYYKHPISRW IARNFYDSPE KIYERTMAVL QIEAEKAELR
160 170 180
VKELEVRKLM HVRGDGPWYY YETIDKELID HSPKATPDN
Length:189
Mass (Da):21,750
Last modified:June 1, 1998 - v1
Checksum:i66D288F7AB7FD5C5
GO
Isoform 2 (identifier: O43674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-93: Missing.

Note: No experimental confirmation available.
Show »
Length:137
Mass (Da):15,667
Checksum:iCD8C5524D8116C46
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050590133Y → H.Corresponds to variant rs4147793dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04251642 – 93Missing in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047181 mRNA. Translation: AAC04266.1.
AC090425 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78393.1.
BC005271 mRNA. Translation: AAH05271.1.
BC093071 mRNA. Translation: AAH93071.1.
BC009796 mRNA. Translation: AAH09796.1.
CCDSiCCDS3234.1. [O43674-1]
CCDS56297.1. [O43674-2]
PIRiJC5820.
RefSeqiNP_001186886.1. NM_001199957.1. [O43674-2]
NP_001186887.1. NM_001199958.1.
NP_002483.1. NM_002492.3. [O43674-1]
UniGeneiHs.730674.

Genome annotation databases

EnsembliENST00000259037; ENSP00000259037; ENSG00000136521. [O43674-1]
ENST00000493866; ENSP00000419656; ENSG00000136521. [O43674-2]
GeneIDi4711.
KEGGihsa:4711.
UCSCiuc003fkc.4. human. [O43674-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047181 mRNA. Translation: AAC04266.1.
AC090425 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78393.1.
BC005271 mRNA. Translation: AAH05271.1.
BC093071 mRNA. Translation: AAH93071.1.
BC009796 mRNA. Translation: AAH09796.1.
CCDSiCCDS3234.1. [O43674-1]
CCDS56297.1. [O43674-2]
PIRiJC5820.
RefSeqiNP_001186886.1. NM_001199957.1. [O43674-2]
NP_001186887.1. NM_001199958.1.
NP_002483.1. NM_002492.3. [O43674-1]
UniGeneiHs.730674.

3D structure databases

ProteinModelPortaliO43674.
SMRiO43674.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110791. 60 interactors.
IntActiO43674. 14 interactors.
STRINGi9606.ENSP00000259037.

Chemistry databases

ChEMBLiCHEMBL2363065.

PTM databases

iPTMnetiO43674.
PhosphoSitePlusiO43674.

Polymorphism and mutation databases

BioMutaiNDUFB5.

Proteomic databases

EPDiO43674.
MaxQBiO43674.
PaxDbiO43674.
PeptideAtlasiO43674.
PRIDEiO43674.
TopDownProteomicsiO43674-1. [O43674-1]
O43674-2. [O43674-2]

Protocols and materials databases

DNASUi4711.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259037; ENSP00000259037; ENSG00000136521. [O43674-1]
ENST00000493866; ENSP00000419656; ENSG00000136521. [O43674-2]
GeneIDi4711.
KEGGihsa:4711.
UCSCiuc003fkc.4. human. [O43674-1]

Organism-specific databases

CTDi4711.
DisGeNETi4711.
GeneCardsiNDUFB5.
HGNCiHGNC:7700. NDUFB5.
HPAiHPA005640.
MIMi603841. gene.
neXtProtiNX_O43674.
OpenTargetsiENSG00000136521.
PharmGKBiPA31511.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4632. Eukaryota.
ENOG4111HCK. LUCA.
GeneTreeiENSGT00390000009980.
HOGENOMiHOG000004849.
HOVERGENiHBG003008.
InParanoidiO43674.
KOiK03961.
PhylomeDBiO43674.
TreeFamiTF313997.

Enzyme and pathway databases

BioCyciZFISH:HS06175-MONOMER.
ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Miscellaneous databases

ChiTaRSiNDUFB5. human.
GenomeRNAii4711.
PROiO43674.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136521.
CleanExiHS_NDUFB5.
ExpressionAtlasiO43674. baseline and differential.
GenevisibleiO43674. HS.

Family and domain databases

InterProiIPR019173. NADH_UbQ_OxRdtase_B5_su.
[Graphical view]
PANTHERiPTHR13178. PTHR13178. 1 hit.
PfamiPF09781. NDUF_B5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB5_HUMAN
AccessioniPrimary (citable) accession number: O43674
Secondary accession number(s): Q561V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.