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O43674 (NDUB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
Alternative name(s):
Complex I-SGDH
Short name=CI-SGDH
NADH-ubiquinone oxidoreductase SGDH subunit
Gene names
Name:NDUFB5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Subunit structure

Complex I is composed of 45 different subunits. Ref.5

Subcellular location

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Sequence similarities

Belongs to the complex I NDUFB5 subunit family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O43674-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O43674-2)

The sequence of this isoform differs from the canonical sequence as follows:
     42-93: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4646Mitochondrion By similarity
Chain47 – 189143NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
PRO_0000020052

Regions

Transmembrane73 – 9321Helical; Potential

Natural variations

Alternative sequence42 – 9352Missing in isoform 2.
VSP_042516
Natural variant1331Y → H.
Corresponds to variant rs4147793 [ dbSNP | Ensembl ].
VAR_050590

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: 66D288F7AB7FD5C5

FASTA18921,750
        10         20         30         40         50         60 
MAAMSLLRRV SVTAVAALSG RPLGTRLGFG GFLTRGFPKA AAPVRHSGDH GKRLFVIRPS 

        70         80         90        100        110        120 
RFYDRRFLKL LRFYIALTGI PVAIFITLVN VFIGQAELAE IPEGYVPEHW EYYKHPISRW 

       130        140        150        160        170        180 
IARNFYDSPE KIYERTMAVL QIEAEKAELR VKELEVRKLM HVRGDGPWYY YETIDKELID 


HSPKATPDN 

« Hide

Isoform 2 [UniParc].

Checksum: CD8C5524D8116C46
Show »

FASTA13715,667

References

« Hide 'large scale' references
[1]"Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits."
Ton C., Hwang D.M., Dempsey A.A., Liew C.-C.
Biochem. Biophys. Res. Commun. 241:589-594(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Heart.
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain, Skin and Urinary bladder.
[5]"The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: MASS SPECTROMETRY, IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF047181 mRNA. Translation: AAC04266.1.
AC090425 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78393.1.
BC005271 mRNA. Translation: AAH05271.1.
BC093071 mRNA. Translation: AAH93071.1.
BC009796 mRNA. Translation: AAH09796.1.
PIRJC5820.
RefSeqNP_001186886.1. NM_001199957.1.
NP_001186887.1. NM_001199958.1.
NP_002483.1. NM_002492.3.
UniGeneHs.730674.

3D structure databases

ProteinModelPortalO43674.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110791. 14 interactions.
IntActO43674. 2 interactions.
STRING9606.ENSP00000259037.

Chemistry

BindingDBO43674.
ChEMBLCHEMBL2363065.
DrugBankDB00157. NADH.

PTM databases

PhosphoSiteO43674.

Proteomic databases

PaxDbO43674.
PRIDEO43674.

Protocols and materials databases

DNASU4711.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259037; ENSP00000259037; ENSG00000136521. [O43674-1]
ENST00000493866; ENSP00000419656; ENSG00000136521. [O43674-2]
GeneID4711.
KEGGhsa:4711.
UCSCuc003fkc.3. human. [O43674-1]
uc003fke.3. human. [O43674-2]

Organism-specific databases

CTD4711.
GeneCardsGC03P179322.
HGNCHGNC:7700. NDUFB5.
HPAHPA005640.
MIM603841. gene.
neXtProtNX_O43674.
PharmGKBPA31511.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG297432.
HOGENOMHOG000004849.
HOVERGENHBG003008.
InParanoidO43674.
KOK03961.
OrthoDBEOG7M98HQ.
PhylomeDBO43674.
TreeFamTF313997.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressO43674.
BgeeO43674.
CleanExHS_NDUFB5.
GenevestigatorO43674.

Family and domain databases

InterProIPR019173. NADH_UbQ_OxRdtase_B5_su.
[Graphical view]
PANTHERPTHR13178. PTHR13178. 1 hit.
PfamPF09781. NDUF_B5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNDUFB5. human.
GenomeRNAi4711.
NextBio18168.
PROO43674.
SOURCESearch...

Entry information

Entry nameNDUB5_HUMAN
AccessionPrimary (citable) accession number: O43674
Secondary accession number(s): Q561V6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: March 19, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM