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O43665

- RGS10_HUMAN

UniProt

O43665 - RGS10_HUMAN

Protein

Regulator of G-protein signaling 10

Gene

RGS10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_19231. G alpha (i) signalling events.
    SignaLinkiO43665.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 10
    Short name:
    RGS10
    Gene namesi
    Name:RGS10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:9992. RGS10.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: Ensembl
    2. cytoplasm Source: RefGenome
    3. dendritic spine Source: Ensembl
    4. neuronal cell body Source: Ensembl
    5. nucleus Source: HPA
    6. plasma membrane Source: RefGenome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34362.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 173173Regulator of G-protein signaling 10PRO_0000204207Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi66 – 661S-palmitoyl cysteine1 Publication

    Post-translational modificationi

    Isoform 3 is phosphorylated on Ser-16.

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    MaxQBiO43665.
    PaxDbiO43665.
    PRIDEiO43665.

    2D gel databases

    OGPiO43665.

    Miscellaneous databases

    PMAP-CutDBO43665.

    Expressioni

    Gene expression databases

    BgeeiO43665.
    CleanExiHS_RGS10.
    GenevestigatoriO43665.

    Organism-specific databases

    HPAiCAB004559.
    HPA021305.

    Interactioni

    Protein-protein interaction databases

    BioGridi111933. 9 interactions.
    DIPiDIP-50368N.
    STRINGi9606.ENSP00000358099.

    Structurei

    Secondary structure

    1
    173
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi25 – 328
    Helixi34 – 396
    Helixi41 – 5313
    Helixi58 – 7114
    Helixi75 – 8915
    Helixi94 – 963
    Helixi103 – 1053
    Helixi108 – 1125
    Turni116 – 1194
    Helixi120 – 13213
    Helixi134 – 1385
    Turni142 – 1443
    Turni146 – 1505

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DLRNMR-A23-158[»]
    2I59NMR-A22-157[»]
    2IHBX-ray2.71B9-152[»]
    ProteinModelPortaliO43665.
    SMRiO43665. Positions 20-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43665.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 148116RGSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG271158.
    HOGENOMiHOG000233512.
    HOVERGENiHBG013233.
    KOiK16449.
    OMAiPKSTAKW.
    OrthoDBiEOG7XDBF0.
    PhylomeDBiO43665.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 1 hit.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43665-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQSELCFADI HDSDGSSSSS HQSLKSTAKW AASLENLLED PEGVKRFREF    50
    LKKEFSEENV LFWLACEDFK KMQDKTQMQE KAKEIYMTFL SSKASSQVNV 100
    EGQSRLNEKI LEEPHPLMFQ KLQDQIFNLM KYDSYSRFLK SDLFLKHKRT 150
    EEEEEDLPDA QTAAKRASRI YNT 173
    Length:173
    Mass (Da):20,236
    Last modified:August 14, 2001 - v2
    Checksum:iCA73D1E38F551EF1
    GO
    Isoform 2 (identifier: O43665-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: MQSELCFAD → MEH

    Show »
    Length:167
    Mass (Da):19,608
    Checksum:iEF36915F1AA23F3B
    GO
    Isoform 3 (identifier: O43665-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-8: MQSELCFA → MFNRAVSRLSRKRPPS

    Show »
    Length:181
    Mass (Da):21,210
    Checksum:iD83CCB98A6EE2182
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti94 – 941A → V.
    Corresponds to variant rs1802228 [ dbSNP | Ensembl ].
    VAR_011896

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99MQSELCFAD → MEH in isoform 2. 2 PublicationsVSP_005681
    Alternative sequencei1 – 88MQSELCFA → MFNRAVSRLSRKRPPS in isoform 3. 2 PublicationsVSP_027366

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF368902 mRNA. Translation: AAK52979.1.
    AF045229 mRNA. Translation: AAC03783.1.
    AF493934 mRNA. Translation: AAM12648.1.
    AK290773 mRNA. Translation: BAF83462.1.
    CR457008 mRNA. Translation: CAG33289.1.
    AL355273, AC012468 Genomic DNA. Translation: CAI16486.1.
    AL355273 Genomic DNA. Translation: CAI16488.1.
    CH471066 Genomic DNA. Translation: EAW49389.1.
    CH471066 Genomic DNA. Translation: EAW49390.1.
    BC009361 mRNA. Translation: AAH09361.1.
    CCDSiCCDS31294.1. [O43665-3]
    CCDS41572.1. [O43665-2]
    PIRiS71812.
    RefSeqiNP_001005339.1. NM_001005339.1. [O43665-3]
    NP_002916.1. NM_002925.3. [O43665-2]
    UniGeneiHs.501200.

    Genome annotation databases

    EnsembliENST00000369101; ENSP00000358097; ENSG00000148908. [O43665-1]
    ENST00000369103; ENSP00000358099; ENSG00000148908. [O43665-3]
    ENST00000392865; ENSP00000376605; ENSG00000148908. [O43665-2]
    GeneIDi6001.
    KEGGihsa:6001.
    UCSCiuc001lee.3. human. [O43665-1]
    uc001lef.3. human. [O43665-2]
    uc001leg.3. human. [O43665-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF368902 mRNA. Translation: AAK52979.1 .
    AF045229 mRNA. Translation: AAC03783.1 .
    AF493934 mRNA. Translation: AAM12648.1 .
    AK290773 mRNA. Translation: BAF83462.1 .
    CR457008 mRNA. Translation: CAG33289.1 .
    AL355273 , AC012468 Genomic DNA. Translation: CAI16486.1 .
    AL355273 Genomic DNA. Translation: CAI16488.1 .
    CH471066 Genomic DNA. Translation: EAW49389.1 .
    CH471066 Genomic DNA. Translation: EAW49390.1 .
    BC009361 mRNA. Translation: AAH09361.1 .
    CCDSi CCDS31294.1. [O43665-3 ]
    CCDS41572.1. [O43665-2 ]
    PIRi S71812.
    RefSeqi NP_001005339.1. NM_001005339.1. [O43665-3 ]
    NP_002916.1. NM_002925.3. [O43665-2 ]
    UniGenei Hs.501200.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DLR NMR - A 23-158 [» ]
    2I59 NMR - A 22-157 [» ]
    2IHB X-ray 2.71 B 9-152 [» ]
    ProteinModelPortali O43665.
    SMRi O43665. Positions 20-157.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111933. 9 interactions.
    DIPi DIP-50368N.
    STRINGi 9606.ENSP00000358099.

    2D gel databases

    OGPi O43665.

    Proteomic databases

    MaxQBi O43665.
    PaxDbi O43665.
    PRIDEi O43665.

    Protocols and materials databases

    DNASUi 6001.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369101 ; ENSP00000358097 ; ENSG00000148908 . [O43665-1 ]
    ENST00000369103 ; ENSP00000358099 ; ENSG00000148908 . [O43665-3 ]
    ENST00000392865 ; ENSP00000376605 ; ENSG00000148908 . [O43665-2 ]
    GeneIDi 6001.
    KEGGi hsa:6001.
    UCSCi uc001lee.3. human. [O43665-1 ]
    uc001lef.3. human. [O43665-2 ]
    uc001leg.3. human. [O43665-3 ]

    Organism-specific databases

    CTDi 6001.
    GeneCardsi GC10M121249.
    HGNCi HGNC:9992. RGS10.
    HPAi CAB004559.
    HPA021305.
    MIMi 602856. gene.
    neXtProti NX_O43665.
    PharmGKBi PA34362.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271158.
    HOGENOMi HOG000233512.
    HOVERGENi HBG013233.
    KOi K16449.
    OMAi PKSTAKW.
    OrthoDBi EOG7XDBF0.
    PhylomeDBi O43665.
    TreeFami TF315837.

    Enzyme and pathway databases

    Reactomei REACT_19231. G alpha (i) signalling events.
    SignaLinki O43665.

    Miscellaneous databases

    EvolutionaryTracei O43665.
    GeneWikii RGS10.
    GenomeRNAii 6001.
    NextBioi 23399.
    PMAP-CutDB O43665.
    PROi O43665.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43665.
    CleanExi HS_RGS10.
    Genevestigatori O43665.

    Family and domain databases

    Gene3Di 1.10.196.10. 1 hit.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RGS10 is a selective activator of G alpha i GTPase activity."
      Hunt T.W., Fields T.A., Casey P.J., Peralta E.G.
      Nature 383:175-177(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cytoplasmic, nuclear, and Golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs."
      Chatterjee T.K., Fisher R.A.
      J. Biol. Chem. 275:24013-24021(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10)."
      Burgon P.G., Lee W.L., Nixon A.B., Peralta E.G., Casey P.J.
      J. Biol. Chem. 276:32828-32834(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    7. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Uterus.
    10. "Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10."
      Tu Y., Popov S., Slaughter C., Ross E.M.
      J. Biol. Chem. 274:38260-38267(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION AT CYS-66.
    11. "Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits."
      Tu Y., Wang J., Ross E.M.
      Science 278:1132-1135(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INHIBITION.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Solution structure of the RGS domain of human regulator of G-protein signaling 10."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 23-158.

    Entry informationi

    Entry nameiRGS10_HUMAN
    AccessioniPrimary (citable) accession number: O43665
    Secondary accession number(s): A8K408
    , B1AMR8, Q6IAZ6, Q96GN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3