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O43665 (RGS10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 10

Short name=RGS10
Gene names
Name:RGS10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein.

Post-translational modification

Isoform 3 is phosphorylated on Ser-16.

Sequence similarities

Contains 1 RGS domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O43665-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O43665-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MQSELCFAD → MEH
Isoform 3 (identifier: O43665-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MQSELCFA → MFNRAVSRLSRKRPPS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 173173Regulator of G-protein signaling 10
PRO_0000204207

Regions

Domain33 – 148116RGS

Amino acid modifications

Lipidation661S-palmitoyl cysteine Ref.10

Natural variations

Alternative sequence1 – 99MQSELCFAD → MEH in isoform 2.
VSP_005681
Alternative sequence1 – 88MQSELCFA → MFNRAVSRLSRKRPPS in isoform 3.
VSP_027366
Natural variant941A → V.
Corresponds to variant rs1802228 [ dbSNP | Ensembl ].
VAR_011896

Secondary structure

.......................... 173
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: CA73D1E38F551EF1

FASTA17320,236
        10         20         30         40         50         60 
MQSELCFADI HDSDGSSSSS HQSLKSTAKW AASLENLLED PEGVKRFREF LKKEFSEENV 

        70         80         90        100        110        120 
LFWLACEDFK KMQDKTQMQE KAKEIYMTFL SSKASSQVNV EGQSRLNEKI LEEPHPLMFQ 

       130        140        150        160        170 
KLQDQIFNLM KYDSYSRFLK SDLFLKHKRT EEEEEDLPDA QTAAKRASRI YNT 

« Hide

Isoform 2 [UniParc].

Checksum: EF36915F1AA23F3B
Show »

FASTA16719,608
Isoform 3 [UniParc].

Checksum: D83CCB98A6EE2182
Show »

FASTA18121,210

References

« Hide 'large scale' references
[1]"RGS10 is a selective activator of G alpha i GTPase activity."
Hunt T.W., Fields T.A., Casey P.J., Peralta E.G.
Nature 383:175-177(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Cytoplasmic, nuclear, and Golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs."
Chatterjee T.K., Fisher R.A.
J. Biol. Chem. 275:24013-24021(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]"Phosphorylation and nuclear translocation of a regulator of G protein signaling (RGS10)."
Burgon P.G., Lee W.L., Nixon A.B., Peralta E.G., Casey P.J.
J. Biol. Chem. 276:32828-32834(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[6]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[7]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Uterus.
[10]"Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10."
Tu Y., Popov S., Slaughter C., Ross E.M.
J. Biol. Chem. 274:38260-38267(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PALMITOYLATION AT CYS-66.
[11]"Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits."
Tu Y., Wang J., Ross E.M.
Science 278:1132-1135(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INHIBITION.
[12]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Solution structure of the RGS domain of human regulator of G-protein signaling 10."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 23-158.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF368902 mRNA. Translation: AAK52979.1.
AF045229 mRNA. Translation: AAC03783.1.
AF493934 mRNA. Translation: AAM12648.1.
AK290773 mRNA. Translation: BAF83462.1.
CR457008 mRNA. Translation: CAG33289.1.
AL355273, AC012468 Genomic DNA. Translation: CAI16486.1.
AL355273 Genomic DNA. Translation: CAI16488.1.
CH471066 Genomic DNA. Translation: EAW49389.1.
CH471066 Genomic DNA. Translation: EAW49390.1.
BC009361 mRNA. Translation: AAH09361.1.
CCDSCCDS31294.1. [O43665-3]
CCDS41572.1. [O43665-2]
PIRS71812.
RefSeqNP_001005339.1. NM_001005339.1. [O43665-3]
NP_002916.1. NM_002925.3. [O43665-2]
UniGeneHs.501200.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2DLRNMR-A23-158[»]
2I59NMR-A22-157[»]
2IHBX-ray2.71B9-152[»]
ProteinModelPortalO43665.
SMRO43665. Positions 20-157.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111933. 8 interactions.
DIPDIP-50368N.
STRING9606.ENSP00000358099.

2D gel databases

OGPO43665.

Proteomic databases

MaxQBO43665.
PaxDbO43665.
PRIDEO43665.

Protocols and materials databases

DNASU6001.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369101; ENSP00000358097; ENSG00000148908. [O43665-1]
ENST00000369103; ENSP00000358099; ENSG00000148908. [O43665-3]
ENST00000392865; ENSP00000376605; ENSG00000148908. [O43665-2]
GeneID6001.
KEGGhsa:6001.
UCSCuc001lee.3. human. [O43665-1]
uc001lef.3. human. [O43665-2]
uc001leg.3. human. [O43665-3]

Organism-specific databases

CTD6001.
GeneCardsGC10M121249.
HGNCHGNC:9992. RGS10.
HPACAB004559.
HPA021305.
MIM602856. gene.
neXtProtNX_O43665.
PharmGKBPA34362.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG271158.
HOGENOMHOG000233512.
HOVERGENHBG013233.
KOK16449.
OMAPKSTAKW.
OrthoDBEOG7XDBF0.
PhylomeDBO43665.
TreeFamTF315837.

Enzyme and pathway databases

SignaLinkO43665.

Gene expression databases

BgeeO43665.
CleanExHS_RGS10.
GenevestigatorO43665.

Family and domain databases

Gene3D1.10.196.10. 1 hit.
InterProIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO43665.
GeneWikiRGS10.
GenomeRNAi6001.
NextBio23399.
PMAP-CutDBO43665.
PROO43665.
SOURCESearch...

Entry information

Entry nameRGS10_HUMAN
AccessionPrimary (citable) accession number: O43665
Secondary accession number(s): A8K408 expand/collapse secondary AC list , B1AMR8, Q6IAZ6, Q96GN0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 14, 2001
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM