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O43657

- TSN6_HUMAN

UniProt

O43657 - TSN6_HUMAN

Protein

Tetraspanin-6

Gene

TSPAN6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
    2. negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway Source: UniProtKB
    3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    4. signal transduction Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-6
    Short name:
    Tspan-6
    Alternative name(s):
    A15 homolog
    Putative NF-kappa-B-activating protein 321
    T245 protein
    Tetraspanin TM4-D
    Transmembrane 4 superfamily member 6
    Gene namesi
    Name:TSPAN6
    Synonyms:TM4SF6
    ORF Names:UNQ767/PRO1560
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:11858. TSPAN6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36559.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245Tetraspanin-6PRO_0000219246Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO43657.
    PaxDbiO43657.
    PeptideAtlasiO43657.
    PRIDEiO43657.

    PTM databases

    PhosphoSiteiO43657.

    Expressioni

    Gene expression databases

    BgeeiO43657.
    CleanExiHS_TSPAN6.
    GenevestigatoriO43657.

    Organism-specific databases

    HPAiHPA004109.

    Interactioni

    Protein-protein interaction databases

    BioGridi112960. 8 interactions.
    IntActiO43657. 3 interactions.
    MINTiMINT-1374157.
    STRINGi9606.ENSP00000362111.

    Structurei

    3D structure databases

    ProteinModelPortaliO43657.
    SMRiO43657. Positions 112-208.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 5919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini81 – 9313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini115 – 20894ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini230 – 24516CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG274015.
    HOVERGENiHBG107306.
    InParanoidiO43657.
    KOiK17295.
    OMAiHCCGVTN.
    OrthoDBiEOG73BVDM.
    PhylomeDBiO43657.
    TreeFamiTF352891.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43657-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPSRRLQT KPVITCFKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF    50
    SLLNEKATNV PFVLIATGTV IILLGTFGCF ATCRASAWML KLYAMFLTLV 100
    FLVELVAAIV GFVFRHEIKN SFKNNYEKAL KQYNSTGDYR SHAVDKIQNT 150
    LHCCGVTDYR DWTDTNYYSE KGFPKSCCKL EDCTPQRDAD KVNNEGCFIK 200
    VMTIIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN QYEIV 245
    Length:245
    Mass (Da):27,563
    Last modified:June 1, 1998 - v1
    Checksum:i811FAB19C2805BE2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti108 – 1081A → T.1 Publication
    Corresponds to variant rs1802288 [ dbSNP | Ensembl ].
    VAR_014494

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053453 mRNA. Translation: AAC69710.1.
    AF043906 mRNA. Translation: AAC64257.1.
    U84895 mRNA. Translation: AAD00560.1.
    AF133426 mRNA. Translation: AAF08365.1.
    AY358825 mRNA. Translation: AAQ89184.1.
    AB097016 mRNA. Translation: BAC77369.1.
    BT006977 mRNA. Translation: AAP35623.1.
    CR457115 mRNA. Translation: CAG33396.1.
    AL035608 Genomic DNA. Translation: CAB55681.1.
    CH471115 Genomic DNA. Translation: EAX02811.1.
    BC012389 mRNA. Translation: AAH12389.1.
    CCDSiCCDS14470.1.
    PIRiA59258.
    RefSeqiNP_001265672.1. NM_001278743.1.
    NP_003261.1. NM_003270.3.
    UniGeneiHs.43233.
    Hs.587521.

    Genome annotation databases

    EnsembliENST00000373020; ENSP00000362111; ENSG00000000003.
    GeneIDi7105.
    KEGGihsa:7105.
    UCSCiuc004ega.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053453 mRNA. Translation: AAC69710.1 .
    AF043906 mRNA. Translation: AAC64257.1 .
    U84895 mRNA. Translation: AAD00560.1 .
    AF133426 mRNA. Translation: AAF08365.1 .
    AY358825 mRNA. Translation: AAQ89184.1 .
    AB097016 mRNA. Translation: BAC77369.1 .
    BT006977 mRNA. Translation: AAP35623.1 .
    CR457115 mRNA. Translation: CAG33396.1 .
    AL035608 Genomic DNA. Translation: CAB55681.1 .
    CH471115 Genomic DNA. Translation: EAX02811.1 .
    BC012389 mRNA. Translation: AAH12389.1 .
    CCDSi CCDS14470.1.
    PIRi A59258.
    RefSeqi NP_001265672.1. NM_001278743.1.
    NP_003261.1. NM_003270.3.
    UniGenei Hs.43233.
    Hs.587521.

    3D structure databases

    ProteinModelPortali O43657.
    SMRi O43657. Positions 112-208.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112960. 8 interactions.
    IntActi O43657. 3 interactions.
    MINTi MINT-1374157.
    STRINGi 9606.ENSP00000362111.

    PTM databases

    PhosphoSitei O43657.

    Proteomic databases

    MaxQBi O43657.
    PaxDbi O43657.
    PeptideAtlasi O43657.
    PRIDEi O43657.

    Protocols and materials databases

    DNASUi 7105.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373020 ; ENSP00000362111 ; ENSG00000000003 .
    GeneIDi 7105.
    KEGGi hsa:7105.
    UCSCi uc004ega.1. human.

    Organism-specific databases

    CTDi 7105.
    GeneCardsi GC0XM099886.
    HGNCi HGNC:11858. TSPAN6.
    HPAi HPA004109.
    MIMi 300191. gene.
    neXtProti NX_O43657.
    PharmGKBi PA36559.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG274015.
    HOVERGENi HBG107306.
    InParanoidi O43657.
    KOi K17295.
    OMAi HCCGVTN.
    OrthoDBi EOG73BVDM.
    PhylomeDBi O43657.
    TreeFami TF352891.

    Miscellaneous databases

    GeneWikii TSPAN6.
    GenomeRNAii 7105.
    NextBioi 27797.
    PROi O43657.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43657.
    CleanExi HS_TSPAN6.
    Genevestigatori O43657.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences and expression of six new members of the tetraspanin/TM4SF family."
      Todd S.C., Doctor V.S., Levy S.
      Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22."
      Maeda K., Matsuhashi S., Hori K., Xin Z., Mukai T., Tabuchi K., Egashira M., Niikawa N.
      Genomics 52:240-242(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The cDNA cloning of a novel gene A15 homologue which encodes a new member of the transmembrane 4 superfamily."
      Maeda K., Matsuhashi Y.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The molecular characterization of four tetraspanins."
      Puls K.L., Ni J., Liu D., Morahan G., Wright M.D.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
      Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-108.
      Tissue: Lung.
    7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    9. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTSN6_HUMAN
    AccessioniPrimary (citable) accession number: O43657
    Secondary accession number(s): Q54A42, Q6IAN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3