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Protein

Tetraspanin-6

Gene

TSPAN6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • signal transducer activity Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
  • negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-6
Short name:
Tspan-6
Alternative name(s):
A15 homolog
Putative NF-kappa-B-activating protein 321
T245 protein
Tetraspanin TM4-D
Transmembrane 4 superfamily member 6
Gene namesi
Name:TSPAN6
Synonyms:TM4SF6
ORF Names:UNQ767/PRO1560
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:11858. TSPAN6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence analysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Topological domaini41 – 5919ExtracellularSequence analysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence analysisAdd
BLAST
Topological domaini81 – 9313CytoplasmicSequence analysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Topological domaini115 – 20894ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence analysisAdd
BLAST
Topological domaini230 – 24516CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36559.

Polymorphism and mutation databases

BioMutaiTSPAN6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Tetraspanin-6PRO_0000219246Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO43657.
MaxQBiO43657.
PaxDbiO43657.
PeptideAtlasiO43657.
PRIDEiO43657.

PTM databases

iPTMnetiO43657.
PhosphoSiteiO43657.
SwissPalmiO43657.

Expressioni

Gene expression databases

BgeeiENSG00000000003.
CleanExiHS_TSPAN6.
ExpressionAtlasiO43657. baseline and differential.
GenevisibleiO43657. HS.

Organism-specific databases

HPAiHPA004109.

Interactioni

Protein-protein interaction databases

BioGridi112960. 19 interactions.
IntActiO43657. 3 interactions.
MINTiMINT-1374157.
STRINGi9606.ENSP00000362111.

Structurei

3D structure databases

ProteinModelPortaliO43657.
SMRiO43657. Positions 112-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOVERGENiHBG107306.
InParanoidiO43657.
KOiK17295.
OMAiEDCSPQR.
OrthoDBiEOG091G0NJA.
PhylomeDBiO43657.
TreeFamiTF352891.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPSRRLQT KPVITCFKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF
60 70 80 90 100
SLLNEKATNV PFVLIATGTV IILLGTFGCF ATCRASAWML KLYAMFLTLV
110 120 130 140 150
FLVELVAAIV GFVFRHEIKN SFKNNYEKAL KQYNSTGDYR SHAVDKIQNT
160 170 180 190 200
LHCCGVTDYR DWTDTNYYSE KGFPKSCCKL EDCTPQRDAD KVNNEGCFIK
210 220 230 240
VMTIIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN QYEIV
Length:245
Mass (Da):27,563
Last modified:June 1, 1998 - v1
Checksum:i811FAB19C2805BE2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081A → T.1 Publication
Corresponds to variant rs1802288 [ dbSNP | Ensembl ].
VAR_014494

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053453 mRNA. Translation: AAC69710.1.
AF043906 mRNA. Translation: AAC64257.1.
U84895 mRNA. Translation: AAD00560.1.
AF133426 mRNA. Translation: AAF08365.1.
AY358825 mRNA. Translation: AAQ89184.1.
AB097016 mRNA. Translation: BAC77369.1.
BT006977 mRNA. Translation: AAP35623.1.
CR457115 mRNA. Translation: CAG33396.1.
AL035608 Genomic DNA. Translation: CAB55681.1.
CH471115 Genomic DNA. Translation: EAX02811.1.
BC012389 mRNA. Translation: AAH12389.1.
CCDSiCCDS14470.1.
PIRiA59258.
RefSeqiNP_001265672.1. NM_001278743.1.
NP_003261.1. NM_003270.3.
UniGeneiHs.43233.
Hs.587521.

Genome annotation databases

EnsembliENST00000373020; ENSP00000362111; ENSG00000000003.
GeneIDi7105.
KEGGihsa:7105.
UCSCiuc004ega.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053453 mRNA. Translation: AAC69710.1.
AF043906 mRNA. Translation: AAC64257.1.
U84895 mRNA. Translation: AAD00560.1.
AF133426 mRNA. Translation: AAF08365.1.
AY358825 mRNA. Translation: AAQ89184.1.
AB097016 mRNA. Translation: BAC77369.1.
BT006977 mRNA. Translation: AAP35623.1.
CR457115 mRNA. Translation: CAG33396.1.
AL035608 Genomic DNA. Translation: CAB55681.1.
CH471115 Genomic DNA. Translation: EAX02811.1.
BC012389 mRNA. Translation: AAH12389.1.
CCDSiCCDS14470.1.
PIRiA59258.
RefSeqiNP_001265672.1. NM_001278743.1.
NP_003261.1. NM_003270.3.
UniGeneiHs.43233.
Hs.587521.

3D structure databases

ProteinModelPortaliO43657.
SMRiO43657. Positions 112-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112960. 19 interactions.
IntActiO43657. 3 interactions.
MINTiMINT-1374157.
STRINGi9606.ENSP00000362111.

PTM databases

iPTMnetiO43657.
PhosphoSiteiO43657.
SwissPalmiO43657.

Polymorphism and mutation databases

BioMutaiTSPAN6.

Proteomic databases

EPDiO43657.
MaxQBiO43657.
PaxDbiO43657.
PeptideAtlasiO43657.
PRIDEiO43657.

Protocols and materials databases

DNASUi7105.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373020; ENSP00000362111; ENSG00000000003.
GeneIDi7105.
KEGGihsa:7105.
UCSCiuc004ega.3. human.

Organism-specific databases

CTDi7105.
GeneCardsiTSPAN6.
HGNCiHGNC:11858. TSPAN6.
HPAiHPA004109.
MIMi300191. gene.
neXtProtiNX_O43657.
PharmGKBiPA36559.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOVERGENiHBG107306.
InParanoidiO43657.
KOiK17295.
OMAiEDCSPQR.
OrthoDBiEOG091G0NJA.
PhylomeDBiO43657.
TreeFamiTF352891.

Miscellaneous databases

ChiTaRSiTSPAN6. human.
GeneWikiiTSPAN6.
GenomeRNAii7105.
PROiO43657.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000000003.
CleanExiHS_TSPAN6.
ExpressionAtlasiO43657. baseline and differential.
GenevisibleiO43657. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN6_HUMAN
AccessioniPrimary (citable) accession number: O43657
Secondary accession number(s): Q54A42, Q6IAN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: September 7, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.