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O43657

- TSN6_HUMAN

UniProt

O43657 - TSN6_HUMAN

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Protein

Tetraspanin-6

Gene

TSPAN6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
  2. negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway Source: UniProtKB
  3. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  4. signal transduction Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-6
Short name:
Tspan-6
Alternative name(s):
A15 homolog
Putative NF-kappa-B-activating protein 321
T245 protein
Tetraspanin TM4-D
Transmembrane 4 superfamily member 6
Gene namesi
Name:TSPAN6
Synonyms:TM4SF6
ORF Names:UNQ767/PRO1560
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:11858. TSPAN6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 5919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Topological domaini81 – 9313CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence AnalysisAdd
BLAST
Topological domaini115 – 20894ExtracellularSequence AnalysisAdd
BLAST
Transmembranei209 – 22921HelicalSequence AnalysisAdd
BLAST
Topological domaini230 – 24516CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36559.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Tetraspanin-6PRO_0000219246Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO43657.
PaxDbiO43657.
PeptideAtlasiO43657.
PRIDEiO43657.

PTM databases

PhosphoSiteiO43657.

Expressioni

Gene expression databases

BgeeiO43657.
CleanExiHS_TSPAN6.
GenevestigatoriO43657.

Organism-specific databases

HPAiHPA004109.

Interactioni

Protein-protein interaction databases

BioGridi112960. 11 interactions.
IntActiO43657. 3 interactions.
MINTiMINT-1374157.
STRINGi9606.ENSP00000362111.

Structurei

3D structure databases

ProteinModelPortaliO43657.
SMRiO43657. Positions 111-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG274015.
GeneTreeiENSGT00760000118875.
HOVERGENiHBG107306.
InParanoidiO43657.
KOiK17295.
OMAiHCCGVTN.
OrthoDBiEOG73BVDM.
PhylomeDBiO43657.
TreeFamiTF352891.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43657-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASPSRRLQT KPVITCFKSV LLIYTFIFWI TGVILLAVGI WGKVSLENYF
60 70 80 90 100
SLLNEKATNV PFVLIATGTV IILLGTFGCF ATCRASAWML KLYAMFLTLV
110 120 130 140 150
FLVELVAAIV GFVFRHEIKN SFKNNYEKAL KQYNSTGDYR SHAVDKIQNT
160 170 180 190 200
LHCCGVTDYR DWTDTNYYSE KGFPKSCCKL EDCTPQRDAD KVNNEGCFIK
210 220 230 240
VMTIIESEMG VVAGISFGVA CFQLIGIFLA YCLSRAITNN QYEIV
Length:245
Mass (Da):27,563
Last modified:June 1, 1998 - v1
Checksum:i811FAB19C2805BE2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081A → T.1 Publication
Corresponds to variant rs1802288 [ dbSNP | Ensembl ].
VAR_014494

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053453 mRNA. Translation: AAC69710.1.
AF043906 mRNA. Translation: AAC64257.1.
U84895 mRNA. Translation: AAD00560.1.
AF133426 mRNA. Translation: AAF08365.1.
AY358825 mRNA. Translation: AAQ89184.1.
AB097016 mRNA. Translation: BAC77369.1.
BT006977 mRNA. Translation: AAP35623.1.
CR457115 mRNA. Translation: CAG33396.1.
AL035608 Genomic DNA. Translation: CAB55681.1.
CH471115 Genomic DNA. Translation: EAX02811.1.
BC012389 mRNA. Translation: AAH12389.1.
CCDSiCCDS14470.1.
PIRiA59258.
RefSeqiNP_001265672.1. NM_001278743.1.
NP_003261.1. NM_003270.3.
UniGeneiHs.43233.
Hs.587521.

Genome annotation databases

EnsembliENST00000373020; ENSP00000362111; ENSG00000000003.
GeneIDi7105.
KEGGihsa:7105.
UCSCiuc004ega.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053453 mRNA. Translation: AAC69710.1 .
AF043906 mRNA. Translation: AAC64257.1 .
U84895 mRNA. Translation: AAD00560.1 .
AF133426 mRNA. Translation: AAF08365.1 .
AY358825 mRNA. Translation: AAQ89184.1 .
AB097016 mRNA. Translation: BAC77369.1 .
BT006977 mRNA. Translation: AAP35623.1 .
CR457115 mRNA. Translation: CAG33396.1 .
AL035608 Genomic DNA. Translation: CAB55681.1 .
CH471115 Genomic DNA. Translation: EAX02811.1 .
BC012389 mRNA. Translation: AAH12389.1 .
CCDSi CCDS14470.1.
PIRi A59258.
RefSeqi NP_001265672.1. NM_001278743.1.
NP_003261.1. NM_003270.3.
UniGenei Hs.43233.
Hs.587521.

3D structure databases

ProteinModelPortali O43657.
SMRi O43657. Positions 111-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112960. 11 interactions.
IntActi O43657. 3 interactions.
MINTi MINT-1374157.
STRINGi 9606.ENSP00000362111.

PTM databases

PhosphoSitei O43657.

Proteomic databases

MaxQBi O43657.
PaxDbi O43657.
PeptideAtlasi O43657.
PRIDEi O43657.

Protocols and materials databases

DNASUi 7105.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373020 ; ENSP00000362111 ; ENSG00000000003 .
GeneIDi 7105.
KEGGi hsa:7105.
UCSCi uc004ega.1. human.

Organism-specific databases

CTDi 7105.
GeneCardsi GC0XM099886.
HGNCi HGNC:11858. TSPAN6.
HPAi HPA004109.
MIMi 300191. gene.
neXtProti NX_O43657.
PharmGKBi PA36559.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG274015.
GeneTreei ENSGT00760000118875.
HOVERGENi HBG107306.
InParanoidi O43657.
KOi K17295.
OMAi HCCGVTN.
OrthoDBi EOG73BVDM.
PhylomeDBi O43657.
TreeFami TF352891.

Miscellaneous databases

ChiTaRSi TSPAN6. human.
GeneWikii TSPAN6.
GenomeRNAii 7105.
NextBioi 27797.
PROi O43657.
SOURCEi Search...

Gene expression databases

Bgeei O43657.
CleanExi HS_TSPAN6.
Genevestigatori O43657.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences and expression of six new members of the tetraspanin/TM4SF family."
    Todd S.C., Doctor V.S., Levy S.
    Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22."
    Maeda K., Matsuhashi S., Hori K., Xin Z., Mukai T., Tabuchi K., Egashira M., Niikawa N.
    Genomics 52:240-242(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The cDNA cloning of a novel gene A15 homologue which encodes a new member of the transmembrane 4 superfamily."
    Maeda K., Matsuhashi Y.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The molecular characterization of four tetraspanins."
    Puls K.L., Ni J., Liu D., Morahan G., Wright M.D.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-108.
    Tissue: Lung.
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTSN6_HUMAN
AccessioniPrimary (citable) accession number: O43657
Secondary accession number(s): Q54A42, Q6IAN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3