Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prostate stem cell antigen

Gene

PSCA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate stem cell antigen
Gene namesi
Name:PSCA
ORF Names:UNQ206/PRO232
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9500. PSCA.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 9575Prostate stem cell antigenPRO_0000036162Add
BLAST
Propeptidei96 – 12328Removed in mature formSequence analysisPRO_0000036163Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 48By similarity
Disulfide bondi26 ↔ 35By similarity
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence analysis
Disulfide bondi41 ↔ 66By similarity
Disulfide bondi70 ↔ 86By similarity
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence analysis
Disulfide bondi87 ↔ 92By similarity
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence analysis
Lipidationi95 – 951GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiO43653.
MaxQBiO43653.
PaxDbiO43653.
PeptideAtlasiO43653.
PRIDEiO43653.

PTM databases

iPTMnetiO43653.

Expressioni

Tissue specificityi

Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level).2 Publications

Inductioni

Down-regulated in gastric cancer cells.1 Publication

Gene expression databases

BgeeiO43653.
CleanExiHS_PSCA.
ExpressionAtlasiO43653. baseline and differential.

Organism-specific databases

HPAiHPA056418.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301258.

Structurei

3D structure databases

ProteinModelPortaliO43653.
SMRiO43653. Positions 21-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 9575UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCNA. Eukaryota.
ENOG4111DN6. LUCA.
HOGENOMiHOG000035114.
HOVERGENiHBG008309.
InParanoidiO43653.
OrthoDBiEOG7M6D9C.
PhylomeDBiO43653.
TreeFamiTF336080.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVLLALLM AGLALQPGTA LLCYSCKAQV SNEDCLQVEN CTQLGEQCWT
60 70 80 90 100
ARIRAVGLLT VISKGCSLNC VDDSQDYYVG KKNITCCDTD LCNASGAHAL
110 120
QPAAAILALL PALGLLLWGP GQL
Length:123
Mass (Da):12,912
Last modified:June 1, 1998 - v1
Checksum:i3FC1271742D657FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → T in AC108002 (PubMed:16421571).Curated

Polymorphismi

Genetic variations in PSCA may influence susceptibility to diffuse-type gastric cancer.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391E → K.1 Publication
Corresponds to variant rs3736001 [ dbSNP | Ensembl ].
VAR_020173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043498 mRNA. Translation: AAC39607.1.
AJ297436 mRNA. Translation: CAB97347.1.
AC108002 Genomic DNA. No translation available.
BC023582 mRNA. Translation: AAH23582.1.
BC065183 mRNA. Translation: AAH65183.1.
AY358912 mRNA. Translation: AAQ89271.1.
UniGeneiHs.652235.

Genome annotation databases

EnsembliENST00000301258; ENSP00000301258; ENSG00000167653.
UCSCiuc003ywu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043498 mRNA. Translation: AAC39607.1.
AJ297436 mRNA. Translation: CAB97347.1.
AC108002 Genomic DNA. No translation available.
BC023582 mRNA. Translation: AAH23582.1.
BC065183 mRNA. Translation: AAH65183.1.
AY358912 mRNA. Translation: AAQ89271.1.
UniGeneiHs.652235.

3D structure databases

ProteinModelPortaliO43653.
SMRiO43653. Positions 21-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301258.

PTM databases

iPTMnetiO43653.

Proteomic databases

EPDiO43653.
MaxQBiO43653.
PaxDbiO43653.
PeptideAtlasiO43653.
PRIDEiO43653.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301258; ENSP00000301258; ENSG00000167653.
UCSCiuc003ywu.4. human.

Organism-specific databases

GeneCardsiPSCA.
H-InvDBHIX0007826.
HIX0034247.
HGNCiHGNC:9500. PSCA.
HPAiHPA056418.
MIMi602470. gene.
neXtProtiNX_O43653.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCNA. Eukaryota.
ENOG4111DN6. LUCA.
HOGENOMiHOG000035114.
HOVERGENiHBG008309.
InParanoidiO43653.
OrthoDBiEOG7M6D9C.
PhylomeDBiO43653.
TreeFamiTF336080.

Miscellaneous databases

PROiO43653.
SOURCEiSearch...

Gene expression databases

BgeeiO43653.
CleanExiHS_PSCA.
ExpressionAtlasiO43653. baseline and differential.

Family and domain databases

InterProiIPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Prostatic carcinoma.
  2. "Reduced expression of PSCA, a member of the LY-6 family of cell surface antigens, in bladder, esophagus, and stomach tumors."
    Bahrenberg G., Brauers A., Joost H.G., Jakse G.
    Biochem. Biophys. Res. Commun. 275:783-788(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Urothelium.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-123.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-35.
  7. "Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer."
    Gu Z., Thomas G., Yamashiro J., Shintaku I.P., Dorey F., Raitano A., Witte O.N., Said J.W., Loda M., Reiter R.E.
    Oncogene 19:1288-1296(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION, ASSOCIATION WITH SUSCEPTIBILITY TO DIFFUSE-TYPE GASTRIC CANCER, VARIANT LYS-39.

Entry informationi

Entry nameiPSCA_HUMAN
AccessioniPrimary (citable) accession number: O43653
Secondary accession number(s): Q6UW92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: July 6, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The start codon presents some polymorphism and the initiation methionine is a threonine on the genome.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.