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Protein

Prostate stem cell antigen

Gene

PSCA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.1 Publication
May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.1 Publication

Caution

The start codon presents some polymorphism and the initiation methionine is a threonine on the genome.Curated

GO - Molecular functioni

  • acetylcholine receptor binding Source: UniProtKB

GO - Biological processi

  • negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • regulation of neurotransmitter receptor activity Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate stem cell antigen
Gene namesi
Name:PSCA
ORF Names:UNQ206/PRO232
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000167653.4
HGNCiHGNC:9500 PSCA
MIMi602470 gene
neXtProtiNX_O43653

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8000

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000003616221 – 95Prostate stem cell antigenAdd BLAST75
PropeptideiPRO_000003616396 – 123Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 48By similarity
Disulfide bondi26 ↔ 35By similarity
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi41 ↔ 66By similarity
Disulfide bondi70 ↔ 86By similarity
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi87 ↔ 92By similarity
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi95GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiO43653
MaxQBiO43653
PaxDbiO43653
PeptideAtlasiO43653
PRIDEiO43653

PTM databases

iPTMnetiO43653
PhosphoSitePlusiO43653

Expressioni

Tissue specificityi

Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients.3 Publications

Inductioni

Down-regulated in gastric cancer cells.1 Publication

Gene expression databases

BgeeiENSG00000167653
CleanExiHS_PSCA
ExpressionAtlasiO43653 baseline and differential

Organism-specific databases

HPAiHPA030783
HPA056418

Interactioni

Subunit structurei

Interacts with CHRNA4.1 Publication

GO - Molecular functioni

  • acetylcholine receptor binding Source: UniProtKB

Protein-protein interaction databases

IntActiO43653, 1 interactor
STRINGi9606.ENSP00000301258

Structurei

3D structure databases

ProteinModelPortaliO43653
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 95UPAR/Ly6Add BLAST75

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCNA Eukaryota
ENOG4111DN6 LUCA
HOGENOMiHOG000035114
HOVERGENiHBG008309
InParanoidiO43653
OrthoDBiEOG091G0V2A
PhylomeDBiO43653
TreeFamiTF336080

Family and domain databases

InterProiView protein in InterPro
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVLLALLM AGLALQPGTA LLCYSCKAQV SNEDCLQVEN CTQLGEQCWT
60 70 80 90 100
ARIRAVGLLT VISKGCSLNC VDDSQDYYVG KKNITCCDTD LCNASGAHAL
110 120
QPAAAILALL PALGLLLWGP GQL
Length:123
Mass (Da):12,912
Last modified:June 1, 1998 - v1
Checksum:i3FC1271742D657FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → T in AC108002 (PubMed:16421571).Curated1

Polymorphismi

Genetic variations in PSCA may influence susceptibility to diffuse-type gastric cancer.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02017339E → K1 PublicationCorresponds to variant dbSNP:rs3736001Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043498 mRNA Translation: AAC39607.1
AJ297436 mRNA Translation: CAB97347.1
AC108002 Genomic DNA No translation available.
BC023582 mRNA Translation: AAH23582.1
BC065183 mRNA Translation: AAH65183.1
AY358912 mRNA Translation: AAQ89271.1
UniGeneiHs.652235

Genome annotation databases

EnsembliENST00000301258; ENSP00000301258; ENSG00000167653
UCSCiuc003ywu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPSCA_HUMAN
AccessioniPrimary (citable) accession number: O43653
Secondary accession number(s): Q6UW92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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