O43645 (O43645_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Interleukin 1 beta EMBL AAC03536.1

Gene names

Name:

IL1b EMBL AAC03536.1

Organism

Homo sapiens (Human) EMBL AAC03536.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	153 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the IL-1 family. RuleBase RU003752

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS000975
Molecular function	Cytokine SAAS SAAS008996
Gene Ontology (GO)
Biological_process	immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: InterPro positive regulation of interleukin-6 production Inferred from direct assay PubMed 11894098. Source: MGI
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine activity Inferred from direct assay PubMed 11894098. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAC03536.1

Sequences

	Sequence		Length	Mass (Da)
	O43645 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: A1AB2B5FE8B47146	FASTA	153	17,426
	10 20 30 40 50 60 APVRSLYCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL 70 80 90 100 110 120 GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW 130 140 150 YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS

References

[1]	Jang J.S., Kim B.E. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF043335 mRNA. Translation: AAC03536.1.
IPI	IPI00307223.
UniGene	Hs.126256.
3D structure databases
ProteinModelPortal	O43645.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG007328.
Family and domain databases
InterPro	IPR008996. Cytokine_IL1-like. IPR002348. IL1_HBGF. IPR020877. Interleukin-1_CS. IPR000975. Interleukin_1. IPR003294. InterleukinIL1AB. IPR003296. InterleukinIL1B. [Graphical view]
Pfam	PF00340. IL1. 1 hit. [Graphical view]
PRINTS	PR00262. IL1HBGF. PR00264. INTERLEUKIN1. PR01359. INTRLEUKIN1B. PR01357. INTRLEUKN1AB.
SMART	SM00125. IL1. 1 hit. [Graphical view]
SUPFAM	SSF50353. Cytok_IL1_like. 1 hit.
PROSITE	PS00253. INTERLEUKIN_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	IL1B. human.

Entry information

Entry name

O43645_HUMAN

Accession

Primary (citable) accession number: O43645

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	May 29, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.