Unreviewed, UniProtKB/TrEMBL O43645 (O43645_HUMAN)

Names and origin

Protein names

Submitted name:
    Interleukin 1 beta EMBL AAC03536.1

Gene names

Name:

IL1b EMBL AAC03536.1

Organism

Homo sapiens (Human) EMBL AAC03536.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	153 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the IL-1 family. RuleBase RU003752V1

Ontologies

Gene Ontology (GO)
Biological process	angiogenesis Inferred from electronic annotation. Source: Compara cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: InterPro neutrophil chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara positive regulation of JNK cascade Inferred from electronic annotation. Source: Compara positive regulation of chemokine biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of interleukin-6 biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara response to ATP Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara
Cellular component	extracellular space Inferred from electronic annotation. Source: Compara vesicle Inferred from electronic annotation. Source: Compara
Molecular function	cytokine activity Inferred from electronic annotation. Source: Compara interleukin-1 receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAC03536.1

Sequences

	Sequence		Length	Mass (Da)
	O43645-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: A1AB2B5FE8B47146	FASTA	153	17,426
	10 20 30 40 50 60 APVRSLYCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL 70 80 90 100 110 120 GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW 130 140 150 YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS

References

[1]	Jang J.S., Kim B.E. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF043335 mRNA. Translation: AAC03536.1.
IPI	IPI00307223.
UniGene	Hs.126256
3D structure databases
HSSP	HSSP built from PDB template 1HIB based on UniProtKB P01584.
SMR	O43645. Positions 1-152.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000125538. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:5992. IL1B.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O43645.
Gene expression databases
ArrayExpress	O43645.
Bgee	O43645.
Family and domain databases
InterPro	IPR002348. IL1_HBGF. IPR000975. Interleukin_1. IPR003294. InterleukinIL1AB. IPR003296. InterleukinIL1B. [Graphical view]
Pfam	PF00340. IL1. 1 hit. [Graphical view]
PRINTS	PR00262. IL1HBGF. PR00264. INTERLEUKIN1. PR01359. INTRLEUKIN1B. PR01357. INTRLEUKN1AB.
ProDom	PD002536. Interleukin_1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00125. IL1. 1 hit. [Graphical view]
PROSITE	PS00253. INTERLEUKIN_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O43645_HUMAN

Accession

Primary (citable) accession number: O43645

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	May 5, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)