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O43639

- NCK2_HUMAN

UniProt

O43639 - NCK2_HUMAN

Protein

Cytoplasmic protein NCK2

Gene

NCK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 2 (10 May 2002)
      Previous versions | rss
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    Functioni

    Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.2 Publications

    GO - Molecular functioni

    1. cytoskeletal adaptor activity Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. receptor signaling complex scaffold activity Source: UniProtKB

    GO - Biological processi

    1. actin filament organization Source: Ensembl
    2. axon guidance Source: Reactome
    3. cell migration Source: Ensembl
    4. epidermal growth factor receptor signaling pathway Source: ProtInc
    5. lamellipodium assembly Source: Ensembl
    6. negative regulation of cell proliferation Source: ProtInc
    7. positive regulation of actin filament polymerization Source: UniProtKB
    8. positive regulation of T cell proliferation Source: UniProtKB
    9. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    10. regulation of epidermal growth factor-activated receptor activity Source: ProtInc
    11. regulation of translation Source: UniProtKB-KW
    12. signal complex assembly Source: UniProtKB
    13. signal transduction Source: ProtInc
    14. T cell activation Source: UniProtKB

    Keywords - Biological processi

    Translation regulation

    Enzyme and pathway databases

    ReactomeiREACT_17025. Downstream signal transduction.
    REACT_19226. Activation of Rac.
    REACT_23832. Nephrin interactions.
    SignaLinkiO43639.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytoplasmic protein NCK2
    Alternative name(s):
    Growth factor receptor-bound protein 4
    NCK adaptor protein 2
    Short name:
    Nck-2
    SH2/SH3 adaptor protein NCK-beta
    Gene namesi
    Name:NCK2
    Synonyms:GRB4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:7665. NCK2.

    Subcellular locationi

    Cytoplasm 1 Publication. Endoplasmic reticulum 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. endoplasmic reticulum Source: UniProtKB-SubCell
    4. vesicle membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi148 – 1481W → K: Abolishes interaction with DOCK1. 1 Publication
    Mutagenesisi234 – 2341W → K: Abolishes interaction with DOCK1. 1 Publication

    Organism-specific databases

    PharmGKBiPA31467.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 380379Cytoplasmic protein NCK2PRO_0000096767Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylthreonine1 Publication
    Modified residuei90 – 901Phosphoserine2 Publications
    Modified residuei110 – 1101Phosphotyrosine2 Publications

    Post-translational modificationi

    Phosphorylated.3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO43639.
    PaxDbiO43639.
    PRIDEiO43639.

    PTM databases

    PhosphoSiteiO43639.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiO43639.
    BgeeiO43639.
    CleanExiHS_NCK2.
    GenevestigatoriO43639.

    Organism-specific databases

    HPAiCAB016116.
    HPA031004.

    Interactioni

    Subunit structurei

    Interacts with DOCK1, LIMS1 and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2. Interacts with FASLG By similarity. Interacts with AXL. Interacts with PAK1, PKN2 and SOS1. Interacts (via SH2 domain) with EGFR. Interacts (via SH2 domain) with DDR1.By similarity8 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DDR1Q083453EBI-713635,EBI-711879
    EFNB2P527997EBI-713635,EBI-7532268
    ERBB2P046262EBI-713635,EBI-641062
    ERBB3P218602EBI-713635,EBI-720706
    GAB1Q134805EBI-713635,EBI-517684
    KITP107212EBI-713635,EBI-1379503
    LIMS1P480592EBI-713635,EBI-306928
    METP085812EBI-713635,EBI-1039152
    RHOUQ7L0Q86EBI-713635,EBI-1638043
    RHOVQ96L334EBI-713635,EBI-8538631
    RTN4Q9NQC32EBI-713635,EBI-715945
    UBCP0CG482EBI-713635,EBI-3390054

    Protein-protein interaction databases

    BioGridi114020. 45 interactions.
    IntActiO43639. 39 interactions.
    MINTiMINT-190960.
    STRINGi9606.ENSP00000233154.

    Structurei

    Secondary structure

    1
    380
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 117
    Beta strandi17 – 204
    Beta strandi28 – 336
    Beta strandi35 – 384
    Beta strandi40 – 423
    Beta strandi48 – 503
    Beta strandi55 – 584
    Beta strandi115 – 1184
    Beta strandi137 – 1437
    Beta strandi147 – 1537
    Beta strandi156 – 1616
    Helixi162 – 1643
    Beta strandi165 – 1673
    Beta strandi196 – 2049
    Beta strandi210 – 2134
    Beta strandi222 – 2265
    Turni230 – 2323
    Beta strandi234 – 2396
    Turni240 – 2423
    Beta strandi243 – 2486
    Beta strandi251 – 2544
    Helixi292 – 30211
    Beta strandi307 – 3126
    Beta strandi314 – 3163
    Beta strandi320 – 3245
    Beta strandi327 – 3293
    Beta strandi331 – 3388
    Beta strandi341 – 3444
    Beta strandi347 – 3515
    Helixi352 – 36110
    Beta strandi364 – 3663
    Turni368 – 3703

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1U5SNMR-A192-262[»]
    1WX6NMR-A188-265[»]
    1Z3KNMR-A283-380[»]
    2B86NMR-A1-59[»]
    2CIAX-ray1.45A284-380[»]
    2FRWNMR-A114-170[»]
    2FRYNMR-A198-256[»]
    2JXBNMR-A1-59[»]
    4E6RX-ray2.20A/B114-170[»]
    ProteinModelPortaliO43639.
    SMRiO43639. Positions 1-59, 114-170, 192-261, 284-380.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43639.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 6160SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini111 – 17060SH3 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini195 – 25763SH3 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini285 – 38096SH2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 3 SH3 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiNOG261435.
    HOGENOMiHOG000290684.
    HOVERGENiHBG000719.
    InParanoidiO43639.
    KOiK07365.
    OMAiYYGNITR.
    OrthoDBiEOG7SV0VJ.
    PhylomeDBiO43639.
    TreeFamiTF351631.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR017304. NCK.
    IPR028524. NCK2.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR22820:SF29. PTHR22820:SF29. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF00018. SH3_1. 2 hits.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037874. Cytoplasmic_NCK. 1 hit.
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 3 hits.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 3 hits.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    PS50002. SH3. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O43639-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY    50
    VPSNYVERKN SLKKGSLVKN LKDTLGLGKT RRKTSARDAS PTPSTDAEYP 100
    ANGSGADRIY DLNIPAFVKF AYVAEREDEL SLVKGSRVTV MEKCSDGWWR 150
    GSYNGQIGWF PSNYVLEEVD EAAAESPSFL SLRKGASLSN GQGSRVLHVV 200
    QTLYPFSSVT EEELNFEKGE TMEVIEKPEN DPEWWKCKNA RGQVGLVPKN 250
    YVVVLSDGPA LHPAHAPQIS YTGPSSSGRF AGREWYYGNV TRHQAECALN 300
    ERGVEGDFLI RDSESSPSDF SVSLKASGKN KHFKVQLVDN VYCIGQRRFH 350
    TMDELVEHYK KAPIFTSEHG EKLYLVRALQ 380
    Length:380
    Mass (Da):42,915
    Last modified:May 10, 2002 - v2
    Checksum:i3A211085E46F4452
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251K → KV in AAC04831. (PubMed:9737977)Curated
    Sequence conflicti100 – 1001P → A in AAC80284. (PubMed:9843575)Curated
    Sequence conflicti296 – 2961E → Q in AAC04831. (PubMed:9737977)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043119 mRNA. Translation: AAC04831.1.
    AF047487 mRNA. Translation: AAC80284.1.
    CH471127 Genomic DNA. Translation: EAX01753.1.
    CH471127 Genomic DNA. Translation: EAX01754.1.
    BC000103 mRNA. Translation: AAH00103.1.
    BC007195 mRNA. Translation: AAH07195.1.
    CCDSiCCDS33266.1.
    RefSeqiNP_001004720.1. NM_001004720.2.
    NP_003572.2. NM_003581.4.
    XP_006712860.1. XM_006712797.1.
    UniGeneiHs.529244.
    Hs.735723.

    Genome annotation databases

    EnsembliENST00000233154; ENSP00000233154; ENSG00000071051.
    ENST00000393349; ENSP00000377018; ENSG00000071051.
    GeneIDi8440.
    KEGGihsa:8440.
    UCSCiuc002tdg.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043119 mRNA. Translation: AAC04831.1 .
    AF047487 mRNA. Translation: AAC80284.1 .
    CH471127 Genomic DNA. Translation: EAX01753.1 .
    CH471127 Genomic DNA. Translation: EAX01754.1 .
    BC000103 mRNA. Translation: AAH00103.1 .
    BC007195 mRNA. Translation: AAH07195.1 .
    CCDSi CCDS33266.1.
    RefSeqi NP_001004720.1. NM_001004720.2.
    NP_003572.2. NM_003581.4.
    XP_006712860.1. XM_006712797.1.
    UniGenei Hs.529244.
    Hs.735723.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1U5S NMR - A 192-262 [» ]
    1WX6 NMR - A 188-265 [» ]
    1Z3K NMR - A 283-380 [» ]
    2B86 NMR - A 1-59 [» ]
    2CIA X-ray 1.45 A 284-380 [» ]
    2FRW NMR - A 114-170 [» ]
    2FRY NMR - A 198-256 [» ]
    2JXB NMR - A 1-59 [» ]
    4E6R X-ray 2.20 A/B 114-170 [» ]
    ProteinModelPortali O43639.
    SMRi O43639. Positions 1-59, 114-170, 192-261, 284-380.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114020. 45 interactions.
    IntActi O43639. 39 interactions.
    MINTi MINT-190960.
    STRINGi 9606.ENSP00000233154.

    PTM databases

    PhosphoSitei O43639.

    Proteomic databases

    MaxQBi O43639.
    PaxDbi O43639.
    PRIDEi O43639.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000233154 ; ENSP00000233154 ; ENSG00000071051 .
    ENST00000393349 ; ENSP00000377018 ; ENSG00000071051 .
    GeneIDi 8440.
    KEGGi hsa:8440.
    UCSCi uc002tdg.3. human.

    Organism-specific databases

    CTDi 8440.
    GeneCardsi GC02P106361.
    HGNCi HGNC:7665. NCK2.
    HPAi CAB016116.
    HPA031004.
    MIMi 604930. gene.
    neXtProti NX_O43639.
    PharmGKBi PA31467.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG261435.
    HOGENOMi HOG000290684.
    HOVERGENi HBG000719.
    InParanoidi O43639.
    KOi K07365.
    OMAi YYGNITR.
    OrthoDBi EOG7SV0VJ.
    PhylomeDBi O43639.
    TreeFami TF351631.

    Enzyme and pathway databases

    Reactomei REACT_17025. Downstream signal transduction.
    REACT_19226. Activation of Rac.
    REACT_23832. Nephrin interactions.
    SignaLinki O43639.

    Miscellaneous databases

    EvolutionaryTracei O43639.
    GeneWikii NCK2.
    GenomeRNAii 8440.
    NextBioi 31578.
    PROi O43639.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43639.
    Bgeei O43639.
    CleanExi HS_NCK2.
    Genevestigatori O43639.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR017304. NCK.
    IPR028524. NCK2.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR22820:SF29. PTHR22820:SF29. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF00018. SH3_1. 2 hits.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037874. Cytoplasmic_NCK. 1 hit.
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 3 hits.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    PS50002. SH3. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity."
      Chen M., She H., Davis E.M., Spicer C.M., Kim L., Ren R., LeBeau M.M., Li W.
      J. Biol. Chem. 273:25171-25178(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways."
      Tu Y., Li F., Wu C.
      Mol. Biol. Cell 9:3367-3382(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH LIMS1.
      Tissue: Lung.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta and Uterus.
    5. "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck."
      Braverman L.E., Quilliam L.A.
      J. Biol. Chem. 274:5542-5549(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH EGFR; PAK1; PKN2 AND SOS1, PHOSPHORYLATION.
    6. "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: a role in cytoskeletal remodeling."
      Turner C.E., Brown M.C., Perrotta J.A., Riedy M.C., Nikolopoulos S.N., McDonald A.R., Bagrodia S., Thomas S.M., Leventhal P.S.
      J. Cell Biol. 145:851-863(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TGFB1I1.
    7. "Identification and kinetic analysis of the interaction between Nck-2 and DOCK180."
      Tu Y., Kucik D.F., Wu C.
      FEBS Lett. 491:193-199(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DOCK1, MUTAGENESIS OF TRP-148 AND TRP-234.
    8. "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."
      Hafizi S., Alindri F., Karlsson R., Dahlbaeck B.
      Biochem. Biophys. Res. Commun. 299:793-800(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AXL.
    9. "Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1."
      Koo D.H., McFadden C., Huang Y., Abdulhussein R., Friese-Hamim M., Vogel W.F.
      FEBS Lett. 580:15-22(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DDR1.
    10. "Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress."
      Latreille M., Larose L.
      J. Biol. Chem. 281:26633-26644(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN COMPLEX WITH PP1 AND PPP1R15B, FUNCTION, SUBCELLULAR LOCATION.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-110, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    12. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
      Voss M., Lettau M., Janssen O.
      BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FASLG.
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    16. "Solution structure of the SH3 domain of the human cytoplasmic protein NCK2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUL-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 188-265.

    Entry informationi

    Entry nameiNCK2_HUMAN
    AccessioniPrimary (citable) accession number: O43639
    Secondary accession number(s): D3DVK1, Q9BWN9, Q9UIC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 10, 2002
    Last modified: October 1, 2014
    This is version 145 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3