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Protein

Cytoplasmic protein NCK2

Gene

NCK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.2 Publications

GO - Molecular functioni

  • cytoskeletal adaptor activity Source: UniProtKB
  • receptor signaling complex scaffold activity Source: UniProtKB
  • SH3/SH2 adaptor activity Source: ParkinsonsUK-UCL

GO - Biological processi

  • actin filament organization Source: Ensembl
  • axon guidance Source: Reactome
  • cell migration Source: Ensembl
  • ephrin receptor signaling pathway Source: Reactome
  • epidermal growth factor receptor signaling pathway Source: ProtInc
  • lamellipodium assembly Source: Ensembl
  • negative regulation of cell proliferation Source: ProtInc
  • negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation Source: ParkinsonsUK-UCL
  • negative regulation of peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
  • positive regulation of actin filament polymerization Source: UniProtKB
  • positive regulation of signal transduction Source: GOC
  • positive regulation of T cell proliferation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of epidermal growth factor-activated receptor activity Source: ProtInc
  • regulation of translation Source: UniProtKB-KW
  • signal complex assembly Source: UniProtKB
  • signal transduction Source: ProtInc
  • T cell activation Source: UniProtKB
  • vascular endothelial growth factor receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Translation regulation

Enzyme and pathway databases

ReactomeiREACT_17025. Downstream signal transduction.
REACT_19226. Activation of Rac.
REACT_23832. Nephrin interactions.
REACT_264047. Ephrin signaling.
REACT_264464. VEGFA-VEGFR2 Pathway.
SignaLinkiO43639.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic protein NCK2
Alternative name(s):
Growth factor receptor-bound protein 4
NCK adaptor protein 2
Short name:
Nck-2
SH2/SH3 adaptor protein NCK-beta
Gene namesi
Name:NCK2
Synonyms:GRB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:7665. NCK2.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Endoplasmic reticulum 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • endoplasmic reticulum Source: ParkinsonsUK-UCL
  • vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi148 – 1481W → K: Abolishes interaction with DOCK1. 1 Publication
Mutagenesisi234 – 2341W → K: Abolishes interaction with DOCK1. 1 Publication

Organism-specific databases

PharmGKBiPA31467.

Polymorphism and mutation databases

BioMutaiNCK2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 380379Cytoplasmic protein NCK2PRO_0000096767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonine1 Publication
Modified residuei90 – 901Phosphoserine1 Publication
Modified residuei110 – 1101Phosphotyrosine1 Publication

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO43639.
PaxDbiO43639.
PRIDEiO43639.

PTM databases

PhosphoSiteiO43639.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiO43639.
CleanExiHS_NCK2.
ExpressionAtlasiO43639. baseline and differential.
GenevestigatoriO43639.

Organism-specific databases

HPAiCAB016116.
HPA031004.

Interactioni

Subunit structurei

Interacts with DOCK1, LIMS1 and TGFB1I1. Part of a complex containing PPP1R15B, PP1 and NCK2. Interacts with FASLG (By similarity). Interacts with AXL. Interacts with PAK1, PKN2 and SOS1. Interacts (via SH2 domain) with EGFR. Interacts (via SH2 domain) with DDR1.By similarity8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB94EBI-713635,EBI-743598
ABI3Q9P2A43EBI-713635,EBI-742038
ARHGAP32A7KAX93EBI-713635,EBI-308663
BCL11AQ9H165-23EBI-713635,EBI-10183342
CBLBQ131914EBI-713635,EBI-744027
CHN1P158826EBI-713635,EBI-718947
CPSF7Q8N6844EBI-713635,EBI-746909
DDR1Q083453EBI-713635,EBI-711879
DRAP1Q149193EBI-713635,EBI-712941
DVL1Q86TH33EBI-713635,EBI-10185025
EFHC2Q5JST63EBI-713635,EBI-2349927
EFNB2P527997EBI-713635,EBI-7532268
EIF3S3Q6IB983EBI-713635,EBI-10184995
ERBB2P046262EBI-713635,EBI-641062
ERBB3P218602EBI-713635,EBI-720706
FAM53CQ9NYF33EBI-713635,EBI-1644252
FCRL2Q96LA53EBI-713635,EBI-10185081
FYBO151173EBI-713635,EBI-1753267
GAB1Q134805EBI-713635,EBI-517684
HOMEZQ8IX15-33EBI-713635,EBI-10172004
HOXC4Q86TF73EBI-713635,EBI-10185009
KITP107212EBI-713635,EBI-1379503
LCP2Q130944EBI-713635,EBI-346946
LIMS1P480592EBI-713635,EBI-306928
LNX1Q8TBB13EBI-713635,EBI-739832
LRRIQ3A6PVS83EBI-713635,EBI-10184751
LZTS2Q9BRK43EBI-713635,EBI-741037
MAGEA6P433603EBI-713635,EBI-1045155
MEOX2A4D1273EBI-713635,EBI-10172134
METP085812EBI-713635,EBI-1039152
NR5A1Q132853EBI-713635,EBI-874629
PAK1Q131534EBI-713635,EBI-1307
PRR20CP864793EBI-713635,EBI-10172814
RASSF7Q028333EBI-713635,EBI-929013
RBM26Q5T8P63EBI-713635,EBI-3232077
RELQ048643EBI-713635,EBI-307352
RHOUQ7L0Q86EBI-713635,EBI-1638043
RHOVQ96L334EBI-713635,EBI-8538631
RTN4Q9NQC32EBI-713635,EBI-715945
SF3B4Q154274EBI-713635,EBI-348469
SORBS2O948753EBI-713635,EBI-311323
SPRY2O435973EBI-713635,EBI-742487
TCF4P158843EBI-713635,EBI-533224
TNRA1L3063EBI-713635,EBI-10182881
TRIM27P143733EBI-713635,EBI-719493
TRIM41Q8WV443EBI-713635,EBI-725997
TRIP6Q156544EBI-713635,EBI-742327
UBCP0CG482EBI-713635,EBI-3390054
VARS2Q5ST30-43EBI-713635,EBI-10244997
VPS37BQ9H9H43EBI-713635,EBI-4400866
WASP427683EBI-713635,EBI-346375
WASLO004013EBI-713635,EBI-957615
ZBTB7BO151563EBI-713635,EBI-740434

Protein-protein interaction databases

BioGridi114020. 124 interactions.
IntActiO43639. 73 interactions.
MINTiMINT-190960.
STRINGi9606.ENSP00000233154.

Structurei

Secondary structure

1
380
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 117Combined sources
Beta strandi17 – 204Combined sources
Beta strandi28 – 336Combined sources
Beta strandi35 – 384Combined sources
Beta strandi40 – 423Combined sources
Beta strandi48 – 503Combined sources
Beta strandi55 – 584Combined sources
Beta strandi115 – 1184Combined sources
Beta strandi137 – 1437Combined sources
Beta strandi147 – 1537Combined sources
Beta strandi156 – 1616Combined sources
Helixi162 – 1643Combined sources
Beta strandi165 – 1673Combined sources
Beta strandi196 – 2049Combined sources
Beta strandi210 – 2134Combined sources
Beta strandi222 – 2265Combined sources
Turni230 – 2323Combined sources
Beta strandi234 – 2396Combined sources
Turni240 – 2423Combined sources
Beta strandi243 – 2486Combined sources
Beta strandi251 – 2544Combined sources
Helixi292 – 30211Combined sources
Beta strandi307 – 3126Combined sources
Beta strandi314 – 3163Combined sources
Beta strandi320 – 3245Combined sources
Beta strandi327 – 3293Combined sources
Beta strandi331 – 3388Combined sources
Beta strandi341 – 3444Combined sources
Beta strandi347 – 3515Combined sources
Helixi352 – 36110Combined sources
Beta strandi364 – 3663Combined sources
Turni368 – 3703Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U5SNMR-A192-262[»]
1WX6NMR-A188-265[»]
1Z3KNMR-A283-380[»]
2B86NMR-A1-59[»]
2CIAX-ray1.45A284-380[»]
2FRWNMR-A114-170[»]
2FRYNMR-A198-256[»]
2JXBNMR-A1-59[»]
4E6RX-ray2.20A/B114-170[»]
ProteinModelPortaliO43639.
SMRiO43639. Positions 1-59, 114-170, 192-261, 284-380.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43639.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 6160SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini111 – 17060SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini195 – 25763SH3 3PROSITE-ProRule annotationAdd
BLAST
Domaini285 – 38096SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 3 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiNOG261435.
GeneTreeiENSGT00550000074482.
HOGENOMiHOG000290684.
HOVERGENiHBG000719.
InParanoidiO43639.
KOiK07365.
OMAiYYGNITR.
OrthoDBiEOG7SV0VJ.
PhylomeDBiO43639.
TreeFamiTF351631.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR017304. NCK.
IPR028524. NCK2.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR22820:SF29. PTHR22820:SF29. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
PF14604. SH3_9. 1 hit.
[Graphical view]
PIRSFiPIRSF037874. Cytoplasmic_NCK. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 3 hits.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY
60 70 80 90 100
VPSNYVERKN SLKKGSLVKN LKDTLGLGKT RRKTSARDAS PTPSTDAEYP
110 120 130 140 150
ANGSGADRIY DLNIPAFVKF AYVAEREDEL SLVKGSRVTV MEKCSDGWWR
160 170 180 190 200
GSYNGQIGWF PSNYVLEEVD EAAAESPSFL SLRKGASLSN GQGSRVLHVV
210 220 230 240 250
QTLYPFSSVT EEELNFEKGE TMEVIEKPEN DPEWWKCKNA RGQVGLVPKN
260 270 280 290 300
YVVVLSDGPA LHPAHAPQIS YTGPSSSGRF AGREWYYGNV TRHQAECALN
310 320 330 340 350
ERGVEGDFLI RDSESSPSDF SVSLKASGKN KHFKVQLVDN VYCIGQRRFH
360 370 380
TMDELVEHYK KAPIFTSEHG EKLYLVRALQ
Length:380
Mass (Da):42,915
Last modified:May 10, 2002 - v2
Checksum:i3A211085E46F4452
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251K → KV in AAC04831 (PubMed:9737977).Curated
Sequence conflicti100 – 1001P → A in AAC80284 (PubMed:9843575).Curated
Sequence conflicti296 – 2961E → Q in AAC04831 (PubMed:9737977).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043119 mRNA. Translation: AAC04831.1.
AF047487 mRNA. Translation: AAC80284.1.
CH471127 Genomic DNA. Translation: EAX01753.1.
CH471127 Genomic DNA. Translation: EAX01754.1.
BC000103 mRNA. Translation: AAH00103.1.
BC007195 mRNA. Translation: AAH07195.1.
CCDSiCCDS33266.1.
RefSeqiNP_001004720.1. NM_001004720.2.
NP_003572.2. NM_003581.4.
XP_006712860.1. XM_006712797.2.
UniGeneiHs.529244.
Hs.735723.

Genome annotation databases

EnsembliENST00000233154; ENSP00000233154; ENSG00000071051.
ENST00000393349; ENSP00000377018; ENSG00000071051.
GeneIDi8440.
KEGGihsa:8440.
UCSCiuc002tdg.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043119 mRNA. Translation: AAC04831.1.
AF047487 mRNA. Translation: AAC80284.1.
CH471127 Genomic DNA. Translation: EAX01753.1.
CH471127 Genomic DNA. Translation: EAX01754.1.
BC000103 mRNA. Translation: AAH00103.1.
BC007195 mRNA. Translation: AAH07195.1.
CCDSiCCDS33266.1.
RefSeqiNP_001004720.1. NM_001004720.2.
NP_003572.2. NM_003581.4.
XP_006712860.1. XM_006712797.2.
UniGeneiHs.529244.
Hs.735723.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U5SNMR-A192-262[»]
1WX6NMR-A188-265[»]
1Z3KNMR-A283-380[»]
2B86NMR-A1-59[»]
2CIAX-ray1.45A284-380[»]
2FRWNMR-A114-170[»]
2FRYNMR-A198-256[»]
2JXBNMR-A1-59[»]
4E6RX-ray2.20A/B114-170[»]
ProteinModelPortaliO43639.
SMRiO43639. Positions 1-59, 114-170, 192-261, 284-380.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114020. 124 interactions.
IntActiO43639. 73 interactions.
MINTiMINT-190960.
STRINGi9606.ENSP00000233154.

PTM databases

PhosphoSiteiO43639.

Polymorphism and mutation databases

BioMutaiNCK2.

Proteomic databases

MaxQBiO43639.
PaxDbiO43639.
PRIDEiO43639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233154; ENSP00000233154; ENSG00000071051.
ENST00000393349; ENSP00000377018; ENSG00000071051.
GeneIDi8440.
KEGGihsa:8440.
UCSCiuc002tdg.3. human.

Organism-specific databases

CTDi8440.
GeneCardsiGC02P106361.
HGNCiHGNC:7665. NCK2.
HPAiCAB016116.
HPA031004.
MIMi604930. gene.
neXtProtiNX_O43639.
PharmGKBiPA31467.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG261435.
GeneTreeiENSGT00550000074482.
HOGENOMiHOG000290684.
HOVERGENiHBG000719.
InParanoidiO43639.
KOiK07365.
OMAiYYGNITR.
OrthoDBiEOG7SV0VJ.
PhylomeDBiO43639.
TreeFamiTF351631.

Enzyme and pathway databases

ReactomeiREACT_17025. Downstream signal transduction.
REACT_19226. Activation of Rac.
REACT_23832. Nephrin interactions.
REACT_264047. Ephrin signaling.
REACT_264464. VEGFA-VEGFR2 Pathway.
SignaLinkiO43639.

Miscellaneous databases

ChiTaRSiNCK2. human.
EvolutionaryTraceiO43639.
GeneWikiiNCK2.
GenomeRNAii8440.
NextBioi31578.
PROiO43639.
SOURCEiSearch...

Gene expression databases

BgeeiO43639.
CleanExiHS_NCK2.
ExpressionAtlasiO43639. baseline and differential.
GenevestigatoriO43639.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR017304. NCK.
IPR028524. NCK2.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR22820:SF29. PTHR22820:SF29. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 2 hits.
PF14604. SH3_9. 1 hit.
[Graphical view]
PIRSFiPIRSF037874. Cytoplasmic_NCK. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 3 hits.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity."
    Chen M., She H., Davis E.M., Spicer C.M., Kim L., Ren R., LeBeau M.M., Li W.
    J. Biol. Chem. 273:25171-25178(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways."
    Tu Y., Li F., Wu C.
    Mol. Biol. Cell 9:3367-3382(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH LIMS1.
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Uterus.
  5. "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck."
    Braverman L.E., Quilliam L.A.
    J. Biol. Chem. 274:5542-5549(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EGFR; PAK1; PKN2 AND SOS1, PHOSPHORYLATION.
  6. "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: a role in cytoskeletal remodeling."
    Turner C.E., Brown M.C., Perrotta J.A., Riedy M.C., Nikolopoulos S.N., McDonald A.R., Bagrodia S., Thomas S.M., Leventhal P.S.
    J. Cell Biol. 145:851-863(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TGFB1I1.
  7. "Identification and kinetic analysis of the interaction between Nck-2 and DOCK180."
    Tu Y., Kucik D.F., Wu C.
    FEBS Lett. 491:193-199(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DOCK1, MUTAGENESIS OF TRP-148 AND TRP-234.
  8. "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin."
    Hafizi S., Alindri F., Karlsson R., Dahlbaeck B.
    Biochem. Biophys. Res. Commun. 299:793-800(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AXL.
  9. "Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1."
    Koo D.H., McFadden C., Huang Y., Abdulhussein R., Friese-Hamim M., Vogel W.F.
    FEBS Lett. 580:15-22(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DDR1.
  10. "Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress."
    Latreille M., Larose L.
    J. Biol. Chem. 281:26633-26644(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN COMPLEX WITH PP1 AND PPP1R15B, FUNCTION, SUBCELLULAR LOCATION.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-110, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  12. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
    Voss M., Lettau M., Janssen O.
    BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FASLG.
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  16. "Solution structure of the SH3 domain of the human cytoplasmic protein NCK2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUL-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 188-265.

Entry informationi

Entry nameiNCK2_HUMAN
AccessioniPrimary (citable) accession number: O43639
Secondary accession number(s): D3DVK1, Q9BWN9, Q9UIC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2002
Last modified: May 27, 2015
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.