FOXS1

Functionⁱ

Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	17 – 108	Fork-headPROSITE-ProRule annotationAdd BLAST		92

GO - Molecular functionⁱ

DNA binding Source: UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: GO_Central
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: Ensembl
transcription factor activity, sequence-specific DNA binding
Source: UniProtKB
Traceable author statementⁱ
- 9325056

Complete GO annotation...

GO - Biological processⁱ

blood vessel development Source: UniProtKB
negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
negative regulation of transcription, DNA-templated Source: UniProtKB
neuromuscular process controlling balance Source: Ensembl
positive regulation of multicellular organism growth Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Forkhead box protein S1 Alternative name(s): Forkhead-like 18 protein Forkhead-related transcription factor 10 Short name: FREAC-10
Gene namesⁱ	Name:FOXS1 Synonyms:FKHL18, FREAC10
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3735. FOXS1.

HGNCⁱ

HGNC:3735. FOXS1.

Subcellular locationⁱ

Nucleus
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU00089

GO - Cellular componentⁱ

nucleus Source: UniProtKB

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000179772.
PharmGKBⁱ	PA162388894.

Polymorphism and mutation databases

BioMutaⁱ	FOXS1.

BioMutaⁱ

FOXS1.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000091893	1 – 330	Forkhead box protein S1Add BLAST		330

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43638.
PaxDbⁱ	O43638.
PeptideAtlas More...PeptideAtlasⁱ	O43638.
PRIDEⁱ	O43638.

PTM databases

iPTMnetⁱ	O43638.
PhosphoSitePlusⁱ	O43638.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000179772.
CleanExⁱ	HS_FOXS1.
Genevisibleⁱ	O43638. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042475.

HPAⁱ

HPA042475.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	108596. 77 interactors.
IntActⁱ	O43638. 67 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1437828.
STRINGⁱ	9606.ENSP00000365145.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43638.
SMRⁱ	O43638.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG2294. Eukaryota. COG5025. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118904.
HOGENOMⁱ	HOG000112635.
HOVERGENⁱ	HBG051661.
InParanoidⁱ	O43638.
KEGG Orthology (KO) More...KOⁱ	K09412.
OMAⁱ	SMCPATT.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HW9.
PhylomeDBⁱ	O43638.
TreeFamⁱ	TF316127.

Family and domain databases

Gene3Dⁱ	1.10.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001766. Fork_head_dom. IPR033067. FoxS1. IPR018122. TF_fork_head_CS_1. IPR030456. TF_fork_head_CS_2. IPR011991. WHTH_DNA-bd_dom.
PANTHERⁱ	PTHR11829:SF226. PTHR11829:SF226. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00250. Forkhead. 1 hit.
PRINTSⁱ	PR00053. FORKHEAD.
SMARTⁱ	View protein in SMART SM00339. FH. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

O43638-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQQQPLPGPG APTTEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG 
        60         70         80         90        100
RFAFYRHNRP GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD 
       110        120        130        140        150
MFEHGSFLRR RRRFTRQTGA EGTRGPAKAR RGPLRATSQD PGVPNATTGR 
       160        170        180        190        200
QCSFPPELPD PKGLSFGGLV GAMPASMCPA TTDGRPRPPM EPKEISTPKP 
       210        220        230        240        250
ACPGELPVAT SSSSCPAFGF PAGFSEAESF NKAPTPVLSP ESGIGSSYQC 
       260        270        280        290        300
RLQALNFCMG ADPGLEHLLA SAAPSPAPPT PPGSLRAPLP LPTDHKEPWV 
       310        320        330
AGGFPVQGGS GYPLGLTPCL YRTPGMFFFE

Length:330

Mass (Da):35,434

Last modified:January 4, 2005 - v2

Checksum:ⁱBBF10321A8DC1744

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_021844	292	P → A. Corresponds to variant dbSNP:rs2296917Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT009768 mRNA. Translation: AAP88770.1. AL160175 Genomic DNA. No translation available. BC013408 mRNA. Translation: AAH13408.1. AF042831 mRNA. Translation: AAC15420.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13192.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_004109.1. NM_004118.3.
UniGeneⁱ	Hs.516971.

Genome annotation databases

Ensemblⁱ	ENST00000375978; ENSP00000365145; ENSG00000179772.
GeneIDⁱ	2307.
KEGGⁱ	hsa:2307.
UCSC genome browser More...UCSCⁱ	uc002wwt.2. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BT009768 mRNA. Translation: AAP88770.1. AL160175 Genomic DNA. No translation available. BC013408 mRNA. Translation: AAH13408.1. AF042831 mRNA. Translation: AAC15420.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13192.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_004109.1. NM_004118.3.
UniGeneⁱ	Hs.516971.

3D structure databases

ProteinModelPortalⁱ	O43638.
SMRⁱ	O43638.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108596. 77 interactors.
IntActⁱ	O43638. 67 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1437828.
STRINGⁱ	9606.ENSP00000365145.

PTM databases

iPTMnetⁱ	O43638.
PhosphoSitePlusⁱ	O43638.

Polymorphism and mutation databases

BioMutaⁱ	FOXS1.

BioMutaⁱ

FOXS1.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O43638.
PaxDbⁱ	O43638.
PeptideAtlas More...PeptideAtlasⁱ	O43638.
PRIDEⁱ	O43638.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2307.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000375978; ENSP00000365145; ENSG00000179772.
GeneIDⁱ	2307.
KEGGⁱ	hsa:2307.
UCSC genome browser More...UCSCⁱ	uc002wwt.2. human.

Organism-specific databases

CTDⁱ	2307.
GeneCardsⁱ	FOXS1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3735. FOXS1.
Human Protein Atlas More...HPAⁱ	HPA042475.
MIMⁱ	602939. gene.
neXtProtⁱ	NX_O43638.
Open Targets More...OpenTargetsⁱ	ENSG00000179772.
PharmGKBⁱ	PA162388894.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2294. Eukaryota. COG5025. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118904.
HOGENOMⁱ	HOG000112635.
HOVERGENⁱ	HBG051661.
InParanoidⁱ	O43638.
KEGG Orthology (KO) More...KOⁱ	K09412.
OMAⁱ	SMCPATT.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HW9.
PhylomeDBⁱ	O43638.
TreeFamⁱ	TF316127.

Miscellaneous databases

GenomeRNAiⁱ	2307.
Protein Ontology More...PROⁱ	PR:O43638.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179772.
CleanExⁱ	HS_FOXS1.
Genevisibleⁱ	O43638. HS.

Family and domain databases

Gene3Dⁱ	1.10.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR001766. Fork_head_dom. IPR033067. FoxS1. IPR018122. TF_fork_head_CS_1. IPR030456. TF_fork_head_CS_2. IPR011991. WHTH_DNA-bd_dom.
PANTHERⁱ	PTHR11829:SF226. PTHR11829:SF226. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00250. Forkhead. 1 hit.
PRINTSⁱ	PR00053. FORKHEAD.
SMARTⁱ	View protein in SMART SM00339. FH. 1 hit.
SUPFAMⁱ	SSF46785. SSF46785. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOXS1_HUMAN
Accessionⁱ	O43638Primary (citable) accession number: O43638 Secondary accession number(s): Q96D28
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	January 4, 2005
	Last modified:	June 7, 2017
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43638 (FOXS1_HUMAN)

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Forkhead box protein S1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ