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O43638 (FOXS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein S1
Alternative name(s):
Forkhead-like 18 protein
Forkhead-related transcription factor 10
Short name=FREAC-10
Gene names
Name:FOXS1
Synonyms:FKHL18, FREAC10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionRepressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNotch signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

artery morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

blood vessel development

Inferred from sequence or structural similarity. Source: UniProtKB

blood vessel remodeling

Inferred from Biological aspect of Ancestor. Source: RefGenome

camera-type eye development

Inferred from Biological aspect of Ancestor. Source: RefGenome

cardiac muscle cell proliferation

Inferred from Biological aspect of Ancestor. Source: RefGenome

collagen fibril organization

Inferred from Biological aspect of Ancestor. Source: RefGenome

embryonic heart tube development

Inferred from Biological aspect of Ancestor. Source: RefGenome

insulin receptor signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

lymphangiogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of apoptotic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of sequence-specific DNA binding transcription factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

neuromuscular process controlling balance

Inferred from Biological aspect of Ancestor. Source: RefGenome

ossification

Inferred from Biological aspect of Ancestor. Source: RefGenome

paraxial mesodermal cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

patterning of blood vessels

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of multicellular organism growth

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of blood vessel size

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of organ growth

Inferred from Biological aspect of Ancestor. Source: RefGenome

somitogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

vascular endothelial growth factor receptor signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

ventricular cardiac muscle tissue morphogenesis

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentnucleus

Inferred from sequence or structural similarity. Source: UniProtKB

transcription factor complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionDNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

DNA binding, bending

Inferred from Biological aspect of Ancestor. Source: RefGenome

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

chromatin DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

double-stranded DNA binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.4. Source: UniProtKB

transcription factor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Forkhead box protein S1
PRO_0000091893

Regions

DNA binding17 – 10892Fork-head

Natural variations

Natural variant2921P → A.
Corresponds to variant rs2296917 [ dbSNP | Ensembl ].
VAR_021844

Sequences

Sequence LengthMass (Da)Tools
O43638 [UniParc].

Last modified January 4, 2005. Version 2.
Checksum: BBF10321A8DC1744

FASTA33035,434
        10         20         30         40         50         60 
MQQQPLPGPG APTTEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG RFAFYRHNRP 

        70         80         90        100        110        120 
GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD MFEHGSFLRR RRRFTRQTGA 

       130        140        150        160        170        180 
EGTRGPAKAR RGPLRATSQD PGVPNATTGR QCSFPPELPD PKGLSFGGLV GAMPASMCPA 

       190        200        210        220        230        240 
TTDGRPRPPM EPKEISTPKP ACPGELPVAT SSSSCPAFGF PAGFSEAESF NKAPTPVLSP 

       250        260        270        280        290        300 
ESGIGSSYQC RLQALNFCMG ADPGLEHLLA SAAPSPAPPT PPGSLRAPLP LPTDHKEPWV 

       310        320        330 
AGGFPVQGGS GYPLGLTPCL YRTPGMFFFE 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Muscle.
[4]"Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene."
Cederberg A., Betz R., Lagercrantz S., Larsson C., Hulander M., Carlsson P., Enerbaeck S.
Genomics 44:344-346(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-119.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT009768 mRNA. Translation: AAP88770.1.
AL160175 Genomic DNA. Translation: CAI12817.1.
BC013408 mRNA. Translation: AAH13408.1.
AF042831 mRNA. Translation: AAC15420.1.
CCDSCCDS13192.1.
RefSeqNP_004109.1. NM_004118.3.
UniGeneHs.516971.

3D structure databases

ProteinModelPortalO43638.
SMRO43638. Positions 18-108.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108596. 3 interactions.
IntActO43638. 1 interaction.
MINTMINT-1437828.
STRING9606.ENSP00000365145.

PTM databases

PhosphoSiteO43638.

Proteomic databases

MaxQBO43638.
PaxDbO43638.
PRIDEO43638.

Protocols and materials databases

DNASU2307.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000375978; ENSP00000365145; ENSG00000179772.
GeneID2307.
KEGGhsa:2307.
UCSCuc002wwt.1. human.

Organism-specific databases

CTD2307.
GeneCardsGC20M030432.
HGNCHGNC:3735. FOXS1.
HPAHPA042475.
MIM602939. gene.
neXtProtNX_O43638.
PharmGKBPA162388894.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000112635.
HOVERGENHBG051661.
InParanoidO43638.
KOK09412.
OMAGGFPVQG.
OrthoDBEOG7C8GHD.
PhylomeDBO43638.
TreeFamTF316127.

Gene expression databases

BgeeO43638.
CleanExHS_FOXS1.
GenevestigatorO43638.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi2307.
NextBio9371.
PROO43638.
SOURCESearch...

Entry information

Entry nameFOXS1_HUMAN
AccessionPrimary (citable) accession number: O43638
Secondary accession number(s): Q96D28
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM