UniProtKB - O43638 (FOXS1_HUMAN)
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Protein
Forkhead box protein S1
Gene
FOXS1
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 17 – 108 | Fork-headPROSITE-ProRule annotationAdd BLAST | 92 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA binding transcription factor activity Source: UniProtKB
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
- RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
- transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- anatomical structure morphogenesis Source: GO_Central
- blood vessel development Source: UniProtKB
- cell differentiation Source: GO_Central
- negative regulation of DNA binding transcription factor activity Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- neuromuscular process controlling balance Source: Ensembl
- positive regulation of multicellular organism growth Source: Ensembl
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein S1Alternative name(s): Forkhead-like 18 protein Forkhead-related transcription factor 10 Short name: FREAC-10 |
Gene namesi | Name:FOXS1 Synonyms:FKHL18, FREAC10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000179772.7 |
HGNCi | HGNC:3735 FOXS1 |
MIMi | 602939 gene |
neXtProti | NX_O43638 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000179772 |
PharmGKBi | PA162388894 |
Polymorphism and mutation databases
BioMutai | FOXS1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000091893 | 1 – 330 | Forkhead box protein S1Add BLAST | 330 |
Proteomic databases
MaxQBi | O43638 |
PaxDbi | O43638 |
PeptideAtlasi | O43638 |
PRIDEi | O43638 |
PTM databases
iPTMneti | O43638 |
PhosphoSitePlusi | O43638 |
Expressioni
Gene expression databases
Bgeei | ENSG00000179772 |
CleanExi | HS_FOXS1 |
Genevisiblei | O43638 HS |
Organism-specific databases
HPAi | HPA042475 |
Interactioni
Protein-protein interaction databases
BioGridi | 10859678 interactors. |
IntActi | O43638 67 interactors. |
MINTi | O43638 |
STRINGi | 9606.ENSP00000365145 |
Structurei
3D structure databases
ProteinModelPortali | O43638 |
SMRi | O43638 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Phylogenomic databases
eggNOGi | KOG2294 Eukaryota COG5025 LUCA |
GeneTreei | ENSGT00760000118904 |
HOGENOMi | HOG000112635 |
HOVERGENi | HBG051661 |
InParanoidi | O43638 |
KOi | K09412 |
OMAi | SMCPATT |
OrthoDBi | EOG091G0HW9 |
PhylomeDBi | O43638 |
TreeFami | TF316127 |
Family and domain databases
CDDi | cd00059 FH, 1 hit |
Gene3Di | 1.10.10.101 hit |
InterProi | View protein in InterPro IPR001766 Fork_head_dom IPR033067 FoxS1 IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf |
PANTHERi | PTHR11829:SF68 PTHR11829:SF68, 1 hit |
Pfami | View protein in Pfam PF00250 Forkhead, 1 hit |
PRINTSi | PR00053 FORKHEAD |
SMARTi | View protein in SMART SM00339 FH, 1 hit |
SUPFAMi | SSF46785 SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit |
i Sequence
Sequence statusi: Complete.
O43638-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQQQPLPGPG APTTEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG
60 70 80 90 100
RFAFYRHNRP GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD
110 120 130 140 150
MFEHGSFLRR RRRFTRQTGA EGTRGPAKAR RGPLRATSQD PGVPNATTGR
160 170 180 190 200
QCSFPPELPD PKGLSFGGLV GAMPASMCPA TTDGRPRPPM EPKEISTPKP
210 220 230 240 250
ACPGELPVAT SSSSCPAFGF PAGFSEAESF NKAPTPVLSP ESGIGSSYQC
260 270 280 290 300
RLQALNFCMG ADPGLEHLLA SAAPSPAPPT PPGSLRAPLP LPTDHKEPWV
310 320 330
AGGFPVQGGS GYPLGLTPCL YRTPGMFFFE
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021844 | 292 | P → A. Corresponds to variant dbSNP:rs2296917Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT009768 mRNA Translation: AAP88770.1 AL160175 Genomic DNA No translation available. BC013408 mRNA Translation: AAH13408.1 AF042831 mRNA Translation: AAC15420.1 |
CCDSi | CCDS13192.1 |
RefSeqi | NP_004109.1, NM_004118.3 |
UniGenei | Hs.516971 |
Genome annotation databases
Ensembli | ENST00000375978; ENSP00000365145; ENSG00000179772 |
GeneIDi | 2307 |
KEGGi | hsa:2307 |
UCSCi | uc002wwt.2 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | FOXS1_HUMAN | |
Accessioni | O43638Primary (citable) accession number: O43638 Secondary accession number(s): Q96D28 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 4, 2005 | |
Last modified: | March 28, 2018 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |