O43638 (FOXS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Forkhead box protein S1

Alternative name(s):
Forkhead-like 18 protein
Forkhead-related transcription factor 10
Short name=FREAC-10

Gene names

Name:	FOXS1
Synonyms:	FKHL18, FREAC10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 fork-head DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Notch signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome artery morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome blood vessel development Inferred from sequence or structural similarity. Source: UniProtKB blood vessel remodeling Inferred from Biological aspect of Ancestor. Source: RefGenome camera-type eye development Inferred from Biological aspect of Ancestor. Source: RefGenome cardiac muscle cell proliferation Inferred from Biological aspect of Ancestor. Source: RefGenome collagen fibril organization Inferred from Biological aspect of Ancestor. Source: RefGenome embryonic heart tube development Inferred from Biological aspect of Ancestor. Source: RefGenome insulin receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome lymphangiogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of apoptotic process Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome negative regulation of transcription, DNA-templated Inferred from sequence or structural similarity. Source: UniProtKB neuromuscular process controlling balance Inferred from Biological aspect of Ancestor. Source: RefGenome ossification Inferred from Biological aspect of Ancestor. Source: RefGenome paraxial mesodermal cell fate commitment Inferred from Biological aspect of Ancestor. Source: RefGenome patterning of blood vessels Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of multicellular organism growth Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of blood vessel size Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of organ growth Inferred from Biological aspect of Ancestor. Source: RefGenome somitogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome transcription from RNA polymerase II promoter Inferred from Biological aspect of Ancestor. Source: GOC vascular endothelial growth factor receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome ventricular cardiac muscle tissue morphogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	nucleus Inferred from sequence or structural similarity. Source: UniProtKB transcription factor complex Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding Inferred from sequence or structural similarity. Source: UniProtKB DNA binding, bending Inferred from Biological aspect of Ancestor. Source: RefGenome RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome chromatin DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome double-stranded DNA binding Inferred from Biological aspect of Ancestor. Source: RefGenome sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Traceable author statement Ref.4. Source: UniProtKB transcription factor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Forkhead box protein S1		PRO_0000091893
Regions
	DNA binding	17 – 108	92	Fork-head
Natural variations
	Natural variant	292	1	P → A. Corresponds to variant rs2296917 [ dbSNP | Ensembl ].		VAR_021844

Sequences

	Sequence		Length	Mass (Da)
	O43638 [UniParc]. Last modified January 4, 2005. Version 2. Checksum: BBF10321A8DC1744	FASTA	330	35,434
	10 20 30 40 50 60 MQQQPLPGPG APTTEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG RFAFYRHNRP 70 80 90 100 110 120 GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD MFEHGSFLRR RRRFTRQTGA 130 140 150 160 170 180 EGTRGPAKAR RGPLRATSQD PGVPNATTGR QCSFPPELPD PKGLSFGGLV GAMPASMCPA 190 200 210 220 230 240 TTDGRPRPPM EPKEISTPKP ACPGELPVAT SSSSCPAFGF PAGFSEAESF NKAPTPVLSP 250 260 270 280 290 300 ESGIGSSYQC RLQALNFCMG ADPGLEHLLA SAAPSPAPPT PPGSLRAPLP LPTDHKEPWV 310 320 330 AGGFPVQGGS GYPLGLTPCL YRTPGMFFFE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
[4]	"Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene." Cederberg A., Betz R., Lagercrantz S., Larsson C., Hulander M., Carlsson P., Enerbaeck S. Genomics 44:344-346(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-119.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BT009768 mRNA. Translation: AAP88770.1. AL160175 Genomic DNA. Translation: CAI12817.1. BC013408 mRNA. Translation: AAH13408.1. AF042831 mRNA. Translation: AAC15420.1.
RefSeq	NP_004109.1. NM_004118.3.
UniGene	Hs.516971.
3D structure databases
ProteinModelPortal	O43638.
SMR	O43638. Positions 18-108.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	108596. 3 interactions.
IntAct	O43638. 1 interaction.
MINT	MINT-1437828.
STRING	9606.ENSP00000365145.
PTM databases
PhosphoSite	O43638.
Proteomic databases
PaxDb	O43638.
PRIDE	O43638.
Protocols and materials databases
DNASU	2307.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000375978; ENSP00000365145; ENSG00000179772.
GeneID	2307.
KEGG	hsa:2307.
UCSC	uc002wwt.1. human.
Organism-specific databases
CTD	2307.
GeneCards	GC20M030432.
HGNC	HGNC:3735. FOXS1.
HPA	HPA042475.
MIM	602939. gene.
neXtProt	NX_O43638.
PharmGKB	PA162388894.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5025.
HOGENOM	HOG000112635.
HOVERGEN	HBG051661.
InParanoid	O43638.
KO	K09412.
OMA	GGFPVQG.
OrthoDB	EOG7C8GHD.
PhylomeDB	O43638.
TreeFam	TF316127.
Gene expression databases
Bgee	O43638.
CleanEx	HS_FOXS1.
Genevestigator	O43638.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR001766. TF_fork_head. IPR018122. TF_fork_head_CS. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00250. Fork_head. 1 hit. [Graphical view]
PRINTS	PR00053. FORKHEAD.
SMART	SM00339. FH. 1 hit. [Graphical view]
PROSITE	PS00657. FORK_HEAD_1. 1 hit. PS00658. FORK_HEAD_2. 1 hit. PS50039. FORK_HEAD_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2307.
NextBio	9371.
PRO	O43638.
SOURCE	Search...

Entry information

Entry name

FOXS1_HUMAN

Accession

Primary (citable) accession number: O43638
Secondary accession number(s): Q96D28

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 4, 2005
Last modified:	April 16, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.