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Protein

Forkhead box protein S1

Gene

FOXS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 108Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein S1
Alternative name(s):
Forkhead-like 18 protein
Forkhead-related transcription factor 10
Short name:
FREAC-10
Gene namesi
Name:FOXS1
Synonyms:FKHL18, FREAC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000179772.7
HGNCiHGNC:3735 FOXS1
MIMi602939 gene
neXtProtiNX_O43638

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179772
PharmGKBiPA162388894

Polymorphism and mutation databases

BioMutaiFOXS1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918931 – 330Forkhead box protein S1Add BLAST330

Proteomic databases

MaxQBiO43638
PaxDbiO43638
PeptideAtlasiO43638
PRIDEiO43638

PTM databases

iPTMnetiO43638
PhosphoSitePlusiO43638

Expressioni

Gene expression databases

BgeeiENSG00000179772
CleanExiHS_FOXS1
GenevisibleiO43638 HS

Organism-specific databases

HPAiHPA042475

Interactioni

Protein-protein interaction databases

BioGridi108596, 78 interactors
IntActiO43638, 67 interactors
MINTiO43638
STRINGi9606.ENSP00000365145

Structurei

3D structure databases

ProteinModelPortaliO43638
SMRiO43638
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000112635
HOVERGENiHBG051661
InParanoidiO43638
KOiK09412
OMAiSMCPATT
OrthoDBiEOG091G0HW9
PhylomeDBiO43638
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR033067 FoxS1
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11829:SF68 PTHR11829:SF68, 1 hit
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

O43638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQQPLPGPG APTTEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG
60 70 80 90 100
RFAFYRHNRP GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD
110 120 130 140 150
MFEHGSFLRR RRRFTRQTGA EGTRGPAKAR RGPLRATSQD PGVPNATTGR
160 170 180 190 200
QCSFPPELPD PKGLSFGGLV GAMPASMCPA TTDGRPRPPM EPKEISTPKP
210 220 230 240 250
ACPGELPVAT SSSSCPAFGF PAGFSEAESF NKAPTPVLSP ESGIGSSYQC
260 270 280 290 300
RLQALNFCMG ADPGLEHLLA SAAPSPAPPT PPGSLRAPLP LPTDHKEPWV
310 320 330
AGGFPVQGGS GYPLGLTPCL YRTPGMFFFE
Length:330
Mass (Da):35,434
Last modified:January 4, 2005 - v2
Checksum:iBBF10321A8DC1744
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021844292P → A. Corresponds to variant dbSNP:rs2296917Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009768 mRNA Translation: AAP88770.1
AL160175 Genomic DNA No translation available.
BC013408 mRNA Translation: AAH13408.1
AF042831 mRNA Translation: AAC15420.1
CCDSiCCDS13192.1
RefSeqiNP_004109.1, NM_004118.3
UniGeneiHs.516971

Genome annotation databases

EnsembliENST00000375978; ENSP00000365145; ENSG00000179772
GeneIDi2307
KEGGihsa:2307
UCSCiuc002wwt.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFOXS1_HUMAN
AccessioniPrimary (citable) accession number: O43638
Secondary accession number(s): Q96D28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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