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UniProtKB - O43638 (FOXS1_HUMAN)

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Protein

Forkhead box protein S1

Gene

FOXS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 108Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein S1
Alternative name(s):
Forkhead-like 18 protein
Forkhead-related transcription factor 10
Short name:
FREAC-10
Gene namesi
Name:FOXS1
Synonyms:FKHL18, FREAC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:3735. FOXS1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179772.
PharmGKBiPA162388894.

Polymorphism and mutation databases

BioMutaiFOXS1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918931 – 330Forkhead box protein S1Add BLAST330

Proteomic databases

MaxQBiO43638.
PaxDbiO43638.
PeptideAtlasiO43638.
PRIDEiO43638.

PTM databases

iPTMnetiO43638.
PhosphoSitePlusiO43638.

Expressioni

Gene expression databases

BgeeiENSG00000179772.
CleanExiHS_FOXS1.
GenevisibleiO43638. HS.

Organism-specific databases

HPAiHPA042475.

Interactioni

Protein-protein interaction databases

BioGridi108596. 77 interactors.
IntActiO43638. 67 interactors.
MINTiMINT-1437828.
STRINGi9606.ENSP00000365145.

Structurei

3D structure databases

ProteinModelPortaliO43638.
SMRiO43638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000112635.
HOVERGENiHBG051661.
InParanoidiO43638.
KOiK09412.
OMAiSMCPATT.
OrthoDBiEOG091G0HW9.
PhylomeDBiO43638.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR033067. FoxS1.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PANTHERiPTHR11829:SF226. PTHR11829:SF226. 1 hit.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

O43638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQQPLPGPG APTTEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG 
        60         70         80         90        100
RFAFYRHNRP GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD 
       110        120        130        140        150
MFEHGSFLRR RRRFTRQTGA EGTRGPAKAR RGPLRATSQD PGVPNATTGR 
       160        170        180        190        200
QCSFPPELPD PKGLSFGGLV GAMPASMCPA TTDGRPRPPM EPKEISTPKP 
       210        220        230        240        250
ACPGELPVAT SSSSCPAFGF PAGFSEAESF NKAPTPVLSP ESGIGSSYQC 
       260        270        280        290        300
RLQALNFCMG ADPGLEHLLA SAAPSPAPPT PPGSLRAPLP LPTDHKEPWV 
       310        320        330
AGGFPVQGGS GYPLGLTPCL YRTPGMFFFE
Length:330
Mass (Da):35,434
Last modified:January 4, 2005 - v2
Checksum:iBBF10321A8DC1744
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021844292P → A. Corresponds to variant dbSNP:rs2296917Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009768 mRNA. Translation: AAP88770.1.
AL160175 Genomic DNA. No translation available.
BC013408 mRNA. Translation: AAH13408.1.
AF042831 mRNA. Translation: AAC15420.1.
CCDSiCCDS13192.1.
RefSeqiNP_004109.1. NM_004118.3.
UniGeneiHs.516971.

Genome annotation databases

EnsembliENST00000375978; ENSP00000365145; ENSG00000179772.
GeneIDi2307.
KEGGihsa:2307.
UCSCiuc002wwt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFOXS1_HUMAN
AccessioniPrimary (citable) accession number: O43638
Secondary accession number(s): Q96D28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 4, 2005
Last modified: July 5, 2017
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot