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Protein

Forkhead box protein S1

Gene

FOXS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi17 – 10892Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein S1
Alternative name(s):
Forkhead-like 18 protein
Forkhead-related transcription factor 10
Short name:
FREAC-10
Gene namesi
Name:FOXS1
Synonyms:FKHL18, FREAC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:3735. FOXS1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388894.

Polymorphism and mutation databases

BioMutaiFOXS1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Forkhead box protein S1PRO_0000091893Add
BLAST

Proteomic databases

MaxQBiO43638.
PaxDbiO43638.
PRIDEiO43638.

PTM databases

PhosphoSiteiO43638.

Expressioni

Gene expression databases

BgeeiO43638.
CleanExiHS_FOXS1.
GenevisibleiO43638. HS.

Organism-specific databases

HPAiHPA042475.

Interactioni

Protein-protein interaction databases

BioGridi108596. 9 interactions.
IntActiO43638. 1 interaction.
MINTiMINT-1437828.
STRINGi9606.ENSP00000365145.

Structurei

3D structure databases

ProteinModelPortaliO43638.
SMRiO43638. Positions 18-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000112635.
HOVERGENiHBG051661.
InParanoidiO43638.
KOiK09412.
OMAiGGFPVQG.
OrthoDBiEOG7C8GHD.
PhylomeDBiO43638.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQQPLPGPG APTTEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG
60 70 80 90 100
RFAFYRHNRP GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD
110 120 130 140 150
MFEHGSFLRR RRRFTRQTGA EGTRGPAKAR RGPLRATSQD PGVPNATTGR
160 170 180 190 200
QCSFPPELPD PKGLSFGGLV GAMPASMCPA TTDGRPRPPM EPKEISTPKP
210 220 230 240 250
ACPGELPVAT SSSSCPAFGF PAGFSEAESF NKAPTPVLSP ESGIGSSYQC
260 270 280 290 300
RLQALNFCMG ADPGLEHLLA SAAPSPAPPT PPGSLRAPLP LPTDHKEPWV
310 320 330
AGGFPVQGGS GYPLGLTPCL YRTPGMFFFE
Length:330
Mass (Da):35,434
Last modified:January 4, 2005 - v2
Checksum:iBBF10321A8DC1744
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti292 – 2921P → A.
Corresponds to variant rs2296917 [ dbSNP | Ensembl ].
VAR_021844

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009768 mRNA. Translation: AAP88770.1.
AL160175 Genomic DNA. Translation: CAI12817.1.
BC013408 mRNA. Translation: AAH13408.1.
AF042831 mRNA. Translation: AAC15420.1.
CCDSiCCDS13192.1.
RefSeqiNP_004109.1. NM_004118.3.
UniGeneiHs.516971.

Genome annotation databases

EnsembliENST00000375978; ENSP00000365145; ENSG00000179772.
GeneIDi2307.
KEGGihsa:2307.
UCSCiuc002wwt.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009768 mRNA. Translation: AAP88770.1.
AL160175 Genomic DNA. Translation: CAI12817.1.
BC013408 mRNA. Translation: AAH13408.1.
AF042831 mRNA. Translation: AAC15420.1.
CCDSiCCDS13192.1.
RefSeqiNP_004109.1. NM_004118.3.
UniGeneiHs.516971.

3D structure databases

ProteinModelPortaliO43638.
SMRiO43638. Positions 18-108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108596. 9 interactions.
IntActiO43638. 1 interaction.
MINTiMINT-1437828.
STRINGi9606.ENSP00000365145.

PTM databases

PhosphoSiteiO43638.

Polymorphism and mutation databases

BioMutaiFOXS1.

Proteomic databases

MaxQBiO43638.
PaxDbiO43638.
PRIDEiO43638.

Protocols and materials databases

DNASUi2307.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375978; ENSP00000365145; ENSG00000179772.
GeneIDi2307.
KEGGihsa:2307.
UCSCiuc002wwt.1. human.

Organism-specific databases

CTDi2307.
GeneCardsiGC20M030432.
HGNCiHGNC:3735. FOXS1.
HPAiHPA042475.
MIMi602939. gene.
neXtProtiNX_O43638.
PharmGKBiPA162388894.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5025.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000112635.
HOVERGENiHBG051661.
InParanoidiO43638.
KOiK09412.
OMAiGGFPVQG.
OrthoDBiEOG7C8GHD.
PhylomeDBiO43638.
TreeFamiTF316127.

Miscellaneous databases

GenomeRNAii2307.
NextBioi9371.
PROiO43638.
SOURCEiSearch...

Gene expression databases

BgeeiO43638.
CleanExiHS_FOXS1.
GenevisibleiO43638. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS_1.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  4. "Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene."
    Cederberg A., Betz R., Lagercrantz S., Larsson C., Hulander M., Carlsson P., Enerbaeck S.
    Genomics 44:344-346(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-119.

Entry informationi

Entry nameiFOXS1_HUMAN
AccessioniPrimary (citable) accession number: O43638
Secondary accession number(s): Q96D28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 4, 2005
Last modified: June 24, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.