Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O43638

- FOXS1_HUMAN

UniProt

O43638 - FOXS1_HUMAN

Protein

Forkhead box protein S1

Gene

FOXS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (04 Jan 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi17 – 10892Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. blood vessel development Source: UniProtKB
    2. negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    3. negative regulation of transcription, DNA-templated Source: UniProtKB
    4. neuromuscular process controlling balance Source: Ensembl
    5. positive regulation of multicellular organism growth Source: Ensembl
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein S1
    Alternative name(s):
    Forkhead-like 18 protein
    Forkhead-related transcription factor 10
    Short name:
    FREAC-10
    Gene namesi
    Name:FOXS1
    Synonyms:FKHL18, FREAC10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:3735. FOXS1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162388894.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Forkhead box protein S1PRO_0000091893Add
    BLAST

    Proteomic databases

    MaxQBiO43638.
    PaxDbiO43638.
    PRIDEiO43638.

    PTM databases

    PhosphoSiteiO43638.

    Expressioni

    Gene expression databases

    BgeeiO43638.
    CleanExiHS_FOXS1.
    GenevestigatoriO43638.

    Organism-specific databases

    HPAiHPA042475.

    Interactioni

    Protein-protein interaction databases

    BioGridi108596. 3 interactions.
    IntActiO43638. 1 interaction.
    MINTiMINT-1437828.
    STRINGi9606.ENSP00000365145.

    Structurei

    3D structure databases

    ProteinModelPortaliO43638.
    SMRiO43638. Positions 18-108.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000112635.
    HOVERGENiHBG051661.
    InParanoidiO43638.
    KOiK09412.
    OMAiGGFPVQG.
    OrthoDBiEOG7C8GHD.
    PhylomeDBiO43638.
    TreeFamiTF316127.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43638-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQQQPLPGPG APTTEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG    50
    RFAFYRHNRP GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD 100
    MFEHGSFLRR RRRFTRQTGA EGTRGPAKAR RGPLRATSQD PGVPNATTGR 150
    QCSFPPELPD PKGLSFGGLV GAMPASMCPA TTDGRPRPPM EPKEISTPKP 200
    ACPGELPVAT SSSSCPAFGF PAGFSEAESF NKAPTPVLSP ESGIGSSYQC 250
    RLQALNFCMG ADPGLEHLLA SAAPSPAPPT PPGSLRAPLP LPTDHKEPWV 300
    AGGFPVQGGS GYPLGLTPCL YRTPGMFFFE 330
    Length:330
    Mass (Da):35,434
    Last modified:January 4, 2005 - v2
    Checksum:iBBF10321A8DC1744
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti292 – 2921P → A.
    Corresponds to variant rs2296917 [ dbSNP | Ensembl ].
    VAR_021844

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT009768 mRNA. Translation: AAP88770.1.
    AL160175 Genomic DNA. Translation: CAI12817.1.
    BC013408 mRNA. Translation: AAH13408.1.
    AF042831 mRNA. Translation: AAC15420.1.
    CCDSiCCDS13192.1.
    RefSeqiNP_004109.1. NM_004118.3.
    UniGeneiHs.516971.

    Genome annotation databases

    EnsembliENST00000375978; ENSP00000365145; ENSG00000179772.
    GeneIDi2307.
    KEGGihsa:2307.
    UCSCiuc002wwt.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT009768 mRNA. Translation: AAP88770.1 .
    AL160175 Genomic DNA. Translation: CAI12817.1 .
    BC013408 mRNA. Translation: AAH13408.1 .
    AF042831 mRNA. Translation: AAC15420.1 .
    CCDSi CCDS13192.1.
    RefSeqi NP_004109.1. NM_004118.3.
    UniGenei Hs.516971.

    3D structure databases

    ProteinModelPortali O43638.
    SMRi O43638. Positions 18-108.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108596. 3 interactions.
    IntActi O43638. 1 interaction.
    MINTi MINT-1437828.
    STRINGi 9606.ENSP00000365145.

    PTM databases

    PhosphoSitei O43638.

    Proteomic databases

    MaxQBi O43638.
    PaxDbi O43638.
    PRIDEi O43638.

    Protocols and materials databases

    DNASUi 2307.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000375978 ; ENSP00000365145 ; ENSG00000179772 .
    GeneIDi 2307.
    KEGGi hsa:2307.
    UCSCi uc002wwt.1. human.

    Organism-specific databases

    CTDi 2307.
    GeneCardsi GC20M030432.
    HGNCi HGNC:3735. FOXS1.
    HPAi HPA042475.
    MIMi 602939. gene.
    neXtProti NX_O43638.
    PharmGKBi PA162388894.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000112635.
    HOVERGENi HBG051661.
    InParanoidi O43638.
    KOi K09412.
    OMAi GGFPVQG.
    OrthoDBi EOG7C8GHD.
    PhylomeDBi O43638.
    TreeFami TF316127.

    Miscellaneous databases

    GenomeRNAii 2307.
    NextBioi 9371.
    PROi O43638.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43638.
    CleanExi HS_FOXS1.
    Genevestigatori O43638.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    4. "Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene."
      Cederberg A., Betz R., Lagercrantz S., Larsson C., Hulander M., Carlsson P., Enerbaeck S.
      Genomics 44:344-346(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-119.

    Entry informationi

    Entry nameiFOXS1_HUMAN
    AccessioniPrimary (citable) accession number: O43638
    Secondary accession number(s): Q96D28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3