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O43638

- FOXS1_HUMAN

UniProt

O43638 - FOXS1_HUMAN

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Protein

Forkhead box protein S1

Gene
FOXS1, FKHL18, FREAC10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi17 – 10892Fork-headAdd
BLAST

GO - Molecular functioni

  1. chromatin DNA binding Source: RefGenome
  2. DNA binding Source: UniProtKB
  3. DNA binding, bending Source: RefGenome
  4. double-stranded DNA binding Source: RefGenome
  5. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  6. sequence-specific DNA binding Source: InterPro
  7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. transcription factor binding Source: RefGenome

GO - Biological processi

  1. artery morphogenesis Source: RefGenome
  2. blood vessel development Source: UniProtKB
  3. blood vessel remodeling Source: RefGenome
  4. camera-type eye development Source: RefGenome
  5. cardiac muscle cell proliferation Source: RefGenome
  6. collagen fibril organization Source: RefGenome
  7. embryonic heart tube development Source: RefGenome
  8. insulin receptor signaling pathway Source: RefGenome
  9. lymphangiogenesis Source: RefGenome
  10. negative regulation of apoptotic process Source: RefGenome
  11. negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  12. negative regulation of transcription, DNA-templated Source: UniProtKB
  13. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  14. neuromuscular process controlling balance Source: RefGenome
  15. Notch signaling pathway Source: RefGenome
  16. ossification Source: RefGenome
  17. paraxial mesodermal cell fate commitment Source: RefGenome
  18. patterning of blood vessels Source: RefGenome
  19. positive regulation of multicellular organism growth Source: RefGenome
  20. positive regulation of transcription from RNA polymerase II promoter Source: RefGenome
  21. regulation of blood vessel size Source: RefGenome
  22. regulation of organ growth Source: RefGenome
  23. somitogenesis Source: RefGenome
  24. transcription from RNA polymerase II promoter Source: GOC
  25. vascular endothelial growth factor receptor signaling pathway Source: RefGenome
  26. ventricular cardiac muscle tissue morphogenesis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein S1
Alternative name(s):
Forkhead-like 18 protein
Forkhead-related transcription factor 10
Short name:
FREAC-10
Gene namesi
Name:FOXS1
Synonyms:FKHL18, FREAC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:3735. FOXS1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388894.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Forkhead box protein S1PRO_0000091893Add
BLAST

Proteomic databases

MaxQBiO43638.
PaxDbiO43638.
PRIDEiO43638.

PTM databases

PhosphoSiteiO43638.

Expressioni

Gene expression databases

BgeeiO43638.
CleanExiHS_FOXS1.
GenevestigatoriO43638.

Organism-specific databases

HPAiHPA042475.

Interactioni

Protein-protein interaction databases

BioGridi108596. 3 interactions.
IntActiO43638. 1 interaction.
MINTiMINT-1437828.
STRINGi9606.ENSP00000365145.

Structurei

3D structure databases

ProteinModelPortaliO43638.
SMRiO43638. Positions 18-108.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000112635.
HOVERGENiHBG051661.
InParanoidiO43638.
KOiK09412.
OMAiGGFPVQG.
OrthoDBiEOG7C8GHD.
PhylomeDBiO43638.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43638-1 [UniParc]FASTAAdd to Basket

« Hide

MQQQPLPGPG APTTEPTKPP YSYIALIAMA IQSSPGQRAT LSGIYRYIMG    50
RFAFYRHNRP GWQNSIRHNL SLNECFVKVP RDDRKPGKGS YWTLDPDCHD 100
MFEHGSFLRR RRRFTRQTGA EGTRGPAKAR RGPLRATSQD PGVPNATTGR 150
QCSFPPELPD PKGLSFGGLV GAMPASMCPA TTDGRPRPPM EPKEISTPKP 200
ACPGELPVAT SSSSCPAFGF PAGFSEAESF NKAPTPVLSP ESGIGSSYQC 250
RLQALNFCMG ADPGLEHLLA SAAPSPAPPT PPGSLRAPLP LPTDHKEPWV 300
AGGFPVQGGS GYPLGLTPCL YRTPGMFFFE 330
Length:330
Mass (Da):35,434
Last modified:January 4, 2005 - v2
Checksum:iBBF10321A8DC1744
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti292 – 2921P → A.
Corresponds to variant rs2296917 [ dbSNP | Ensembl ].
VAR_021844

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT009768 mRNA. Translation: AAP88770.1.
AL160175 Genomic DNA. Translation: CAI12817.1.
BC013408 mRNA. Translation: AAH13408.1.
AF042831 mRNA. Translation: AAC15420.1.
CCDSiCCDS13192.1.
RefSeqiNP_004109.1. NM_004118.3.
UniGeneiHs.516971.

Genome annotation databases

EnsembliENST00000375978; ENSP00000365145; ENSG00000179772.
GeneIDi2307.
KEGGihsa:2307.
UCSCiuc002wwt.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT009768 mRNA. Translation: AAP88770.1 .
AL160175 Genomic DNA. Translation: CAI12817.1 .
BC013408 mRNA. Translation: AAH13408.1 .
AF042831 mRNA. Translation: AAC15420.1 .
CCDSi CCDS13192.1.
RefSeqi NP_004109.1. NM_004118.3.
UniGenei Hs.516971.

3D structure databases

ProteinModelPortali O43638.
SMRi O43638. Positions 18-108.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108596. 3 interactions.
IntActi O43638. 1 interaction.
MINTi MINT-1437828.
STRINGi 9606.ENSP00000365145.

PTM databases

PhosphoSitei O43638.

Proteomic databases

MaxQBi O43638.
PaxDbi O43638.
PRIDEi O43638.

Protocols and materials databases

DNASUi 2307.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000375978 ; ENSP00000365145 ; ENSG00000179772 .
GeneIDi 2307.
KEGGi hsa:2307.
UCSCi uc002wwt.1. human.

Organism-specific databases

CTDi 2307.
GeneCardsi GC20M030432.
HGNCi HGNC:3735. FOXS1.
HPAi HPA042475.
MIMi 602939. gene.
neXtProti NX_O43638.
PharmGKBi PA162388894.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000112635.
HOVERGENi HBG051661.
InParanoidi O43638.
KOi K09412.
OMAi GGFPVQG.
OrthoDBi EOG7C8GHD.
PhylomeDBi O43638.
TreeFami TF316127.

Miscellaneous databases

GenomeRNAii 2307.
NextBioi 9371.
PROi O43638.
SOURCEi Search...

Gene expression databases

Bgeei O43638.
CleanExi HS_FOXS1.
Genevestigatori O43638.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  4. "Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene."
    Cederberg A., Betz R., Lagercrantz S., Larsson C., Hulander M., Carlsson P., Enerbaeck S.
    Genomics 44:344-346(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-119.

Entry informationi

Entry nameiFOXS1_HUMAN
AccessioniPrimary (citable) accession number: O43638
Secondary accession number(s): Q96D28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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