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O43623

- SNAI2_HUMAN

UniProt

O43623 - SNAI2_HUMAN

Protein

Zinc finger protein SNAI2

Gene

SNAI2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 146 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells By similarity. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.By similarity6 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri128 – 15023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri159 – 18123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri185 – 20723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri213 – 23523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri241 – 26424C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW
    3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: BHF-UCL
    4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    5. sequence-specific DNA binding Source: BHF-UCL

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: UniProtKB
    2. cartilage morphogenesis Source: Ensembl
    3. cell migration involved in endocardial cushion formation Source: BHF-UCL
    4. cellular response to epidermal growth factor stimulus Source: BHF-UCL
    5. cellular response to fibroblast growth factor stimulus Source: Ensembl
    6. cellular response to ionizing radiation Source: Ensembl
    7. desmosome disassembly Source: BHF-UCL
    8. embryo development Source: Ensembl
    9. epithelial to mesenchymal transition Source: BHF-UCL
    10. epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
    11. epithelium development Source: BHF-UCL
    12. negative regulation of anoikis Source: BHF-UCL
    13. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
    14. negative regulation of catenin import into nucleus Source: BHF-UCL
    15. negative regulation of cell adhesion involved in substrate-bound cell migration Source: Ensembl
    16. negative regulation of cell adhesion mediated by integrin Source: BHF-UCL
    17. negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    18. negative regulation of chondrocyte differentiation Source: BHF-UCL
    19. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
    20. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
    21. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
    22. negative regulation of keratinocyte proliferation Source: BHF-UCL
    23. negative regulation of stem cell proliferation Source: Ensembl
    24. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    25. negative regulation of vitamin D biosynthetic process Source: BHF-UCL
    26. negative regulation of vitamin D receptor signaling pathway Source: BHF-UCL
    27. neural crest cell development Source: BHF-UCL
    28. Notch signaling pathway Source: BHF-UCL
    29. osteoblast differentiation Source: UniProtKB
    30. palate development Source: Ensembl
    31. pigmentation Source: BHF-UCL
    32. positive regulation of cell migration Source: BHF-UCL
    33. positive regulation of fat cell differentiation Source: Ensembl
    34. positive regulation of histone acetylation Source: Ensembl
    35. regulation of branching involved in salivary gland morphogenesis Source: Ensembl
    36. regulation of chemokine production Source: BHF-UCL
    37. regulation of osteoblast differentiation Source: BHF-UCL
    38. regulation of tight junction assembly Source: BHF-UCL
    39. sensory perception of sound Source: BHF-UCL
    40. white fat cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein SNAI2
    Alternative name(s):
    Neural crest transcription factor Slug
    Protein snail homolog 2
    Gene namesi
    Name:SNAI2
    Synonyms:SLUG, SLUGH
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:11094. SNAI2.

    Subcellular locationi

    Nucleus. Cytoplasm
    Note: Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nuclear chromatin Source: BHF-UCL
    3. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Waardenburg syndrome 2D (WS2D) [MIM:608890]: WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Piebald trait (PBT) [MIM:172800]: Autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi87 – 871S → A: Increases protein stability. Does not affect repressor activity on E-cadherin/CDH1 promoter. 1 Publication
    Mutagenesisi92 – 921S → A: Increases protein stability, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-96. 1 Publication
    Mutagenesisi96 – 961S → A: Increases protein stability, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-92. 1 Publication
    Mutagenesisi100 – 1001S → A: Increases protein stability and half-life, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-104. 1 Publication
    Mutagenesisi104 – 1041S → A: Increases protein stability and half-life, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-100. 1 Publication
    Mutagenesisi166 – 1661K → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-175. 1 Publication
    Mutagenesisi175 – 1751K → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-166. 1 Publication
    Mutagenesisi192 – 1921K → E: Abolishes binding to KPNA2 and impairs binding to KPNB1, IPO7 and TMPO1; when associated with E-196. 1 Publication
    Mutagenesisi196 – 1961R → E: Abolishes binding to KPNA2 and impairs binding to KPNB1, IPO7 and TMPO1; when associated with E-192. 1 Publication
    Mutagenesisi225 – 2251R → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-229. 1 Publication
    Mutagenesisi229 – 2291R → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-225. 1 Publication

    Keywords - Diseasei

    Deafness, Waardenburg syndrome

    Organism-specific databases

    MIMi172800. phenotype.
    608890. phenotype.
    Orphaneti2884. Piebaldism.
    895. Waardenburg syndrome type 2.
    PharmGKBiPA35945.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Zinc finger protein SNAI2PRO_0000047032Add
    BLAST

    Post-translational modificationi

    GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.1 Publication

    Proteomic databases

    PaxDbiO43623.
    PRIDEiO43623.

    PTM databases

    PhosphoSiteiO43623.

    Expressioni

    Tissue specificityi

    Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).4 Publications

    Gene expression databases

    BgeeiO43623.
    CleanExiHS_SNAI2.
    GenevestigatoriO43623.

    Organism-specific databases

    HPAiCAB011671.

    Interactioni

    Subunit structurei

    Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) By similarity. Interacts (via zinc fingers) with KPNA2, KPNB1, and TNPO1. May interact (via zinc fingers) with IPO7.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi112476. 7 interactions.
    STRINGi9606.ENSP00000020945.

    Structurei

    3D structure databases

    ProteinModelPortaliO43623.
    SMRiO43623. Positions 128-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2020SNAG domainBy similarityAdd
    BLAST

    Domaini

    Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain.

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri128 – 15023C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri159 – 18123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri185 – 20723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri213 – 23523C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri241 – 26424C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000261665.
    HOVERGENiHBG007477.
    InParanoidiO43623.
    KOiK05706.
    OMAiEDEQMLP.
    OrthoDBiEOG7P2XSG.
    PhylomeDBiO43623.
    TreeFamiTF315515.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43623-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLYESYSMP VIPQPEILSS    50
    GAYSPITVWT TAAPFHAQLP NGLSPLSGYS SSLGRVSPPP PSDTSSKDHS 100
    GSESPISDEE ERLQSKLSDP HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH 150
    CDAQSRKSFS CKYCDKEYVS LGALKMHIRT HTLPCVCKIC GKAFSRPWLL 200
    QGHIRTHTGE KPFSCPHCNR AFADRSNLRA HLQTHSDVKK YQCKNCSKTF 250
    SRMSLLHKHE ESGCCVAH 268
    Length:268
    Mass (Da):29,986
    Last modified:June 1, 1998 - v1
    Checksum:i63F068C8E6B275D4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti126 – 1261E → K in BAD97088. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311P → T.
    Corresponds to variant rs11544360 [ dbSNP | Ensembl ].
    VAR_069163
    Natural varianti119 – 1191D → E in a patient with neural tube defects. 1 Publication
    VAR_009873
    Natural varianti234 – 2341T → I.
    Corresponds to variant rs13280993 [ dbSNP | Ensembl ].
    VAR_069164

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042001 Genomic DNA. Translation: AAC34288.1.
    AF084243 Genomic DNA. Translation: AAD55240.1.
    AK312661 mRNA. Translation: BAG35543.1.
    AK223368 mRNA. Translation: BAD97088.1.
    CH471068 Genomic DNA. Translation: EAW86700.1.
    BC014890 mRNA. Translation: AAH14890.1.
    BC015895 mRNA. Translation: AAH15895.1.
    CCDSiCCDS6146.1.
    RefSeqiNP_003059.1. NM_003068.4.
    UniGeneiHs.360174.

    Genome annotation databases

    EnsembliENST00000020945; ENSP00000020945; ENSG00000019549.
    ENST00000396822; ENSP00000380034; ENSG00000019549.
    GeneIDi6591.
    KEGGihsa:6591.
    UCSCiuc003xqp.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042001 Genomic DNA. Translation: AAC34288.1 .
    AF084243 Genomic DNA. Translation: AAD55240.1 .
    AK312661 mRNA. Translation: BAG35543.1 .
    AK223368 mRNA. Translation: BAD97088.1 .
    CH471068 Genomic DNA. Translation: EAW86700.1 .
    BC014890 mRNA. Translation: AAH14890.1 .
    BC015895 mRNA. Translation: AAH15895.1 .
    CCDSi CCDS6146.1.
    RefSeqi NP_003059.1. NM_003068.4.
    UniGenei Hs.360174.

    3D structure databases

    ProteinModelPortali O43623.
    SMRi O43623. Positions 128-264.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112476. 7 interactions.
    STRINGi 9606.ENSP00000020945.

    PTM databases

    PhosphoSitei O43623.

    Proteomic databases

    PaxDbi O43623.
    PRIDEi O43623.

    Protocols and materials databases

    DNASUi 6591.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000020945 ; ENSP00000020945 ; ENSG00000019549 .
    ENST00000396822 ; ENSP00000380034 ; ENSG00000019549 .
    GeneIDi 6591.
    KEGGi hsa:6591.
    UCSCi uc003xqp.3. human.

    Organism-specific databases

    CTDi 6591.
    GeneCardsi GC08M049830.
    HGNCi HGNC:11094. SNAI2.
    HPAi CAB011671.
    MIMi 172800. phenotype.
    602150. gene.
    608890. phenotype.
    neXtProti NX_O43623.
    Orphaneti 2884. Piebaldism.
    895. Waardenburg syndrome type 2.
    PharmGKBi PA35945.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000261665.
    HOVERGENi HBG007477.
    InParanoidi O43623.
    KOi K05706.
    OMAi EDEQMLP.
    OrthoDBi EOG7P2XSG.
    PhylomeDBi O43623.
    TreeFami TF315515.

    Miscellaneous databases

    GeneWikii SNAI2.
    GenomeRNAii 6591.
    NextBioi 25641.
    PROi O43623.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43623.
    CleanExi HS_SNAI2.
    Genevestigatori O43623.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human Slug is a repressor that localizes to sites of active transcription."
      Hemavathy K., Guru S.C., Harris J., Chen J.D., Ip Y.T.
      Mol. Cell. Biol. 20:5087-5095(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Melanocyte.
    2. "Human SLUG gene organization, expression, and chromosome map location on 8q."
      Cohen M.E., Yin M., Paznekas W.A., Schertzer M., Wood S., Jabs E.W.
      Genomics 51:468-471(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region."
      Stegmann K., Boecker J., Kosan C., Ermert A., Kunz J., Koch M.C.
      Mutat. Res. 406:63-69(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-119.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Dermoid cancer.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    8. "The SLUG zinc-finger protein represses E-cadherin in breast cancer."
      Hajra K.M., Chen D.Y., Fearon E.R.
      Cancer Res. 62:1613-1618(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. Cited for: INVOLVEMENT IN WS2D.
    10. Cited for: INVOLVEMENT IN PBT.
    11. "Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells."
      Tripathi M.K., Misra S., Khedkar S.V., Hamilton N., Irvin-Wilson C., Sharan C., Sealy L., Chaudhuri G.
      J. Biol. Chem. 280:17163-17171(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes."
      Turner F.E., Broad S., Khanim F.L., Jeanes A., Talma S., Hughes S., Tselepis C., Hotchin N.A.
      J. Biol. Chem. 281:21321-21331(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    13. Cited for: FUNCTION, TISSUE SPECIFICITY.
    14. "Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors."
      Mingot J.M., Vega S., Maestro B., Sanz J.M., Nieto M.A.
      J. Cell Sci. 122:1452-1460(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KPNA2; KPNB1; TNPO1 AND IPO7, MUTAGENESIS OF LYS-166; LYS-175; LYS-192; ARG-196; ARG-225 AND ARG-229.
    15. Cited for: FUNCTION, TISSUE SPECIFICITY.
    16. "Functional regulation of Slug/Snail2 is dependent on GSK-3beta-mediated phosphorylation."
      Kim J.Y., Kim Y.M., Yang C.H., Cho S.K., Lee J.W., Cho M.
      FEBS J. 279:2929-2939(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION, MUTAGENESIS OF SER-87; SER-92; SER-96; SER-100 AND SER-104.

    Entry informationi

    Entry nameiSNAI2_HUMAN
    AccessioniPrimary (citable) accession number: O43623
    Secondary accession number(s): B2R6P6, Q53FC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 146 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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