O43623 (SNAI2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein SNAI2

Alternative name(s):
Neural crest transcription factor Slug
Protein snail homolog 2

Gene names

Name:	SNAI2
Synonyms:	SLUG, SLUGH

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells By similarity. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. Ref.1 Ref.8 Ref.11 Ref.12 Ref.13 Ref.15
Subunit structure	Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) By similarity. Interacts (via zinc fingers) with KPNA2, KPNB1, and TNPO1. May interact (via zinc fingers) with IPO7. Ref.14
Subcellular location	Nucleus. Cytoplasm. Note: Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions. Ref.1 Ref.12 Ref.16
Tissue specificity	Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level). Ref.1 Ref.12 Ref.13 Ref.15
Domain	Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain.
Post-translational modification	GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.
Involvement in disease	Waardenburg syndrome 2D (WS2D) [MIM:608890]: WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.9 Piebald trait (PBT) [MIM:172800]: Autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10
Sequence similarities	Belongs to the snail C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Disease	Deafness Waardenburg syndrome
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Notch signaling pathway Inferred from mutant phenotype PubMed 18663143. Source: BHF-UCL canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 20128911. Source: UniProtKB cartilage morphogenesis Inferred from electronic annotation. Source: Compara cell migration involved in endocardial cushion formation Inferred from sequence or structural similarity. Source: BHF-UCL cellular response to epidermal growth factor stimulus Inferred from direct assay PubMed 18716062. Source: BHF-UCL cellular response to fibroblast growth factor stimulus Inferred from electronic annotation. Source: Compara cellular response to ionizing radiation Inferred from electronic annotation. Source: Compara desmosome disassembly Inferred from mutant phenotype PubMed 9182671. Source: BHF-UCL embryo development Inferred from electronic annotation. Source: Compara epithelial to mesenchymal transition involved in endocardial cushion formation Inferred from sequence or structural similarity. Source: BHF-UCL epithelium development Inferred from sequence or structural similarity PubMed 18716062. Source: BHF-UCL negative regulation of DNA damage response, signal transduction by p53 class mediator Inferred from mutant phenotype PubMed 15314165. Source: BHF-UCL negative regulation of anoikis Inferred from mutant phenotype PubMed 17984306. Source: BHF-UCL negative regulation of canonical Wnt receptor signaling pathway Inferred from direct assay PubMed 19502595. Source: BHF-UCL negative regulation of catenin import into nucleus Inferred from direct assay PubMed 19502595. Source: BHF-UCL negative regulation of cell adhesion involved in substrate-bound cell migration Inferred from electronic annotation. Source: Compara negative regulation of cell adhesion mediated by integrin Inferred by curator Ref.12. Source: BHF-UCL negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 15737616Ref.12PubMed 17984306. Source: BHF-UCL negative regulation of chondrocyte differentiation Inferred from mutant phenotype Ref.13. Source: BHF-UCL negative regulation of keratinocyte proliferation Inferred from direct assay Ref.12. Source: BHF-UCL negative regulation of stem cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of vitamin D biosynthetic process Inferred from direct assay PubMed 18485278PubMed 19502595. Source: BHF-UCL negative regulation of vitamin D receptor signaling pathway Inferred from direct assay PubMed 19502595. Source: BHF-UCL neural crest cell development Inferred from mutant phenotype Ref.9. Source: BHF-UCL osteoblast differentiation Inferred from expression pattern PubMed 20128911. Source: UniProtKB palate development Inferred from electronic annotation. Source: Compara pigmentation Inferred from mutant phenotype Ref.9. Source: BHF-UCL positive regulation of cell migration Inferred from mutant phenotype PubMed 15314165. Source: BHF-UCL positive regulation of fat cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of histone acetylation Inferred from electronic annotation. Source: Compara regulation of chemokine production Inferred from mutant phenotype Ref.15. Source: BHF-UCL regulation of osteoblast differentiation Inferred from mutant phenotype Ref.13Ref.15. Source: BHF-UCL regulation of tight junction assembly Inferred from mutant phenotype PubMed 15314165. Source: BHF-UCL sensory perception of sound Inferred from mutant phenotype Ref.9. Source: BHF-UCL white fat cell differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear chromatin Inferred from direct assay Ref.13. Source: BHF-UCL
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Inferred from direct assay Ref.1Ref.8Ref.12PubMed 18663143. Source: BHF-UCL RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara chromatin binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding Inferred from direct assay PubMed 10518215Ref.1. Source: BHF-UCL zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Zinc finger protein SNAI2		PRO_0000047032
Regions
	Zinc finger	128 – 150	23	C2H2-type 1
	Zinc finger	159 – 181	23	C2H2-type 2
	Zinc finger	185 – 207	23	C2H2-type 3
	Zinc finger	213 – 235	23	C2H2-type 4
	Zinc finger	241 – 264	24	C2H2-type 5; atypical
	Region	1 – 20	20	SNAG domain By similarity
Natural variations
	Natural variant	31	1	P → T. Corresponds to variant rs11544360 [ dbSNP | Ensembl ].		VAR_069163
	Natural variant	119	1	D → E in a patient with neural tube defects. Ref.3		VAR_009873
	Natural variant	234	1	T → I. Corresponds to variant rs13280993 [ dbSNP | Ensembl ].		VAR_069164
Experimental info
	Mutagenesis	87	1	S → A: Increases protein stability. Does not affect repressor activity on E-cadherin/CDH1 promoter. Ref.16
	Mutagenesis	92	1	S → A: Increases protein stability, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-96. Ref.16
	Mutagenesis	96	1	S → A: Increases protein stability, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-92. Ref.16
	Mutagenesis	100	1	S → A: Increases protein stability and half-life, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-104. Ref.16
	Mutagenesis	104	1	S → A: Increases protein stability and half-life, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-100. Ref.16
	Mutagenesis	166	1	K → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-175. Ref.14
	Mutagenesis	175	1	K → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-166. Ref.14
	Mutagenesis	192	1	K → E: Abolishes binding to KPNA2 and impairs binding to KPNB1, IPO7 and TMPO1; when associated with E-196. Ref.14
	Mutagenesis	196	1	R → E: Abolishes binding to KPNA2 and impairs binding to KPNB1, IPO7 and TMPO1; when associated with E-192. Ref.14
	Mutagenesis	225	1	R → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-229. Ref.14
	Mutagenesis	229	1	R → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-225. Ref.14
	Sequence conflict	126	1	E → K in BAD97088. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	O43623 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 63F068C8E6B275D4	FASTA	268	29,986
	10 20 30 40 50 60 MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLYESYSMP VIPQPEILSS GAYSPITVWT 70 80 90 100 110 120 TAAPFHAQLP NGLSPLSGYS SSLGRVSPPP PSDTSSKDHS GSESPISDEE ERLQSKLSDP 130 140 150 160 170 180 HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH CDAQSRKSFS CKYCDKEYVS LGALKMHIRT 190 200 210 220 230 240 HTLPCVCKIC GKAFSRPWLL QGHIRTHTGE KPFSCPHCNR AFADRSNLRA HLQTHSDVKK 250 260 YQCKNCSKTF SRMSLLHKHE ESGCCVAH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human Slug is a repressor that localizes to sites of active transcription." Hemavathy K., Guru S.C., Harris J., Chen J.D., Ip Y.T. Mol. Cell. Biol. 20:5087-5095(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Melanocyte.
[2]	"Human SLUG gene organization, expression, and chromosome map location on 8q." Cohen M.E., Yin M., Paznekas W.A., Schertzer M., Wood S., Jabs E.W. Genomics 51:468-471(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region." Stegmann K., Boecker J., Kosan C., Ermert A., Kunz J., Koch M.C. Mutat. Res. 406:63-69(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-119.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Dermoid cancer.
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[8]	"The SLUG zinc-finger protein represses E-cadherin in breast cancer." Hajra K.M., Chen D.Y., Fearon E.R. Cancer Res. 62:1613-1618(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"SLUG (SNAI2) deletions in patients with Waardenburg disease." Sanchez-Martin M., Rodriguez-Garcia A., Perez-Losada J., Sagrera A., Read A.P., Sanchez-Garcia I. Hum. Mol. Genet. 11:3231-3236(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN WS2D.
[10]	"Deletion of the SLUG (SNAI2) gene results in human piebaldism." Sanchez-Martin M., Perez-Losada J., Rodriguez-Garcia A., Gonzalez-Sanchez B., Korf B.R., Kuster W., Moss C., Spritz R.A., Sanchez-Garcia I. Am. J. Med. Genet. A 122:125-132(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN PBT.
[11]	"Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells." Tripathi M.K., Misra S., Khedkar S.V., Hamilton N., Irvin-Wilson C., Sharan C., Sealy L., Chaudhuri G. J. Biol. Chem. 280:17163-17171(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[12]	"Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes." Turner F.E., Broad S., Khanim F.L., Jeanes A., Talma S., Hughes S., Tselepis C., Hotchin N.A. J. Biol. Chem. 281:21321-21331(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[13]	"Slug gene expression supports human osteoblast maturation." Lambertini E., Lisignoli G., Torreggiani E., Manferdini C., Gabusi E., Franceschetti T., Penolazzi L., Gambari R., Facchini A., Piva R. Cell. Mol. Life Sci. 66:3641-3653(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[14]	"Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors." Mingot J.M., Vega S., Maestro B., Sanz J.M., Nieto M.A. J. Cell Sci. 122:1452-1460(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH KPNA2; KPNB1; TNPO1 AND IPO7, MUTAGENESIS OF LYS-166; LYS-175; LYS-192; ARG-196; ARG-225 AND ARG-229.
[15]	"Slug contributes to the regulation of CXCL12 expression in human osteoblasts." Piva R., Manferdini C., Lambertini E., Torreggiani E., Penolazzi L., Gambari R., Pastore A., Pelucchi S., Gabusi E., Piacentini A., Filardo G., Facchini A., Lisignoli G. Exp. Cell Res. 317:1159-1168(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[16]	"Functional regulation of Slug/Snail2 is dependent on GSK-3beta-mediated phosphorylation." Kim J.Y., Kim Y.M., Yang C.H., Cho S.K., Lee J.W., Cho M. FEBS J. 279:2929-2939(2012) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION, MUTAGENESIS OF SER-87; SER-92; SER-96; SER-100 AND SER-104.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF042001 Genomic DNA. Translation: AAC34288.1. AF084243 Genomic DNA. Translation: AAD55240.1. AK312661 mRNA. Translation: BAG35543.1. AK223368 mRNA. Translation: BAD97088.1. CH471068 Genomic DNA. Translation: EAW86700.1. BC014890 mRNA. Translation: AAH14890.1. BC015895 mRNA. Translation: AAH15895.1.
IPI	IPI00013394.
RefSeq	NP_003059.1. NM_003068.4.
UniGene	Hs.360174.
3D structure databases
ProteinModelPortal	O43623.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000020945.
PTM databases
PhosphoSite	O43623.
Proteomic databases
PaxDb	O43623.
PRIDE	O43623.
Protocols and materials databases
DNASU	6591.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000020945; ENSP00000020945; ENSG00000019549. ENST00000396822; ENSP00000380034; ENSG00000019549.
GeneID	6591.
KEGG	hsa:6591.
UCSC	uc003xqp.3. human.
Organism-specific databases
CTD	6591.
GeneCards	GC08M049830.
HGNC	HGNC:11094. SNAI2.
HPA	CAB011671.
MIM	172800. phenotype. 602150. gene. 608890. phenotype.
neXtProt	NX_O43623.
Orphanet	2884. Piebaldism. 895. Waardenburg syndrome type 2.
PharmGKB	PA35945.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000261665.
HOVERGEN	HBG007477.
InParanoid	O43623.
KO	K05706.
OMA	FHSPLPN.
OrthoDB	EOG4H9XM9.
Enzyme and pathway databases
Pathway_Interaction_DB	kitpathway. Signaling events mediated by Stem cell factor receptor (c-Kit).
Gene expression databases
Bgee	O43623.
CleanEx	HS_SNAI2.
Genevestigator	O43623.
GermOnline	ENSG00000019549. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 4 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6591.
NextBio	25641.
SOURCE	Search...

Entry information

Entry name

SNAI2_HUMAN

Accession

Primary (citable) accession number: O43623
Secondary accession number(s): B2R6P6, Q53FC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 1, 1998
Last modified:	May 29, 2013
This is version 135 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.