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O43623

- SNAI2_HUMAN

UniProt

O43623 - SNAI2_HUMAN

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Protein

Zinc finger protein SNAI2

Gene

SNAI2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.By similarity6 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri128 – 15023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri159 – 18123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri185 – 20723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 23523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26424C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: BHF-UCL
  4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  5. sequence-specific DNA binding Source: BHF-UCL

GO - Biological processi

  1. canonical Wnt signaling pathway Source: UniProtKB
  2. cartilage morphogenesis Source: Ensembl
  3. cell migration involved in endocardial cushion formation Source: BHF-UCL
  4. cellular response to epidermal growth factor stimulus Source: BHF-UCL
  5. cellular response to fibroblast growth factor stimulus Source: Ensembl
  6. cellular response to ionizing radiation Source: Ensembl
  7. desmosome disassembly Source: BHF-UCL
  8. embryo development Source: Ensembl
  9. epithelial to mesenchymal transition Source: BHF-UCL
  10. epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
  11. epithelium development Source: BHF-UCL
  12. negative regulation of anoikis Source: BHF-UCL
  13. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  14. negative regulation of catenin import into nucleus Source: BHF-UCL
  15. negative regulation of cell adhesion involved in substrate-bound cell migration Source: Ensembl
  16. negative regulation of cell adhesion mediated by integrin Source: BHF-UCL
  17. negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  18. negative regulation of chondrocyte differentiation Source: BHF-UCL
  19. negative regulation of DNA damage response, signal transduction by p53 class mediator Source: BHF-UCL
  20. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
  21. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
  22. negative regulation of keratinocyte proliferation Source: BHF-UCL
  23. negative regulation of stem cell proliferation Source: Ensembl
  24. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  25. negative regulation of vitamin D biosynthetic process Source: BHF-UCL
  26. negative regulation of vitamin D receptor signaling pathway Source: BHF-UCL
  27. neural crest cell development Source: BHF-UCL
  28. Notch signaling pathway Source: BHF-UCL
  29. osteoblast differentiation Source: UniProtKB
  30. palate development Source: Ensembl
  31. pigmentation Source: BHF-UCL
  32. positive regulation of cell migration Source: BHF-UCL
  33. positive regulation of fat cell differentiation Source: Ensembl
  34. positive regulation of histone acetylation Source: Ensembl
  35. regulation of branching involved in salivary gland morphogenesis Source: Ensembl
  36. regulation of chemokine production Source: BHF-UCL
  37. regulation of osteoblast differentiation Source: BHF-UCL
  38. regulation of tight junction assembly Source: BHF-UCL
  39. sensory perception of sound Source: BHF-UCL
  40. white fat cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein SNAI2
Alternative name(s):
Neural crest transcription factor Slug
Protein snail homolog 2
Gene namesi
Name:SNAI2
Synonyms:SLUG, SLUGH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:11094. SNAI2.

Subcellular locationi

Nucleus. Cytoplasm
Note: Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nuclear chromatin Source: BHF-UCL
  3. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Waardenburg syndrome 2D (WS2D) [MIM:608890]: WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Piebald trait (PBT) [MIM:172800]: Autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi87 – 871S → A: Increases protein stability. Does not affect repressor activity on E-cadherin/CDH1 promoter. 1 Publication
Mutagenesisi92 – 921S → A: Increases protein stability, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-96. 1 Publication
Mutagenesisi96 – 961S → A: Increases protein stability, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-92. 1 Publication
Mutagenesisi100 – 1001S → A: Increases protein stability and half-life, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-104. 1 Publication
Mutagenesisi104 – 1041S → A: Increases protein stability and half-life, nuclear accumulation and repressor activity on E-cadherin/CDH1 promoter; when associated with A-100. 1 Publication
Mutagenesisi166 – 1661K → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-175. 1 Publication
Mutagenesisi175 – 1751K → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-166. 1 Publication
Mutagenesisi192 – 1921K → E: Abolishes binding to KPNA2 and impairs binding to KPNB1, IPO7 and TMPO1; when associated with E-196. 1 Publication
Mutagenesisi196 – 1961R → E: Abolishes binding to KPNA2 and impairs binding to KPNB1, IPO7 and TMPO1; when associated with E-192. 1 Publication
Mutagenesisi225 – 2251R → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-229. 1 Publication
Mutagenesisi229 – 2291R → E: Abolishes binding to KPNA2, KPNB1 and IPO7 and impairs binding to TMPO1; when associated with E-225. 1 Publication

Keywords - Diseasei

Deafness, Waardenburg syndrome

Organism-specific databases

MIMi172800. phenotype.
608890. phenotype.
Orphaneti2884. Piebaldism.
895. Waardenburg syndrome type 2.
PharmGKBiPA35945.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Zinc finger protein SNAI2PRO_0000047032Add
BLAST

Post-translational modificationi

GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.1 Publication

Proteomic databases

PaxDbiO43623.
PRIDEiO43623.

PTM databases

PhosphoSiteiO43623.

Expressioni

Tissue specificityi

Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).4 Publications

Gene expression databases

BgeeiO43623.
CleanExiHS_SNAI2.
GenevestigatoriO43623.

Organism-specific databases

HPAiCAB011671.

Interactioni

Subunit structurei

Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) (By similarity). Interacts (via zinc fingers) with KPNA2, KPNB1, and TNPO1. May interact (via zinc fingers) with IPO7.By similarity1 Publication

Protein-protein interaction databases

BioGridi112476. 19 interactions.
STRINGi9606.ENSP00000020945.

Structurei

3D structure databases

ProteinModelPortaliO43623.
SMRiO43623. Positions 128-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020SNAG domainBy similarityAdd
BLAST

Domaini

Repression activity depends on the C-terminal DNA-binding zinc fingers and on the N-terminal repression domain.

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri128 – 15023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri159 – 18123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri185 – 20723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri213 – 23523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26424C2H2-type 5; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00390000011027.
HOGENOMiHOG000261665.
HOVERGENiHBG007477.
InParanoidiO43623.
KOiK05706.
OMAiEDEQMLP.
OrthoDBiEOG7P2XSG.
PhylomeDBiO43623.
TreeFamiTF315515.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43623-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRSFLVKKH FNASKKPNYS ELDTHTVIIS PYLYESYSMP VIPQPEILSS
60 70 80 90 100
GAYSPITVWT TAAPFHAQLP NGLSPLSGYS SSLGRVSPPP PSDTSSKDHS
110 120 130 140 150
GSESPISDEE ERLQSKLSDP HAIEAEKFQC NLCNKTYSTF SGLAKHKQLH
160 170 180 190 200
CDAQSRKSFS CKYCDKEYVS LGALKMHIRT HTLPCVCKIC GKAFSRPWLL
210 220 230 240 250
QGHIRTHTGE KPFSCPHCNR AFADRSNLRA HLQTHSDVKK YQCKNCSKTF
260
SRMSLLHKHE ESGCCVAH
Length:268
Mass (Da):29,986
Last modified:June 1, 1998 - v1
Checksum:i63F068C8E6B275D4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261E → K in BAD97088. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311P → T.
Corresponds to variant rs11544360 [ dbSNP | Ensembl ].
VAR_069163
Natural varianti119 – 1191D → E in a patient with neural tube defects. 1 Publication
VAR_009873
Natural varianti234 – 2341T → I.
Corresponds to variant rs13280993 [ dbSNP | Ensembl ].
VAR_069164

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042001 Genomic DNA. Translation: AAC34288.1.
AF084243 Genomic DNA. Translation: AAD55240.1.
AK312661 mRNA. Translation: BAG35543.1.
AK223368 mRNA. Translation: BAD97088.1.
CH471068 Genomic DNA. Translation: EAW86700.1.
BC014890 mRNA. Translation: AAH14890.1.
BC015895 mRNA. Translation: AAH15895.1.
CCDSiCCDS6146.1.
RefSeqiNP_003059.1. NM_003068.4.
UniGeneiHs.360174.

Genome annotation databases

EnsembliENST00000020945; ENSP00000020945; ENSG00000019549.
ENST00000396822; ENSP00000380034; ENSG00000019549.
GeneIDi6591.
KEGGihsa:6591.
UCSCiuc003xqp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042001 Genomic DNA. Translation: AAC34288.1 .
AF084243 Genomic DNA. Translation: AAD55240.1 .
AK312661 mRNA. Translation: BAG35543.1 .
AK223368 mRNA. Translation: BAD97088.1 .
CH471068 Genomic DNA. Translation: EAW86700.1 .
BC014890 mRNA. Translation: AAH14890.1 .
BC015895 mRNA. Translation: AAH15895.1 .
CCDSi CCDS6146.1.
RefSeqi NP_003059.1. NM_003068.4.
UniGenei Hs.360174.

3D structure databases

ProteinModelPortali O43623.
SMRi O43623. Positions 128-264.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112476. 19 interactions.
STRINGi 9606.ENSP00000020945.

PTM databases

PhosphoSitei O43623.

Proteomic databases

PaxDbi O43623.
PRIDEi O43623.

Protocols and materials databases

DNASUi 6591.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000020945 ; ENSP00000020945 ; ENSG00000019549 .
ENST00000396822 ; ENSP00000380034 ; ENSG00000019549 .
GeneIDi 6591.
KEGGi hsa:6591.
UCSCi uc003xqp.3. human.

Organism-specific databases

CTDi 6591.
GeneCardsi GC08M049830.
HGNCi HGNC:11094. SNAI2.
HPAi CAB011671.
MIMi 172800. phenotype.
602150. gene.
608890. phenotype.
neXtProti NX_O43623.
Orphaneti 2884. Piebaldism.
895. Waardenburg syndrome type 2.
PharmGKBi PA35945.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00390000011027.
HOGENOMi HOG000261665.
HOVERGENi HBG007477.
InParanoidi O43623.
KOi K05706.
OMAi EDEQMLP.
OrthoDBi EOG7P2XSG.
PhylomeDBi O43623.
TreeFami TF315515.

Miscellaneous databases

GeneWikii SNAI2.
GenomeRNAii 6591.
NextBioi 25641.
PROi O43623.
SOURCEi Search...

Gene expression databases

Bgeei O43623.
CleanExi HS_SNAI2.
Genevestigatori O43623.

Family and domain databases

Gene3Di 3.30.160.60. 4 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human Slug is a repressor that localizes to sites of active transcription."
    Hemavathy K., Guru S.C., Harris J., Chen J.D., Ip Y.T.
    Mol. Cell. Biol. 20:5087-5095(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Melanocyte.
  2. "Human SLUG gene organization, expression, and chromosome map location on 8q."
    Cohen M.E., Yin M., Paznekas W.A., Schertzer M., Wood S., Jabs E.W.
    Genomics 51:468-471(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region."
    Stegmann K., Boecker J., Kosan C., Ermert A., Kunz J., Koch M.C.
    Mutat. Res. 406:63-69(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-119.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Dermoid cancer.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  8. "The SLUG zinc-finger protein represses E-cadherin in breast cancer."
    Hajra K.M., Chen D.Y., Fearon E.R.
    Cancer Res. 62:1613-1618(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. Cited for: INVOLVEMENT IN WS2D.
  10. Cited for: INVOLVEMENT IN PBT.
  11. "Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells."
    Tripathi M.K., Misra S., Khedkar S.V., Hamilton N., Irvin-Wilson C., Sharan C., Sealy L., Chaudhuri G.
    J. Biol. Chem. 280:17163-17171(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes."
    Turner F.E., Broad S., Khanim F.L., Jeanes A., Talma S., Hughes S., Tselepis C., Hotchin N.A.
    J. Biol. Chem. 281:21321-21331(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  13. Cited for: FUNCTION, TISSUE SPECIFICITY.
  14. "Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors."
    Mingot J.M., Vega S., Maestro B., Sanz J.M., Nieto M.A.
    J. Cell Sci. 122:1452-1460(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KPNA2; KPNB1; TNPO1 AND IPO7, MUTAGENESIS OF LYS-166; LYS-175; LYS-192; ARG-196; ARG-225 AND ARG-229.
  15. Cited for: FUNCTION, TISSUE SPECIFICITY.
  16. "Functional regulation of Slug/Snail2 is dependent on GSK-3beta-mediated phosphorylation."
    Kim J.Y., Kim Y.M., Yang C.H., Cho S.K., Lee J.W., Cho M.
    FEBS J. 279:2929-2939(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION, MUTAGENESIS OF SER-87; SER-92; SER-96; SER-100 AND SER-104.

Entry informationi

Entry nameiSNAI2_HUMAN
AccessioniPrimary (citable) accession number: O43623
Secondary accession number(s): B2R6P6, Q53FC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3