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Protein

Trafficking protein particle complex subunit 3

Gene

TRAPPC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000054116-MONOMER.
ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 3
Alternative name(s):
BET3 homolog
Gene namesi
Name:TRAPPC3
Synonyms:BET3
ORF Names:CDABP0066
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19942. TRAPPC3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi68C → S: Loss of palmitoylation. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000054116.
PharmGKBiPA134972272.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115721 – 180Trafficking protein particle complex subunit 3Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi68S-palmitoyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

EPDiO43617.
MaxQBiO43617.
PaxDbiO43617.
PeptideAtlasiO43617.
PRIDEiO43617.
TopDownProteomicsiO43617-1. [O43617-1]

PTM databases

iPTMnetiO43617.
PhosphoSitePlusiO43617.
SwissPalmiO43617.

Expressioni

Gene expression databases

BgeeiENSG00000054116.
CleanExiHS_TRAPPC3.
ExpressionAtlasiO43617. baseline and differential.
GenevisibleiO43617. HS.

Organism-specific databases

HPAiHPA028408.

Interactioni

Subunit structurei

Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Heterodimer with TRAPPC6A. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PLEKHF2Q9H8W43EBI-743566,EBI-742388
TRAPPC13A5PLN92EBI-743566,EBI-2857298
TRAPPC2P0DI81-34EBI-743566,EBI-11961968
TRAPPC2LQ9UL336EBI-743566,EBI-747601
TRAPPC2LQ9UL33-24EBI-743566,EBI-11119202
TRAPPC6AO758657EBI-743566,EBI-743573
TRAPPC6AO75865-27EBI-743566,EBI-8451480
TRAPPC6BQ86SZ22EBI-743566,EBI-6160531
TRAPPC8Q9Y2L52EBI-743566,EBI-2820056

Protein-protein interaction databases

BioGridi117997. 29 interactors.
DIPiDIP-47627N.
IntActiO43617. 17 interactors.
MINTiMINT-5002244.
STRINGi9606.ENSP00000362261.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 34Combined sources18
Helixi37 – 62Combined sources26
Helixi71 – 80Combined sources10
Helixi82 – 87Combined sources6
Beta strandi92 – 94Combined sources3
Beta strandi102 – 109Combined sources8
Helixi120 – 122Combined sources3
Turni127 – 129Combined sources3
Helixi130 – 140Combined sources11
Turni141 – 143Combined sources3
Beta strandi144 – 152Combined sources9
Helixi154 – 156Combined sources3
Beta strandi159 – 170Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SZ7X-ray1.55A2-180[»]
2C0JX-ray2.20A15-175[»]
2CFHX-ray2.30A/B1-180[»]
3KXCX-ray2.00A1-180[»]
ProteinModelPortaliO43617.
SMRiO43617.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43617.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3330. Eukaryota.
ENOG410Z1VV. LUCA.
GeneTreeiENSGT00390000003880.
HOGENOMiHOG000186184.
HOVERGENiHBG055045.
InParanoidiO43617.
KOiK20302.
PhylomeDBiO43617.
TreeFamiTF300091.

Family and domain databases

CDDicd14942. TRAPPC3_bet3. 1 hit.
InterProiIPR016721. Bet3.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR007194. TRAPP_component.
[Graphical view]
PANTHERiPTHR13048. PTHR13048. 1 hit.
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
PIRSFiPIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
SUPFAMiSSF111126. SSF111126. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43617-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDKMGFN
60 70 80 90 100
IGVRLIEDFL ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG
110 120 130 140 150
DEFSLILENN PLVDFVELPD NHSSLIYSNL LCGVLRGALE MVQMAVEAKF
160 170 180
VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE
Length:180
Mass (Da):20,274
Last modified:June 1, 1998 - v1
Checksum:iB5E2D92BE8A39599
GO
Isoform 2 (identifier: O43617-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: Gene prediction based on EST data.
Show »
Length:134
Mass (Da):15,005
Checksum:i927EE13435BDE8B9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470151 – 46Missing in isoform 2. CuratedAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224335 mRNA. Translation: CAA11902.1.
AF041432 mRNA. Translation: AAB96936.1.
AY007139 mRNA. Translation: AAG02000.1.
AK315610 mRNA. Translation: BAG37979.1.
AC114484 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07385.1.
CH471059 Genomic DNA. Translation: EAX07386.1.
CH471059 Genomic DNA. Translation: EAX07387.1.
BC007662 mRNA. Translation: AAH07662.1.
CCDSiCCDS404.1. [O43617-1]
CCDS59194.1. [O43617-2]
RefSeqiNP_001257823.1. NM_001270894.1.
NP_001257824.1. NM_001270895.1. [O43617-2]
NP_001257825.1. NM_001270896.1. [O43617-2]
NP_001257826.1. NM_001270897.1.
NP_055223.1. NM_014408.4. [O43617-1]
UniGeneiHs.523131.

Genome annotation databases

EnsembliENST00000373162; ENSP00000362256; ENSG00000054116. [O43617-2]
ENST00000373163; ENSP00000362257; ENSG00000054116. [O43617-2]
ENST00000373166; ENSP00000362261; ENSG00000054116. [O43617-1]
ENST00000617904; ENSP00000480648; ENSG00000054116. [O43617-2]
GeneIDi27095.
KEGGihsa:27095.
UCSCiuc001bzx.5. human. [O43617-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224335 mRNA. Translation: CAA11902.1.
AF041432 mRNA. Translation: AAB96936.1.
AY007139 mRNA. Translation: AAG02000.1.
AK315610 mRNA. Translation: BAG37979.1.
AC114484 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07385.1.
CH471059 Genomic DNA. Translation: EAX07386.1.
CH471059 Genomic DNA. Translation: EAX07387.1.
BC007662 mRNA. Translation: AAH07662.1.
CCDSiCCDS404.1. [O43617-1]
CCDS59194.1. [O43617-2]
RefSeqiNP_001257823.1. NM_001270894.1.
NP_001257824.1. NM_001270895.1. [O43617-2]
NP_001257825.1. NM_001270896.1. [O43617-2]
NP_001257826.1. NM_001270897.1.
NP_055223.1. NM_014408.4. [O43617-1]
UniGeneiHs.523131.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SZ7X-ray1.55A2-180[»]
2C0JX-ray2.20A15-175[»]
2CFHX-ray2.30A/B1-180[»]
3KXCX-ray2.00A1-180[»]
ProteinModelPortaliO43617.
SMRiO43617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117997. 29 interactors.
DIPiDIP-47627N.
IntActiO43617. 17 interactors.
MINTiMINT-5002244.
STRINGi9606.ENSP00000362261.

PTM databases

iPTMnetiO43617.
PhosphoSitePlusiO43617.
SwissPalmiO43617.

Proteomic databases

EPDiO43617.
MaxQBiO43617.
PaxDbiO43617.
PeptideAtlasiO43617.
PRIDEiO43617.
TopDownProteomicsiO43617-1. [O43617-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373162; ENSP00000362256; ENSG00000054116. [O43617-2]
ENST00000373163; ENSP00000362257; ENSG00000054116. [O43617-2]
ENST00000373166; ENSP00000362261; ENSG00000054116. [O43617-1]
ENST00000617904; ENSP00000480648; ENSG00000054116. [O43617-2]
GeneIDi27095.
KEGGihsa:27095.
UCSCiuc001bzx.5. human. [O43617-1]

Organism-specific databases

CTDi27095.
GeneCardsiTRAPPC3.
HGNCiHGNC:19942. TRAPPC3.
HPAiHPA028408.
MIMi610955. gene.
neXtProtiNX_O43617.
OpenTargetsiENSG00000054116.
PharmGKBiPA134972272.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3330. Eukaryota.
ENOG410Z1VV. LUCA.
GeneTreeiENSGT00390000003880.
HOGENOMiHOG000186184.
HOVERGENiHBG055045.
InParanoidiO43617.
KOiK20302.
PhylomeDBiO43617.
TreeFamiTF300091.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000054116-MONOMER.
ReactomeiR-HSA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

ChiTaRSiTRAPPC3. human.
EvolutionaryTraceiO43617.
GeneWikiiTRAPPC3.
GenomeRNAii27095.
PROiO43617.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000054116.
CleanExiHS_TRAPPC3.
ExpressionAtlasiO43617. baseline and differential.
GenevisibleiO43617. HS.

Family and domain databases

CDDicd14942. TRAPPC3_bet3. 1 hit.
InterProiIPR016721. Bet3.
IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR007194. TRAPP_component.
[Graphical view]
PANTHERiPTHR13048. PTHR13048. 1 hit.
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
PIRSFiPIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
SUPFAMiSSF111126. SSF111126. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTPPC3_HUMAN
AccessioniPrimary (citable) accession number: O43617
Secondary accession number(s): A6NDN0, B2RDN2, D3DPS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.