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O43617

- TPPC3_HUMAN

UniProt

O43617 - TPPC3_HUMAN

Protein

Trafficking protein particle complex subunit 3

Gene

TRAPPC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    May play a role in vesicular transport from endoplasmic reticulum to Golgi.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: Ensembl

    Keywords - Biological processi

    ER-Golgi transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trafficking protein particle complex subunit 3
    Alternative name(s):
    BET3 homolog
    Gene namesi
    Name:TRAPPC3
    Synonyms:BET3
    ORF Names:CDABP0066
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19942. TRAPPC3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. endoplasmic reticulum Source: UniProtKB-SubCell
    3. Golgi membrane Source: Ensembl
    4. TRAPP complex Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi68 – 681C → S: Loss of palmitoylation. 1 Publication

    Organism-specific databases

    PharmGKBiPA134972272.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 180180Trafficking protein particle complex subunit 3PRO_0000211572Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi68 – 681S-palmitoyl cysteine1 Publication

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiO43617.
    PaxDbiO43617.
    PRIDEiO43617.

    PTM databases

    PhosphoSiteiO43617.

    Expressioni

    Gene expression databases

    ArrayExpressiO43617.
    BgeeiO43617.
    CleanExiHS_TRAPPC3.
    GenevestigatoriO43617.

    Organism-specific databases

    HPAiHPA028408.

    Interactioni

    Subunit structurei

    Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Heterodimer with TRAPPC6A. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRAPPC13A5PLN92EBI-743566,EBI-2857298
    TRAPPC2LQ9UL333EBI-743566,EBI-747601
    TRAPPC6AO758652EBI-743566,EBI-743573
    TRAPPC6AO75865-23EBI-743566,EBI-8451480
    TRAPPC6BQ86SZ22EBI-743566,EBI-6160531
    TRAPPC8Q9Y2L52EBI-743566,EBI-2820056

    Protein-protein interaction databases

    BioGridi117997. 17 interactions.
    DIPiDIP-47627N.
    IntActiO43617. 12 interactions.
    MINTiMINT-5002244.
    STRINGi9606.ENSP00000362261.

    Structurei

    Secondary structure

    1
    180
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi17 – 3418
    Helixi37 – 6226
    Helixi71 – 8010
    Helixi82 – 876
    Beta strandi92 – 943
    Beta strandi102 – 1098
    Helixi120 – 1223
    Turni127 – 1293
    Helixi130 – 14011
    Turni141 – 1433
    Beta strandi144 – 1529
    Helixi154 – 1563
    Beta strandi159 – 17012

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1SZ7X-ray1.55A2-180[»]
    2C0JX-ray2.20A15-175[»]
    2CFHX-ray2.30A/B1-180[»]
    3KXCX-ray2.00A1-180[»]
    ProteinModelPortaliO43617.
    SMRiO43617. Positions 13-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43617.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG286899.
    HOGENOMiHOG000186184.
    HOVERGENiHBG055045.
    InParanoidiO43617.
    OMAiLWYSNIL.
    OrthoDBiEOG73JKWX.
    PhylomeDBiO43617.
    TreeFamiTF300091.

    Family and domain databases

    InterProiIPR024096. NO_sig/Golgi_transp_ligand-bd.
    IPR007194. TRAPP_component.
    IPR016721. TRAPP_I_complex_Bet3.
    [Graphical view]
    PANTHERiPTHR13048. PTHR13048. 1 hit.
    PfamiPF04051. TRAPP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
    SUPFAMiSSF111126. SSF111126. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43617-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDKMGFN    50
    IGVRLIEDFL ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG 100
    DEFSLILENN PLVDFVELPD NHSSLIYSNL LCGVLRGALE MVQMAVEAKF 150
    VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE 180
    Length:180
    Mass (Da):20,274
    Last modified:June 1, 1998 - v1
    Checksum:iB5E2D92BE8A39599
    GO
    Isoform 2 (identifier: O43617-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-46: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:134
    Mass (Da):15,005
    Checksum:i927EE13435BDE8B9
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4646Missing in isoform 2. CuratedVSP_047015Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ224335 mRNA. Translation: CAA11902.1.
    AF041432 mRNA. Translation: AAB96936.1.
    AY007139 mRNA. Translation: AAG02000.1.
    AK315610 mRNA. Translation: BAG37979.1.
    AC114484 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX07385.1.
    CH471059 Genomic DNA. Translation: EAX07386.1.
    CH471059 Genomic DNA. Translation: EAX07387.1.
    BC007662 mRNA. Translation: AAH07662.1.
    CCDSiCCDS404.1. [O43617-1]
    CCDS59194.1. [O43617-2]
    RefSeqiNP_001257823.1. NM_001270894.1.
    NP_001257824.1. NM_001270895.1. [O43617-2]
    NP_001257825.1. NM_001270896.1. [O43617-2]
    NP_001257826.1. NM_001270897.1.
    NP_055223.1. NM_014408.4. [O43617-1]
    UniGeneiHs.523131.

    Genome annotation databases

    EnsembliENST00000373162; ENSP00000362256; ENSG00000054116. [O43617-2]
    ENST00000373163; ENSP00000362257; ENSG00000054116. [O43617-2]
    ENST00000373166; ENSP00000362261; ENSG00000054116. [O43617-1]
    GeneIDi27095.
    KEGGihsa:27095.
    UCSCiuc001bzx.4. human. [O43617-1]
    uc031pls.1. human.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ224335 mRNA. Translation: CAA11902.1 .
    AF041432 mRNA. Translation: AAB96936.1 .
    AY007139 mRNA. Translation: AAG02000.1 .
    AK315610 mRNA. Translation: BAG37979.1 .
    AC114484 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX07385.1 .
    CH471059 Genomic DNA. Translation: EAX07386.1 .
    CH471059 Genomic DNA. Translation: EAX07387.1 .
    BC007662 mRNA. Translation: AAH07662.1 .
    CCDSi CCDS404.1. [O43617-1 ]
    CCDS59194.1. [O43617-2 ]
    RefSeqi NP_001257823.1. NM_001270894.1.
    NP_001257824.1. NM_001270895.1. [O43617-2 ]
    NP_001257825.1. NM_001270896.1. [O43617-2 ]
    NP_001257826.1. NM_001270897.1.
    NP_055223.1. NM_014408.4. [O43617-1 ]
    UniGenei Hs.523131.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1SZ7 X-ray 1.55 A 2-180 [» ]
    2C0J X-ray 2.20 A 15-175 [» ]
    2CFH X-ray 2.30 A/B 1-180 [» ]
    3KXC X-ray 2.00 A 1-180 [» ]
    ProteinModelPortali O43617.
    SMRi O43617. Positions 13-171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117997. 17 interactions.
    DIPi DIP-47627N.
    IntActi O43617. 12 interactions.
    MINTi MINT-5002244.
    STRINGi 9606.ENSP00000362261.

    PTM databases

    PhosphoSitei O43617.

    Proteomic databases

    MaxQBi O43617.
    PaxDbi O43617.
    PRIDEi O43617.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373162 ; ENSP00000362256 ; ENSG00000054116 . [O43617-2 ]
    ENST00000373163 ; ENSP00000362257 ; ENSG00000054116 . [O43617-2 ]
    ENST00000373166 ; ENSP00000362261 ; ENSG00000054116 . [O43617-1 ]
    GeneIDi 27095.
    KEGGi hsa:27095.
    UCSCi uc001bzx.4. human. [O43617-1 ]
    uc031pls.1. human.

    Organism-specific databases

    CTDi 27095.
    GeneCardsi GC01M036602.
    HGNCi HGNC:19942. TRAPPC3.
    HPAi HPA028408.
    MIMi 610955. gene.
    neXtProti NX_O43617.
    PharmGKBi PA134972272.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286899.
    HOGENOMi HOG000186184.
    HOVERGENi HBG055045.
    InParanoidi O43617.
    OMAi LWYSNIL.
    OrthoDBi EOG73JKWX.
    PhylomeDBi O43617.
    TreeFami TF300091.

    Miscellaneous databases

    ChiTaRSi TRAPPC3. human.
    EvolutionaryTracei O43617.
    GeneWikii TRAPPC3.
    GenomeRNAii 27095.
    NextBioi 35462482.
    PROi O43617.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43617.
    Bgeei O43617.
    CleanExi HS_TRAPPC3.
    Genevestigatori O43617.

    Family and domain databases

    InterProi IPR024096. NO_sig/Golgi_transp_ligand-bd.
    IPR007194. TRAPP_component.
    IPR016721. TRAPP_I_complex_Bet3.
    [Graphical view ]
    PANTHERi PTHR13048. PTHR13048. 1 hit.
    Pfami PF04051. TRAPP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
    SUPFAMi SSF111126. SSF111126. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion."
      Sacher M., Jiang Y., Barrowman J., Scarpa A., Burston J., Zhang L., Schieltz D., Yates J.R. III, Abeliovich H., Ferro-Novick S.
      EMBO J. 17:2494-2503(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Placenta.
    2. Eva L., Subramaniam V.N., Hong W.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Pediatric leukemia cDNA sequencing project."
      Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Leukemia.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    8. Cited for: IDENTIFICATION IN TRAPP COMPLEX.
    9. "TRAPPC2L is a novel, highly conserved TRAPP-interacting protein."
      Scrivens P.J., Shahrzad N., Moores A., Morin A., Brunet S., Sacher M.
      Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN TRAPP COMPLEX, INTERACTION WITH TRAPPC2L.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."
      Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.
      Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN TRAPP COMPLEX.
    12. "Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization."
      Turnbull A.P., Kummel D., Prinz B., Holz C., Schultchen J., Lang C., Niesen F.H., Hofmann K.P., Delbruck H., Behlke J., Muller E.C., Jarosch E., Sommer T., Heinemann U.
      EMBO J. 24:875-884(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 2-180, SUBUNIT, MUTAGENESIS OF CYS-68, PALMITOYLATION AT CYS-68.
    13. "Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p."
      Kim M.-S., Yi M.-J., Lee K.-H., Wagner J., Munger C., Kim Y.-G., Whiteway M., Cygler M., Oh B.-H., Sacher M.
      Traffic 6:1183-1195(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 15-175 IN COMPLEX WITH TRAPPC6A.

    Entry informationi

    Entry nameiTPPC3_HUMAN
    AccessioniPrimary (citable) accession number: O43617
    Secondary accession number(s): A6NDN0, B2RDN2, D3DPS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3