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O43617

- TPPC3_HUMAN

UniProt

O43617 - TPPC3_HUMAN

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Protein

Trafficking protein particle complex subunit 3

Gene

TRAPPC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 3
Alternative name(s):
BET3 homolog
Gene namesi
Name:TRAPPC3
Synonyms:BET3
ORF Names:CDABP0066
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:19942. TRAPPC3.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. Golgi membrane Source: Ensembl
  4. TRAPP complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi68 – 681C → S: Loss of palmitoylation. 1 Publication

Organism-specific databases

PharmGKBiPA134972272.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 180180Trafficking protein particle complex subunit 3PRO_0000211572Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi68 – 681S-palmitoyl cysteine1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

MaxQBiO43617.
PaxDbiO43617.
PRIDEiO43617.

PTM databases

PhosphoSiteiO43617.

Expressioni

Gene expression databases

BgeeiO43617.
CleanExiHS_TRAPPC3.
ExpressionAtlasiO43617. baseline and differential.
GenevestigatoriO43617.

Organism-specific databases

HPAiHPA028408.

Interactioni

Subunit structurei

Homodimer. Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Heterodimer with TRAPPC6A. The heterodimer TRAPPC3-TRAPPC6A interacts with TRAPPC2L.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAPPC13A5PLN92EBI-743566,EBI-2857298
TRAPPC2LQ9UL333EBI-743566,EBI-747601
TRAPPC6AO758652EBI-743566,EBI-743573
TRAPPC6AO75865-23EBI-743566,EBI-8451480
TRAPPC6BQ86SZ22EBI-743566,EBI-6160531
TRAPPC8Q9Y2L52EBI-743566,EBI-2820056

Protein-protein interaction databases

BioGridi117997. 22 interactions.
DIPiDIP-47627N.
IntActiO43617. 12 interactions.
MINTiMINT-5002244.
STRINGi9606.ENSP00000362261.

Structurei

Secondary structure

1
180
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 3418Combined sources
Helixi37 – 6226Combined sources
Helixi71 – 8010Combined sources
Helixi82 – 876Combined sources
Beta strandi92 – 943Combined sources
Beta strandi102 – 1098Combined sources
Helixi120 – 1223Combined sources
Turni127 – 1293Combined sources
Helixi130 – 14011Combined sources
Turni141 – 1433Combined sources
Beta strandi144 – 1529Combined sources
Helixi154 – 1563Combined sources
Beta strandi159 – 17012Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SZ7X-ray1.55A2-180[»]
2C0JX-ray2.20A15-175[»]
2CFHX-ray2.30A/B1-180[»]
3KXCX-ray2.00A1-180[»]
ProteinModelPortaliO43617.
SMRiO43617. Positions 13-171.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43617.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG286899.
GeneTreeiENSGT00390000003880.
HOGENOMiHOG000186184.
HOVERGENiHBG055045.
InParanoidiO43617.
OMAiLWYSNIL.
OrthoDBiEOG73JKWX.
PhylomeDBiO43617.
TreeFamiTF300091.

Family and domain databases

InterProiIPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR007194. TRAPP_component.
IPR016721. TRAPP_I_complex_Bet3.
[Graphical view]
PANTHERiPTHR13048. PTHR13048. 1 hit.
PfamiPF04051. TRAPP. 1 hit.
[Graphical view]
PIRSFiPIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
SUPFAMiSSF111126. SSF111126. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43617-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDKMGFN
60 70 80 90 100
IGVRLIEDFL ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG
110 120 130 140 150
DEFSLILENN PLVDFVELPD NHSSLIYSNL LCGVLRGALE MVQMAVEAKF
160 170 180
VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE
Length:180
Mass (Da):20,274
Last modified:June 1, 1998 - v1
Checksum:iB5E2D92BE8A39599
GO
Isoform 2 (identifier: O43617-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: Gene prediction based on EST data.

Show »
Length:134
Mass (Da):15,005
Checksum:i927EE13435BDE8B9
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4646Missing in isoform 2. CuratedVSP_047015Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224335 mRNA. Translation: CAA11902.1.
AF041432 mRNA. Translation: AAB96936.1.
AY007139 mRNA. Translation: AAG02000.1.
AK315610 mRNA. Translation: BAG37979.1.
AC114484 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07385.1.
CH471059 Genomic DNA. Translation: EAX07386.1.
CH471059 Genomic DNA. Translation: EAX07387.1.
BC007662 mRNA. Translation: AAH07662.1.
CCDSiCCDS404.1. [O43617-1]
CCDS59194.1. [O43617-2]
RefSeqiNP_001257823.1. NM_001270894.1.
NP_001257824.1. NM_001270895.1. [O43617-2]
NP_001257825.1. NM_001270896.1. [O43617-2]
NP_001257826.1. NM_001270897.1.
NP_055223.1. NM_014408.4. [O43617-1]
UniGeneiHs.523131.

Genome annotation databases

EnsembliENST00000373162; ENSP00000362256; ENSG00000054116. [O43617-2]
ENST00000373163; ENSP00000362257; ENSG00000054116. [O43617-2]
ENST00000373166; ENSP00000362261; ENSG00000054116. [O43617-1]
ENST00000617904; ENSP00000480648; ENSG00000054116. [O43617-2]
GeneIDi27095.
KEGGihsa:27095.
UCSCiuc001bzx.4. human. [O43617-1]
uc031pls.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224335 mRNA. Translation: CAA11902.1 .
AF041432 mRNA. Translation: AAB96936.1 .
AY007139 mRNA. Translation: AAG02000.1 .
AK315610 mRNA. Translation: BAG37979.1 .
AC114484 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07385.1 .
CH471059 Genomic DNA. Translation: EAX07386.1 .
CH471059 Genomic DNA. Translation: EAX07387.1 .
BC007662 mRNA. Translation: AAH07662.1 .
CCDSi CCDS404.1. [O43617-1 ]
CCDS59194.1. [O43617-2 ]
RefSeqi NP_001257823.1. NM_001270894.1.
NP_001257824.1. NM_001270895.1. [O43617-2 ]
NP_001257825.1. NM_001270896.1. [O43617-2 ]
NP_001257826.1. NM_001270897.1.
NP_055223.1. NM_014408.4. [O43617-1 ]
UniGenei Hs.523131.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1SZ7 X-ray 1.55 A 2-180 [» ]
2C0J X-ray 2.20 A 15-175 [» ]
2CFH X-ray 2.30 A/B 1-180 [» ]
3KXC X-ray 2.00 A 1-180 [» ]
ProteinModelPortali O43617.
SMRi O43617. Positions 13-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117997. 22 interactions.
DIPi DIP-47627N.
IntActi O43617. 12 interactions.
MINTi MINT-5002244.
STRINGi 9606.ENSP00000362261.

PTM databases

PhosphoSitei O43617.

Proteomic databases

MaxQBi O43617.
PaxDbi O43617.
PRIDEi O43617.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373162 ; ENSP00000362256 ; ENSG00000054116 . [O43617-2 ]
ENST00000373163 ; ENSP00000362257 ; ENSG00000054116 . [O43617-2 ]
ENST00000373166 ; ENSP00000362261 ; ENSG00000054116 . [O43617-1 ]
ENST00000617904 ; ENSP00000480648 ; ENSG00000054116 . [O43617-2 ]
GeneIDi 27095.
KEGGi hsa:27095.
UCSCi uc001bzx.4. human. [O43617-1 ]
uc031pls.1. human.

Organism-specific databases

CTDi 27095.
GeneCardsi GC01M036602.
HGNCi HGNC:19942. TRAPPC3.
HPAi HPA028408.
MIMi 610955. gene.
neXtProti NX_O43617.
PharmGKBi PA134972272.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG286899.
GeneTreei ENSGT00390000003880.
HOGENOMi HOG000186184.
HOVERGENi HBG055045.
InParanoidi O43617.
OMAi LWYSNIL.
OrthoDBi EOG73JKWX.
PhylomeDBi O43617.
TreeFami TF300091.

Miscellaneous databases

ChiTaRSi TRAPPC3. human.
EvolutionaryTracei O43617.
GeneWikii TRAPPC3.
GenomeRNAii 27095.
NextBioi 35462482.
PROi O43617.
SOURCEi Search...

Gene expression databases

Bgeei O43617.
CleanExi HS_TRAPPC3.
ExpressionAtlasi O43617. baseline and differential.
Genevestigatori O43617.

Family and domain databases

InterProi IPR024096. NO_sig/Golgi_transp_ligand-bd.
IPR007194. TRAPP_component.
IPR016721. TRAPP_I_complex_Bet3.
[Graphical view ]
PANTHERi PTHR13048. PTHR13048. 1 hit.
Pfami PF04051. TRAPP. 1 hit.
[Graphical view ]
PIRSFi PIRSF018293. TRAPP_I_complex_Bet3. 1 hit.
SUPFAMi SSF111126. SSF111126. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion."
    Sacher M., Jiang Y., Barrowman J., Scarpa A., Burston J., Zhang L., Schieltz D., Yates J.R. III, Abeliovich H., Ferro-Novick S.
    EMBO J. 17:2494-2503(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. Eva L., Subramaniam V.N., Hong W.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Pediatric leukemia cDNA sequencing project."
    Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Leukemia.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  8. Cited for: IDENTIFICATION IN TRAPP COMPLEX.
  9. "TRAPPC2L is a novel, highly conserved TRAPP-interacting protein."
    Scrivens P.J., Shahrzad N., Moores A., Morin A., Brunet S., Sacher M.
    Traffic 10:724-736(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN TRAPP COMPLEX, INTERACTION WITH TRAPPC2L.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking."
    Scrivens P.J., Noueihed B., Shahrzad N., Hul S., Brunet S., Sacher M.
    Mol. Biol. Cell 22:2083-2093(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN TRAPP COMPLEX.
  12. "Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization."
    Turnbull A.P., Kummel D., Prinz B., Holz C., Schultchen J., Lang C., Niesen F.H., Hofmann K.P., Delbruck H., Behlke J., Muller E.C., Jarosch E., Sommer T., Heinemann U.
    EMBO J. 24:875-884(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 2-180, SUBUNIT, MUTAGENESIS OF CYS-68, PALMITOYLATION AT CYS-68.
  13. "Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p."
    Kim M.-S., Yi M.-J., Lee K.-H., Wagner J., Munger C., Kim Y.-G., Whiteway M., Cygler M., Oh B.-H., Sacher M.
    Traffic 6:1183-1195(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 15-175 IN COMPLEX WITH TRAPPC6A.

Entry informationi

Entry nameiTPPC3_HUMAN
AccessioniPrimary (citable) accession number: O43617
Secondary accession number(s): A6NDN0, B2RDN2, D3DPS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 1998
Last modified: November 26, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3