true
2000-05-30
2024-03-27
181
OX2R_HUMAN
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
Sakurai T.
Amemiya A.
Ishii M.
Matsuzaki I.
Chemelli R.M.
Tanaka H.
Williams S.C.
Richardson J.A.
Kozlowski G.P.
Wilson S.
Arch J.R.S.
Buckingham R.E.
Haynes A.C.
Carr S.A.
Annan R.S.
McNulty D.E.
Liu W.-S.
Terrett J.A.
Elshourbagy N.A.
Bergsma D.J.
Yanagisawa M.
doi:10.1016/s0092-8674(00)80949-6
1998
Cell
92
573-585
NUCLEOTIDE SEQUENCE [MRNA]
FUNCTION
SUBCELLULAR LOCATION
VARIANT VAL-308
Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.
Olafsdottir B.R.
Rye D.B.
Scammell T.E.
Matheson J.K.
Stefansson K.
Gulcher J.R.
doi:10.1212/wnl.57.10.1896
2001
Neurology
57
1896-1899
NUCLEOTIDE SEQUENCE [GENOMIC DNA]
VARIANTS SER-10; THR-11; VAL-293 AND VAL-308
The DNA sequence and analysis of human chromosome 6.
Mungall A.J.
Palmer S.A.
Sims S.K.
Edwards C.A.
Ashurst J.L.
Wilming L.
Jones M.C.
Horton R.
Hunt S.E.
Scott C.E.
Gilbert J.G.R.
Clamp M.E.
Bethel G.
Milne S.
Ainscough R.
Almeida J.P.
Ambrose K.D.
Andrews T.D.
Ashwell R.I.S.
Babbage A.K.
Bagguley C.L.
Bailey J.
Banerjee R.
Barker D.J.
Barlow K.F.
Bates K.
Beare D.M.
Beasley H.
Beasley O.
Bird C.P.
Blakey S.E.
Bray-Allen S.
Brook J.
Brown A.J.
Brown J.Y.
Burford D.C.
Burrill W.
Burton J.
Carder C.
Carter N.P.
Chapman J.C.
Clark S.Y.
Clark G.
Clee C.M.
Clegg S.
Cobley V.
Collier R.E.
Collins J.E.
Colman L.K.
Corby N.R.
Coville G.J.
Culley K.M.
Dhami P.
Davies J.
Dunn M.
Earthrowl M.E.
Ellington A.E.
Evans K.A.
Faulkner L.
Francis M.D.
Frankish A.
Frankland J.
French L.
Garner P.
Garnett J.
Ghori M.J.
Gilby L.M.
Gillson C.J.
Glithero R.J.
Grafham D.V.
Grant M.
Gribble S.
Griffiths C.
Griffiths M.N.D.
Hall R.
Halls K.S.
Hammond S.
Harley J.L.
Hart E.A.
Heath P.D.
Heathcott R.
Holmes S.J.
Howden P.J.
Howe K.L.
Howell G.R.
Huckle E.
Humphray S.J.
Humphries M.D.
Hunt A.R.
Johnson C.M.
Joy A.A.
Kay M.
Keenan S.J.
Kimberley A.M.
King A.
Laird G.K.
Langford C.
Lawlor S.
Leongamornlert D.A.
Leversha M.
Lloyd C.R.
Lloyd D.M.
Loveland J.E.
Lovell J.
Martin S.
Mashreghi-Mohammadi M.
Maslen G.L.
Matthews L.
McCann O.T.
McLaren S.J.
McLay K.
McMurray A.
Moore M.J.F.
Mullikin J.C.
Niblett D.
Nickerson T.
Novik K.L.
Oliver K.
Overton-Larty E.K.
Parker A.
Patel R.
Pearce A.V.
Peck A.I.
Phillimore B.J.C.T.
Phillips S.
Plumb R.W.
Porter K.M.
Ramsey Y.
Ranby S.A.
Rice C.M.
Ross M.T.
Searle S.M.
Sehra H.K.
Sheridan E.
Skuce C.D.
Smith S.
Smith M.
Spraggon L.
Squares S.L.
Steward C.A.
Sycamore N.
Tamlyn-Hall G.
Tester J.
Theaker A.J.
Thomas D.W.
Thorpe A.
Tracey A.
Tromans A.
Tubby B.
Wall M.
Wallis J.M.
West A.P.
White S.S.
Whitehead S.L.
Whittaker H.
Wild A.
Willey D.J.
Wilmer T.E.
Wood J.M.
Wray P.W.
Wyatt J.C.
Young L.
Younger R.M.
Bentley D.R.
Coulson A.
Durbin R.M.
Hubbard T.
Sulston J.E.
Dunham I.
Rogers J.
Beck S.
doi:10.1038/nature02055
2003
Nature
425
805-811
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Mural R.J.
Istrail S.
Sutton G.G.
Florea L.
Halpern A.L.
Mobarry C.M.
Lippert R.
Walenz B.
Shatkay H.
Dew I.
Miller J.R.
Flanigan M.J.
Edwards N.J.
Bolanos R.
Fasulo D.
Halldorsson B.V.
Hannenhalli S.
Turner R.
Yooseph S.
Lu F.
Nusskern D.R.
Shue B.C.
Zheng X.H.
Zhong F.
Delcher A.L.
Huson D.H.
Kravitz S.A.
Mouchard L.
Reinert K.
Remington K.A.
Clark A.G.
Waterman M.S.
Eichler E.E.
Adams M.D.
Hunkapiller M.W.
Myers E.W.
Venter J.C.
2005-07
EMBL/GenBank/DDBJ
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Hypocretin/orexin, sleep and narcolepsy.
Hungs M.
Mignot E.
doi:10.1002/bies.1058
2001
Bioessays
23
397-408
REVIEW
To eat or to sleep? Orexin in the regulation of feeding and wakefulness.
Willie J.T.
Chemelli R.M.
Sinton C.M.
Yanagisawa M.
doi:10.1146/annurev.neuro.24.1.429
2001
Annu. Rev. Neurosci.
24
429-458
REVIEW
Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Yin J.
Babaoglu K.
Brautigam C.A.
Clark L.
Shao Z.
Scheuermann T.H.
Harrell C.M.
Gotter A.L.
Roecker A.J.
Winrow C.J.
Renger J.J.
Coleman P.J.
Rosenbaum D.M.
doi:10.1038/nsmb.3183
2016
Nat. Struct. Mol. Biol.
23
293-299
FUNCTION
SUBCELLULAR LOCATION
TOPOLOGY
MUTAGENESIS OF 33-ASP--HIS-49; TRP-44 AND ASN-324
DOMAIN
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant.
Yin J.
Mobarec J.C.
Kolb P.
Rosenbaum D.M.
doi:10.1038/nature14035
2015
Nature
519
247-250
X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 3-254 AND 294-388 IN COMPLEX WITH THE INHIBITOR SUVOREXANT
TOPOLOGY
SUBCELLULAR LOCATION
DISULFIDE BONDS
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation.
Hong C.
Byrne N.J.
Zamlynny B.
Tummala S.
Xiao L.
Shipman J.M.
Partridge A.T.
Minnick C.
Breslin M.J.
Rudd M.T.
Stachel S.J.
Rada V.L.
Kern J.C.
Armacost K.A.
Hollingsworth S.A.
O'Brien J.A.
Hall D.L.
McDonald T.P.
Strickland C.
Brooun A.
Soisson S.M.
Hollenstein K.
doi:10.1038/s41467-021-21087-6
2021
Nat. Commun.
12
815
STRUCTURE BY ELECTRON MICROSCOPY (3.00 ANGSTROMS) OF 3-389 IN COMPLEX WITH HCRT 70-97
2.50
A=3-254
A=294-388
1.96
A=3-254
A=294-386
2.30
A=3-254
A=294-388
2.74
A=1-254
A=294-307
2.74
A/B=1-254
A/B=294-307
2.61
A=1-254
A=294-388
3.20
R=3-389
3.00
R=3-389
3.17
R=1-444
3.30
R=3-408
2.89
A=33-394
35
1
Daridorexant
Lemborexant
Suvorexant
3 sites, No reported glycans
3 sites
397 antibodies from 38 providers
HCRTR2
Not detected
gene
Eukaryota
Orexin and neuropeptides FF and QRFP bind to their respective receptors
G alpha (q) signalling events
15 hits in 1144 CRISPR screens
human
Tclin
Protein
Expressed in male germ line stem cell (sensu Vertebrata) in testis and 39 other cell types or tissues
baseline and differential
7tmA_OXR
Rhodopsin 7-helix transmembrane proteins
GPCR_Rhodpsn
GPCR_Rhodpsn_7TM
Orexin_rcpt
Orexin_rcpt_2
G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN
LEUCOKININ RECEPTOR-RELATED
7tm_1
Orexin_rec2
GPCRRHODOPSN
OREXIN2R
OREXINR
7TM_GPCR_Srsx
Family A G protein-coupled receptor-like
G_PROTEIN_RECEP_F1_1
G_PROTEIN_RECEP_F1_2
HS
Orexin receptor type 2
Ox-2-R
Ox2-R
Ox2R
Hypocretin receptor type 2
HCRTR2
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).
The N-terminal region is required for orexin signaling.
Belongs to the G-protein coupled receptor 1 family.
Orexin receptor type 2
50694
1
444
Extracellular
54
Helical; Name=1
55
75
Cytoplasmic
76
88
Helical; Name=2
89
110
Extracellular
111
127
Helical; Name=3
128
150
Cytoplasmic
151
170
Helical; Name=4
171
191
Extracellular
192
222
Helical; Name=5
223
243
Cytoplasmic
244
304
Helical; Name=6
305
326
Extracellular
327
342
Helical; Name=7
343
366
Cytoplasmic
367
Disordered
20
Required for response to orexin-A
33
49
324
Important for responses to orexin
44
N-linked (GlcNAc...) asparagine
14
N-linked (GlcNAc...) asparagine
22
N-linked (GlcNAc...) asparagine
202
210
S
10
T
11
V
293
V
308
Abolishes response to orexin-A.
Abolishes response to orexin-A.
N
Strongly impairs response to orexin-A.
A
40
47
81
83
85
106
108
117
123
156
158
160
166
183
185
190
196
199
207
212
215
217
218
231
233
251
252
254
294
328
332
335
339
369
381
antagonist
false
3
PPIA
2008-09-23
2
50694
39b332b6597d69e34f67a65a34484917
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
true
true
true
true
true
true
true
true
true
true
true
true
true
true
true