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O43614 (OX2R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orexin receptor type 2

Short name=Ox-2-R
Short name=Ox2-R
Short name=Ox2R
Alternative name(s):
Hypocretin receptor type 2
Gene names
Name:HCRTR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Orexin receptor type 2
PRO_0000069989

Regions

Topological domain1 – 5454Extracellular Potential
Transmembrane55 – 7521Helical; Name=1; Potential
Topological domain76 – 8813Cytoplasmic Potential
Transmembrane89 – 11022Helical; Name=2; Potential
Topological domain111 – 12717Extracellular Potential
Transmembrane128 – 15023Helical; Name=3; Potential
Topological domain151 – 17222Cytoplasmic Potential
Transmembrane173 – 19321Helical; Name=4; Potential
Topological domain194 – 22431Extracellular Potential
Transmembrane225 – 24723Helical; Name=5; Potential
Topological domain248 – 30457Cytoplasmic Potential
Transmembrane305 – 32723Helical; Name=6; Potential
Topological domain328 – 34215Extracellular Potential
Transmembrane343 – 36624Helical; Name=7; Potential
Topological domain367 – 44478Cytoplasmic Potential

Amino acid modifications

Glycosylation141N-linked (GlcNAc...) Potential
Glycosylation221N-linked (GlcNAc...) Potential
Glycosylation2021N-linked (GlcNAc...) Potential

Natural variations

Natural variant101P → S. Ref.2
Corresponds to variant rs41271310 [ dbSNP | Ensembl ].
VAR_044507
Natural variant111P → T. Ref.2
Corresponds to variant rs41271312 [ dbSNP | Ensembl ].
VAR_044508
Natural variant2931I → V. Ref.2
VAR_044509
Natural variant3081I → V. Ref.1 Ref.2
Corresponds to variant rs2653349 [ dbSNP | Ensembl ].
VAR_044510

Sequences

Sequence LengthMass (Da)Tools
O43614 [UniParc].

Last modified September 23, 2008. Version 2.
Checksum: C4C9A153D42254C6

FASTA44450,694
        10         20         30         40         50         60 
MSGTKLEDSP PCRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP KEYEWVLIAG 

        70         80         90        100        110        120 
YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD VLVTITCLPA TLVVDITETW 

       130        140        150        160        170        180 
FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL DRWYAICHPL MFKSTAKRAR NSIVIIWIVS 

       190        200        210        220        230        240 
CIIMIPQAIV MECSTVFPGL ANKTTLFTVC DERWGGEIYP KMYHICFFLV TYMAPLCLMV 

       250        260        270        280        290        300 
LAYLQIFRKL WCRQIPGTSS VVQRKWKPLQ PVSQPRGPGQ PTKSRMSAVA AEIKQIRARR 

       310        320        330        340        350        360 
KTARMLMIVL LVFAICYLPI SILNVLKRVF GMFAHTEDRE TVYAWFTFSH WLVYANSAAN 

       370        380        390        400        410        420 
PIIYNFLSGK FREEFKAAFS CCCLGVHHRQ EDRLTRGRTS TESRKSLTTQ ISNFDNISKL 

       430        440 
SEQVVLTSIS TLPAANGAGP LQNW 

« Hide

References

« Hide 'large scale' references
[1]"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior."
Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.-S., Terrett J.A. expand/collapse author list , Elshourbagy N.A., Bergsma D.J., Yanagisawa M.
Cell 92:573-585(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-308.
[2]"Polymorphisms in hypocretin/orexin pathway genes and narcolepsy."
Olafsdottir B.R., Rye D.B., Scammell T.E., Matheson J.K., Stefansson K., Gulcher J.R.
Neurology 57:1896-1899(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-10; THR-11; VAL-293 AND VAL-308.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Hypocretin/orexin, sleep and narcolepsy."
Hungs M., Mignot E.
Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[6]"To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF041245 mRNA. Translation: AAC39602.1.
AY062031 Genomic DNA. Translation: AAL47215.1.
AL591718, AL449104 Genomic DNA. Translation: CAH73407.1.
AL449104, AL591718 Genomic DNA. Translation: CAI19665.1.
CH471081 Genomic DNA. Translation: EAX04440.1.
RefSeqNP_001517.2. NM_001526.3.
UniGeneHs.151624.
Hs.699147.

3D structure databases

ProteinModelPortalO43614.
SMRO43614. Positions 56-382.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000359899.

Chemistry

BindingDBO43614.
ChEMBLCHEMBL4792.
GuidetoPHARMACOLOGY322.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO43614.

Proteomic databases

PaxDbO43614.
PRIDEO43614.

Protocols and materials databases

DNASU3062.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370862; ENSP00000359899; ENSG00000137252.
GeneID3062.
KEGGhsa:3062.
UCSCuc003pcl.3. human.

Organism-specific databases

CTD3062.
GeneCardsGC06P055085.
HGNCHGNC:4849. HCRTR2.
HPAHPA054516.
MIM602393. gene.
neXtProtNX_O43614.
PharmGKBPA29223.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG253280.
HOGENOMHOG000230498.
HOVERGENHBG101173.
InParanoidO43614.
KOK04239.
OMAVHHRQED.
OrthoDBEOG7CG72H.
PhylomeDBO43614.
TreeFamTF315303.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO43614.
BgeeO43614.
CleanExHS_HCRTR2.
GenevestigatorO43614.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHypocretin_(orexin)_receptor_2.
GenomeRNAi3062.
NextBio12115.
PROO43614.
SOURCESearch...

Entry information

Entry nameOX2R_HUMAN
AccessionPrimary (citable) accession number: O43614
Secondary accession number(s): Q5VTM0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 23, 2008
Last modified: March 19, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries