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O43614

- OX2R_HUMAN

UniProt

O43614 - OX2R_HUMAN

Protein

Orexin receptor type 2

Gene

HCRTR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.

    GO - Molecular functioni

    1. neuropeptide receptor activity Source: ProtInc
    2. orexin receptor activity Source: Ensembl
    3. peptide hormone binding Source: Ensembl

    GO - Biological processi

    1. circadian sleep/wake cycle process Source: InterPro
    2. feeding behavior Source: ProtInc
    3. neuropeptide signaling pathway Source: ProtInc
    4. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    5. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orexin receptor type 2
    Short name:
    Ox-2-R
    Short name:
    Ox2-R
    Short name:
    Ox2R
    Alternative name(s):
    Hypocretin receptor type 2
    Gene namesi
    Name:HCRTR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4849. HCRTR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29223.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Orexin receptor type 2PRO_0000069989Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO43614.
    PRIDEiO43614.

    PTM databases

    PhosphoSiteiO43614.

    Expressioni

    Gene expression databases

    ArrayExpressiO43614.
    BgeeiO43614.
    CleanExiHS_HCRTR2.
    GenevestigatoriO43614.

    Organism-specific databases

    HPAiHPA054516.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000359899.

    Structurei

    3D structure databases

    ProteinModelPortaliO43614.
    SMRiO43614. Positions 56-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5454ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini76 – 8813CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini111 – 12717ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini151 – 17222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini194 – 22431ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 30457CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini328 – 34215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini367 – 44478CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei55 – 7521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 11022Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei128 – 15023Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei225 – 24723Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei305 – 32723Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei343 – 36624Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253280.
    HOGENOMiHOG000230498.
    HOVERGENiHBG101173.
    InParanoidiO43614.
    KOiK04239.
    OMAiVHHRQED.
    OrthoDBiEOG7CG72H.
    PhylomeDBiO43614.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000204. Orexin_rcpt.
    IPR004060. Orexin_rcpt_2.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    PF03827. Orexin_rec2. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01522. OREXIN2R.
    PR01064. OREXINR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43614-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGTKLEDSP PCRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP    50
    KEYEWVLIAG YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD 100
    VLVTITCLPA TLVVDITETW FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL 150
    DRWYAICHPL MFKSTAKRAR NSIVIIWIVS CIIMIPQAIV MECSTVFPGL 200
    ANKTTLFTVC DERWGGEIYP KMYHICFFLV TYMAPLCLMV LAYLQIFRKL 250
    WCRQIPGTSS VVQRKWKPLQ PVSQPRGPGQ PTKSRMSAVA AEIKQIRARR 300
    KTARMLMIVL LVFAICYLPI SILNVLKRVF GMFAHTEDRE TVYAWFTFSH 350
    WLVYANSAAN PIIYNFLSGK FREEFKAAFS CCCLGVHHRQ EDRLTRGRTS 400
    TESRKSLTTQ ISNFDNISKL SEQVVLTSIS TLPAANGAGP LQNW 444
    Length:444
    Mass (Da):50,694
    Last modified:September 23, 2008 - v2
    Checksum:iC4C9A153D42254C6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101P → S.1 Publication
    Corresponds to variant rs41271310 [ dbSNP | Ensembl ].
    VAR_044507
    Natural varianti11 – 111P → T.1 Publication
    Corresponds to variant rs41271312 [ dbSNP | Ensembl ].
    VAR_044508
    Natural varianti293 – 2931I → V.1 Publication
    VAR_044509
    Natural varianti308 – 3081I → V.2 Publications
    Corresponds to variant rs2653349 [ dbSNP | Ensembl ].
    VAR_044510

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041245 mRNA. Translation: AAC39602.1.
    AY062031 Genomic DNA. Translation: AAL47215.1.
    AL591718, AL449104 Genomic DNA. Translation: CAH73407.1.
    AL449104, AL591718 Genomic DNA. Translation: CAI19665.1.
    CH471081 Genomic DNA. Translation: EAX04440.1.
    CCDSiCCDS4956.1.
    RefSeqiNP_001517.2. NM_001526.3.
    XP_006715137.1. XM_006715074.1.
    UniGeneiHs.151624.
    Hs.699147.

    Genome annotation databases

    EnsembliENST00000370862; ENSP00000359899; ENSG00000137252.
    GeneIDi3062.
    KEGGihsa:3062.
    UCSCiuc003pcl.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041245 mRNA. Translation: AAC39602.1 .
    AY062031 Genomic DNA. Translation: AAL47215.1 .
    AL591718 , AL449104 Genomic DNA. Translation: CAH73407.1 .
    AL449104 , AL591718 Genomic DNA. Translation: CAI19665.1 .
    CH471081 Genomic DNA. Translation: EAX04440.1 .
    CCDSi CCDS4956.1.
    RefSeqi NP_001517.2. NM_001526.3.
    XP_006715137.1. XM_006715074.1.
    UniGenei Hs.151624.
    Hs.699147.

    3D structure databases

    ProteinModelPortali O43614.
    SMRi O43614. Positions 56-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000359899.

    Chemistry

    BindingDBi O43614.
    ChEMBLi CHEMBL4792.
    GuidetoPHARMACOLOGYi 322.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O43614.

    Proteomic databases

    PaxDbi O43614.
    PRIDEi O43614.

    Protocols and materials databases

    DNASUi 3062.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370862 ; ENSP00000359899 ; ENSG00000137252 .
    GeneIDi 3062.
    KEGGi hsa:3062.
    UCSCi uc003pcl.3. human.

    Organism-specific databases

    CTDi 3062.
    GeneCardsi GC06P055085.
    HGNCi HGNC:4849. HCRTR2.
    HPAi HPA054516.
    MIMi 602393. gene.
    neXtProti NX_O43614.
    PharmGKBi PA29223.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253280.
    HOGENOMi HOG000230498.
    HOVERGENi HBG101173.
    InParanoidi O43614.
    KOi K04239.
    OMAi VHHRQED.
    OrthoDBi EOG7CG72H.
    PhylomeDBi O43614.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Hypocretin_(orexin)_receptor_2.
    GenomeRNAii 3062.
    NextBioi 12115.
    PROi O43614.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43614.
    Bgeei O43614.
    CleanExi HS_HCRTR2.
    Genevestigatori O43614.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000204. Orexin_rcpt.
    IPR004060. Orexin_rcpt_2.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    PF03827. Orexin_rec2. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01522. OREXIN2R.
    PR01064. OREXINR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-308.
    2. "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy."
      Olafsdottir B.R., Rye D.B., Scammell T.E., Matheson J.K., Stefansson K., Gulcher J.R.
      Neurology 57:1896-1899(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-10; THR-11; VAL-293 AND VAL-308.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Hypocretin/orexin, sleep and narcolepsy."
      Hungs M., Mignot E.
      Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    6. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
      Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
      Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiOX2R_HUMAN
    AccessioniPrimary (citable) accession number: O43614
    Secondary accession number(s): Q5VTM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3