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Protein

Orexin receptor type 2

Gene

HCRTR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.

GO - Molecular functioni

  1. neuropeptide receptor activity Source: ProtInc
  2. orexin receptor activity Source: GO_Central
  3. peptide binding Source: GO_Central
  4. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. cellular response to hormone stimulus Source: GO_Central
  2. circadian sleep/wake cycle process Source: InterPro
  3. feeding behavior Source: ProtInc
  4. neuropeptide signaling pathway Source: ProtInc
  5. phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  6. regulation of circadian sleep/wake cycle, sleep Source: GO_Central
  7. response to peptide Source: GO_Central
  8. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin receptor type 2
Short name:
Ox-2-R
Short name:
Ox2-R
Short name:
Ox2R
Alternative name(s):
Hypocretin receptor type 2
Gene namesi
Name:HCRTR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4849. HCRTR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454ExtracellularSequence AnalysisAdd
BLAST
Transmembranei55 – 7521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini76 – 8813CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei89 – 11022Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini111 – 12717ExtracellularSequence AnalysisAdd
BLAST
Transmembranei128 – 15023Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini151 – 17222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei173 – 19321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini194 – 22431ExtracellularSequence AnalysisAdd
BLAST
Transmembranei225 – 24723Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini248 – 30457CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei305 – 32723Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini328 – 34215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei343 – 36624Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini367 – 44478CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Orexin receptor type 2PRO_0000069989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO43614.
PRIDEiO43614.

PTM databases

PhosphoSiteiO43614.

Expressioni

Gene expression databases

BgeeiO43614.
CleanExiHS_HCRTR2.
ExpressionAtlasiO43614. baseline and differential.
GenevestigatoriO43614.

Organism-specific databases

HPAiHPA054516.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000359899.

Structurei

Secondary structure

1
444
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi54 – 8128Combined sources
Helixi83 – 853Combined sources
Helixi88 – 10619Combined sources
Helixi108 – 11710Combined sources
Helixi124 – 15633Combined sources
Helixi166 – 18318Combined sources
Helixi185 – 1906Combined sources
Beta strandi191 – 1966Combined sources
Beta strandi207 – 2126Combined sources
Beta strandi215 – 2173Combined sources
Helixi218 – 23114Combined sources
Helixi233 – 25119Combined sources
Helixi294 – 32835Combined sources
Helixi340 – 36728Combined sources
Helixi369 – 37810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4S0VX-ray2.50A3-254[»]
A294-388[»]
ProteinModelPortaliO43614.
SMRiO43614. Positions 56-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253280.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiO43614.
KOiK04239.
OMAiNSIVVIW.
OrthoDBiEOG7CG72H.
PhylomeDBiO43614.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTKLEDSP PCRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP
60 70 80 90 100
KEYEWVLIAG YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD
110 120 130 140 150
VLVTITCLPA TLVVDITETW FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL
160 170 180 190 200
DRWYAICHPL MFKSTAKRAR NSIVIIWIVS CIIMIPQAIV MECSTVFPGL
210 220 230 240 250
ANKTTLFTVC DERWGGEIYP KMYHICFFLV TYMAPLCLMV LAYLQIFRKL
260 270 280 290 300
WCRQIPGTSS VVQRKWKPLQ PVSQPRGPGQ PTKSRMSAVA AEIKQIRARR
310 320 330 340 350
KTARMLMIVL LVFAICYLPI SILNVLKRVF GMFAHTEDRE TVYAWFTFSH
360 370 380 390 400
WLVYANSAAN PIIYNFLSGK FREEFKAAFS CCCLGVHHRQ EDRLTRGRTS
410 420 430 440
TESRKSLTTQ ISNFDNISKL SEQVVLTSIS TLPAANGAGP LQNW
Length:444
Mass (Da):50,694
Last modified:September 22, 2008 - v2
Checksum:iC4C9A153D42254C6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101P → S.1 Publication
Corresponds to variant rs41271310 [ dbSNP | Ensembl ].
VAR_044507
Natural varianti11 – 111P → T.1 Publication
Corresponds to variant rs41271312 [ dbSNP | Ensembl ].
VAR_044508
Natural varianti293 – 2931I → V.1 Publication
VAR_044509
Natural varianti308 – 3081I → V.2 Publications
Corresponds to variant rs2653349 [ dbSNP | Ensembl ].
VAR_044510

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041245 mRNA. Translation: AAC39602.1.
AY062031 Genomic DNA. Translation: AAL47215.1.
AL591718, AL449104 Genomic DNA. Translation: CAH73407.1.
AL449104, AL591718 Genomic DNA. Translation: CAI19665.1.
CH471081 Genomic DNA. Translation: EAX04440.1.
CCDSiCCDS4956.1.
RefSeqiNP_001517.2. NM_001526.3.
XP_006715137.1. XM_006715074.1.
UniGeneiHs.151624.
Hs.699147.

Genome annotation databases

EnsembliENST00000370862; ENSP00000359899; ENSG00000137252.
ENST00000615358; ENSP00000477548; ENSG00000137252.
GeneIDi3062.
KEGGihsa:3062.
UCSCiuc003pcl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041245 mRNA. Translation: AAC39602.1.
AY062031 Genomic DNA. Translation: AAL47215.1.
AL591718, AL449104 Genomic DNA. Translation: CAH73407.1.
AL449104, AL591718 Genomic DNA. Translation: CAI19665.1.
CH471081 Genomic DNA. Translation: EAX04440.1.
CCDSiCCDS4956.1.
RefSeqiNP_001517.2. NM_001526.3.
XP_006715137.1. XM_006715074.1.
UniGeneiHs.151624.
Hs.699147.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4S0VX-ray2.50A3-254[»]
A294-388[»]
ProteinModelPortaliO43614.
SMRiO43614. Positions 56-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000359899.

Chemistry

BindingDBiO43614.
ChEMBLiCHEMBL3307226.
GuidetoPHARMACOLOGYi322.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO43614.

Proteomic databases

PaxDbiO43614.
PRIDEiO43614.

Protocols and materials databases

DNASUi3062.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370862; ENSP00000359899; ENSG00000137252.
ENST00000615358; ENSP00000477548; ENSG00000137252.
GeneIDi3062.
KEGGihsa:3062.
UCSCiuc003pcl.3. human.

Organism-specific databases

CTDi3062.
GeneCardsiGC06P055085.
HGNCiHGNC:4849. HCRTR2.
HPAiHPA054516.
MIMi602393. gene.
neXtProtiNX_O43614.
PharmGKBiPA29223.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG253280.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiO43614.
KOiK04239.
OMAiNSIVVIW.
OrthoDBiEOG7CG72H.
PhylomeDBiO43614.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiHypocretin_(orexin)_receptor_2.
GenomeRNAii3062.
NextBioi12115.
PROiO43614.
SOURCEiSearch...

Gene expression databases

BgeeiO43614.
CleanExiHS_HCRTR2.
ExpressionAtlasiO43614. baseline and differential.
GenevestigatoriO43614.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004060. Orexin_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF03827. Orexin_rec2. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01522. OREXIN2R.
PR01064. OREXINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-308.
  2. "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy."
    Olafsdottir B.R., Rye D.B., Scammell T.E., Matheson J.K., Stefansson K., Gulcher J.R.
    Neurology 57:1896-1899(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-10; THR-11; VAL-293 AND VAL-308.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Hypocretin/orexin, sleep and narcolepsy."
    Hungs M., Mignot E.
    Bioessays 23:397-408(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  6. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
    Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
    Annu. Rev. Neurosci. 24:429-458(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiOX2R_HUMAN
AccessioniPrimary (citable) accession number: O43614
Secondary accession number(s): Q5VTM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: September 22, 2008
Last modified: March 31, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.