O43614 (OX2R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Orexin receptor type 2
Short name=Ox-2-R
Short name=Ox2-R
Short name=Ox2R

Alternative name(s):
Hypocretin receptor type 2

Gene names

Name:

HCRTR2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	feeding behavior Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	neuropeptide receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 444	444	Orexin receptor type 2		PRO_0000069989
Regions
	Topological domain	1 – 54	54	Extracellular Potential
	Transmembrane	55 – 75	21	Helical; Name=1; Potential
	Topological domain	76 – 88	13	Cytoplasmic Potential
	Transmembrane	89 – 110	22	Helical; Name=2; Potential
	Topological domain	111 – 127	17	Extracellular Potential
	Transmembrane	128 – 150	23	Helical; Name=3; Potential
	Topological domain	151 – 172	22	Cytoplasmic Potential
	Transmembrane	173 – 193	21	Helical; Name=4; Potential
	Topological domain	194 – 224	31	Extracellular Potential
	Transmembrane	225 – 247	23	Helical; Name=5; Potential
	Topological domain	248 – 304	57	Cytoplasmic Potential
	Transmembrane	305 – 327	23	Helical; Name=6; Potential
	Topological domain	328 – 342	15	Extracellular Potential
	Transmembrane	343 – 366	24	Helical; Name=7; Potential
	Topological domain	367 – 444	78	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	14	1	N-linked (GlcNAc...) Potential
	Glycosylation	22	1	N-linked (GlcNAc...) Potential
	Glycosylation	202	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	10	1	P → S. Ref.2 Corresponds to variant rs41271310 [ dbSNP | Ensembl ].		VAR_044507
	Natural variant	11	1	P → T. Ref.2 Corresponds to variant rs41271312 [ dbSNP | Ensembl ].		VAR_044508
	Natural variant	293	1	I → V. Ref.2		VAR_044509
	Natural variant	308	1	I → V. Ref.1 Ref.2 Corresponds to variant rs2653349 [ dbSNP | Ensembl ].		VAR_044510

Sequences

	Sequence		Length	Mass (Da)
	O43614 [UniParc]. Last modified September 23, 2008. Version 2. Checksum: C4C9A153D42254C6	FASTA	444	50,694
	10 20 30 40 50 60 MSGTKLEDSP PCRNWSSASE LNETQEPFLN PTDYDDEEFL RYLWREYLHP KEYEWVLIAG 70 80 90 100 110 120 YIIVFVVALI GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD VLVTITCLPA TLVVDITETW 130 140 150 160 170 180 FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL DRWYAICHPL MFKSTAKRAR NSIVIIWIVS 190 200 210 220 230 240 CIIMIPQAIV MECSTVFPGL ANKTTLFTVC DERWGGEIYP KMYHICFFLV TYMAPLCLMV 250 260 270 280 290 300 LAYLQIFRKL WCRQIPGTSS VVQRKWKPLQ PVSQPRGPGQ PTKSRMSAVA AEIKQIRARR 310 320 330 340 350 360 KTARMLMIVL LVFAICYLPI SILNVLKRVF GMFAHTEDRE TVYAWFTFSH WLVYANSAAN 370 380 390 400 410 420 PIIYNFLSGK FREEFKAAFS CCCLGVHHRQ EDRLTRGRTS TESRKSLTTQ ISNFDNISKL 430 440 SEQVVLTSIS TLPAANGAGP LQNW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior." Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.-S., Terrett J.A. , Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Cell 92:573-585(1998) [PubMed: 9491897] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-308.
[2]	"Polymorphisms in hypocretin/orexin pathway genes and narcolepsy." Olafsdottir B.R., Rye D.B., Scammell T.E., Matheson J.K., Stefansson K., Gulcher J.R. Neurology 57:1896-1899(2001) [PubMed: 11723285] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-10; THR-11; VAL-293 AND VAL-308.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Hypocretin/orexin, sleep and narcolepsy." Hungs M., Mignot E. Bioessays 23:397-408(2001) [PubMed: 11340621] [Abstract] Cited for: REVIEW.
[6]	"To eat or to sleep? Orexin in the regulation of feeding and wakefulness." Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M. Annu. Rev. Neurosci. 24:429-458(2001) [PubMed: 11283317] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF041245 mRNA. Translation: AAC39602.1. AY062031 Genomic DNA. Translation: AAL47215.1. AL591718, AL449104 Genomic DNA. Translation: CAH73407.1. AL449104, AL591718 Genomic DNA. Translation: CAI19665.1. CH471081 Genomic DNA. Translation: EAX04440.1.
IPI	IPI00013376.
RefSeq	NP_001517.2. NM_001526.3.
UniGene	Hs.151624. Hs.699147.
3D structure databases
ProteinModelPortal	O43614.
SMR	O43614. Positions 52-382.
ModBase	Search...
Protein-protein interaction databases
STRING	O43614.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	O43614.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370862; ENSP00000359899; ENSG00000137252.
GeneID	3062.
KEGG	hsa:3062.
UCSC	uc003pcl.1. human.
Organism-specific databases
CTD	3062.
GeneCards	GC06P055085.
HGNC	HGNC:4849. HCRTR2.
MIM	602393. gene.
neXtProt	NX_O43614.
PharmGKB	PA29223.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06220.
HOGENOM	HBG283700.
HOVERGEN	HBG101173.
InParanoid	O43614.
OMA	DSPPCRN.
OrthoDB	EOG4JM7PV.
PhylomeDB	O43614.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	O43614.
Bgee	O43614.
CleanEx	HS_HCRTR2.
Genevestigator	O43614.
GermOnline	ENSG00000137252. Homo sapiens.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000204. Orexin_rcpt. IPR004060. Orexin_rcpt_2. [Graphical view]
KO	K04239.
Pfam	PF00001. 7tm_1. 1 hit. PF03827. Orexin_rec2. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01522. OREXIN2R. PR01064. OREXINR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	12115.
SOURCE	Search...

Entry information

Entry name

OX2R_HUMAN

Accession

Primary (citable) accession number: O43614
Secondary accession number(s): Q5VTM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.