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O43613

- OX1R_HUMAN

UniProt

O43613 - OX1R_HUMAN

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Protein

Orexin receptor type 1

Gene
HCRTR1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade By similarity.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. orexin receptor activity Source: InterPro
  3. peptide hormone binding Source: Ensembl

GO - Biological processi

  1. feeding behavior Source: ProtInc
  2. neuropeptide signaling pathway Source: ProtInc
  3. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin receptor type 1
Short name:
Ox-1-R
Short name:
Ox1-R
Short name:
Ox1R
Alternative name(s):
Hypocretin receptor type 1
Gene namesi
Name:HCRTR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:4848. HCRTR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646Extracellular Reviewed predictionAdd
BLAST
Transmembranei47 – 6721Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini68 – 8013Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei81 – 10222Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini103 – 11917Extracellular Reviewed predictionAdd
BLAST
Transmembranei120 – 14223Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini143 – 16422Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei165 – 18521Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini186 – 21631Extracellular Reviewed predictionAdd
BLAST
Transmembranei217 – 23923Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini240 – 29859Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei299 – 32123Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini322 – 33615Extracellular Reviewed predictionAdd
BLAST
Transmembranei337 – 36024Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini361 – 42565Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Orexin receptor type 1PRO_0000069984Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi194 – 1941N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO43613.
PRIDEiO43613.

PTM databases

PhosphoSiteiO43613.

Expressioni

Gene expression databases

BgeeiO43613.
CleanExiHS_HCRTR1.
GenevestigatoriO43613.

Organism-specific databases

HPAiHPA014018.

Interactioni

Protein-protein interaction databases

BioGridi109311. 2 interactions.
STRINGi9606.ENSP00000362810.

Structurei

3D structure databases

ProteinModelPortaliO43613.
SMRiO43613. Positions 48-370.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253280.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiO43613.
KOiK04238.
OMAiRDYLYPK.
OrthoDBiEOG7CG72H.
PhylomeDBiO43613.
TreeFamiTF315303.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004059. Orexin_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01521. OREXIN1R.
PR01064. OREXINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43613-1 [UniParc]FASTAAdd to Basket

« Hide

MEPSATPGAQ MGVPPGSREP SPVPPDYEDE FLRYLWRDYL YPKQYEWVLI    50
AAYVAVFVVA LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL 100
PASLLVDITE SWLFGHALCK VIPYLQAVSV SVAVLTLSFI ALDRWYAICH 150
PLLFKSTARR ARGSILGIWA VSLAIMVPQA AVMECSSVLP ELANRTRLFS 200
VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR KLWGRQIPGT 250
TSALVRNWKR PSDQLGDLEQ GLSGEPQPRA RAFLAEVKQM RARRKTAKML 300
MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN 350
SAANPIIYNF LSGKFREQFK AAFSCCLPGL GPCGSLKAPS PRSSASHKSL 400
SLQSRCSISK ISEHVVLTSV TTVLP 425
Length:425
Mass (Da):47,536
Last modified:July 22, 2008 - v2
Checksum:iB650B37F3A2CA096
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671G → S.1 Publication
Corresponds to variant rs144603792 [ dbSNP | Ensembl ].
VAR_044505
Natural varianti279 – 2791R → Q.1 Publication
Corresponds to variant rs7516785 [ dbSNP | Ensembl ].
VAR_033480
Natural varianti281 – 2811R → H.1 Publication
Corresponds to variant rs41439244 [ dbSNP | Ensembl ].
VAR_044506
Natural varianti408 – 4081I → V.2 Publications
Corresponds to variant rs2271933 [ dbSNP | Ensembl ].
VAR_022063

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti280 – 2801A → G in AAC39601. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041243 mRNA. Translation: AAC39601.1.
AF202084
, AF202078, AF202079, AF202080, AF202081, AF202082, AF202083 Genomic DNA. Translation: AAG28020.1.
AY062030 Genomic DNA. Translation: AAL47214.1.
AY070269 Genomic DNA. Translation: AAL50221.1.
AK290521 mRNA. Translation: BAF83210.1.
AC114488 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07602.1.
BC074796 mRNA. Translation: AAH74796.1.
CCDSiCCDS344.1.
RefSeqiNP_001516.2. NM_001525.2.
UniGeneiHs.388226.

Genome annotation databases

EnsembliENST00000373706; ENSP00000362810; ENSG00000121764.
ENST00000403528; ENSP00000384387; ENSG00000121764.
GeneIDi3061.
KEGGihsa:3061.
UCSCiuc001btc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF041243 mRNA. Translation: AAC39601.1 .
AF202084
, AF202078 , AF202079 , AF202080 , AF202081 , AF202082 , AF202083 Genomic DNA. Translation: AAG28020.1 .
AY062030 Genomic DNA. Translation: AAL47214.1 .
AY070269 Genomic DNA. Translation: AAL50221.1 .
AK290521 mRNA. Translation: BAF83210.1 .
AC114488 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07602.1 .
BC074796 mRNA. Translation: AAH74796.1 .
CCDSi CCDS344.1.
RefSeqi NP_001516.2. NM_001525.2.
UniGenei Hs.388226.

3D structure databases

ProteinModelPortali O43613.
SMRi O43613. Positions 48-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109311. 2 interactions.
STRINGi 9606.ENSP00000362810.

Chemistry

BindingDBi O43613.
ChEMBLi CHEMBL5113.
GuidetoPHARMACOLOGYi 321.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O43613.

Proteomic databases

PaxDbi O43613.
PRIDEi O43613.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373706 ; ENSP00000362810 ; ENSG00000121764 .
ENST00000403528 ; ENSP00000384387 ; ENSG00000121764 .
GeneIDi 3061.
KEGGi hsa:3061.
UCSCi uc001btc.4. human.

Organism-specific databases

CTDi 3061.
GeneCardsi GC01P032083.
HGNCi HGNC:4848. HCRTR1.
HPAi HPA014018.
MIMi 602392. gene.
neXtProti NX_O43613.
PharmGKBi PA29222.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253280.
HOGENOMi HOG000230498.
HOVERGENi HBG101173.
InParanoidi O43613.
KOi K04238.
OMAi RDYLYPK.
OrthoDBi EOG7CG72H.
PhylomeDBi O43613.
TreeFami TF315303.

Enzyme and pathway databases

Reactomei REACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikii Hypocretin_(orexin)_receptor_1.
GenomeRNAii 3061.
NextBioi 12111.
PROi O43613.
SOURCEi Search...

Gene expression databases

Bgeei O43613.
CleanExi HS_HCRTR1.
Genevestigatori O43613.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004059. Orexin_rcpt_1.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01521. OREXIN1R.
PR01064. OREXINR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy."
    Olafsdottir B.R., Rye D.B., Scammell T.E., Matheson J.K., Stefansson K., Gulcher J.R.
    Neurology 57:1896-1899(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-167; GLN-279; HIS-281 AND VAL-408.
  4. "Genomic sequence of the hypocretin (orexin) receptor 1 (HCRTR1)."
    Yeager M., Welch R., Haque K., Bergen A.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-408.
    Tissue: Brain.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "Hypocretin/orexin, sleep and narcolepsy."
    Hungs M., Mignot E.
    Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
    Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
    Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiOX1R_HUMAN
AccessioniPrimary (citable) accession number: O43613
Secondary accession number(s): A8K3A6, Q9HBV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 22, 2008
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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