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Protein

Orexin receptor type 1

Gene

HCRTR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to hormone stimulus Source: GO_Central
  • feeding behavior Source: ProtInc
  • neuropeptide signaling pathway Source: ProtInc
  • regulation of circadian sleep/wake cycle, sleep Source: GO_Central
  • response to peptide Source: GO_Central
  • synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Orexin receptor type 1
Short name:
Ox-1-R
Short name:
Ox1-R
Short name:
Ox1R
Alternative name(s):
Hypocretin receptor type 1
Gene namesi
Name:HCRTR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4848. HCRTR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646ExtracellularSequence AnalysisAdd
BLAST
Transmembranei47 – 6721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini68 – 8013CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei81 – 10222Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini103 – 11917ExtracellularSequence AnalysisAdd
BLAST
Transmembranei120 – 14223Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini143 – 16422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini186 – 21631ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 23923Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini240 – 29859CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei299 – 32123Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini322 – 33615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei337 – 36024Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini361 – 42565CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29222.

Polymorphism and mutation databases

BioMutaiHCRTR1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Orexin receptor type 1PRO_0000069984Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO43613.
PRIDEiO43613.

PTM databases

PhosphoSiteiO43613.

Expressioni

Gene expression databases

BgeeiO43613.
CleanExiHS_HCRTR1.
ExpressionAtlasiO43613. baseline.
GenevisibleiO43613. HS.

Organism-specific databases

HPAiHPA014018.

Interactioni

Protein-protein interaction databases

BioGridi109311. 2 interactions.
STRINGi9606.ENSP00000362810.

Structurei

3D structure databases

ProteinModelPortaliO43613.
SMRiO43613. Positions 42-246, 277-375.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG253280.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiO43613.
KOiK04238.
OMAiRDYLYPK.
OrthoDBiEOG7CG72H.
PhylomeDBiO43613.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004059. Orexin_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01521. OREXIN1R.
PR01064. OREXINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPSATPGAQ MGVPPGSREP SPVPPDYEDE FLRYLWRDYL YPKQYEWVLI
60 70 80 90 100
AAYVAVFVVA LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL
110 120 130 140 150
PASLLVDITE SWLFGHALCK VIPYLQAVSV SVAVLTLSFI ALDRWYAICH
160 170 180 190 200
PLLFKSTARR ARGSILGIWA VSLAIMVPQA AVMECSSVLP ELANRTRLFS
210 220 230 240 250
VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR KLWGRQIPGT
260 270 280 290 300
TSALVRNWKR PSDQLGDLEQ GLSGEPQPRA RAFLAEVKQM RARRKTAKML
310 320 330 340 350
MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN
360 370 380 390 400
SAANPIIYNF LSGKFREQFK AAFSCCLPGL GPCGSLKAPS PRSSASHKSL
410 420
SLQSRCSISK ISEHVVLTSV TTVLP
Length:425
Mass (Da):47,536
Last modified:July 22, 2008 - v2
Checksum:iB650B37F3A2CA096
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti280 – 2801A → G in AAC39601 (PubMed:9491897).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti167 – 1671G → S.1 Publication
Corresponds to variant rs144603792 [ dbSNP | Ensembl ].
VAR_044505
Natural varianti279 – 2791R → Q.1 Publication
Corresponds to variant rs7516785 [ dbSNP | Ensembl ].
VAR_033480
Natural varianti281 – 2811R → H.1 Publication
Corresponds to variant rs41439244 [ dbSNP | Ensembl ].
VAR_044506
Natural varianti408 – 4081I → V.2 Publications
Corresponds to variant rs2271933 [ dbSNP | Ensembl ].
VAR_022063

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041243 mRNA. Translation: AAC39601.1.
AF202084
, AF202078, AF202079, AF202080, AF202081, AF202082, AF202083 Genomic DNA. Translation: AAG28020.1.
AY062030 Genomic DNA. Translation: AAL47214.1.
AY070269 Genomic DNA. Translation: AAL50221.1.
AK290521 mRNA. Translation: BAF83210.1.
AC114488 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07602.1.
BC074796 mRNA. Translation: AAH74796.1.
CCDSiCCDS344.1.
RefSeqiNP_001516.2. NM_001525.2.
UniGeneiHs.388226.

Genome annotation databases

EnsembliENST00000373706; ENSP00000362810; ENSG00000121764.
ENST00000403528; ENSP00000384387; ENSG00000121764.
GeneIDi3061.
KEGGihsa:3061.
UCSCiuc001btc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF041243 mRNA. Translation: AAC39601.1.
AF202084
, AF202078, AF202079, AF202080, AF202081, AF202082, AF202083 Genomic DNA. Translation: AAG28020.1.
AY062030 Genomic DNA. Translation: AAL47214.1.
AY070269 Genomic DNA. Translation: AAL50221.1.
AK290521 mRNA. Translation: BAF83210.1.
AC114488 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07602.1.
BC074796 mRNA. Translation: AAH74796.1.
CCDSiCCDS344.1.
RefSeqiNP_001516.2. NM_001525.2.
UniGeneiHs.388226.

3D structure databases

ProteinModelPortaliO43613.
SMRiO43613. Positions 42-246, 277-375.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109311. 2 interactions.
STRINGi9606.ENSP00000362810.

Chemistry

BindingDBiO43613.
ChEMBLiCHEMBL5113.
GuidetoPHARMACOLOGYi321.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO43613.

Polymorphism and mutation databases

BioMutaiHCRTR1.

Proteomic databases

PaxDbiO43613.
PRIDEiO43613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373706; ENSP00000362810; ENSG00000121764.
ENST00000403528; ENSP00000384387; ENSG00000121764.
GeneIDi3061.
KEGGihsa:3061.
UCSCiuc001btc.4. human.

Organism-specific databases

CTDi3061.
GeneCardsiGC01P032083.
HGNCiHGNC:4848. HCRTR1.
HPAiHPA014018.
MIMi602392. gene.
neXtProtiNX_O43613.
PharmGKBiPA29222.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG253280.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000230498.
HOVERGENiHBG101173.
InParanoidiO43613.
KOiK04238.
OMAiRDYLYPK.
OrthoDBiEOG7CG72H.
PhylomeDBiO43613.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiHCRTR1. human.
GeneWikiiHypocretin_(orexin)_receptor_1.
GenomeRNAii3061.
NextBioi12111.
PROiO43613.
SOURCEiSearch...

Gene expression databases

BgeeiO43613.
CleanExiHS_HCRTR1.
ExpressionAtlasiO43613. baseline.
GenevisibleiO43613. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000204. Orexin_rcpt.
IPR004059. Orexin_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01521. OREXIN1R.
PR01064. OREXINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy."
    Olafsdottir B.R., Rye D.B., Scammell T.E., Matheson J.K., Stefansson K., Gulcher J.R.
    Neurology 57:1896-1899(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-167; GLN-279; HIS-281 AND VAL-408.
  4. "Genomic sequence of the hypocretin (orexin) receptor 1 (HCRTR1)."
    Yeager M., Welch R., Haque K., Bergen A.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-408.
    Tissue: Brain.
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. "Hypocretin/orexin, sleep and narcolepsy."
    Hungs M., Mignot E.
    Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
    Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
    Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiOX1R_HUMAN
AccessioniPrimary (citable) accession number: O43613
Secondary accession number(s): A8K3A6, Q9HBV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 22, 2008
Last modified: June 24, 2015
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.