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O43613

- OX1R_HUMAN

UniProt

O43613 - OX1R_HUMAN

Protein

Orexin receptor type 1

Gene

HCRTR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Functioni

    Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade By similarity.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. orexin receptor activity Source: InterPro
    3. peptide hormone binding Source: Ensembl

    GO - Biological processi

    1. feeding behavior Source: ProtInc
    2. neuropeptide signaling pathway Source: ProtInc
    3. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orexin receptor type 1
    Short name:
    Ox-1-R
    Short name:
    Ox1-R
    Short name:
    Ox1R
    Alternative name(s):
    Hypocretin receptor type 1
    Gene namesi
    Name:HCRTR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:4848. HCRTR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29222.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Orexin receptor type 1PRO_0000069984Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO43613.
    PRIDEiO43613.

    PTM databases

    PhosphoSiteiO43613.

    Expressioni

    Gene expression databases

    BgeeiO43613.
    CleanExiHS_HCRTR1.
    GenevestigatoriO43613.

    Organism-specific databases

    HPAiHPA014018.

    Interactioni

    Protein-protein interaction databases

    BioGridi109311. 2 interactions.
    STRINGi9606.ENSP00000362810.

    Structurei

    3D structure databases

    ProteinModelPortaliO43613.
    SMRiO43613. Positions 48-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4646ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini68 – 8013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini103 – 11917ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini143 – 16422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini186 – 21631ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini240 – 29859CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini322 – 33615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini361 – 42565CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei81 – 10222Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 14223Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 23923Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei299 – 32123Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei337 – 36024Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG253280.
    HOGENOMiHOG000230498.
    HOVERGENiHBG101173.
    InParanoidiO43613.
    KOiK04238.
    OMAiRDYLYPK.
    OrthoDBiEOG7CG72H.
    PhylomeDBiO43613.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000204. Orexin_rcpt.
    IPR004059. Orexin_rcpt_1.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01521. OREXIN1R.
    PR01064. OREXINR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43613-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPSATPGAQ MGVPPGSREP SPVPPDYEDE FLRYLWRDYL YPKQYEWVLI    50
    AAYVAVFVVA LVGNTLVCLA VWRNHHMRTV TNYFIVNLSL ADVLVTAICL 100
    PASLLVDITE SWLFGHALCK VIPYLQAVSV SVAVLTLSFI ALDRWYAICH 150
    PLLFKSTARR ARGSILGIWA VSLAIMVPQA AVMECSSVLP ELANRTRLFS 200
    VCDERWADDL YPKIYHSCFF IVTYLAPLGL MAMAYFQIFR KLWGRQIPGT 250
    TSALVRNWKR PSDQLGDLEQ GLSGEPQPRA RAFLAEVKQM RARRKTAKML 300
    MVVLLVFALC YLPISVLNVL KRVFGMFRQA SDREAVYACF TFSHWLVYAN 350
    SAANPIIYNF LSGKFREQFK AAFSCCLPGL GPCGSLKAPS PRSSASHKSL 400
    SLQSRCSISK ISEHVVLTSV TTVLP 425
    Length:425
    Mass (Da):47,536
    Last modified:July 22, 2008 - v2
    Checksum:iB650B37F3A2CA096
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti280 – 2801A → G in AAC39601. (PubMed:9491897)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti167 – 1671G → S.1 Publication
    Corresponds to variant rs144603792 [ dbSNP | Ensembl ].
    VAR_044505
    Natural varianti279 – 2791R → Q.1 Publication
    Corresponds to variant rs7516785 [ dbSNP | Ensembl ].
    VAR_033480
    Natural varianti281 – 2811R → H.1 Publication
    Corresponds to variant rs41439244 [ dbSNP | Ensembl ].
    VAR_044506
    Natural varianti408 – 4081I → V.2 Publications
    Corresponds to variant rs2271933 [ dbSNP | Ensembl ].
    VAR_022063

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041243 mRNA. Translation: AAC39601.1.
    AF202084
    , AF202078, AF202079, AF202080, AF202081, AF202082, AF202083 Genomic DNA. Translation: AAG28020.1.
    AY062030 Genomic DNA. Translation: AAL47214.1.
    AY070269 Genomic DNA. Translation: AAL50221.1.
    AK290521 mRNA. Translation: BAF83210.1.
    AC114488 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX07602.1.
    BC074796 mRNA. Translation: AAH74796.1.
    CCDSiCCDS344.1.
    RefSeqiNP_001516.2. NM_001525.2.
    UniGeneiHs.388226.

    Genome annotation databases

    EnsembliENST00000373706; ENSP00000362810; ENSG00000121764.
    ENST00000403528; ENSP00000384387; ENSG00000121764.
    GeneIDi3061.
    KEGGihsa:3061.
    UCSCiuc001btc.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF041243 mRNA. Translation: AAC39601.1 .
    AF202084
    , AF202078 , AF202079 , AF202080 , AF202081 , AF202082 , AF202083 Genomic DNA. Translation: AAG28020.1 .
    AY062030 Genomic DNA. Translation: AAL47214.1 .
    AY070269 Genomic DNA. Translation: AAL50221.1 .
    AK290521 mRNA. Translation: BAF83210.1 .
    AC114488 Genomic DNA. No translation available.
    CH471059 Genomic DNA. Translation: EAX07602.1 .
    BC074796 mRNA. Translation: AAH74796.1 .
    CCDSi CCDS344.1.
    RefSeqi NP_001516.2. NM_001525.2.
    UniGenei Hs.388226.

    3D structure databases

    ProteinModelPortali O43613.
    SMRi O43613. Positions 48-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109311. 2 interactions.
    STRINGi 9606.ENSP00000362810.

    Chemistry

    BindingDBi O43613.
    ChEMBLi CHEMBL5113.
    GuidetoPHARMACOLOGYi 321.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O43613.

    Proteomic databases

    PaxDbi O43613.
    PRIDEi O43613.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373706 ; ENSP00000362810 ; ENSG00000121764 .
    ENST00000403528 ; ENSP00000384387 ; ENSG00000121764 .
    GeneIDi 3061.
    KEGGi hsa:3061.
    UCSCi uc001btc.4. human.

    Organism-specific databases

    CTDi 3061.
    GeneCardsi GC01P032083.
    HGNCi HGNC:4848. HCRTR1.
    HPAi HPA014018.
    MIMi 602392. gene.
    neXtProti NX_O43613.
    PharmGKBi PA29222.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253280.
    HOGENOMi HOG000230498.
    HOVERGENi HBG101173.
    InParanoidi O43613.
    KOi K04238.
    OMAi RDYLYPK.
    OrthoDBi EOG7CG72H.
    PhylomeDBi O43613.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_16973. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii Hypocretin_(orexin)_receptor_1.
    GenomeRNAii 3061.
    NextBioi 12111.
    PROi O43613.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43613.
    CleanExi HS_HCRTR1.
    Genevestigatori O43613.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000204. Orexin_rcpt.
    IPR004059. Orexin_rcpt_1.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01521. OREXIN1R.
    PR01064. OREXINR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy."
      Olafsdottir B.R., Rye D.B., Scammell T.E., Matheson J.K., Stefansson K., Gulcher J.R.
      Neurology 57:1896-1899(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-167; GLN-279; HIS-281 AND VAL-408.
    4. "Genomic sequence of the hypocretin (orexin) receptor 1 (HCRTR1)."
      Yeager M., Welch R., Haque K., Bergen A.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-408.
      Tissue: Brain.
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    9. "Hypocretin/orexin, sleep and narcolepsy."
      Hungs M., Mignot E.
      Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    10. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
      Willie J.T., Chemelli R.M., Sinton C.M., Yanagisawa M.
      Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiOX1R_HUMAN
    AccessioniPrimary (citable) accession number: O43613
    Secondary accession number(s): A8K3A6, Q9HBV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3