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O43610

- SPY3_HUMAN

UniProt

O43610 - SPY3_HUMAN

Protein

Protein sprouty homolog 3

Gene

SPRY3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (21 Feb 2001)
      Previous versions | rss
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    Functioni

    May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB
    2. regulation of signal transduction Source: InterPro

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein sprouty homolog 3
    Short name:
    Spry-3
    Gene namesi
    Name:SPRY3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:11271. SPRY3.

    Subcellular locationi

    Cytoplasm. Membrane; Peripheral membrane protein
    Note: Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36100.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Protein sprouty homolog 3PRO_0000076904Add
    BLAST

    Proteomic databases

    PaxDbiO43610.
    PRIDEiO43610.

    PTM databases

    PhosphoSiteiO43610.

    Expressioni

    Tissue specificityi

    Widely expressed; particularly in the fetal tissues.

    Inductioni

    By FGF signaling.

    Gene expression databases

    BgeeiO43610.
    CleanExiHS_SPRY3.
    GenevestigatoriO43610.

    Organism-specific databases

    HPAiCAB013505.

    Interactioni

    Protein-protein interaction databases

    BioGridi115545. 1 interaction.
    STRINGi9606.ENSP00000302978.

    Structurei

    3D structure databases

    ProteinModelPortaliO43610.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini154 – 260107SPRPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi147 – 270124Cys-richAdd
    BLAST

    Domaini

    The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

    Sequence similaritiesi

    Belongs to the sprouty family.Curated
    Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG128987.
    HOGENOMiHOG000233079.
    HOVERGENiHBG003544.
    InParanoidiO43610.
    KOiK17384.
    OMAiGRCKCVL.
    OrthoDBiEOG7G4QDV.
    PhylomeDBiO43610.
    TreeFamiTF325070.

    Family and domain databases

    InterProiIPR007875. Sprouty.
    [Graphical view]
    PfamiPF05210. Sprouty. 1 hit.
    [Graphical view]
    PROSITEiPS51227. SPR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43610-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAAVTDDFQ QILPIEQLRS THASNDYVER PPAPCKQALS SPSLIVQTHK    50
    SDWSLATMPT SLPRSLSQCH QLQPLPQHLS QSSIASSMSH STTASDQRLL 100
    ASITPSPSGQ SIIRTQPGAG VHPKADGALK GEAEQSAGHP SEHLFICEEC 150
    GRCKCVPCTA ARPLPSCWLC NQRCLCSAES LLDYGTCLCC VKGLFYHCST 200
    DDEDNCADEP CSCGPSSCFV RWAAMSLISL FLPCLCCYLP TRGCLHLCQQ 250
    GYDSLRRPGC RCKRHTNTVC RKISSGSAPF PKAQEKSV 288
    Length:288
    Mass (Da):31,222
    Last modified:February 21, 2001 - v2
    Checksum:i62C59F5E897D99B8
    GO

    Sequence cautioni

    The sequence AAC39567.1 differs from that shown. Reason: Frameshift at position 96.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 931T → P in AAC39567. (PubMed:9458049)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti161 – 1611A → T.
    Corresponds to variant rs35474915 [ dbSNP | Ensembl ].
    VAR_034519

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271735 Genomic DNA. Translation: CAB96768.1.
    AK289543 mRNA. Translation: BAF82232.1.
    CH471247 Genomic DNA. Translation: EAW55876.1.
    BC069609 mRNA. Translation: AAH69609.1.
    BC074972 mRNA. Translation: AAH74972.1.
    BC074973 mRNA. Translation: AAH74973.1.
    AF041038 mRNA. Translation: AAC39567.1. Frameshift.
    CCDSiCCDS14769.4.
    RefSeqiNP_005831.1. NM_005840.1.
    XP_005274699.1. XM_005274642.2.
    XP_005274700.1. XM_005274643.2.
    XP_005274857.1. XM_005274800.2.
    UniGeneiHs.381912.

    Genome annotation databases

    EnsembliENST00000302805; ENSP00000302978; ENSG00000168939.
    GeneIDi10251.
    KEGGihsa:10251.
    UCSCiuc004fnq.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ271735 Genomic DNA. Translation: CAB96768.1 .
    AK289543 mRNA. Translation: BAF82232.1 .
    CH471247 Genomic DNA. Translation: EAW55876.1 .
    BC069609 mRNA. Translation: AAH69609.1 .
    BC074972 mRNA. Translation: AAH74972.1 .
    BC074973 mRNA. Translation: AAH74973.1 .
    AF041038 mRNA. Translation: AAC39567.1 . Frameshift.
    CCDSi CCDS14769.4.
    RefSeqi NP_005831.1. NM_005840.1.
    XP_005274699.1. XM_005274642.2.
    XP_005274700.1. XM_005274643.2.
    XP_005274857.1. XM_005274800.2.
    UniGenei Hs.381912.

    3D structure databases

    ProteinModelPortali O43610.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115545. 1 interaction.
    STRINGi 9606.ENSP00000302978.

    PTM databases

    PhosphoSitei O43610.

    Proteomic databases

    PaxDbi O43610.
    PRIDEi O43610.

    Protocols and materials databases

    DNASUi 10251.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302805 ; ENSP00000302978 ; ENSG00000168939 .
    GeneIDi 10251.
    KEGGi hsa:10251.
    UCSCi uc004fnq.1. human.

    Organism-specific databases

    CTDi 10251.
    GeneCardsi GC0XP154997.
    HGNCi HGNC:11271. SPRY3.
    HPAi CAB013505.
    MIMi 300531. gene.
    neXtProti NX_O43610.
    PharmGKBi PA36100.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG128987.
    HOGENOMi HOG000233079.
    HOVERGENi HBG003544.
    InParanoidi O43610.
    KOi K17384.
    OMAi GRCKCVL.
    OrthoDBi EOG7G4QDV.
    PhylomeDBi O43610.
    TreeFami TF325070.

    Miscellaneous databases

    GeneWikii SPRY3.
    GenomeRNAii 10251.
    NextBioi 38842.
    PROi O43610.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43610.
    CleanExi HS_SPRY3.
    Genevestigatori O43610.

    Family and domain databases

    InterProi IPR007875. Sprouty.
    [Graphical view ]
    Pfami PF05210. Sprouty. 1 hit.
    [Graphical view ]
    PROSITEi PS51227. SPR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways."
      Hacohen N., Kramer S., Sutherland D., Hiromi Y., Krasnow M.A.
      Cell 92:253-263(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 93-191.

    Entry informationi

    Entry nameiSPY3_HUMAN
    AccessioniPrimary (citable) accession number: O43610
    Secondary accession number(s): A8K0H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: February 21, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3