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Protein

Protein sprouty homolog 3

Gene

SPRY3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Miscellaneous

The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.

GO - Biological processi

  • axon development Source: InterPro
  • multicellular organism development Source: UniProtKB
  • regulation of signal transduction Source: InterPro

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sprouty homolog 3
Short name:
Spry-3
Gene namesi
Name:SPRY3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000168939.11.
HGNCiHGNC:11271. SPRY3.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10251.
OpenTargetsiENSG00000168939.
PharmGKBiPA36100.

Polymorphism and mutation databases

BioMutaiSPRY3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769041 – 288Protein sprouty homolog 3Add BLAST288

Proteomic databases

MaxQBiO43610.
PaxDbiO43610.
PeptideAtlasiO43610.
PRIDEiO43610.

PTM databases

iPTMnetiO43610.
PhosphoSitePlusiO43610.

Expressioni

Tissue specificityi

Widely expressed; particularly in the fetal tissues.

Inductioni

By FGF signaling.

Gene expression databases

BgeeiENSG00000168939.
CleanExiHS_SPRY3.
GenevisibleiO43610. HS.

Organism-specific databases

HPAiCAB013505.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BEX2Q9BXY84EBI-12290641,EBI-745073

Protein-protein interaction databases

BioGridi115545. 1 interactor.
IntActiO43610. 27 interactors.
STRINGi9606.ENSP00000302978.

Structurei

3D structure databases

ProteinModelPortaliO43610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 260SPRPROSITE-ProRule annotationAdd BLAST107

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi147 – 270Cys-richAdd BLAST124

Domaini

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

Sequence similaritiesi

Belongs to the sprouty family.Curated

Phylogenomic databases

eggNOGiENOG410IKW1. Eukaryota.
ENOG4111S05. LUCA.
GeneTreeiENSGT00390000003535.
HOGENOMiHOG000233079.
HOVERGENiHBG003544.
InParanoidiO43610.
KOiK17384.
OMAiGRCKCVL.
OrthoDBiEOG091G0DOQ.
PhylomeDBiO43610.
TreeFamiTF325070.

Family and domain databases

InterProiView protein in InterPro
IPR007875. Sprouty.
IPR030786. SPRY3.
PANTHERiPTHR12365:SF9. PTHR12365:SF9. 1 hit.
PfamiView protein in Pfam
PF05210. Sprouty. 1 hit.
PROSITEiView protein in PROSITE
PS51227. SPR. 1 hit.

Sequencei

Sequence statusi: Complete.

O43610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAAVTDDFQ QILPIEQLRS THASNDYVER PPAPCKQALS SPSLIVQTHK
60 70 80 90 100
SDWSLATMPT SLPRSLSQCH QLQPLPQHLS QSSIASSMSH STTASDQRLL
110 120 130 140 150
ASITPSPSGQ SIIRTQPGAG VHPKADGALK GEAEQSAGHP SEHLFICEEC
160 170 180 190 200
GRCKCVPCTA ARPLPSCWLC NQRCLCSAES LLDYGTCLCC VKGLFYHCST
210 220 230 240 250
DDEDNCADEP CSCGPSSCFV RWAAMSLISL FLPCLCCYLP TRGCLHLCQQ
260 270 280
GYDSLRRPGC RCKRHTNTVC RKISSGSAPF PKAQEKSV
Length:288
Mass (Da):31,222
Last modified:February 21, 2001 - v2
Checksum:i62C59F5E897D99B8
GO

Sequence cautioni

The sequence AAC39567 differs from that shown. Reason: Frameshift at position 96.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93T → P in AAC39567 (PubMed:9458049).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034519161A → T. Corresponds to variant dbSNP:rs35474915Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ271735 Genomic DNA. Translation: CAB96768.1.
AK289543 mRNA. Translation: BAF82232.1.
CH471247 Genomic DNA. Translation: EAW55876.1.
BC069609 mRNA. Translation: AAH69609.1.
BC074972 mRNA. Translation: AAH74972.1.
BC074973 mRNA. Translation: AAH74973.1.
AF041038 mRNA. Translation: AAC39567.1. Frameshift.
CCDSiCCDS14769.4.
RefSeqiNP_001291919.1. NM_001304990.1.
NP_005831.1. NM_005840.2.
UniGeneiHs.381912.

Genome annotation databases

EnsembliENST00000302805; ENSP00000302978; ENSG00000168939.
GeneIDi10251.
KEGGihsa:10251.
UCSCiuc004fnq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPY3_HUMAN
AccessioniPrimary (citable) accession number: O43610
Secondary accession number(s): A8K0H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: October 25, 2017
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families