SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O43609

- SPY1_HUMAN

UniProt

O43609 - SPY1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein sprouty homolog 1

Gene
SPRY1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. epidermal growth factor receptor signaling pathway Source: Reactome
  2. metanephros development Source: Ensembl
  3. negative regulation of cell proliferation Source: Ensembl
  4. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
  5. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  6. negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  7. negative regulation of MAP kinase activity Source: Ensembl
  8. negative regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
  9. negative regulation of Ras GTPase activity Source: Ensembl
  10. negative regulation of Ras protein signal transduction Source: Ensembl
  11. organ induction Source: Ensembl
  12. ureteric bud development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

ReactomeiREACT_12484. EGFR downregulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sprouty homolog 1
Short name:
Spry-1
Gene namesi
Name:SPRY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:11269. SPRY1.

Subcellular locationi

Cytoplasm. Membrane; Peripheral membrane protein
Note: Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Protein sprouty homolog 1PRO_0000076898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO43609.
PaxDbiO43609.
PRIDEiO43609.

PTM databases

PhosphoSiteiO43609.

Expressioni

Inductioni

By FGF signaling.

Gene expression databases

ArrayExpressiO43609.
BgeeiO43609.
CleanExiHS_SPRY1.
GenevestigatoriO43609.

Organism-specific databases

HPAiCAB013538.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Hoxa1P090223EBI-3866665,EBI-3957603From a different organism.

Protein-protein interaction databases

BioGridi115546. 21 interactions.
IntActiO43609. 11 interactions.
MINTiMINT-6169704.
STRINGi9606.ENSP00000343785.

Structurei

3D structure databases

ProteinModelPortaliO43609.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini183 – 295113SPRAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 310130Cys-richAdd
BLAST

Domaini

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

Sequence similaritiesi

Belongs to the sprouty family.

Phylogenomic databases

eggNOGiNOG83905.
HOGENOMiHOG000233079.
HOVERGENiHBG003544.
InParanoidiO43609.
KOiK04704.
OMAiQHKFICE.
PhylomeDBiO43609.
TreeFamiTF325070.

Family and domain databases

InterProiIPR007875. Sprouty.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
[Graphical view]
PROSITEiPS51227. SPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43609-1 [UniParc]FASTAAdd to Basket

« Hide

MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS    50
NEYTEGPSVV KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA 100
VLPSNARGPI LSRSTSTGSA ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS 150
ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI CEQCGKCKCG ECTAPRTLPS 200
CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS YSDNPCSCSQ 250
SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS 300
NTVYCKLESC PSRGQGKPS 319
Length:319
Mass (Da):35,122
Last modified:May 10, 2004 - v2
Checksum:i40E2D4D12816E057
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY192146 mRNA. Translation: AAP20102.1.
CH471056 Genomic DNA. Translation: EAX05209.1.
CH471056 Genomic DNA. Translation: EAX05210.1.
CH471056 Genomic DNA. Translation: EAX05211.1.
BC063856 mRNA. Translation: AAH63856.1.
AY590694 mRNA. Translation: AAT06102.1.
AF041037 mRNA. Translation: AAC39566.1.
CCDSiCCDS3731.1.
RefSeqiNP_001244967.1. NM_001258038.1.
NP_001244968.1. NM_001258039.1.
NP_005832.1. NM_005841.2.
NP_955359.1. NM_199327.2.
XP_005262743.1. XM_005262686.1.
UniGeneiHs.744854.

Genome annotation databases

EnsembliENST00000339241; ENSP00000343785; ENSG00000164056.
ENST00000394339; ENSP00000377871; ENSG00000164056.
GeneIDi10252.
KEGGihsa:10252.
UCSCiuc003ifa.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY192146 mRNA. Translation: AAP20102.1 .
CH471056 Genomic DNA. Translation: EAX05209.1 .
CH471056 Genomic DNA. Translation: EAX05210.1 .
CH471056 Genomic DNA. Translation: EAX05211.1 .
BC063856 mRNA. Translation: AAH63856.1 .
AY590694 mRNA. Translation: AAT06102.1 .
AF041037 mRNA. Translation: AAC39566.1 .
CCDSi CCDS3731.1.
RefSeqi NP_001244967.1. NM_001258038.1.
NP_001244968.1. NM_001258039.1.
NP_005832.1. NM_005841.2.
NP_955359.1. NM_199327.2.
XP_005262743.1. XM_005262686.1.
UniGenei Hs.744854.

3D structure databases

ProteinModelPortali O43609.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115546. 21 interactions.
IntActi O43609. 11 interactions.
MINTi MINT-6169704.
STRINGi 9606.ENSP00000343785.

PTM databases

PhosphoSitei O43609.

Proteomic databases

MaxQBi O43609.
PaxDbi O43609.
PRIDEi O43609.

Protocols and materials databases

DNASUi 10252.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339241 ; ENSP00000343785 ; ENSG00000164056 .
ENST00000394339 ; ENSP00000377871 ; ENSG00000164056 .
GeneIDi 10252.
KEGGi hsa:10252.
UCSCi uc003ifa.4. human.

Organism-specific databases

CTDi 10252.
GeneCardsi GC04P124317.
HGNCi HGNC:11269. SPRY1.
HPAi CAB013538.
MIMi 602465. gene.
neXtProti NX_O43609.
PharmGKBi PA36098.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG83905.
HOGENOMi HOG000233079.
HOVERGENi HBG003544.
InParanoidi O43609.
KOi K04704.
OMAi QHKFICE.
PhylomeDBi O43609.
TreeFami TF325070.

Enzyme and pathway databases

Reactomei REACT_12484. EGFR downregulation.

Miscellaneous databases

GeneWikii SPRY1.
GenomeRNAii 10252.
NextBioi 38846.
PROi O43609.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43609.
Bgeei O43609.
CleanExi HS_SPRY1.
Genevestigatori O43609.

Family and domain databases

InterProi IPR007875. Sprouty.
[Graphical view ]
Pfami PF05210. Sprouty. 1 hit.
[Graphical view ]
PROSITEi PS51227. SPR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and expression analysis of a novel splice variant of human Sprouty1 gene."
    Wang L., Ji C., Wu H., Xu J., Wu Q., Dai J., Yin G., Ye X., Gu S., Xie Y., Mao Y.
    Int. J. Mol. Med. 12:783-787(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.
  4. Raya A., de la Luna S.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-319.
  5. "Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways."
    Hacohen N., Kramer S., Sutherland D., Hiromi Y., Krasnow M.A.
    Cell 92:253-263(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-319.
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPY1_HUMAN
AccessioniPrimary (citable) accession number: O43609
Secondary accession number(s): D3DNX6, Q6PNE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 10, 2004
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi