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O43609

- SPY1_HUMAN

UniProt

O43609 - SPY1_HUMAN

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Protein

Protein sprouty homolog 1

Gene

SPRY1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

GO - Biological processi

  1. epidermal growth factor receptor signaling pathway Source: Reactome
  2. multicellular organismal development Source: UniProtKB-KW
  3. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

ReactomeiREACT_12484. EGFR downregulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sprouty homolog 1
Short name:
Spry-1
Gene namesi
Name:SPRY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:11269. SPRY1.

Subcellular locationi

Cytoplasm. Membrane; Peripheral membrane protein
Note: Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Protein sprouty homolog 1PRO_0000076898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO43609.
PaxDbiO43609.
PRIDEiO43609.

PTM databases

PhosphoSiteiO43609.

Expressioni

Inductioni

By FGF signaling.

Gene expression databases

BgeeiO43609.
CleanExiHS_SPRY1.
ExpressionAtlasiO43609. baseline and differential.
GenevestigatoriO43609.

Organism-specific databases

HPAiCAB013538.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Hoxa1P090223EBI-3866665,EBI-3957603From a different organism.

Protein-protein interaction databases

BioGridi115546. 21 interactions.
IntActiO43609. 11 interactions.
MINTiMINT-6169704.
STRINGi9606.ENSP00000343785.

Structurei

3D structure databases

ProteinModelPortaliO43609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini183 – 295113SPRPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 310130Cys-richAdd
BLAST

Domaini

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

Sequence similaritiesi

Belongs to the sprouty family.Curated
Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG83905.
GeneTreeiENSGT00390000003535.
HOGENOMiHOG000233079.
HOVERGENiHBG003544.
InParanoidiO43609.
KOiK04704.
OMAiQHKFICE.
PhylomeDBiO43609.
TreeFamiTF325070.

Family and domain databases

InterProiIPR007875. Sprouty.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
[Graphical view]
PROSITEiPS51227. SPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43609-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS
60 70 80 90 100
NEYTEGPSVV KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA
110 120 130 140 150
VLPSNARGPI LSRSTSTGSA ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS
160 170 180 190 200
ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI CEQCGKCKCG ECTAPRTLPS
210 220 230 240 250
CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS YSDNPCSCSQ
260 270 280 290 300
SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS
310
NTVYCKLESC PSRGQGKPS
Length:319
Mass (Da):35,122
Last modified:May 10, 2004 - v2
Checksum:i40E2D4D12816E057
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY192146 mRNA. Translation: AAP20102.1.
CH471056 Genomic DNA. Translation: EAX05209.1.
CH471056 Genomic DNA. Translation: EAX05210.1.
CH471056 Genomic DNA. Translation: EAX05211.1.
BC063856 mRNA. Translation: AAH63856.1.
AY590694 mRNA. Translation: AAT06102.1.
AF041037 mRNA. Translation: AAC39566.1.
CCDSiCCDS3731.1.
RefSeqiNP_001244967.1. NM_001258038.1.
NP_001244968.1. NM_001258039.1.
NP_005832.1. NM_005841.2.
NP_955359.1. NM_199327.2.
XP_005262743.1. XM_005262686.1.
UniGeneiHs.744854.

Genome annotation databases

EnsembliENST00000339241; ENSP00000343785; ENSG00000164056.
ENST00000394339; ENSP00000377871; ENSG00000164056.
ENST00000610581; ENSP00000481675; ENSG00000164056.
ENST00000622283; ENSP00000480540; ENSG00000164056.
GeneIDi10252.
KEGGihsa:10252.
UCSCiuc003ifa.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY192146 mRNA. Translation: AAP20102.1 .
CH471056 Genomic DNA. Translation: EAX05209.1 .
CH471056 Genomic DNA. Translation: EAX05210.1 .
CH471056 Genomic DNA. Translation: EAX05211.1 .
BC063856 mRNA. Translation: AAH63856.1 .
AY590694 mRNA. Translation: AAT06102.1 .
AF041037 mRNA. Translation: AAC39566.1 .
CCDSi CCDS3731.1.
RefSeqi NP_001244967.1. NM_001258038.1.
NP_001244968.1. NM_001258039.1.
NP_005832.1. NM_005841.2.
NP_955359.1. NM_199327.2.
XP_005262743.1. XM_005262686.1.
UniGenei Hs.744854.

3D structure databases

ProteinModelPortali O43609.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115546. 21 interactions.
IntActi O43609. 11 interactions.
MINTi MINT-6169704.
STRINGi 9606.ENSP00000343785.

PTM databases

PhosphoSitei O43609.

Proteomic databases

MaxQBi O43609.
PaxDbi O43609.
PRIDEi O43609.

Protocols and materials databases

DNASUi 10252.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000339241 ; ENSP00000343785 ; ENSG00000164056 .
ENST00000394339 ; ENSP00000377871 ; ENSG00000164056 .
ENST00000610581 ; ENSP00000481675 ; ENSG00000164056 .
ENST00000622283 ; ENSP00000480540 ; ENSG00000164056 .
GeneIDi 10252.
KEGGi hsa:10252.
UCSCi uc003ifa.4. human.

Organism-specific databases

CTDi 10252.
GeneCardsi GC04P124317.
HGNCi HGNC:11269. SPRY1.
HPAi CAB013538.
MIMi 602465. gene.
neXtProti NX_O43609.
PharmGKBi PA36098.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG83905.
GeneTreei ENSGT00390000003535.
HOGENOMi HOG000233079.
HOVERGENi HBG003544.
InParanoidi O43609.
KOi K04704.
OMAi QHKFICE.
PhylomeDBi O43609.
TreeFami TF325070.

Enzyme and pathway databases

Reactomei REACT_12484. EGFR downregulation.

Miscellaneous databases

ChiTaRSi SPRY1. human.
GeneWikii SPRY1.
GenomeRNAii 10252.
NextBioi 38846.
PROi O43609.
SOURCEi Search...

Gene expression databases

Bgeei O43609.
CleanExi HS_SPRY1.
ExpressionAtlasi O43609. baseline and differential.
Genevestigatori O43609.

Family and domain databases

InterProi IPR007875. Sprouty.
[Graphical view ]
Pfami PF05210. Sprouty. 1 hit.
[Graphical view ]
PROSITEi PS51227. SPR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and expression analysis of a novel splice variant of human Sprouty1 gene."
    Wang L., Ji C., Wu H., Xu J., Wu Q., Dai J., Yin G., Ye X., Gu S., Xie Y., Mao Y.
    Int. J. Mol. Med. 12:783-787(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.
  4. Raya A., de la Luna S.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-319.
  5. "Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways."
    Hacohen N., Kramer S., Sutherland D., Hiromi Y., Krasnow M.A.
    Cell 92:253-263(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-319.
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPY1_HUMAN
AccessioniPrimary (citable) accession number: O43609
Secondary accession number(s): D3DNX6, Q6PNE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 10, 2004
Last modified: November 26, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3