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O43609

- SPY1_HUMAN

UniProt

O43609 - SPY1_HUMAN

Protein

Protein sprouty homolog 1

Gene

SPRY1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. epidermal growth factor receptor signaling pathway Source: Reactome
    2. metanephros development Source: Ensembl
    3. negative regulation of cell proliferation Source: Ensembl
    4. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
    5. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
    6. negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
    7. negative regulation of MAP kinase activity Source: Ensembl
    8. negative regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
    9. negative regulation of Ras GTPase activity Source: Ensembl
    10. negative regulation of Ras protein signal transduction Source: Ensembl
    11. organ induction Source: Ensembl
    12. ureteric bud development Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein

    Enzyme and pathway databases

    ReactomeiREACT_12484. EGFR downregulation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein sprouty homolog 1
    Short name:
    Spry-1
    Gene namesi
    Name:SPRY1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:11269. SPRY1.

    Subcellular locationi

    Cytoplasm. Membrane; Peripheral membrane protein
    Note: Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36098.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Protein sprouty homolog 1PRO_0000076898Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO43609.
    PaxDbiO43609.
    PRIDEiO43609.

    PTM databases

    PhosphoSiteiO43609.

    Expressioni

    Inductioni

    By FGF signaling.

    Gene expression databases

    ArrayExpressiO43609.
    BgeeiO43609.
    CleanExiHS_SPRY1.
    GenevestigatoriO43609.

    Organism-specific databases

    HPAiCAB013538.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Hoxa1P090223EBI-3866665,EBI-3957603From a different organism.

    Protein-protein interaction databases

    BioGridi115546. 21 interactions.
    IntActiO43609. 11 interactions.
    MINTiMINT-6169704.
    STRINGi9606.ENSP00000343785.

    Structurei

    3D structure databases

    ProteinModelPortaliO43609.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini183 – 295113SPRPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi181 – 310130Cys-richAdd
    BLAST

    Domaini

    The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

    Sequence similaritiesi

    Belongs to the sprouty family.Curated
    Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG83905.
    HOGENOMiHOG000233079.
    HOVERGENiHBG003544.
    InParanoidiO43609.
    KOiK04704.
    OMAiQHKFICE.
    PhylomeDBiO43609.
    TreeFamiTF325070.

    Family and domain databases

    InterProiIPR007875. Sprouty.
    [Graphical view]
    PfamiPF05210. Sprouty. 1 hit.
    [Graphical view]
    PROSITEiPS51227. SPR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43609-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS    50
    NEYTEGPSVV KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA 100
    VLPSNARGPI LSRSTSTGSA ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS 150
    ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI CEQCGKCKCG ECTAPRTLPS 200
    CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS YSDNPCSCSQ 250
    SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS 300
    NTVYCKLESC PSRGQGKPS 319
    Length:319
    Mass (Da):35,122
    Last modified:May 10, 2004 - v2
    Checksum:i40E2D4D12816E057
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY192146 mRNA. Translation: AAP20102.1.
    CH471056 Genomic DNA. Translation: EAX05209.1.
    CH471056 Genomic DNA. Translation: EAX05210.1.
    CH471056 Genomic DNA. Translation: EAX05211.1.
    BC063856 mRNA. Translation: AAH63856.1.
    AY590694 mRNA. Translation: AAT06102.1.
    AF041037 mRNA. Translation: AAC39566.1.
    CCDSiCCDS3731.1.
    RefSeqiNP_001244967.1. NM_001258038.1.
    NP_001244968.1. NM_001258039.1.
    NP_005832.1. NM_005841.2.
    NP_955359.1. NM_199327.2.
    XP_005262743.1. XM_005262686.1.
    UniGeneiHs.744854.

    Genome annotation databases

    EnsembliENST00000339241; ENSP00000343785; ENSG00000164056.
    ENST00000394339; ENSP00000377871; ENSG00000164056.
    GeneIDi10252.
    KEGGihsa:10252.
    UCSCiuc003ifa.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY192146 mRNA. Translation: AAP20102.1 .
    CH471056 Genomic DNA. Translation: EAX05209.1 .
    CH471056 Genomic DNA. Translation: EAX05210.1 .
    CH471056 Genomic DNA. Translation: EAX05211.1 .
    BC063856 mRNA. Translation: AAH63856.1 .
    AY590694 mRNA. Translation: AAT06102.1 .
    AF041037 mRNA. Translation: AAC39566.1 .
    CCDSi CCDS3731.1.
    RefSeqi NP_001244967.1. NM_001258038.1.
    NP_001244968.1. NM_001258039.1.
    NP_005832.1. NM_005841.2.
    NP_955359.1. NM_199327.2.
    XP_005262743.1. XM_005262686.1.
    UniGenei Hs.744854.

    3D structure databases

    ProteinModelPortali O43609.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115546. 21 interactions.
    IntActi O43609. 11 interactions.
    MINTi MINT-6169704.
    STRINGi 9606.ENSP00000343785.

    PTM databases

    PhosphoSitei O43609.

    Proteomic databases

    MaxQBi O43609.
    PaxDbi O43609.
    PRIDEi O43609.

    Protocols and materials databases

    DNASUi 10252.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339241 ; ENSP00000343785 ; ENSG00000164056 .
    ENST00000394339 ; ENSP00000377871 ; ENSG00000164056 .
    GeneIDi 10252.
    KEGGi hsa:10252.
    UCSCi uc003ifa.4. human.

    Organism-specific databases

    CTDi 10252.
    GeneCardsi GC04P124317.
    HGNCi HGNC:11269. SPRY1.
    HPAi CAB013538.
    MIMi 602465. gene.
    neXtProti NX_O43609.
    PharmGKBi PA36098.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83905.
    HOGENOMi HOG000233079.
    HOVERGENi HBG003544.
    InParanoidi O43609.
    KOi K04704.
    OMAi QHKFICE.
    PhylomeDBi O43609.
    TreeFami TF325070.

    Enzyme and pathway databases

    Reactomei REACT_12484. EGFR downregulation.

    Miscellaneous databases

    GeneWikii SPRY1.
    GenomeRNAii 10252.
    NextBioi 38846.
    PROi O43609.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43609.
    Bgeei O43609.
    CleanExi HS_SPRY1.
    Genevestigatori O43609.

    Family and domain databases

    InterProi IPR007875. Sprouty.
    [Graphical view ]
    Pfami PF05210. Sprouty. 1 hit.
    [Graphical view ]
    PROSITEi PS51227. SPR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and expression analysis of a novel splice variant of human Sprouty1 gene."
      Wang L., Ji C., Wu H., Xu J., Wu Q., Dai J., Yin G., Ye X., Gu S., Xie Y., Mao Y.
      Int. J. Mol. Med. 12:783-787(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: PNS.
    4. Raya A., de la Luna S.
      Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-319.
    5. "Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways."
      Hacohen N., Kramer S., Sutherland D., Hiromi Y., Krasnow M.A.
      Cell 92:253-263(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-319.
    6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSPY1_HUMAN
    AccessioniPrimary (citable) accession number: O43609
    Secondary accession number(s): D3DNX6, Q6PNE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3