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Protein

Protein sprouty homolog 1

Gene

SPRY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

GO - Biological processi

  1. bud elongation involved in lung branching Source: Ensembl
  2. epidermal growth factor receptor signaling pathway Source: Reactome
  3. establishment of mitotic spindle orientation Source: Ensembl
  4. metanephros development Source: Ensembl
  5. negative regulation of cell proliferation Source: Ensembl
  6. negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
  7. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  8. negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
  9. negative regulation of MAP kinase activity Source: Ensembl
  10. negative regulation of neurotrophin TRK receptor signaling pathway Source: Ensembl
  11. negative regulation of Ras GTPase activity Source: Ensembl
  12. negative regulation of Ras protein signal transduction Source: Ensembl
  13. organ induction Source: Ensembl
  14. ureteric bud development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

ReactomeiREACT_12484. EGFR downregulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sprouty homolog 1
Short name:
Spry-1
Gene namesi
Name:SPRY1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:11269. SPRY1.

Subcellular locationi

Cytoplasm. Membrane; Peripheral membrane protein
Note: Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Protein sprouty homolog 1PRO_0000076898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO43609.
PaxDbiO43609.
PRIDEiO43609.

PTM databases

PhosphoSiteiO43609.

Expressioni

Inductioni

By FGF signaling.

Gene expression databases

BgeeiO43609.
CleanExiHS_SPRY1.
ExpressionAtlasiO43609. baseline and differential.
GenevestigatoriO43609.

Organism-specific databases

HPAiCAB013538.
HPA051369.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Hoxa1P090223EBI-3866665,EBI-3957603From a different organism.

Protein-protein interaction databases

BioGridi115546. 38 interactions.
IntActiO43609. 11 interactions.
MINTiMINT-6169704.
STRINGi9606.ENSP00000343785.

Structurei

3D structure databases

ProteinModelPortaliO43609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini183 – 295113SPRPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi181 – 310130Cys-richAdd
BLAST

Domaini

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

Sequence similaritiesi

Belongs to the sprouty family.Curated
Contains 1 SPR (sprouty) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG83905.
GeneTreeiENSGT00390000003535.
HOGENOMiHOG000233079.
HOVERGENiHBG003544.
InParanoidiO43609.
KOiK04704.
OMAiCGECTAP.
PhylomeDBiO43609.
TreeFamiTF325070.

Family and domain databases

InterProiIPR007875. Sprouty.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
[Graphical view]
PROSITEiPS51227. SPR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS
60 70 80 90 100
NEYTEGPSVV KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA
110 120 130 140 150
VLPSNARGPI LSRSTSTGSA ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS
160 170 180 190 200
ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI CEQCGKCKCG ECTAPRTLPS
210 220 230 240 250
CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS YSDNPCSCSQ
260 270 280 290 300
SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS
310
NTVYCKLESC PSRGQGKPS
Length:319
Mass (Da):35,122
Last modified:May 10, 2004 - v2
Checksum:i40E2D4D12816E057
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY192146 mRNA. Translation: AAP20102.1.
CH471056 Genomic DNA. Translation: EAX05209.1.
CH471056 Genomic DNA. Translation: EAX05210.1.
CH471056 Genomic DNA. Translation: EAX05211.1.
BC063856 mRNA. Translation: AAH63856.1.
AY590694 mRNA. Translation: AAT06102.1.
AF041037 mRNA. Translation: AAC39566.1.
CCDSiCCDS3731.1.
RefSeqiNP_001244967.1. NM_001258038.1.
NP_001244968.1. NM_001258039.1.
NP_005832.1. NM_005841.2.
NP_955359.1. NM_199327.2.
XP_005262743.1. XM_005262686.1.
UniGeneiHs.744854.

Genome annotation databases

EnsembliENST00000339241; ENSP00000343785; ENSG00000164056.
ENST00000394339; ENSP00000377871; ENSG00000164056.
ENST00000610581; ENSP00000481675; ENSG00000164056.
ENST00000622283; ENSP00000480540; ENSG00000164056.
GeneIDi10252.
KEGGihsa:10252.
UCSCiuc003ifa.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY192146 mRNA. Translation: AAP20102.1.
CH471056 Genomic DNA. Translation: EAX05209.1.
CH471056 Genomic DNA. Translation: EAX05210.1.
CH471056 Genomic DNA. Translation: EAX05211.1.
BC063856 mRNA. Translation: AAH63856.1.
AY590694 mRNA. Translation: AAT06102.1.
AF041037 mRNA. Translation: AAC39566.1.
CCDSiCCDS3731.1.
RefSeqiNP_001244967.1. NM_001258038.1.
NP_001244968.1. NM_001258039.1.
NP_005832.1. NM_005841.2.
NP_955359.1. NM_199327.2.
XP_005262743.1. XM_005262686.1.
UniGeneiHs.744854.

3D structure databases

ProteinModelPortaliO43609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115546. 38 interactions.
IntActiO43609. 11 interactions.
MINTiMINT-6169704.
STRINGi9606.ENSP00000343785.

PTM databases

PhosphoSiteiO43609.

Proteomic databases

MaxQBiO43609.
PaxDbiO43609.
PRIDEiO43609.

Protocols and materials databases

DNASUi10252.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339241; ENSP00000343785; ENSG00000164056.
ENST00000394339; ENSP00000377871; ENSG00000164056.
ENST00000610581; ENSP00000481675; ENSG00000164056.
ENST00000622283; ENSP00000480540; ENSG00000164056.
GeneIDi10252.
KEGGihsa:10252.
UCSCiuc003ifa.4. human.

Organism-specific databases

CTDi10252.
GeneCardsiGC04P124317.
HGNCiHGNC:11269. SPRY1.
HPAiCAB013538.
HPA051369.
MIMi602465. gene.
neXtProtiNX_O43609.
PharmGKBiPA36098.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG83905.
GeneTreeiENSGT00390000003535.
HOGENOMiHOG000233079.
HOVERGENiHBG003544.
InParanoidiO43609.
KOiK04704.
OMAiCGECTAP.
PhylomeDBiO43609.
TreeFamiTF325070.

Enzyme and pathway databases

ReactomeiREACT_12484. EGFR downregulation.

Miscellaneous databases

ChiTaRSiSPRY1. human.
GeneWikiiSPRY1.
GenomeRNAii10252.
NextBioi38846.
PROiO43609.
SOURCEiSearch...

Gene expression databases

BgeeiO43609.
CleanExiHS_SPRY1.
ExpressionAtlasiO43609. baseline and differential.
GenevestigatoriO43609.

Family and domain databases

InterProiIPR007875. Sprouty.
[Graphical view]
PfamiPF05210. Sprouty. 1 hit.
[Graphical view]
PROSITEiPS51227. SPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and expression analysis of a novel splice variant of human Sprouty1 gene."
    Wang L., Ji C., Wu H., Xu J., Wu Q., Dai J., Yin G., Ye X., Gu S., Xie Y., Mao Y.
    Int. J. Mol. Med. 12:783-787(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PNS.
  4. Raya A., de la Luna S.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-319.
  5. "Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways."
    Hacohen N., Kramer S., Sutherland D., Hiromi Y., Krasnow M.A.
    Cell 92:253-263(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-319.
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPY1_HUMAN
AccessioniPrimary (citable) accession number: O43609
Secondary accession number(s): D3DNX6, Q6PNE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 10, 2004
Last modified: March 4, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.