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O43609 (SPY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein sprouty homolog 1

Short name=Spry-1
Gene names
Name:SPRY1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Subcellular location

Cytoplasm. Membrane; Peripheral membrane protein. Note: Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

Induction

By FGF signaling.

Domain

The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.

Sequence similarities

Belongs to the sprouty family.

Contains 1 SPR (sprouty) domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   Molecular functionDevelopmental protein
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processepidermal growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

metanephros development

Inferred from electronic annotation. Source: Ensembl

negative regulation of ERK1 and ERK2 cascade

Inferred from electronic annotation. Source: Ensembl

negative regulation of MAP kinase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of Ras GTPase activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of Ras protein signal transduction

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of epidermal growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

negative regulation of fibroblast growth factor receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of neurotrophin TRK receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

organ induction

Inferred from electronic annotation. Source: Ensembl

ureteric bud development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Hoxa1P090223EBI-3866665,EBI-3957603From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Protein sprouty homolog 1
PRO_0000076898

Regions

Domain183 – 295113SPR
Compositional bias181 – 310130Cys-rich

Amino acid modifications

Modified residue11N-acetylmethionine Ref.6

Sequences

Sequence LengthMass (Da)Tools
O43609 [UniParc].

Last modified May 10, 2004. Version 2.
Checksum: 40E2D4D12816E057

FASTA31935,122
        10         20         30         40         50         60 
MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS NEYTEGPSVV 

        70         80         90        100        110        120 
KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA VLPSNARGPI LSRSTSTGSA 

       130        140        150        160        170        180 
ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI 

       190        200        210        220        230        240 
CEQCGKCKCG ECTAPRTLPS CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS 

       250        260        270        280        290        300 
YSDNPCSCSQ SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS 

       310 
NTVYCKLESC PSRGQGKPS 

« Hide

References

« Hide 'large scale' references
[1]"Identification and expression analysis of a novel splice variant of human Sprouty1 gene."
Wang L., Ji C., Wu H., Xu J., Wu Q., Dai J., Yin G., Ye X., Gu S., Xie Y., Mao Y.
Int. J. Mol. Med. 12:783-787(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: PNS.
[4]Raya A., de la Luna S.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-319.
[5]"Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways."
Hacohen N., Kramer S., Sutherland D., Hiromi Y., Krasnow M.A.
Cell 92:253-263(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-319.
[6]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY192146 mRNA. Translation: AAP20102.1.
CH471056 Genomic DNA. Translation: EAX05209.1.
CH471056 Genomic DNA. Translation: EAX05210.1.
CH471056 Genomic DNA. Translation: EAX05211.1.
BC063856 mRNA. Translation: AAH63856.1.
AY590694 mRNA. Translation: AAT06102.1.
AF041037 mRNA. Translation: AAC39566.1.
RefSeqNP_001244967.1. NM_001258038.1.
NP_001244968.1. NM_001258039.1.
NP_005832.1. NM_005841.2.
NP_955359.1. NM_199327.2.
XP_005262743.1. XM_005262686.1.
UniGeneHs.744854.

3D structure databases

ProteinModelPortalO43609.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115546. 21 interactions.
IntActO43609. 11 interactions.
MINTMINT-6169704.
STRING9606.ENSP00000343785.

PTM databases

PhosphoSiteO43609.

Proteomic databases

PaxDbO43609.
PRIDEO43609.

Protocols and materials databases

DNASU10252.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339241; ENSP00000343785; ENSG00000164056.
ENST00000394339; ENSP00000377871; ENSG00000164056.
GeneID10252.
KEGGhsa:10252.
UCSCuc003ifa.4. human.

Organism-specific databases

CTD10252.
GeneCardsGC04P124317.
HGNCHGNC:11269. SPRY1.
HPACAB013538.
MIM602465. gene.
neXtProtNX_O43609.
PharmGKBPA36098.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG83905.
HOGENOMHOG000233079.
HOVERGENHBG003544.
InParanoidO43609.
KOK04704.
OMAQHKFICE.
PhylomeDBO43609.
TreeFamTF325070.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.

Gene expression databases

ArrayExpressO43609.
BgeeO43609.
CleanExHS_SPRY1.
GenevestigatorO43609.

Family and domain databases

InterProIPR007875. Sprouty.
[Graphical view]
PfamPF05210. Sprouty. 1 hit.
[Graphical view]
PROSITEPS51227. SPR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSPRY1.
GenomeRNAi10252.
NextBio38846.
PROO43609.
SOURCESearch...

Entry information

Entry nameSPY1_HUMAN
AccessionPrimary (citable) accession number: O43609
Secondary accession number(s): D3DNX6, Q6PNE0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 10, 2004
Last modified: March 19, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM