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O43603 (GALR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galanin receptor type 2

Short name=GAL2-R
Short name=GALR-2
Gene names
Name:GALR2
Synonyms:GALNR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenylate cyclase-modulating G-protein coupled receptor signaling pathway

Traceable author statement Ref.3. Source: ProtInc

cell surface receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

digestion

Traceable author statement Ref.4. Source: ProtInc

feeding behavior

Traceable author statement Ref.1. Source: ProtInc

learning or memory

Traceable author statement Ref.1. Source: ProtInc

multicellular organismal development

Traceable author statement Ref.1. Source: ProtInc

muscle contraction

Traceable author statement Ref.1. Source: ProtInc

negative regulation of adenylate cyclase activity

Inferred from electronic annotation. Source: InterPro

neuron projection development

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Traceable author statement Ref.1. Source: GOC

positive regulation of cytosolic calcium ion concentration

Traceable author statement Ref.3. Source: ProtInc

positive regulation of large conductance calcium-activated potassium channel activity

Inferred from mutant phenotype PubMed 24602615. Source: UniProt

synaptic transmission

Traceable author statement Ref.4. Source: ProtInc

   Cellular_componentintegral component of membrane

Traceable author statement Ref.1. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functiongalanin receptor activity

Traceable author statement Ref.1. Source: ProtInc

protein binding

Inferred from physical interaction PubMed 23597562. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GALP224662EBI-6624855,EBI-6624800

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Galanin receptor type 2
PRO_0000069466

Regions

Topological domain1 – 2828Extracellular Potential
Transmembrane29 – 4921Helical; Name=1; Potential
Topological domain50 – 6011Cytoplasmic Potential
Transmembrane61 – 8121Helical; Name=2; Potential
Topological domain82 – 9918Extracellular Potential
Transmembrane100 – 12122Helical; Name=3; Potential
Topological domain122 – 14120Cytoplasmic Potential
Transmembrane142 – 16221Helical; Name=4; Potential
Topological domain163 – 18725Extracellular Potential
Transmembrane188 – 20821Helical; Name=5; Potential
Topological domain209 – 23729Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 2602Extracellular Potential
Transmembrane261 – 28121Helical; Name=7; Potential
Topological domain282 – 387106Cytoplasmic Potential

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation111N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 175 By similarity

Sequences

Sequence LengthMass (Da)Tools
O43603 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: C2D2FCB93E53C47E

FASTA38741,700
        10         20         30         40         50         60 
MNVSGCPGAG NASQAGGGGG WHPEAVIVPL LFALIFLVGT VGNTLVLAVL LRGGQAVSTT 

        70         80         90        100        110        120 
NLFILNLGVA DLCFILCCVP FQATIYTLDG WVFGSLLCKA VHFLIFLTMH ASSFTLAAVS 

       130        140        150        160        170        180 
LDRYLAIRYP LHSRELRTPR NALAAIGLIW GLSLLFSGPY LSYYRQSQLA NLTVCHPAWS 

       190        200        210        220        230        240 
APRRRAMDIC TFVFSYLLPV LVLGLTYART LRYLWRAVDP VAAGSGARRA KRKVTRMILI 

       250        260        270        280        290        300 
VAALFCLCWM PHHALILCVW FGQFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR 

       310        320        330        340        350        360 
KGFRTICAGL LGRAPGRASG RVCAAARGTH SGSVLERESS DLLHMSEAAG ALRPCPGASQ 

       370        380 
PCILEPCPGP SWQGPKAGDS ILTVDVA 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression of the human galanin receptor GalR2."
Bloomquist B.T., Beauchamp M.R., Zhelnin L., Brown S.-E., Gore-Willse A.R., Gregor P., Cornfield L.J.
Biochem. Biophys. Res. Commun. 243:474-479(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning and characterization of the human galanin GALR2 receptor."
Borowsky B., Walker M.W., Huang L.-Y., Jones K.A., Smith K.E., Bard J., Branchek T.A., Gerald C.
Peptides 19:1771-1781(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor."
Fathi Z., Battaglino P.M., Iben L.G., Li H., Baker E., Zhang D., McGovern R., Mahle C.D., Sutherland G.R., Iismaa T.P., Dickinson K.E.J., Zimanyi I.A.
Brain Res. Mol. Brain Res. 58:156-169(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3."
Kolakowski L.F. Jr., O'Neill G.P., Howard A.D., Broussard S.R., Sullivan K.A., Feighner S.D., Sawzdargo M., Nguyen T., Kargman S., Shiao L.-L., Hreniuk D.L., Tan C.P., Evans J., Abramovitz M., Chateauneuf A., Coulombe N., Ng G., Johnson M.P. expand/collapse author list , Tharian A., Khoshbouei H., George S.R., Smith R.G., O'Dowd B.F.
J. Neurochem. 71:2239-2251(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]Martin A.L., Kaighin V.A., Aronstam R.S.
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hippocampus.
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF040630 mRNA. Translation: AAC39634.1.
AF080586 mRNA. Translation: AAD08671.1.
AF058762 Genomic DNA. Translation: AAC18118.1.
AF042782 Genomic DNA. Translation: AAC36587.1.
EF577401 mRNA. Translation: ABQ52421.1.
CH471099 Genomic DNA. Translation: EAW89364.1.
BC069130 mRNA. Translation: AAH69130.1.
BC074914 mRNA. Translation: AAH74914.1.
BC074915 mRNA. Translation: AAH74915.1.
BC109051 mRNA. Translation: AAI09052.1.
BC109052 mRNA. Translation: AAI09053.1.
CCDSCCDS11739.1.
PIRJC5949.
RefSeqNP_003848.1. NM_003857.3.
UniGeneHs.666366.

3D structure databases

ProteinModelPortalO43603.
SMRO43603. Positions 25-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO43603. 1 interaction.
STRING9606.ENSP00000329684.

Chemistry

BindingDBO43603.
ChEMBLCHEMBL3176.
GuidetoPHARMACOLOGY244.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO43603.

Proteomic databases

PaxDbO43603.
PRIDEO43603.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329003; ENSP00000329684; ENSG00000182687.
GeneID8811.
KEGGhsa:8811.
UCSCuc002jqm.1. human.

Organism-specific databases

CTD8811.
GeneCardsGC17P074070.
HGNCHGNC:4133. GALR2.
HPAHPA044513.
MIM603691. gene.
neXtProtNX_O43603.
PharmGKBPA28546.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG320953.
HOGENOMHOG000230487.
HOVERGENHBG101447.
InParanoidO43603.
KOK04231.
OMAFRKICAG.
OrthoDBEOG7327PK.
PhylomeDBO43603.
TreeFamTF315737.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeO43603.
CleanExHS_GALR2.
GenevestigatorO43603.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGalanin_receptor_2.
GenomeRNAi8811.
NextBio33048.
PROO43603.
SOURCESearch...

Entry information

Entry nameGALR2_HUMAN
AccessionPrimary (citable) accession number: O43603
Secondary accession number(s): A5JUU4, Q32MN8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries