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Protein

Galanin receptor type 2

Gene

GALR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).6 Publications

GO - Molecular functioni

  • galanin receptor activity Source: UniProtKB
  • neuropeptide binding Source: Ensembl
  • peptide hormone binding Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • chemical synaptic transmission Source: ProtInc
  • digestion Source: ProtInc
  • feeding behavior Source: ProtInc
  • inositol phosphate metabolic process Source: Ensembl
  • learning or memory Source: ProtInc
  • multicellular organism development Source: ProtInc
  • muscle contraction Source: ProtInc
  • negative regulation of adenylate cyclase activity Source: InterPro
  • neuron projection development Source: Ensembl
  • phosphatidylinositol metabolic process Source: Ensembl
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc
  • positive regulation of large conductance calcium-activated potassium channel activity Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-33326-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiO43603.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 2
Short name:
GAL2-R
Short name:
GALR-2
Gene namesi
Name:GALR2
Synonyms:GALNR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:4133. GALR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 60CytoplasmicSequence analysisAdd BLAST11
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 99ExtracellularSequence analysisAdd BLAST18
Transmembranei100 – 121Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini122 – 141CytoplasmicSequence analysisAdd BLAST20
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 187ExtracellularSequence analysisAdd BLAST25
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 237CytoplasmicSequence analysisAdd BLAST29
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 260ExtracellularSequence analysis2
Transmembranei261 – 281Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini282 – 387CytoplasmicSequence analysisAdd BLAST106

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8811.
OpenTargetsiENSG00000182687.
PharmGKBiPA28546.

Chemistry databases

ChEMBLiCHEMBL3176.
GuidetoPHARMACOLOGYi244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694661 – 387Galanin receptor type 2Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43603.
PeptideAtlasiO43603.
PRIDEiO43603.

PTM databases

iPTMnetiO43603.
PhosphoSitePlusiO43603.

Expressioni

Tissue specificityi

Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.

Gene expression databases

BgeeiENSG00000182687.
CleanExiHS_GALR2.
GenevisibleiO43603. HS.

Organism-specific databases

HPAiHPA044513.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GALP224662EBI-6624855,EBI-6624800

Protein-protein interaction databases

IntActiO43603. 2 interactors.
STRINGi9606.ENSP00000329684.

Chemistry databases

BindingDBiO43603.

Structurei

3D structure databases

ProteinModelPortaliO43603.
SMRiO43603.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiO43603.
KOiK04231.
OMAiFRKICAG.
OrthoDBiEOG091G0ZDG.
PhylomeDBiO43603.
TreeFamiTF315737.

Family and domain databases

InterProiIPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVSGCPGAG NASQAGGGGG WHPEAVIVPL LFALIFLVGT VGNTLVLAVL
60 70 80 90 100
LRGGQAVSTT NLFILNLGVA DLCFILCCVP FQATIYTLDG WVFGSLLCKA
110 120 130 140 150
VHFLIFLTMH ASSFTLAAVS LDRYLAIRYP LHSRELRTPR NALAAIGLIW
160 170 180 190 200
GLSLLFSGPY LSYYRQSQLA NLTVCHPAWS APRRRAMDIC TFVFSYLLPV
210 220 230 240 250
LVLGLTYART LRYLWRAVDP VAAGSGARRA KRKVTRMILI VAALFCLCWM
260 270 280 290 300
PHHALILCVW FGQFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR
310 320 330 340 350
KGFRTICAGL LGRAPGRASG RVCAAARGTH SGSVLERESS DLLHMSEAAG
360 370 380
ALRPCPGASQ PCILEPCPGP SWQGPKAGDS ILTVDVA
Length:387
Mass (Da):41,700
Last modified:June 1, 1998 - v1
Checksum:iC2D2FCB93E53C47E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040630 mRNA. Translation: AAC39634.1.
AF080586 mRNA. Translation: AAD08671.1.
AF058762 Genomic DNA. Translation: AAC18118.1.
AF042782 Genomic DNA. Translation: AAC36587.1.
EF577401 mRNA. Translation: ABQ52421.1.
CH471099 Genomic DNA. Translation: EAW89364.1.
BC069130 mRNA. Translation: AAH69130.1.
BC074914 mRNA. Translation: AAH74914.1.
BC074915 mRNA. Translation: AAH74915.1.
BC109051 mRNA. Translation: AAI09052.1.
BC109052 mRNA. Translation: AAI09053.1.
CCDSiCCDS11739.1.
PIRiJC5949.
RefSeqiNP_003848.1. NM_003857.3.
UniGeneiHs.666366.

Genome annotation databases

EnsembliENST00000329003; ENSP00000329684; ENSG00000182687.
GeneIDi8811.
KEGGihsa:8811.
UCSCiuc002jqm.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040630 mRNA. Translation: AAC39634.1.
AF080586 mRNA. Translation: AAD08671.1.
AF058762 Genomic DNA. Translation: AAC18118.1.
AF042782 Genomic DNA. Translation: AAC36587.1.
EF577401 mRNA. Translation: ABQ52421.1.
CH471099 Genomic DNA. Translation: EAW89364.1.
BC069130 mRNA. Translation: AAH69130.1.
BC074914 mRNA. Translation: AAH74914.1.
BC074915 mRNA. Translation: AAH74915.1.
BC109051 mRNA. Translation: AAI09052.1.
BC109052 mRNA. Translation: AAI09053.1.
CCDSiCCDS11739.1.
PIRiJC5949.
RefSeqiNP_003848.1. NM_003857.3.
UniGeneiHs.666366.

3D structure databases

ProteinModelPortaliO43603.
SMRiO43603.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO43603. 2 interactors.
STRINGi9606.ENSP00000329684.

Chemistry databases

BindingDBiO43603.
ChEMBLiCHEMBL3176.
GuidetoPHARMACOLOGYi244.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO43603.
PhosphoSitePlusiO43603.

Proteomic databases

PaxDbiO43603.
PeptideAtlasiO43603.
PRIDEiO43603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329003; ENSP00000329684; ENSG00000182687.
GeneIDi8811.
KEGGihsa:8811.
UCSCiuc002jqm.3. human.

Organism-specific databases

CTDi8811.
DisGeNETi8811.
GeneCardsiGALR2.
HGNCiHGNC:4133. GALR2.
HPAiHPA044513.
MIMi603691. gene.
neXtProtiNX_O43603.
OpenTargetsiENSG00000182687.
PharmGKBiPA28546.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiO43603.
KOiK04231.
OMAiFRKICAG.
OrthoDBiEOG091G0ZDG.
PhylomeDBiO43603.
TreeFamiTF315737.

Enzyme and pathway databases

BioCyciZFISH:G66-33326-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiO43603.

Miscellaneous databases

GeneWikiiGalanin_receptor_2.
GenomeRNAii8811.
PROiO43603.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182687.
CleanExiHS_GALR2.
GenevisibleiO43603. HS.

Family and domain databases

InterProiIPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGALR2_HUMAN
AccessioniPrimary (citable) accession number: O43603
Secondary accession number(s): A5JUU4, Q32MN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.