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O43603

- GALR2_HUMAN

UniProt

O43603 - GALR2_HUMAN

Protein

Galanin receptor type 2

Gene

GALR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Jun 1998)
      Previous versions | rss
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    Functioni

    Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).1 Publication

    GO - Molecular functioni

    1. galanin receptor activity Source: UniProtKB
    2. peptide hormone binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
    2. cell surface receptor signaling pathway Source: ProtInc
    3. digestion Source: ProtInc
    4. feeding behavior Source: ProtInc
    5. learning or memory Source: ProtInc
    6. multicellular organismal development Source: ProtInc
    7. muscle contraction Source: ProtInc
    8. negative regulation of adenylate cyclase activity Source: InterPro
    9. neuron projection development Source: Ensembl
    10. neuropeptide signaling pathway Source: GOC
    11. positive regulation of cytosolic calcium ion concentration Source: ProtInc
    12. positive regulation of large conductance calcium-activated potassium channel activity Source: UniProt
    13. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    14. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galanin receptor type 2
    Short name:
    GAL2-R
    Short name:
    GALR-2
    Gene namesi
    Name:GALR2
    Synonyms:GALNR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:4133. GALR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28546.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 387387Galanin receptor type 2PRO_0000069466Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 175PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO43603.
    PRIDEiO43603.

    PTM databases

    PhosphoSiteiO43603.

    Expressioni

    Tissue specificityi

    Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.

    Gene expression databases

    BgeeiO43603.
    CleanExiHS_GALR2.
    GenevestigatoriO43603.

    Organism-specific databases

    HPAiHPA044513.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GALP224662EBI-6624855,EBI-6624800

    Protein-protein interaction databases

    IntActiO43603. 1 interaction.
    STRINGi9606.ENSP00000329684.

    Structurei

    3D structure databases

    ProteinModelPortaliO43603.
    SMRiO43603. Positions 25-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 6011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini82 – 9918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 18725ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 23729CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 2602ExtracellularSequence Analysis
    Topological domaini282 – 387106CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei261 – 28121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320953.
    HOGENOMiHOG000230487.
    HOVERGENiHBG101447.
    InParanoidiO43603.
    KOiK04231.
    OMAiFRKICAG.
    OrthoDBiEOG7327PK.
    PhylomeDBiO43603.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR003907. GAL2_rcpt.
    IPR000405. Galanin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01419. GALANIN2R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O43603-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVSGCPGAG NASQAGGGGG WHPEAVIVPL LFALIFLVGT VGNTLVLAVL    50
    LRGGQAVSTT NLFILNLGVA DLCFILCCVP FQATIYTLDG WVFGSLLCKA 100
    VHFLIFLTMH ASSFTLAAVS LDRYLAIRYP LHSRELRTPR NALAAIGLIW 150
    GLSLLFSGPY LSYYRQSQLA NLTVCHPAWS APRRRAMDIC TFVFSYLLPV 200
    LVLGLTYART LRYLWRAVDP VAAGSGARRA KRKVTRMILI VAALFCLCWM 250
    PHHALILCVW FGQFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR 300
    KGFRTICAGL LGRAPGRASG RVCAAARGTH SGSVLERESS DLLHMSEAAG 350
    ALRPCPGASQ PCILEPCPGP SWQGPKAGDS ILTVDVA 387
    Length:387
    Mass (Da):41,700
    Last modified:June 1, 1998 - v1
    Checksum:iC2D2FCB93E53C47E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF040630 mRNA. Translation: AAC39634.1.
    AF080586 mRNA. Translation: AAD08671.1.
    AF058762 Genomic DNA. Translation: AAC18118.1.
    AF042782 Genomic DNA. Translation: AAC36587.1.
    EF577401 mRNA. Translation: ABQ52421.1.
    CH471099 Genomic DNA. Translation: EAW89364.1.
    BC069130 mRNA. Translation: AAH69130.1.
    BC074914 mRNA. Translation: AAH74914.1.
    BC074915 mRNA. Translation: AAH74915.1.
    BC109051 mRNA. Translation: AAI09052.1.
    BC109052 mRNA. Translation: AAI09053.1.
    CCDSiCCDS11739.1.
    PIRiJC5949.
    RefSeqiNP_003848.1. NM_003857.3.
    UniGeneiHs.666366.

    Genome annotation databases

    EnsembliENST00000329003; ENSP00000329684; ENSG00000182687.
    GeneIDi8811.
    KEGGihsa:8811.
    UCSCiuc002jqm.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF040630 mRNA. Translation: AAC39634.1 .
    AF080586 mRNA. Translation: AAD08671.1 .
    AF058762 Genomic DNA. Translation: AAC18118.1 .
    AF042782 Genomic DNA. Translation: AAC36587.1 .
    EF577401 mRNA. Translation: ABQ52421.1 .
    CH471099 Genomic DNA. Translation: EAW89364.1 .
    BC069130 mRNA. Translation: AAH69130.1 .
    BC074914 mRNA. Translation: AAH74914.1 .
    BC074915 mRNA. Translation: AAH74915.1 .
    BC109051 mRNA. Translation: AAI09052.1 .
    BC109052 mRNA. Translation: AAI09053.1 .
    CCDSi CCDS11739.1.
    PIRi JC5949.
    RefSeqi NP_003848.1. NM_003857.3.
    UniGenei Hs.666366.

    3D structure databases

    ProteinModelPortali O43603.
    SMRi O43603. Positions 25-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O43603. 1 interaction.
    STRINGi 9606.ENSP00000329684.

    Chemistry

    BindingDBi O43603.
    ChEMBLi CHEMBL3176.
    GuidetoPHARMACOLOGYi 244.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O43603.

    Proteomic databases

    PaxDbi O43603.
    PRIDEi O43603.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329003 ; ENSP00000329684 ; ENSG00000182687 .
    GeneIDi 8811.
    KEGGi hsa:8811.
    UCSCi uc002jqm.1. human.

    Organism-specific databases

    CTDi 8811.
    GeneCardsi GC17P074070.
    HGNCi HGNC:4133. GALR2.
    HPAi HPA044513.
    MIMi 603691. gene.
    neXtProti NX_O43603.
    PharmGKBi PA28546.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG320953.
    HOGENOMi HOG000230487.
    HOVERGENi HBG101447.
    InParanoidi O43603.
    KOi K04231.
    OMAi FRKICAG.
    OrthoDBi EOG7327PK.
    PhylomeDBi O43603.
    TreeFami TF315737.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Galanin_receptor_2.
    GenomeRNAii 8811.
    NextBioi 33048.
    PROi O43603.
    SOURCEi Search...

    Gene expression databases

    Bgeei O43603.
    CleanExi HS_GALR2.
    Genevestigatori O43603.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR003907. GAL2_rcpt.
    IPR000405. Galanin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01419. GALANIN2R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and characterization of the human galanin GALR2 receptor."
      Borowsky B., Walker M.W., Huang L.-Y., Jones K.A., Smith K.E., Bard J., Branchek T.A., Gerald C.
      Peptides 19:1771-1781(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor."
      Fathi Z., Battaglino P.M., Iben L.G., Li H., Baker E., Zhang D., McGovern R., Mahle C.D., Sutherland G.R., Iismaa T.P., Dickinson K.E.J., Zimanyi I.A.
      Brain Res. Mol. Brain Res. 58:156-169(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. Martin A.L., Kaighin V.A., Aronstam R.S.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hippocampus.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III."
      Kim D.K., Yun S., Son G.H., Hwang J.I., Park C.R., Kim J.I., Kim K., Vaudry H., Seong J.Y.
      Endocrinology 155:1864-1873(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION AS A RECEPTOR FOR SPEXIN-1, PHYLOGENY.

    Entry informationi

    Entry nameiGALR2_HUMAN
    AccessioniPrimary (citable) accession number: O43603
    Secondary accession number(s): A5JUU4, Q32MN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3