Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O43603

- GALR2_HUMAN

UniProt

O43603 - GALR2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Galanin receptor type 2

Gene

GALR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).1 Publication

GO - Molecular functioni

  1. galanin receptor activity Source: UniProtKB
  2. peptide hormone binding Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  2. cell surface receptor signaling pathway Source: ProtInc
  3. digestion Source: ProtInc
  4. feeding behavior Source: ProtInc
  5. learning or memory Source: ProtInc
  6. multicellular organismal development Source: ProtInc
  7. muscle contraction Source: ProtInc
  8. negative regulation of adenylate cyclase activity Source: InterPro
  9. neuron projection development Source: Ensembl
  10. neuropeptide signaling pathway Source: GOC
  11. positive regulation of cytosolic calcium ion concentration Source: ProtInc
  12. positive regulation of large conductance calcium-activated potassium channel activity Source: UniProt
  13. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  14. synaptic transmission Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 2
Short name:
GAL2-R
Short name:
GALR-2
Gene namesi
Name:GALR2
Synonyms:GALNR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:4133. GALR2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei29 – 4921Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 6011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini82 – 9918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12122Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14120CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 18725ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini209 – 23729CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 2602ExtracellularSequence Analysis
Transmembranei261 – 28121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini282 – 387106CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Galanin receptor type 2PRO_0000069466Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO43603.
PRIDEiO43603.

PTM databases

PhosphoSiteiO43603.

Expressioni

Tissue specificityi

Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.

Gene expression databases

BgeeiO43603.
CleanExiHS_GALR2.
GenevestigatoriO43603.

Organism-specific databases

HPAiHPA044513.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GALP224662EBI-6624855,EBI-6624800

Protein-protein interaction databases

IntActiO43603. 1 interaction.
STRINGi9606.ENSP00000329684.

Structurei

3D structure databases

ProteinModelPortaliO43603.
SMRiO43603. Positions 25-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320953.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiO43603.
KOiK04231.
OMAiFRKICAG.
OrthoDBiEOG7327PK.
PhylomeDBiO43603.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43603-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVSGCPGAG NASQAGGGGG WHPEAVIVPL LFALIFLVGT VGNTLVLAVL
60 70 80 90 100
LRGGQAVSTT NLFILNLGVA DLCFILCCVP FQATIYTLDG WVFGSLLCKA
110 120 130 140 150
VHFLIFLTMH ASSFTLAAVS LDRYLAIRYP LHSRELRTPR NALAAIGLIW
160 170 180 190 200
GLSLLFSGPY LSYYRQSQLA NLTVCHPAWS APRRRAMDIC TFVFSYLLPV
210 220 230 240 250
LVLGLTYART LRYLWRAVDP VAAGSGARRA KRKVTRMILI VAALFCLCWM
260 270 280 290 300
PHHALILCVW FGQFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR
310 320 330 340 350
KGFRTICAGL LGRAPGRASG RVCAAARGTH SGSVLERESS DLLHMSEAAG
360 370 380
ALRPCPGASQ PCILEPCPGP SWQGPKAGDS ILTVDVA
Length:387
Mass (Da):41,700
Last modified:June 1, 1998 - v1
Checksum:iC2D2FCB93E53C47E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040630 mRNA. Translation: AAC39634.1.
AF080586 mRNA. Translation: AAD08671.1.
AF058762 Genomic DNA. Translation: AAC18118.1.
AF042782 Genomic DNA. Translation: AAC36587.1.
EF577401 mRNA. Translation: ABQ52421.1.
CH471099 Genomic DNA. Translation: EAW89364.1.
BC069130 mRNA. Translation: AAH69130.1.
BC074914 mRNA. Translation: AAH74914.1.
BC074915 mRNA. Translation: AAH74915.1.
BC109051 mRNA. Translation: AAI09052.1.
BC109052 mRNA. Translation: AAI09053.1.
CCDSiCCDS11739.1.
PIRiJC5949.
RefSeqiNP_003848.1. NM_003857.3.
UniGeneiHs.666366.

Genome annotation databases

EnsembliENST00000329003; ENSP00000329684; ENSG00000182687.
GeneIDi8811.
KEGGihsa:8811.
UCSCiuc002jqm.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040630 mRNA. Translation: AAC39634.1 .
AF080586 mRNA. Translation: AAD08671.1 .
AF058762 Genomic DNA. Translation: AAC18118.1 .
AF042782 Genomic DNA. Translation: AAC36587.1 .
EF577401 mRNA. Translation: ABQ52421.1 .
CH471099 Genomic DNA. Translation: EAW89364.1 .
BC069130 mRNA. Translation: AAH69130.1 .
BC074914 mRNA. Translation: AAH74914.1 .
BC074915 mRNA. Translation: AAH74915.1 .
BC109051 mRNA. Translation: AAI09052.1 .
BC109052 mRNA. Translation: AAI09053.1 .
CCDSi CCDS11739.1.
PIRi JC5949.
RefSeqi NP_003848.1. NM_003857.3.
UniGenei Hs.666366.

3D structure databases

ProteinModelPortali O43603.
SMRi O43603. Positions 25-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O43603. 1 interaction.
STRINGi 9606.ENSP00000329684.

Chemistry

BindingDBi O43603.
ChEMBLi CHEMBL3176.
GuidetoPHARMACOLOGYi 244.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O43603.

Proteomic databases

PaxDbi O43603.
PRIDEi O43603.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329003 ; ENSP00000329684 ; ENSG00000182687 .
GeneIDi 8811.
KEGGi hsa:8811.
UCSCi uc002jqm.1. human.

Organism-specific databases

CTDi 8811.
GeneCardsi GC17P074070.
HGNCi HGNC:4133. GALR2.
HPAi HPA044513.
MIMi 603691. gene.
neXtProti NX_O43603.
PharmGKBi PA28546.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG320953.
GeneTreei ENSGT00760000118797.
HOGENOMi HOG000230487.
HOVERGENi HBG101447.
InParanoidi O43603.
KOi K04231.
OMAi FRKICAG.
OrthoDBi EOG7327PK.
PhylomeDBi O43603.
TreeFami TF315737.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Galanin_receptor_2.
GenomeRNAii 8811.
NextBioi 33048.
PROi O43603.
SOURCEi Search...

Gene expression databases

Bgeei O43603.
CleanExi HS_GALR2.
Genevestigatori O43603.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and characterization of the human galanin GALR2 receptor."
    Borowsky B., Walker M.W., Huang L.-Y., Jones K.A., Smith K.E., Bard J., Branchek T.A., Gerald C.
    Peptides 19:1771-1781(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor."
    Fathi Z., Battaglino P.M., Iben L.G., Li H., Baker E., Zhang D., McGovern R., Mahle C.D., Sutherland G.R., Iismaa T.P., Dickinson K.E.J., Zimanyi I.A.
    Brain Res. Mol. Brain Res. 58:156-169(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Martin A.L., Kaighin V.A., Aronstam R.S.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III."
    Kim D.K., Yun S., Son G.H., Hwang J.I., Park C.R., Kim J.I., Kim K., Vaudry H., Seong J.Y.
    Endocrinology 155:1864-1873(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS A RECEPTOR FOR SPEXIN-1, PHYLOGENY.

Entry informationi

Entry nameiGALR2_HUMAN
AccessioniPrimary (citable) accession number: O43603
Secondary accession number(s): A5JUU4, Q32MN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: June 1, 1998
Last modified: October 29, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3