Reviewed, UniProtKB/Swiss-Prot O43583 (DENR_HUMAN)

Names and origin

Protein names

Recommended name:
    Density-regulated protein
      Short name=DRP
Alternative name(s):
    Protein DRP1
    Smooth muscle cell-associated protein 3
      Short name=SMAP-3

Gene names

Name:	DENR
Synonyms:	DRP1
ORF Names:	H14

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with MCTS1. Ref.5
Tissue specificity	Expressed in a variety of tissues, with the highest amounts in skeletal and cardiac muscle.
Sequence similarities	Belongs to the DENR family. Contains 1 SUI1 domain.

Ontologies

Keywords
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	translational initiation Inferred from electronic annotation. Source: InterPro
Molecular function	translation initiation factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Density-regulated protein		PRO_0000130600
Regions
	Domain	115 – 182	68	SUI1
Amino acid modifications
	Modified residue	69	1	Phosphothreonine Ref.6
	Modified residue	73	1	Phosphoserine Ref.6 Ref.7
Experimental info
	Sequence conflict	49 – 50	2	DV → HE Ref.4

Sequences

	Sequence		Length	Mass (Da)
	O43583-1 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: 023F70E0C6C0B25D	FASTA	198	22,092
	10 20 30 40 50 60 MAADISESSG ADCKGDPRNS AKLDADYPLR VLYCGVCSLP TEYCEYMPDV AKCRQWLEKN 70 80 90 100 110 120 FPNEFAKLTV ENSPKQEAGI SEGQGTAGEE EEKKKQKRGG RGQIKQKKKT VPQKVTIAKI 130 140 150 160 170 180 PRAKKKYVTR VCGLATFEID LKEAQRFFAQ KFSCGASVTG EDEIIIQGDF TDDIIDVIQE 190 KWPEVDDDSI EDLGEVKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Drp, a novel protein expressed at high cell density but not during growth arrest." Deyo J.E., Chiao P.J., Tainsky M.A. DNA Cell Biol. 17:437-447(1998) [PubMed: 9628587] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning and characterization of human smooth muscle cell associated protein-3 (SMAP-3)." Nishimoto S., Toyoda H., Tawara J., Aoki T., Komurasaki T. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[4]	"Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells." Oh J.J., Grosshans D.R., Wong S.G., Slamon D.J. Nucleic Acids Res. 27:4008-4017(1999) [PubMed: 10497265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-198.
[5]	"MCT-1 protein interacts with the cap complex and modulates messenger RNA translational profiles." Reinert L.S., Shi B., Nandi S., Mazan-Mamczarz K., Vitolo M., Bachman K.E., He H., Gartenhaus R.B. Cancer Res. 66:8994-9001(2006) [PubMed: 16982740] [Abstract] Cited for: INTERACTION WITH MCTS1.
[6]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69 AND SER-73, MASS SPECTROMETRY.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73, MASS SPECTROMETRY.
[8]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF038554 mRNA. Translation: AAC02985.2. AB014731 mRNA. Translation: BAB20268.1. BC007860 mRNA. Translation: AAH07860.1. AF103800 mRNA. Translation: AAF02420.1.
IPI	IPI00306280.
RefSeq	NP_003668.2.
UniGene	Hs.22393
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O43583. 1 interaction.
PTM databases
PhosphoSite	O43583.
Proteomic databases
PRIDE	O43583.
Genome annotation databases
Ensembl	ENSG00000139726. Homo sapiens. [Contig view]
GeneID	8562.
KEGG	hsa:8562.
Organism-specific databases
GeneCards	GC12P121762.
H-InvDB	HIX0011097.
HGNC	HGNC:2769. DENR.
MIM	604550. gene.
PharmGKB	PA27252.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O43583.
HOVERGEN	O43583.
Gene expression databases
ArrayExpress	O43583.
Bgee	O43583.
CleanEx	HS_DENR.
GermOnline	ENSG00000139726. Homo sapiens.
Family and domain databases
InterPro	IPR005873. Drp1. IPR001950. TIF_SUI1. [Graphical view]
Pfam	PF01253. SUI1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01159. DRP1. 1 hit.
PROSITE	PS50296. SUI1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	32095.
SOURCE	Search...

Entry information

Entry name

DENR_HUMAN

Accession

Primary (citable) accession number: O43583
Secondary accession number(s): Q9H3U6, Q9UKZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	April 27, 2001
Last modified:	June 16, 2009
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)