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O43581

- SYT7_HUMAN

UniProt

O43581 - SYT7_HUMAN

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Protein

Synaptotagmin-7

Gene
SYT7, PCANAP7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis By similarity.

Cofactori

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi166 – 1661Calcium 1 By similarity
Metal bindingi166 – 1661Calcium 2 By similarity
Metal bindingi172 – 1721Calcium 1 By similarity
Metal bindingi225 – 2251Calcium 1 By similarity
Metal bindingi225 – 2251Calcium 2 By similarity
Metal bindingi227 – 2271Calcium 1 By similarity
Metal bindingi227 – 2271Calcium 2 By similarity
Metal bindingi227 – 2271Calcium 3 By similarity
Metal bindingi230 – 2301Calcium 3 By similarity
Metal bindingi233 – 2331Calcium 2 By similarity
Metal bindingi233 – 2331Calcium 3 By similarity

GO - Molecular functioni

  1. calcium ion binding Source: Ensembl
  2. transporter activity Source: InterPro

GO - Biological processi

  1. exocytosis Source: InterPro
  2. plasma membrane repair Source: Ensembl
  3. positive regulation of calcium ion-dependent exocytosis Source: Ensembl
  4. regulation of insulin secretion Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-7
Alternative name(s):
IPCA-7
Prostate cancer-associated protein 7
Synaptotagmin VII
Short name:
SytVII
Gene namesi
Name:SYT7
Synonyms:PCANAP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:11514. SYT7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616Vesicular Reviewed predictionAdd
BLAST
Transmembranei17 – 3721Helical; Reviewed predictionAdd
BLAST
Topological domaini38 – 403366Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dense core granule Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. lysosome Source: Ensembl
  5. plasma membrane Source: Ensembl
  6. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36295.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Synaptotagmin-7PRO_0000183957Add
BLAST

Proteomic databases

MaxQBiO43581.
PaxDbiO43581.
PRIDEiO43581.

PTM databases

PhosphoSiteiO43581.

Expressioni

Tissue specificityi

Expressed in a variety of adult and fetal tissues.

Gene expression databases

ArrayExpressiO43581.
BgeeiO43581.
CleanExiHS_SYT7.
GenevestigatoriO43581.

Organism-specific databases

HPAiHPA012869.

Interactioni

Subunit structurei

Interacts with SYNCRIP isoform 3 C-terminus By similarity.

Protein-protein interaction databases

BioGridi114525. 2 interactions.
STRINGi9606.ENSP00000263846.

Structurei

Secondary structure

1
403
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi138 – 1458
Beta strandi147 – 1493
Beta strandi152 – 16110
Beta strandi166 – 1694
Beta strandi173 – 1819
Beta strandi184 – 1885
Beta strandi202 – 2065
Helixi211 – 2144
Beta strandi217 – 2259
Beta strandi228 – 2314
Beta strandi233 – 2419
Turni242 – 2443
Beta strandi251 – 2555

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D8KNMR-A132-259[»]
ProteinModelPortaliO43581.
SMRiO43581. Positions 133-403.

Miscellaneous databases

EvolutionaryTraceiO43581.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 239103C2 1Add
BLAST
Domaini268 – 371104C2 2Add
BLAST

Domaini

The second C2 domain/C2B is responsible for SYNCRIP binding By similarity.

Sequence similaritiesi

Belongs to the synaptotagmin family.
Contains 2 C2 domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5038.
HOGENOMiHOG000232126.
HOVERGENiHBG005010.
InParanoidiO43581.
PhylomeDBiO43581.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR015427. Synaptotagmin7.
[Graphical view]
PANTHERiPTHR10024:SF97. PTHR10024:SF97. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43581-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK    50
NSLETVGTPD SGRGRSEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTEP 100
RSSVSDLVNS LTSEMLMLSP GSEEDEAHEG CSRENLGRIQ FSVGYNFQES 150
TLTVKIMKAQ ELPAKDFSGT SDPFVKIYLL PDKKHKLETK VKRKNLNPHW 200
NETFLFEGFP YEKVVQRILY LQVLDYDRFS RNDPIGEVSI PLNKVDLTQM 250
QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG 300
TSDPYVKVWL MYKDKRVEKK KTVTMKRNLN PIFNESFAFD IPTEKLRETT 350
IIITVMDKDK LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ 400
LKA 403
Length:403
Mass (Da):45,501
Last modified:September 23, 2008 - v3
Checksum:iC9BFB26D298EDBE4
GO
Isoform 2 (identifier: O43581-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-71: I → INGTLLSGAK...HLAAGKLNLS

Note: No experimental confirmation available.

Show »
Length:478
Mass (Da):52,821
Checksum:i6F6B1DD2C9AFF15F
GO

Sequence cautioni

The sequence AAB92667.1 differs from that shown. Reason: Frameshift at positions 6, 10 and 15.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti332 – 3321I → N.1 Publication
Corresponds to variant rs407740 [ dbSNP | Ensembl ].
VAR_052241

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei71 – 711I → INGTLLSGAKVAAAAGLAVE REGRLGEKPAPVPPPGEDAL RSGGAAPSEPGSGGKAGRGR WRTVQSHLAAGKLNLS in isoform 2. VSP_045991

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541V → L in AAB92667. 1 Publication
Sequence conflicti188 – 1881E → K in AAB92667. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038535 mRNA. Translation: AAB92667.1. Frameshift.
AP002754 Genomic DNA. No translation available.
AP003108 Genomic DNA. No translation available.
AP003559 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73956.1.
BC125170 mRNA. Translation: AAI25171.1.
BC125171 mRNA. No translation available.
CCDSiCCDS31577.1. [O43581-1]
CCDS58139.1. [O43581-2]
RefSeqiNP_001238994.1. NM_001252065.1. [O43581-2]
NP_004191.2. NM_004200.3. [O43581-1]
UniGeneiHs.131188.
Hs.684589.

Genome annotation databases

EnsembliENST00000263846; ENSP00000263846; ENSG00000011347. [O43581-1]
ENST00000540677; ENSP00000444201; ENSG00000011347. [O43581-2]
GeneIDi9066.
KEGGihsa:9066.
UCSCiuc001nrv.3. human. [O43581-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF038535 mRNA. Translation: AAB92667.1 . Frameshift.
AP002754 Genomic DNA. No translation available.
AP003108 Genomic DNA. No translation available.
AP003559 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73956.1 .
BC125170 mRNA. Translation: AAI25171.1 .
BC125171 mRNA. No translation available.
CCDSi CCDS31577.1. [O43581-1 ]
CCDS58139.1. [O43581-2 ]
RefSeqi NP_001238994.1. NM_001252065.1. [O43581-2 ]
NP_004191.2. NM_004200.3. [O43581-1 ]
UniGenei Hs.131188.
Hs.684589.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2D8K NMR - A 132-259 [» ]
ProteinModelPortali O43581.
SMRi O43581. Positions 133-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114525. 2 interactions.
STRINGi 9606.ENSP00000263846.

PTM databases

PhosphoSitei O43581.

Proteomic databases

MaxQBi O43581.
PaxDbi O43581.
PRIDEi O43581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263846 ; ENSP00000263846 ; ENSG00000011347 . [O43581-1 ]
ENST00000540677 ; ENSP00000444201 ; ENSG00000011347 . [O43581-2 ]
GeneIDi 9066.
KEGGi hsa:9066.
UCSCi uc001nrv.3. human. [O43581-1 ]

Organism-specific databases

CTDi 9066.
GeneCardsi GC11M061282.
H-InvDB HIX0009693.
HGNCi HGNC:11514. SYT7.
HPAi HPA012869.
MIMi 604146. gene.
neXtProti NX_O43581.
PharmGKBi PA36295.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5038.
HOGENOMi HOG000232126.
HOVERGENi HBG005010.
InParanoidi O43581.
PhylomeDBi O43581.
TreeFami TF315600.

Miscellaneous databases

ChiTaRSi SYT7. human.
EvolutionaryTracei O43581.
GeneWikii SYT7.
GenomeRNAii 9066.
NextBioi 33971.
PROi O43581.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43581.
Bgeei O43581.
CleanExi HS_SYT7.
Genevestigatori O43581.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR015427. Synaptotagmin7.
[Graphical view ]
PANTHERi PTHR10024:SF97. PTHR10024:SF97. 1 hit.
Pfami PF00168. C2. 2 hits.
[Graphical view ]
PRINTSi PR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTi SM00239. C2. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes."
    Cooper P.R., Nowak N.J., Higgins M.J., Church D.M., Shows T.B.
    Genomics 49:419-429(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASN-332.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  5. "Solution structure of the first C2 domain of synaptotagmin VII."
    RIKEN structural genomics initiative (RSGI)
    Submitted (JUN-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 132-259.

Entry informationi

Entry nameiSYT7_HUMAN
AccessioniPrimary (citable) accession number: O43581
Secondary accession number(s): F5GZU9, Q08AH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi