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O43581

- SYT7_HUMAN

UniProt

O43581 - SYT7_HUMAN

Protein

Synaptotagmin-7

Gene

SYT7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

    Cofactori

    Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi166 – 1661Calcium 1By similarity
    Metal bindingi166 – 1661Calcium 2By similarity
    Metal bindingi172 – 1721Calcium 1By similarity
    Metal bindingi225 – 2251Calcium 1By similarity
    Metal bindingi225 – 2251Calcium 2By similarity
    Metal bindingi227 – 2271Calcium 1By similarity
    Metal bindingi227 – 2271Calcium 2By similarity
    Metal bindingi227 – 2271Calcium 3By similarity
    Metal bindingi230 – 2301Calcium 3By similarity
    Metal bindingi233 – 2331Calcium 2By similarity
    Metal bindingi233 – 2331Calcium 3By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: Ensembl
    2. transporter activity Source: InterPro

    GO - Biological processi

    1. exocytosis Source: InterPro
    2. plasma membrane repair Source: Ensembl
    3. positive regulation of calcium ion-dependent exocytosis Source: Ensembl
    4. regulation of insulin secretion Source: Ensembl

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-7
    Alternative name(s):
    IPCA-7
    Prostate cancer-associated protein 7
    Synaptotagmin VII
    Short name:
    SytVII
    Gene namesi
    Name:SYT7
    Synonyms:PCANAP7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:11514. SYT7.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. dense core granule Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. lysosome Source: Ensembl
    5. plasma membrane Source: Ensembl
    6. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36295.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403Synaptotagmin-7PRO_0000183957Add
    BLAST

    Proteomic databases

    MaxQBiO43581.
    PaxDbiO43581.
    PRIDEiO43581.

    PTM databases

    PhosphoSiteiO43581.

    Expressioni

    Tissue specificityi

    Expressed in a variety of adult and fetal tissues.

    Gene expression databases

    ArrayExpressiO43581.
    BgeeiO43581.
    CleanExiHS_SYT7.
    GenevestigatoriO43581.

    Organism-specific databases

    HPAiHPA012869.

    Interactioni

    Subunit structurei

    Interacts with SYNCRIP isoform 3 C-terminus.By similarity

    Protein-protein interaction databases

    BioGridi114525. 2 interactions.
    STRINGi9606.ENSP00000263846.

    Structurei

    Secondary structure

    1
    403
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi138 – 1458
    Beta strandi147 – 1493
    Beta strandi152 – 16110
    Beta strandi166 – 1694
    Beta strandi173 – 1819
    Beta strandi184 – 1885
    Beta strandi202 – 2065
    Helixi211 – 2144
    Beta strandi217 – 2259
    Beta strandi228 – 2314
    Beta strandi233 – 2419
    Turni242 – 2443
    Beta strandi251 – 2555

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2D8KNMR-A132-259[»]
    ProteinModelPortaliO43581.
    SMRiO43581. Positions 133-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43581.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616VesicularSequence AnalysisAdd
    BLAST
    Topological domaini38 – 403366CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini137 – 239103C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini268 – 371104C2 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The second C2 domain/C2B is responsible for SYNCRIP binding.By similarity

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5038.
    HOGENOMiHOG000232126.
    HOVERGENiHBG005010.
    InParanoidiO43581.
    PhylomeDBiO43581.
    TreeFamiTF315600.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR015427. Synaptotagmin7.
    [Graphical view]
    PANTHERiPTHR10024:SF97. PTHR10024:SF97. 1 hit.
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    PRINTSiPR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTiSM00239. C2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43581-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK    50
    NSLETVGTPD SGRGRSEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTEP 100
    RSSVSDLVNS LTSEMLMLSP GSEEDEAHEG CSRENLGRIQ FSVGYNFQES 150
    TLTVKIMKAQ ELPAKDFSGT SDPFVKIYLL PDKKHKLETK VKRKNLNPHW 200
    NETFLFEGFP YEKVVQRILY LQVLDYDRFS RNDPIGEVSI PLNKVDLTQM 250
    QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG 300
    TSDPYVKVWL MYKDKRVEKK KTVTMKRNLN PIFNESFAFD IPTEKLRETT 350
    IIITVMDKDK LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ 400
    LKA 403
    Length:403
    Mass (Da):45,501
    Last modified:September 23, 2008 - v3
    Checksum:iC9BFB26D298EDBE4
    GO
    Isoform 2 (identifier: O43581-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         71-71: I → INGTLLSGAK...HLAAGKLNLS

    Note: No experimental confirmation available.

    Show »
    Length:478
    Mass (Da):52,821
    Checksum:i6F6B1DD2C9AFF15F
    GO

    Sequence cautioni

    The sequence AAB92667.1 differs from that shown. Reason: Frameshift at positions 6, 10 and 15.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541V → L in AAB92667. (PubMed:9615227)Curated
    Sequence conflicti188 – 1881E → K in AAB92667. (PubMed:9615227)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti332 – 3321I → N.1 Publication
    Corresponds to variant rs407740 [ dbSNP | Ensembl ].
    VAR_052241

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei71 – 711I → INGTLLSGAKVAAAAGLAVE REGRLGEKPAPVPPPGEDAL RSGGAAPSEPGSGGKAGRGR WRTVQSHLAAGKLNLS in isoform 2. 1 PublicationVSP_045991

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038535 mRNA. Translation: AAB92667.1. Frameshift.
    AP002754 Genomic DNA. No translation available.
    AP003108 Genomic DNA. No translation available.
    AP003559 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73956.1.
    BC125170 mRNA. Translation: AAI25171.1.
    BC125171 mRNA. No translation available.
    CCDSiCCDS31577.1. [O43581-1]
    CCDS58139.1. [O43581-2]
    RefSeqiNP_001238994.1. NM_001252065.1. [O43581-2]
    NP_004191.2. NM_004200.3. [O43581-1]
    UniGeneiHs.131188.
    Hs.684589.

    Genome annotation databases

    EnsembliENST00000263846; ENSP00000263846; ENSG00000011347. [O43581-1]
    ENST00000540677; ENSP00000444201; ENSG00000011347. [O43581-2]
    GeneIDi9066.
    KEGGihsa:9066.
    UCSCiuc001nrv.3. human. [O43581-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF038535 mRNA. Translation: AAB92667.1 . Frameshift.
    AP002754 Genomic DNA. No translation available.
    AP003108 Genomic DNA. No translation available.
    AP003559 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73956.1 .
    BC125170 mRNA. Translation: AAI25171.1 .
    BC125171 mRNA. No translation available.
    CCDSi CCDS31577.1. [O43581-1 ]
    CCDS58139.1. [O43581-2 ]
    RefSeqi NP_001238994.1. NM_001252065.1. [O43581-2 ]
    NP_004191.2. NM_004200.3. [O43581-1 ]
    UniGenei Hs.131188.
    Hs.684589.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2D8K NMR - A 132-259 [» ]
    ProteinModelPortali O43581.
    SMRi O43581. Positions 133-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114525. 2 interactions.
    STRINGi 9606.ENSP00000263846.

    PTM databases

    PhosphoSitei O43581.

    Proteomic databases

    MaxQBi O43581.
    PaxDbi O43581.
    PRIDEi O43581.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263846 ; ENSP00000263846 ; ENSG00000011347 . [O43581-1 ]
    ENST00000540677 ; ENSP00000444201 ; ENSG00000011347 . [O43581-2 ]
    GeneIDi 9066.
    KEGGi hsa:9066.
    UCSCi uc001nrv.3. human. [O43581-1 ]

    Organism-specific databases

    CTDi 9066.
    GeneCardsi GC11M061282.
    H-InvDB HIX0009693.
    HGNCi HGNC:11514. SYT7.
    HPAi HPA012869.
    MIMi 604146. gene.
    neXtProti NX_O43581.
    PharmGKBi PA36295.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5038.
    HOGENOMi HOG000232126.
    HOVERGENi HBG005010.
    InParanoidi O43581.
    PhylomeDBi O43581.
    TreeFami TF315600.

    Miscellaneous databases

    ChiTaRSi SYT7. human.
    EvolutionaryTracei O43581.
    GeneWikii SYT7.
    GenomeRNAii 9066.
    NextBioi 33971.
    PROi O43581.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43581.
    Bgeei O43581.
    CleanExi HS_SYT7.
    Genevestigatori O43581.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR015427. Synaptotagmin7.
    [Graphical view ]
    PANTHERi PTHR10024:SF97. PTHR10024:SF97. 1 hit.
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    PRINTSi PR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTi SM00239. C2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes."
      Cooper P.R., Nowak N.J., Higgins M.J., Church D.M., Shows T.B.
      Genomics 49:419-429(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASN-332.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    5. "Solution structure of the first C2 domain of synaptotagmin VII."
      RIKEN structural genomics initiative (RSGI)
      Submitted (JUN-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 132-259.

    Entry informationi

    Entry nameiSYT7_HUMAN
    AccessioniPrimary (citable) accession number: O43581
    Secondary accession number(s): F5GZU9, Q08AH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3