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O43581 (SYT7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptotagmin-7
Alternative name(s):
IPCA-7
Prostate cancer-associated protein 7
Synaptotagmin VII
Short name=SytVII
Gene names
Name:SYT7
Synonyms:PCANAP7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis By similarity.

Cofactor

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Subunit structure

Interacts with SYNCRIP isoform 3C-terminus By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Single-pass membrane protein By similarity.

Tissue specificity

Expressed in a variety of adult and fetal tissues.

Domain

The second C2 domain/C2B is responsible for SYNCRIP binding By similarity.

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Sequence caution

The sequence AAB92667.1 differs from that shown. Reason: Frameshift at positions 6, 10 and 15.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O43581-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O43581-2)

The sequence of this isoform differs from the canonical sequence as follows:
     71-71: I → INGTLLSGAK...HLAAGKLNLS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Synaptotagmin-7
PRO_0000183957

Regions

Topological domain1 – 1616Vesicular Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 403366Cytoplasmic Potential
Domain137 – 239103C2 1
Domain268 – 371104C2 2

Sites

Metal binding1661Calcium 1 By similarity
Metal binding1661Calcium 2 By similarity
Metal binding1721Calcium 1 By similarity
Metal binding2251Calcium 1 By similarity
Metal binding2251Calcium 2 By similarity
Metal binding2271Calcium 1 By similarity
Metal binding2271Calcium 2 By similarity
Metal binding2271Calcium 3 By similarity
Metal binding2301Calcium 3 By similarity
Metal binding2331Calcium 2 By similarity
Metal binding2331Calcium 3 By similarity

Natural variations

Alternative sequence711I → INGTLLSGAKVAAAAGLAVE REGRLGEKPAPVPPPGEDAL RSGGAAPSEPGSGGKAGRGR WRTVQSHLAAGKLNLS in isoform 2.
VSP_045991
Natural variant3321I → N. Ref.1
Corresponds to variant rs407740 [ dbSNP | Ensembl ].
VAR_052241

Experimental info

Sequence conflict1541V → L in AAB92667. Ref.1
Sequence conflict1881E → K in AAB92667. Ref.1

Secondary structure

.......................... 403
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 23, 2008. Version 3.
Checksum: C9BFB26D298EDBE4

FASTA40345,501
        10         20         30         40         50         60 
MYRDPEAASP GAPSRDVLLV SAIITVSLSV TVVLCGLCHW CQRKLGKRYK NSLETVGTPD 

        70         80         90        100        110        120 
SGRGRSEKKA IKLPAGGKAV NTAPVPGQTP HDESDRRTEP RSSVSDLVNS LTSEMLMLSP 

       130        140        150        160        170        180 
GSEEDEAHEG CSRENLGRIQ FSVGYNFQES TLTVKIMKAQ ELPAKDFSGT SDPFVKIYLL 

       190        200        210        220        230        240 
PDKKHKLETK VKRKNLNPHW NETFLFEGFP YEKVVQRILY LQVLDYDRFS RNDPIGEVSI 

       250        260        270        280        290        300 
PLNKVDLTQM QTFWKDLKPC SDGSGSRGEL LLSLCYNPSA NSIIVNIIKA RNLKAMDIGG 

       310        320        330        340        350        360 
TSDPYVKVWL MYKDKRVEKK KTVTMKRNLN PIFNESFAFD IPTEKLRETT IIITVMDKDK 

       370        380        390        400 
LSRNDVIGKI YLSWKSGPGE VKHWKDMIAR PRQPVAQWHQ LKA 

« Hide

Isoform 2 [UniParc].

Checksum: 6F6B1DD2C9AFF15F
Show »

FASTA47852,821

References

« Hide 'large scale' references
[1]"Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes."
Cooper P.R., Nowak N.J., Higgins M.J., Church D.M., Shows T.B.
Genomics 49:419-429(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASN-332.
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[5]"Solution structure of the first C2 domain of synaptotagmin VII."
RIKEN structural genomics initiative (RSGI)
Submitted (JUN-2006) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 132-259.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF038535 mRNA. Translation: AAB92667.1. Frameshift.
AP002754 Genomic DNA. No translation available.
AP003108 Genomic DNA. No translation available.
AP003559 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73956.1.
BC125170 mRNA. Translation: AAI25171.1.
BC125171 mRNA. No translation available.
RefSeqNP_001238994.1. NM_001252065.1.
NP_004191.2. NM_004200.3.
UniGeneHs.131188.
Hs.684589.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2D8KNMR-A132-259[»]
ProteinModelPortalO43581.
SMRO43581. Positions 133-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114525. 2 interactions.
STRING9606.ENSP00000263846.

PTM databases

PhosphoSiteO43581.

Proteomic databases

PaxDbO43581.
PRIDEO43581.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263846; ENSP00000263846; ENSG00000011347. [O43581-1]
ENST00000540677; ENSP00000444201; ENSG00000011347. [O43581-2]
GeneID9066.
KEGGhsa:9066.
UCSCuc001nrv.3. human. [O43581-1]

Organism-specific databases

CTD9066.
GeneCardsGC11M061282.
H-InvDBHIX0009693.
HGNCHGNC:11514. SYT7.
HPAHPA012869.
MIM604146. gene.
neXtProtNX_O43581.
PharmGKBPA36295.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5038.
HOGENOMHOG000232126.
HOVERGENHBG005010.
InParanoidO43581.
PhylomeDBO43581.
TreeFamTF315600.

Gene expression databases

ArrayExpressO43581.
BgeeO43581.
CleanExHS_SYT7.
GenevestigatorO43581.

Family and domain databases

Gene3D2.60.40.150. 2 hits.
InterProIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR015427. Synaptotagmin7.
[Graphical view]
PANTHERPTHR10024:SF29. PTHR10024:SF29. 1 hit.
PfamPF00168. C2. 2 hits.
[Graphical view]
PRINTSPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTSM00239. C2. 2 hits.
[Graphical view]
SUPFAMSSF49562. SSF49562. 2 hits.
PROSITEPS50004. C2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSYT7. human.
EvolutionaryTraceO43581.
GeneWikiSYT7.
GenomeRNAi9066.
NextBio33971.
PROO43581.
SOURCESearch...

Entry information

Entry nameSYT7_HUMAN
AccessionPrimary (citable) accession number: O43581
Secondary accession number(s): F5GZU9, Q08AH6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM