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Protein

A-kinase anchor protein 10, mitochondrial

Gene

AKAP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity).By similarity

GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB

GO - Biological processi

  • blood coagulation Source: Reactome
  • protein localization Source: GO_Central
  • signal transduction Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 10, mitochondrial
Short name:
AKAP-10
Alternative name(s):
Dual specificity A kinase-anchoring protein 2
Short name:
D-AKAP-2
Protein kinase A-anchoring protein 10
Short name:
PRKA10
Gene namesi
Name:AKAP10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108599.14
HGNCiHGNC:368 AKAP10
MIMi604694 gene
neXtProtiNX_O43572

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion

Pathology & Biotechi

Involvement in diseasei

Sudden cardiac death (SCD)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry. Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability.
Disease descriptionUnexpected rapid death due to cardiovascular collapse in a short time period, generally within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death.
See also OMIM:115080

Organism-specific databases

DisGeNETi11216
MalaCardsiAKAP10
MIMi115080 phenotype
OpenTargetsiENSG00000108599
PharmGKBiPA24662

Polymorphism and mutation databases

BioMutaiAKAP10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000003040429 – 662A-kinase anchor protein 10, mitochondrialAdd BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO43572
MaxQBiO43572
PaxDbiO43572
PeptideAtlasiO43572
PRIDEiO43572

PTM databases

iPTMnetiO43572
PhosphoSitePlusiO43572
SwissPalmiO43572

Expressioni

Gene expression databases

BgeeiENSG00000108599
CleanExiHS_AKAP10
ExpressionAtlasiO43572 baseline and differential
GenevisibleiO43572 HS

Organism-specific databases

HPAiHPA028901

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRKAR1AP005142EBI-752153,EBI-1041635From Bos taurus.

GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116385, 8 interactors
DIPiDIP-48753N
IntActiO43572, 3 interactors
MINTiO43572
STRINGi9606.ENSP00000225737

Structurei

Secondary structure

1662
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi629 – 653Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IM4X-ray2.28C623-662[»]
3TMHX-ray3.80D/H/L623-662[»]
ProteinModelPortaliO43572
SMRiO43572
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43572

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 369RGS 1PROSITE-ProRule annotationAdd BLAST245
Domaini379 – 505RGS 2PROSITE-ProRule annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni634 – 647PKA-RII subunit bindingAdd BLAST14

Domaini

RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG3590 Eukaryota
ENOG410YH1M LUCA
GeneTreeiENSGT00390000015077
HOGENOMiHOG000273900
HOVERGENiHBG050469
InParanoidiO43572
KOiK16526
OMAiEQDAVNT
OrthoDBiEOG091G0962
PhylomeDBiO43572
TreeFamiTF105409

Family and domain databases

CDDicd12804 AKAP10_AKB, 1 hit
InterProiView protein in InterPro
IPR037719 AKAP10_AKB_dom
IPR016137 RGS
IPR036305 RGS_sf
PfamiView protein in Pfam
PF00615 RGS, 2 hits
SMARTiView protein in SMART
SM00315 RGS, 2 hits
SUPFAMiSSF48097 SSF48097, 3 hits
PROSITEiView protein in PROSITE
PS50132 RGS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGAGPSPRQ SPRTLRPDPG PAMSFFRRKV KGKEQEKTSD VKSIKASISV
60 70 80 90 100
HSPQKSTKNH ALLEAAGPSH VAINAISANM DSFSSSRTAT LKKQPSHMEA
110 120 130 140 150
AHFGDLGRSC LDYQTQETKS SLSKTLEQVL HDTIVLPYFI QFMELRRMEH
160 170 180 190 200
LVKFWLEAES FHSTTWSRIR AHSLNTVKQS SLAEPVSPSK KHETTASFLT
210 220 230 240 250
DSLDKRLEDS GSAQLFMTHS EGIDLNNRTN STQNHLLLSQ ECDSAHSLRL
260 270 280 290 300
EMARAGTHQV SMETQESSST LTVASRNSPA SPLKELSGKL MKSIEQDAVN
310 320 330 340 350
TFTKYISPDA AKPIPITEAM RNDIIARICG EDGQVDPNCF VLAQSIVFSA
360 370 380 390 400
MEQEHFSEFL RSHHFCKYQI EVLTSGTVYL ADILFCESAL FYFSEYMEKE
410 420 430 440 450
DAVNILQFWL AADNFQSQLA AKKGQYDGQE AQNDAMILYD KYFSLQATHP
460 470 480 490 500
LGFDDVVRLE IESNICREGG PLPNCFTTPL RQAWTTMEKV FLPGFLSSNL
510 520 530 540 550
YYKYLNDLIH SVRGDEFLGG NVSLTAPGSV GPPDESHPGS SDSSASQSSV
560 570 580 590 600
KKASIKILKN FDEAIIVDAA SLDPESLYQR TYAGKMTFGR VSDLGQFIRE
610 620 630 640 650
SEPEPDVRKS KGSMFSQAMK KWVQGNTDEA QEELAWKIAK MIVSDIMQQA
660
QYDQPLEKST KL
Length:662
Mass (Da):73,818
Last modified:July 19, 2005 - v2
Checksum:iB7A6D92CA2D3D794
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177V → M in AAB92260 (Ref. 2) Curated1
Sequence conflicti524L → P in AAB92260 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024607249R → H. Corresponds to variant dbSNP:rs2108978Ensembl.1
Natural variantiVAR_024608646I → V Associated with increased basal heart rate and decreased heart rate variability. 1 PublicationCorresponds to variant dbSNP:rs203462Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037439 mRNA Translation: AAB92260.1
AK312438 mRNA Translation: BAG35347.1
CH471212 Genomic DNA Translation: EAW50913.1
BC017055 mRNA Translation: AAH17055.1
CCDSiCCDS11214.1
RefSeqiNP_009133.2, NM_007202.3
UniGeneiHs.642676

Genome annotation databases

EnsembliENST00000225737; ENSP00000225737; ENSG00000108599
GeneIDi11216
KEGGihsa:11216
UCSCiuc002gwo.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAKA10_HUMAN
AccessioniPrimary (citable) accession number: O43572
Secondary accession number(s): B2R650, Q96AJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health