Reviewed, UniProtKB/Swiss-Prot O43567 (RNF13_HUMAN)

Names and origin

Protein names

Recommended name:
    RING finger protein 13

Gene names

Name:	RNF13
Synonyms:	RZF

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 RING-type zinc finger.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	RING finger protein 13		PRO_0000056054
Regions
	Zinc finger	240 – 282	43	RING-type
Amino acid modifications
	Modified residue	292	1	Phosphoserine By similarity
	Modified residue	294	1	Phosphoserine By similarity
	Modified residue	296	1	Phosphothreonine By similarity
	Modified residue	298	1	Phosphoserine By similarity
	Modified residue	299	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O43567-1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 4600727D0F197653	FASTA	381	42,814
	10 20 30 40 50 60 MLLSIGMLML SATQVYTILT VQLFAFLNLL PVEADILAYN FENASQTFDD LPARFGYRLP 70 80 90 100 110 120 AEGLKGFLIN SKPENACEPI VPPPVKDNSS GTFIVLIRRL DCNFDIKVLN AQRAGYKAAI 130 140 150 160 170 180 VHNVDSDDLI SMGSNDIEVL KKIDIPSVFI GESSANSLKD EFTYEKGGHL ILVPEFSLPL 190 200 210 220 230 240 EYYLIPFLII VGICLILIVI FMITKFVQDR HRARRNRLRK DQLKKLPVHK FKKGDEYDVC 250 260 270 280 290 300 AICLDEYEDG DKLRILPCSH AYHCKCVDPW LTKTKKTCPV CKQKVVPSQG DSDSDTDSSQ 310 320 330 340 350 360 EENEVTEHTP LLRPLASVSA QSFGALSESR SHQNMTESSD YEEDDNEDTD SSDAENEINE 370 380 HDVVVQLQPN GERDYNIANT V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The gene for a RING zinc finger protein is expressed in the inner chick ear after noise exposure." Lomax M.I., Warner S.J., Bersirli C.G., Gong T.-W.L. Prim. Sens. Neuron 2:305-316(1998) Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Yu W., Gibbs R.A. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Urinary bladder.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF037204 mRNA. Translation: AAC03769.1. AF070558 mRNA. Translation: AAC28641.1. BC009803 mRNA. Translation: AAH09803.1. BC009781 mRNA. Translation: AAH09781.1.
IPI	IPI00151036.
RefSeq	NP_009213.1. NP_899237.1.
UniGene	Hs.12333 Hs.712766
3D structure databases
SMR	O43567. Positions 221-290.
ModBase	Search...
Proteomic databases
PRIDE	O43567.
Genome annotation databases
Ensembl	ENST00000344229; ENSP00000341361; ENSG00000082996; Homo sapiens. [Genome view] ENST00000392894; ENSP00000376628; ENSG00000082996; Homo sapiens. [Genome view]
GeneID	11342.
KEGG	hsa:11342.
UCSC	uc003exn.2. human.
Organism-specific databases
CTD	11342.
GeneCards	GC03P151013.
HGNC	HGNC:10057. RNF13.
HPA	HPA008709.
MIM	609247. gene.
PharmGKB	PA34422.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06360.
HOGENOM	HBG748141.
HOVERGEN	O43567.
InParanoid	O43567.
OMA	HIILVPE.
OrthoDB	EOG9J6V9S.
PhylomeDB	O43567.
Gene expression databases
ArrayExpress	O43567.
Bgee	O43567.
CleanEx	HS_RNF13.
Genevestigator	O43567.
GermOnline	ENSG00000082996. Homo sapiens.
Family and domain databases
InterPro	IPR003137. PA. IPR018957. Znf_C3HC4_RING-type. IPR001841. Znf_RING. [Graphical view]
Pfam	PF02225. PA. 1 hit. PF00097. zf-C3HC4. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	43096.
SOURCE	Search...

Entry information

Entry name

RNF13_HUMAN

Accession

Primary (citable) accession number: O43567

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	June 1, 1998
Last modified:	January 19, 2010
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.