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O43555

- GON2_HUMAN

UniProt

O43555 - GON2_HUMAN

Protein

Progonadoliberin-2

Gene

GNRH2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

    GO - Molecular functioni

    1. hormone activity Source: ProtInc

    GO - Biological processi

    1. multicellular organismal development Source: InterPro
    2. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_16942. Hormone ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Progonadoliberin-2
    Alternative name(s):
    Progonadoliberin II
    Cleaved into the following 2 chains:
    Alternative name(s):
    Gonadoliberin II
    Gonadotropin-releasing hormone II
    Short name:
    GnRH II
    Luliberin II
    Luteinizing hormone-releasing hormone II
    Short name:
    LH-RH II
    Alternative name(s):
    GnRH-associated peptide II
    Gene namesi
    Name:GNRH2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:4420. GNRH2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28799.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 12097Progonadoliberin-2PRO_0000012456Add
    BLAST
    Peptidei24 – 3310Gonadoliberin-2PRO_0000012457
    Peptidei37 – 12084GnRH-associated peptide 2PRO_0000012458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331Glycine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PRIDEiO43555.

    Expressioni

    Tissue specificityi

    Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate.

    Gene expression databases

    ArrayExpressiO43555.
    BgeeiO43555.
    CleanExiHS_GNRH2.
    GenevestigatoriO43555.

    Organism-specific databases

    HPAiHPA004338.

    Interactioni

    Protein-protein interaction databases

    BioGridi109059. 1 interaction.
    STRINGi9606.ENSP00000245983.

    Structurei

    3D structure databases

    ProteinModelPortaliO43555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GnRH family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG135653.
    HOGENOMiHOG000112757.
    HOVERGENiHBG005044.
    InParanoidiO43555.
    KOiK05252.
    OMAiPSEAQHW.
    OrthoDBiEOG7Z0JZH.
    PhylomeDBiO43555.
    TreeFamiTF353529.

    Family and domain databases

    InterProiIPR002012. GnRH.
    IPR019792. Gonadoliberin_I.
    [Graphical view]
    PANTHERiPTHR10522. PTHR10522. 1 hit.
    PfamiPF00446. GnRH. 1 hit.
    [Graphical view]
    PROSITEiPS00473. GNRH. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: O43555-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP    50
    PGRALDTAAG SPVQTAHGLP SDALAPLDDS MPWEGRTTAQ WSLHRKRHLA 100
    RTLLTAAREP RPAPPSSNKV 120
    Length:120
    Mass (Da):12,918
    Last modified:June 1, 1998 - v1
    Checksum:iD58CDA14B6D6FB8D
    GO
    Isoform 2 (identifier: O43555-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-59: Missing.

    Show »
    Length:112
    Mass (Da):12,162
    Checksum:iC8F8DD070CF32CF5
    GO
    Isoform 3 (identifier: O43555-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-58: Missing.

    Show »
    Length:113
    Mass (Da):12,233
    Checksum:iB4638FE343839E78
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161A → V.
    Corresponds to variant rs6051545 [ dbSNP | Ensembl ].
    VAR_053109

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei52 – 598Missing in isoform 2. CuratedVSP_001825
    Alternative sequencei52 – 587Missing in isoform 3. 1 PublicationVSP_001826

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF036329 Genomic DNA. Translation: AAC02980.1.
    AF036330 mRNA. Translation: AAC02981.1.
    AL121905 Genomic DNA. Translation: CAC10338.1.
    AL121905 Genomic DNA. Translation: CAC29100.1.
    AL121905 Genomic DNA. Translation: CAC29101.1.
    CH471133 Genomic DNA. Translation: EAX10559.1.
    BC069362 mRNA. Translation: AAH69362.1.
    BC115399 mRNA. Translation: AAI15400.1.
    BC115400 mRNA. Translation: AAI15401.1.
    CCDSiCCDS13040.1. [O43555-1]
    CCDS13041.1. [O43555-3]
    CCDS13042.1. [O43555-2]
    RefSeqiNP_001492.1. NM_001501.1. [O43555-1]
    NP_847901.1. NM_178331.1. [O43555-3]
    NP_847902.1. NM_178332.1. [O43555-2]
    XP_006723623.1. XM_006723560.1. [O43555-3]
    UniGeneiHs.129715.

    Genome annotation databases

    EnsembliENST00000245983; ENSP00000245983; ENSG00000125787. [O43555-1]
    ENST00000359100; ENSP00000352003; ENSG00000125787. [O43555-3]
    ENST00000380346; ENSP00000369704; ENSG00000125787. [O43555-2]
    ENST00000380347; ENSP00000369705; ENSG00000125787. [O43555-3]
    GeneIDi2797.
    KEGGihsa:2797.
    UCSCiuc002whp.1. human. [O43555-3]
    uc002whq.1. human. [O43555-2]
    uc002whr.1. human. [O43555-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF036329 Genomic DNA. Translation: AAC02980.1 .
    AF036330 mRNA. Translation: AAC02981.1 .
    AL121905 Genomic DNA. Translation: CAC10338.1 .
    AL121905 Genomic DNA. Translation: CAC29100.1 .
    AL121905 Genomic DNA. Translation: CAC29101.1 .
    CH471133 Genomic DNA. Translation: EAX10559.1 .
    BC069362 mRNA. Translation: AAH69362.1 .
    BC115399 mRNA. Translation: AAI15400.1 .
    BC115400 mRNA. Translation: AAI15401.1 .
    CCDSi CCDS13040.1. [O43555-1 ]
    CCDS13041.1. [O43555-3 ]
    CCDS13042.1. [O43555-2 ]
    RefSeqi NP_001492.1. NM_001501.1. [O43555-1 ]
    NP_847901.1. NM_178331.1. [O43555-3 ]
    NP_847902.1. NM_178332.1. [O43555-2 ]
    XP_006723623.1. XM_006723560.1. [O43555-3 ]
    UniGenei Hs.129715.

    3D structure databases

    ProteinModelPortali O43555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109059. 1 interaction.
    STRINGi 9606.ENSP00000245983.

    Proteomic databases

    PRIDEi O43555.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000245983 ; ENSP00000245983 ; ENSG00000125787 . [O43555-1 ]
    ENST00000359100 ; ENSP00000352003 ; ENSG00000125787 . [O43555-3 ]
    ENST00000380346 ; ENSP00000369704 ; ENSG00000125787 . [O43555-2 ]
    ENST00000380347 ; ENSP00000369705 ; ENSG00000125787 . [O43555-3 ]
    GeneIDi 2797.
    KEGGi hsa:2797.
    UCSCi uc002whp.1. human. [O43555-3 ]
    uc002whq.1. human. [O43555-2 ]
    uc002whr.1. human. [O43555-1 ]

    Organism-specific databases

    CTDi 2797.
    GeneCardsi GC20P003043.
    HGNCi HGNC:4420. GNRH2.
    HPAi HPA004338.
    MIMi 602352. gene.
    neXtProti NX_O43555.
    PharmGKBi PA28799.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG135653.
    HOGENOMi HOG000112757.
    HOVERGENi HBG005044.
    InParanoidi O43555.
    KOi K05252.
    OMAi PSEAQHW.
    OrthoDBi EOG7Z0JZH.
    PhylomeDBi O43555.
    TreeFami TF353529.

    Enzyme and pathway databases

    Reactomei REACT_16942. Hormone ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    GeneWikii GNRH2.
    GenomeRNAii 2797.
    NextBioi 11019.
    PROi O43555.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43555.
    Bgeei O43555.
    CleanExi HS_GNRH2.
    Genevestigatori O43555.

    Family and domain databases

    InterProi IPR002012. GnRH.
    IPR019792. Gonadoliberin_I.
    [Graphical view ]
    PANTHERi PTHR10522. PTHR10522. 1 hit.
    Pfami PF00446. GnRH. 1 hit.
    [Graphical view ]
    PROSITEi PS00473. GNRH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).

    Entry informationi

    Entry nameiGON2_HUMAN
    AccessioniPrimary (citable) accession number: O43555
    Secondary accession number(s): Q14C68
    , Q14C69, Q9BYN9, Q9BYP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: June 1, 1998
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3