O43555 (GON2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Progonadoliberin-2

Alternative name(s):
Progonadoliberin II

Cleaved into the following 2 chains:

1. Gonadoliberin-2
   Alternative name(s):
   Gonadoliberin II
   Gonadotropin-releasing hormone II
   Short name=GnRH II
   Luliberin II
   Luteinizing hormone-releasing hormone II
   Short name=LH-RH II
2. GnRH-associated peptide 2
   Alternative name(s):
   GnRH-associated peptide II

Gene names

Name:

GNRH2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Subcellular location	Secreted.
Tissue specificity	Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate.
Sequence similarities	Belongs to the GnRH family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: InterPro signal transduction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	extracellular region Traceable author statement. Source: Reactome
Molecular_function	hormone activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: O43555-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43555-2)

The sequence of this isoform differs from the canonical sequence as follows:
     52-59: Missing.

Isoform 3 (identifier: O43555-3)

The sequence of this isoform differs from the canonical sequence as follows:
     52-58: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 120	97	Progonadoliberin-2		PRO_0000012456
	Peptide	24 – 33	10	Gonadoliberin-2		PRO_0000012457
	Peptide	37 – 120	84	GnRH-associated peptide 2		PRO_0000012458
Amino acid modifications
	Modified residue	33	1	Glycine amide
Natural variations
	Alternative sequence	52 – 59	8	Missing in isoform 2.		VSP_001825
	Alternative sequence	52 – 58	7	Missing in isoform 3.		VSP_001826
	Natural variant	16	1	A → V. Corresponds to variant rs6051545 [ dbSNP | Ensembl ].		VAR_053109

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: D58CDA14B6D6FB8D	FASTA	120	12,918
	10 20 30 40 50 60 MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP PGRALDTAAG 70 80 90 100 110 120 SPVQTAHGLP SDALAPLDDS MPWEGRTTAQ WSLHRKRHLA RTLLTAAREP RPAPPSSNKV
	Isoform 2 [UniParc]. Checksum: C8F8DD070CF32CF5	FASTA	112	12,162
	10 20 30 40 50 60 MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP PGSPVQTAHG 70 80 90 100 110 LPSDALAPLD DSMPWEGRTT AQWSLHRKRH LARTLLTAAR EPRPAPPSSN KV
	Isoform 3 [UniParc]. Checksum: B4638FE343839E78	FASTA	113	12,233
	10 20 30 40 50 60 MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP PAGSPVQTAH 70 80 90 100 110 GLPSDALAPL DDSMPWEGRT TAQWSLHRKR HLARTLLTAA REPRPAPPSS NKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Second gene for gonadotropin-releasing hormone in humans." White R.B., Eisen J.A., Kasten T.L., Fernald R.D. Proc. Natl. Acad. Sci. U.S.A. 95:305-309(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF036329 Genomic DNA. Translation: AAC02980.1. AF036330 mRNA. Translation: AAC02981.1. AL121905 Genomic DNA. Translation: CAC10338.1. AL121905 Genomic DNA. Translation: CAC29100.1. AL121905 Genomic DNA. Translation: CAC29101.1. CH471133 Genomic DNA. Translation: EAX10559.1. BC069362 mRNA. Translation: AAH69362.1. BC115399 mRNA. Translation: AAI15400.1. BC115400 mRNA. Translation: AAI15401.1.
IPI	IPI00012880. IPI00221119. IPI00221120.
RefSeq	NP_001492.1. NM_001501.1. NP_847901.1. NM_178331.1. NP_847902.1. NM_178332.1.
UniGene	Hs.129715.
3D structure databases
ProteinModelPortal	O43555.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000245983.
Proteomic databases
PRIDE	O43555.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000245983; ENSP00000245983; ENSG00000125787. ENST00000359100; ENSP00000352003; ENSG00000125787. ENST00000359987; ENSP00000353077; ENSG00000125787. ENST00000380346; ENSP00000369704; ENSG00000125787. ENST00000380347; ENSP00000369705; ENSG00000125787.
GeneID	2797.
KEGG	hsa:2797.
UCSC	uc002whp.1. human. uc002whq.1. human. uc002whr.1. human.
Organism-specific databases
CTD	2797.
GeneCards	GC20P003033.
HGNC	HGNC:4420. GNRH2.
HPA	HPA004338.
MIM	602352. gene.
neXtProt	NX_O43555.
PharmGKB	PA28799.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG135653.
HOGENOM	HOG000112757.
HOVERGEN	HBG005044.
InParanoid	O43555.
KO	K05252.
OMA	PSEAQHW.
OrthoDB	EOG402WTQ.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	O43555.
Bgee	O43555.
CleanEx	HS_GNRH2.
Genevestigator	O43555.
GermOnline	ENSG00000125787. Homo sapiens.
Family and domain databases
InterPro	IPR002012. GnRH. [Graphical view]
Pfam	PF00446. GnRH. 1 hit. [Graphical view]
PROSITE	PS00473. GNRH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2797.
NextBio	11019.
SOURCE	Search...

Entry information

Entry name

GON2_HUMAN

Accession

Primary (citable) accession number: O43555
Secondary accession number(s): Q14C68 , Q14C69, Q9BYN9, Q9BYP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	April 3, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.