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Protein

Progonadoliberin-2

Gene

GNRH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

GO - Molecular functioni

  • hormone activity Source: ProtInc

GO - Biological processi

  • multicellular organismal development Source: InterPro
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_16942. Hormone ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Progonadoliberin-2
Alternative name(s):
Progonadoliberin II
Cleaved into the following 2 chains:
Alternative name(s):
Gonadoliberin II
Gonadotropin-releasing hormone II
Short name:
GnRH II
Luliberin II
Luteinizing hormone-releasing hormone II
Short name:
LH-RH II
Alternative name(s):
GnRH-associated peptide II
Gene namesi
Name:GNRH2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:4420. GNRH2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28799.

Polymorphism and mutation databases

BioMutaiGNRH2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 12097Progonadoliberin-2PRO_0000012456Add
BLAST
Peptidei24 – 3310Gonadoliberin-2PRO_0000012457
Peptidei37 – 12084GnRH-associated peptide 2PRO_0000012458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331Glycine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PRIDEiO43555.

Expressioni

Tissue specificityi

Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate.

Gene expression databases

BgeeiO43555.
CleanExiHS_GNRH2.
GenevestigatoriO43555.

Organism-specific databases

HPAiHPA004338.

Interactioni

Protein-protein interaction databases

BioGridi109059. 1 interaction.
STRINGi9606.ENSP00000245983.

Structurei

3D structure databases

ProteinModelPortaliO43555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GnRH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG135653.
GeneTreeiENSGT00390000005119.
HOGENOMiHOG000112757.
HOVERGENiHBG005044.
InParanoidiO43555.
KOiK05252.
OMAiPSEAQHW.
OrthoDBiEOG7Z0JZH.
PhylomeDBiO43555.
TreeFamiTF353529.

Family and domain databases

InterProiIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
[Graphical view]
PANTHERiPTHR10522. PTHR10522. 1 hit.
PfamiPF00446. GnRH. 1 hit.
[Graphical view]
PROSITEiPS00473. GNRH. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: O43555-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP
60 70 80 90 100
PGRALDTAAG SPVQTAHGLP SDALAPLDDS MPWEGRTTAQ WSLHRKRHLA
110 120
RTLLTAAREP RPAPPSSNKV
Length:120
Mass (Da):12,918
Last modified:June 1, 1998 - v1
Checksum:iD58CDA14B6D6FB8D
GO
Isoform 2 (identifier: O43555-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-59: Missing.

Show »
Length:112
Mass (Da):12,162
Checksum:iC8F8DD070CF32CF5
GO
Isoform 3 (identifier: O43555-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-58: Missing.

Show »
Length:113
Mass (Da):12,233
Checksum:iB4638FE343839E78
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161A → V.
Corresponds to variant rs6051545 [ dbSNP | Ensembl ].
VAR_053109

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei52 – 598Missing in isoform 2. CuratedVSP_001825
Alternative sequencei52 – 587Missing in isoform 3. 1 PublicationVSP_001826

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036329 Genomic DNA. Translation: AAC02980.1.
AF036330 mRNA. Translation: AAC02981.1.
AL121905 Genomic DNA. Translation: CAC10338.1.
AL121905 Genomic DNA. Translation: CAC29100.1.
AL121905 Genomic DNA. Translation: CAC29101.1.
CH471133 Genomic DNA. Translation: EAX10559.1.
BC069362 mRNA. Translation: AAH69362.1.
BC115399 mRNA. Translation: AAI15400.1.
BC115400 mRNA. Translation: AAI15401.1.
CCDSiCCDS13040.1. [O43555-1]
CCDS13041.1. [O43555-3]
CCDS13042.1. [O43555-2]
RefSeqiNP_001492.1. NM_001501.1. [O43555-1]
NP_847901.1. NM_178331.1. [O43555-3]
NP_847902.1. NM_178332.1. [O43555-2]
UniGeneiHs.129715.

Genome annotation databases

EnsembliENST00000245983; ENSP00000245983; ENSG00000125787. [O43555-1]
ENST00000359100; ENSP00000352003; ENSG00000125787. [O43555-3]
ENST00000380346; ENSP00000369704; ENSG00000125787. [O43555-2]
ENST00000380347; ENSP00000369705; ENSG00000125787. [O43555-3]
GeneIDi2797.
KEGGihsa:2797.
UCSCiuc002whp.1. human. [O43555-3]
uc002whq.1. human. [O43555-2]
uc002whr.1. human. [O43555-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF036329 Genomic DNA. Translation: AAC02980.1.
AF036330 mRNA. Translation: AAC02981.1.
AL121905 Genomic DNA. Translation: CAC10338.1.
AL121905 Genomic DNA. Translation: CAC29100.1.
AL121905 Genomic DNA. Translation: CAC29101.1.
CH471133 Genomic DNA. Translation: EAX10559.1.
BC069362 mRNA. Translation: AAH69362.1.
BC115399 mRNA. Translation: AAI15400.1.
BC115400 mRNA. Translation: AAI15401.1.
CCDSiCCDS13040.1. [O43555-1]
CCDS13041.1. [O43555-3]
CCDS13042.1. [O43555-2]
RefSeqiNP_001492.1. NM_001501.1. [O43555-1]
NP_847901.1. NM_178331.1. [O43555-3]
NP_847902.1. NM_178332.1. [O43555-2]
UniGeneiHs.129715.

3D structure databases

ProteinModelPortaliO43555.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109059. 1 interaction.
STRINGi9606.ENSP00000245983.

Polymorphism and mutation databases

BioMutaiGNRH2.

Proteomic databases

PRIDEiO43555.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245983; ENSP00000245983; ENSG00000125787. [O43555-1]
ENST00000359100; ENSP00000352003; ENSG00000125787. [O43555-3]
ENST00000380346; ENSP00000369704; ENSG00000125787. [O43555-2]
ENST00000380347; ENSP00000369705; ENSG00000125787. [O43555-3]
GeneIDi2797.
KEGGihsa:2797.
UCSCiuc002whp.1. human. [O43555-3]
uc002whq.1. human. [O43555-2]
uc002whr.1. human. [O43555-1]

Organism-specific databases

CTDi2797.
GeneCardsiGC20P003048.
HGNCiHGNC:4420. GNRH2.
HPAiHPA004338.
MIMi602352. gene.
neXtProtiNX_O43555.
PharmGKBiPA28799.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG135653.
GeneTreeiENSGT00390000005119.
HOGENOMiHOG000112757.
HOVERGENiHBG005044.
InParanoidiO43555.
KOiK05252.
OMAiPSEAQHW.
OrthoDBiEOG7Z0JZH.
PhylomeDBiO43555.
TreeFamiTF353529.

Enzyme and pathway databases

ReactomeiREACT_16942. Hormone ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

GeneWikiiGNRH2.
GenomeRNAii2797.
NextBioi11019.
PROiO43555.
SOURCEiSearch...

Gene expression databases

BgeeiO43555.
CleanExiHS_GNRH2.
GenevestigatoriO43555.

Family and domain databases

InterProiIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
[Graphical view]
PANTHERiPTHR10522. PTHR10522. 1 hit.
PfamiPF00446. GnRH. 1 hit.
[Graphical view]
PROSITEiPS00473. GNRH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).

Entry informationi

Entry nameiGON2_HUMAN
AccessioniPrimary (citable) accession number: O43555
Secondary accession number(s): Q14C68
, Q14C69, Q9BYN9, Q9BYP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: May 27, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.