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O43555 (GON2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Progonadoliberin-2
Alternative name(s):
Progonadoliberin II

Cleaved into the following 2 chains:

  1. Gonadoliberin-2
    Alternative name(s):
    Gonadoliberin II
    Gonadotropin-releasing hormone II
    Short name=GnRH II
    Luliberin II
    Luteinizing hormone-releasing hormone II
    Short name=LH-RH II
  2. GnRH-associated peptide 2
    Alternative name(s):
    GnRH-associated peptide II
Gene names
Name:GNRH2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

Subcellular location

Secreted.

Tissue specificity

Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate.

Sequence similarities

Belongs to the GnRH family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: InterPro

signal transduction

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

   Molecular_functionhormone activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: O43555-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O43555-2)

The sequence of this isoform differs from the canonical sequence as follows:
     52-59: Missing.
Isoform 3 (identifier: O43555-3)

The sequence of this isoform differs from the canonical sequence as follows:
     52-58: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 12097Progonadoliberin-2
PRO_0000012456
Peptide24 – 3310Gonadoliberin-2
PRO_0000012457
Peptide37 – 12084GnRH-associated peptide 2
PRO_0000012458

Amino acid modifications

Modified residue331Glycine amide By similarity

Natural variations

Alternative sequence52 – 598Missing in isoform 2.
VSP_001825
Alternative sequence52 – 587Missing in isoform 3.
VSP_001826
Natural variant161A → V.
Corresponds to variant rs6051545 [ dbSNP | Ensembl ].
VAR_053109

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: D58CDA14B6D6FB8D

FASTA12012,918
        10         20         30         40         50         60 
MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP PGRALDTAAG 

        70         80         90        100        110        120 
SPVQTAHGLP SDALAPLDDS MPWEGRTTAQ WSLHRKRHLA RTLLTAAREP RPAPPSSNKV 

« Hide

Isoform 2 [UniParc].

Checksum: C8F8DD070CF32CF5
Show »

FASTA11212,162
Isoform 3 [UniParc].

Checksum: B4638FE343839E78
Show »

FASTA11312,233

References

« Hide 'large scale' references
[1]"Second gene for gonadotropin-releasing hormone in humans."
White R.B., Eisen J.A., Kasten T.L., Fernald R.D.
Proc. Natl. Acad. Sci. U.S.A. 95:305-309(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[2]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF036329 Genomic DNA. Translation: AAC02980.1.
AF036330 mRNA. Translation: AAC02981.1.
AL121905 Genomic DNA. Translation: CAC10338.1.
AL121905 Genomic DNA. Translation: CAC29100.1.
AL121905 Genomic DNA. Translation: CAC29101.1.
CH471133 Genomic DNA. Translation: EAX10559.1.
BC069362 mRNA. Translation: AAH69362.1.
BC115399 mRNA. Translation: AAI15400.1.
BC115400 mRNA. Translation: AAI15401.1.
CCDSCCDS13040.1. [O43555-1]
CCDS13041.1. [O43555-3]
CCDS13042.1. [O43555-2]
RefSeqNP_001492.1. NM_001501.1. [O43555-1]
NP_847901.1. NM_178331.1. [O43555-3]
NP_847902.1. NM_178332.1. [O43555-2]
XP_006723623.1. XM_006723560.1. [O43555-3]
UniGeneHs.129715.

3D structure databases

ProteinModelPortalO43555.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109059. 1 interaction.
STRING9606.ENSP00000245983.

Proteomic databases

PRIDEO43555.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000245983; ENSP00000245983; ENSG00000125787. [O43555-1]
ENST00000359100; ENSP00000352003; ENSG00000125787. [O43555-3]
ENST00000359987; ENSP00000353077; ENSG00000125787. [O43555-2]
ENST00000380346; ENSP00000369704; ENSG00000125787. [O43555-2]
ENST00000380347; ENSP00000369705; ENSG00000125787. [O43555-3]
GeneID2797.
KEGGhsa:2797.
UCSCuc002whp.1. human. [O43555-3]
uc002whq.1. human. [O43555-2]
uc002whr.1. human. [O43555-1]

Organism-specific databases

CTD2797.
GeneCardsGC20P003043.
HGNCHGNC:4420. GNRH2.
HPAHPA004338.
MIM602352. gene.
neXtProtNX_O43555.
PharmGKBPA28799.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG135653.
HOGENOMHOG000112757.
HOVERGENHBG005044.
InParanoidO43555.
KOK05252.
OMAPSEAQHW.
OrthoDBEOG7Z0JZH.
PhylomeDBO43555.
TreeFamTF353529.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO43555.
BgeeO43555.
CleanExHS_GNRH2.
GenevestigatorO43555.

Family and domain databases

InterProIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
[Graphical view]
PANTHERPTHR10522. PTHR10522. 1 hit.
PfamPF00446. GnRH. 1 hit.
[Graphical view]
PROSITEPS00473. GNRH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGNRH2.
GenomeRNAi2797.
NextBio11019.
PROO43555.
SOURCESearch...

Entry information

Entry nameGON2_HUMAN
AccessionPrimary (citable) accession number: O43555
Secondary accession number(s): Q14C68 expand/collapse secondary AC list , Q14C69, Q9BYN9, Q9BYP0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM