Reviewed, UniProtKB/Swiss-Prot O43555 (GON2_HUMAN)

Names and origin

Protein names

Recommended name:
    Progonadoliberin-2
Alternative name(s):
    Progonadoliberin II
Cleaved into the following 2 chains:
    1- Recommended name:
            Gonadoliberin-2
        Alternative name(s):
            Gonadoliberin II
            Luteinizing hormone-releasing hormone II
              Short name=LH-RH II
            Gonadotropin-releasing hormone II
              Short name=GnRH II
            Luliberin II
    2- Recommended name:
            GnRH-associated peptide 2
        Alternative name(s):
            GnRH-associated peptide II

Gene names

Name:

GNRH2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Subcellular location	Secreted.
Tissue specificity	Midbrain; expressed at significantly higher levels outside the brain (up to 30-fold), particularly in the kidney, bone marrow and prostate.
Sequence similarities	Belongs to the GnRH family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Pyrrolidone carboxylic acid
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: InterPro signal transduction Ref.1 Traceable author statement. Source: ProtInc
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell soluble fraction Ref.1 Traceable author statement. Source: ProtInc
Molecular function	hormone activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: O43555-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43555-2)

The sequence of this isoform differs from the canonical sequence as follows:
     52-59: Missing.

Isoform 3 (identifier: O43555-3)

The sequence of this isoform differs from the canonical sequence as follows:
     52-58: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 120	97	Progonadoliberin-2		PRO_0000012456
	Peptide	24 – 33	10	Gonadoliberin-2		PRO_0000012457
	Peptide	37 – 120	84	GnRH-associated peptide 2		PRO_0000012458
Amino acid modifications
	Modified residue	24	1	Pyrrolidone carboxylic acid By similarity
	Modified residue	33	1	Glycine amide
Natural variations
	Alternative sequence	52 – 59	8	Missing in isoform 2.		VSP_001825
	Alternative sequence	52 – 58	7	Missing in isoform 3.		VSP_001826
	Natural variant	16	1	A → V: dbSNP rs6051545.		VAR_053109

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: D58CDA14B6D6FB8D	FASTA	120	12,918
	10 20 30 40 50 60 MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP PGRALDTAAG 70 80 90 100 110 120 SPVQTAHGLP SDALAPLDDS MPWEGRTTAQ WSLHRKRHLA RTLLTAAREP RPAPPSSNKV
	Isoform 2. Checksum: C8F8DD070CF32CF5	FASTA	112	12,162
	10 20 30 40 50 60 MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP PGSPVQTAHG 70 80 90 100 110 LPSDALAPLD DSMPWEGRTT AQWSLHRKRH LARTLLTAAR EPRPAPPSSN KV
	Isoform 3. Checksum: B4638FE343839E78	FASTA	113	12,233
	10 20 30 40 50 60 MASSRRGLLL LLLLTAHLGP SEAQHWSHGW YPGGKRALSS AQDPQNALRP PAGSPVQTAH 70 80 90 100 110 GLPSDALAPL DDSMPWEGRT TAQWSLHRKR HLARTLLTAA REPRPAPPSS NKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Second gene for gonadotropin-releasing hormone in humans." White R.B., Eisen J.A., Kasten T.L., Fernald R.D. Proc. Natl. Acad. Sci. U.S.A. 95:305-309(1998) [PubMed: 9419371] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 3).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF036329 Genomic DNA. Translation: AAC02980.1. AF036330 mRNA. Translation: AAC02981.1. AL121905 Genomic DNA. Translation: CAC10338.1. AL121905 Genomic DNA. Translation: CAC29100.1. AL121905 Genomic DNA. Translation: CAC29101.1. BC069362 mRNA. Translation: AAH69362.1. BC115400 mRNA. Translation: AAI15401.1.
IPI	IPI00012880. IPI00221119. IPI00221120.
RefSeq	NP_001492.1.
UniGene	Hs.129715
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	O43555.
Genome annotation databases
Ensembl	ENSG00000125787. Homo sapiens. [Contig view]
GeneID	2797.
KEGG	hsa:2797.
Organism-specific databases
GeneCards	GC20P002972.
H-InvDB	HIX0040499.
HGNC	HGNC:4420. GNRH2.
HPA	HPA004338.
MIM	602352. gene.
PharmGKB	PA28799.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O43555.
HOVERGEN	O43555.
OMA	O43555. PSEAQHW.
Gene expression databases
ArrayExpress	O43555.
Bgee	O43555.
CleanEx	HS_GNRH2.
GermOnline	ENSG00000125787. Homo sapiens.
Family and domain databases
InterPro	IPR002012. GnRH. IPR019792. Gonadoliberin_I. [Graphical view]
PANTHER	PTHR10522. GnRH. 1 hit.
Pfam	PF00446. GnRH. 1 hit. [Graphical view]
PROSITE	PS00473. GNRH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	11019.
SOURCE	Search...

Entry information

Entry name

GON2_HUMAN

Accession

Primary (citable) accession number: O43555
Secondary accession number(s): Q14C68, Q9BYN9, Q9BYP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	June 16, 2009
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)