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Protein

DNA repair protein XRCC2

Gene

XRCC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.5 Publications

GO - Molecular functioni

GO - Biological processi

  • centrosome organization Source: UniProtKB
  • DNA repair Source: BHF-UCL
  • DNA synthesis involved in DNA repair Source: Reactome
  • double-strand break repair via homologous recombination Source: UniProtKB
  • in utero embryonic development Source: Ensembl
  • meiotic DNA recombinase assembly Source: GO_Central
  • meiotic nuclear division Source: ProtInc
  • mitotic cell cycle Source: UniProtKB
  • mitotic recombination Source: GO_Central
  • multicellular organism growth Source: Ensembl
  • negative regulation of neuron apoptotic process Source: Ensembl
  • positive regulation of neurogenesis Source: Ensembl
  • reciprocal meiotic recombination Source: GO_Central
  • regulation of fibroblast apoptotic process Source: Ensembl
  • response to gamma radiation Source: Ensembl
  • response to ionizing radiation Source: GO_Central
  • response to X-ray Source: Ensembl
  • somitogenesis Source: Ensembl
  • strand displacement Source: Reactome
  • strand invasion Source: UniProtKB
Complete GO annotation...

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair

Enzyme and pathway databases

BioCyciZFISH:G66-30970-MONOMER.
ReactomeiR-HSA-5685942. HDR through Homologous Recombination (HRR).
R-HSA-5693554. Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).
R-HSA-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates.
R-HSA-5693579. Homologous DNA Pairing and Strand Exchange.
R-HSA-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein XRCC2
Alternative name(s):
X-ray repair cross-complementing protein 2
Gene namesi
Name:XRCC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:12829. XRCC2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: UniProtKB-KW
  • nucleoplasm Source: Reactome
  • Rad51B-Rad51C-Rad51D-XRCC2 complex Source: UniProtKB
  • replication fork Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7516.
MalaCardsiXRCC2.
OpenTargetsiENSG00000196584.
Orphaneti227535. Hereditary breast cancer.
PharmGKBiPA37421.

Polymorphism and mutation databases

BioMutaiXRCC2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001229481 – 280DNA repair protein XRCC2Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO43543.
PaxDbiO43543.
PeptideAtlasiO43543.
PRIDEiO43543.

PTM databases

iPTMnetiO43543.
PhosphoSitePlusiO43543.

Expressioni

Gene expression databases

BgeeiENSG00000196584.
CleanExiHS_XRCC2.
GenevisibleiO43543. HS.

Organism-specific databases

HPAiHPA065153.

Interactioni

Subunit structurei

Interacts with RAD51D. Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA.6 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113350. 13 interactors.
DIPiDIP-24242N.
IntActiO43543. 10 interactors.
MINTiMINT-137755.
STRINGi9606.ENSP00000352271.

Structurei

3D structure databases

ProteinModelPortaliO43543.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2859. Eukaryota.
ENOG4112B2N. LUCA.
GeneTreeiENSGT00390000020445.
HOGENOMiHOG000004802.
HOVERGENiHBG079347.
InParanoidiO43543.
KOiK10879.
OMAiDTDYHFD.
OrthoDBiEOG091G0G4E.
PhylomeDBiO43543.
TreeFamiTF101202.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013632. DNA_recomb/repair_Rad51_C.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR030547. XRCC2.
[Graphical view]
PANTHERiPTHR22942:SF44. PTHR22942:SF44. 1 hit.
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSAFHRAES GTELLARLEG RSSLKEIEPN LFADEDSPVH GDILEFHGPE
60 70 80 90 100
GTGKTEMLYH LTARCILPKS EGGLEVEVLF IDTDYHFDML RLVTILEHRL
110 120 130 140 150
SQSSEEIIKY CLGRFFLVYC SSSTHLLLTL YSLESMFCSH PSLCLLILDS
160 170 180 190 200
LSAFYWIDRV NGGESVNLQE STLRKCSQCL EKLVNDYRLV LFATTQTIMQ
210 220 230 240 250
KASSSSEEPS HASRRLCDVD IDYRPYLCKA WQQLVKHRMF FSKQDDSQSS
260 270 280
NQFSLVSRCL KSNSLKKHFF IIGESGVEFC
Length:280
Mass (Da):31,956
Last modified:June 1, 1998 - v1
Checksum:i5656277E74C06074
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02040316A → S Polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. Corresponds to variant dbSNP:rs49870902 PublicationsEnsembl.1
Natural variantiVAR_07716747H → R Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_07716861L → I Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_07716975E → Q Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_07717091R → W Rare variant; found in breast cancer; unknown pathological significance; moderately decreased function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_07717195I → V Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 3 Publications1
Natural variantiVAR_077172118V → A Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077173120C → Y Rare variant; found in breast cancer; unknown pathological significance; moderately decreased function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077174133L → P Rare variant; found in breast cancer; unknown pathological significance; moderately decreased function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077175164E → Q Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077176170E → A Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077177188R → C Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_020404188R → H Polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. Corresponds to variant dbSNP:rs32185362 PublicationsEnsembl.1
Natural variantiVAR_077178194T → M Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077179199M → L Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077180207E → G Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077181220D → V Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_029294221I → T. Corresponds to variant dbSNP:rs32185371 PublicationEnsembl.1
Natural variantiVAR_077182231W → C Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077183238R → S Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077184248Q → E Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077185258R → C Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 2 Publications1
Natural variantiVAR_077186270F → V Rare polymorphism; does not affect function in double-strand break repair via homologous recombination as shown in rescue assays of XRCC2-deficient cells. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035587 mRNA. Translation: AAC05369.1.
AC003109 Genomic DNA. Translation: AAC05802.1.
Y08837 mRNA. Translation: CAA70065.1.
Y17033 Genomic DNA. Translation: CAA76597.1.
AF520762 Genomic DNA. Translation: AAM55241.1.
AK313607 mRNA. Translation: BAG36372.1.
CH471173 Genomic DNA. Translation: EAW53968.1.
BC042137 mRNA. Translation: AAH42137.1.
CCDSiCCDS5933.1.
RefSeqiNP_005422.1. NM_005431.1.
UniGeneiHs.647093.

Genome annotation databases

EnsembliENST00000359321; ENSP00000352271; ENSG00000196584.
GeneIDi7516.
KEGGihsa:7516.
UCSCiuc003wld.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF035587 mRNA. Translation: AAC05369.1.
AC003109 Genomic DNA. Translation: AAC05802.1.
Y08837 mRNA. Translation: CAA70065.1.
Y17033 Genomic DNA. Translation: CAA76597.1.
AF520762 Genomic DNA. Translation: AAM55241.1.
AK313607 mRNA. Translation: BAG36372.1.
CH471173 Genomic DNA. Translation: EAW53968.1.
BC042137 mRNA. Translation: AAH42137.1.
CCDSiCCDS5933.1.
RefSeqiNP_005422.1. NM_005431.1.
UniGeneiHs.647093.

3D structure databases

ProteinModelPortaliO43543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113350. 13 interactors.
DIPiDIP-24242N.
IntActiO43543. 10 interactors.
MINTiMINT-137755.
STRINGi9606.ENSP00000352271.

PTM databases

iPTMnetiO43543.
PhosphoSitePlusiO43543.

Polymorphism and mutation databases

BioMutaiXRCC2.

Proteomic databases

MaxQBiO43543.
PaxDbiO43543.
PeptideAtlasiO43543.
PRIDEiO43543.

Protocols and materials databases

DNASUi7516.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359321; ENSP00000352271; ENSG00000196584.
GeneIDi7516.
KEGGihsa:7516.
UCSCiuc003wld.4. human.

Organism-specific databases

CTDi7516.
DisGeNETi7516.
GeneCardsiXRCC2.
HGNCiHGNC:12829. XRCC2.
HPAiHPA065153.
MalaCardsiXRCC2.
MIMi600375. gene.
neXtProtiNX_O43543.
OpenTargetsiENSG00000196584.
Orphaneti227535. Hereditary breast cancer.
PharmGKBiPA37421.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2859. Eukaryota.
ENOG4112B2N. LUCA.
GeneTreeiENSGT00390000020445.
HOGENOMiHOG000004802.
HOVERGENiHBG079347.
InParanoidiO43543.
KOiK10879.
OMAiDTDYHFD.
OrthoDBiEOG091G0G4E.
PhylomeDBiO43543.
TreeFamiTF101202.

Enzyme and pathway databases

BioCyciZFISH:G66-30970-MONOMER.
ReactomeiR-HSA-5685942. HDR through Homologous Recombination (HRR).
R-HSA-5693554. Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).
R-HSA-5693568. Resolution of D-loop Structures through Holliday Junction Intermediates.
R-HSA-5693579. Homologous DNA Pairing and Strand Exchange.
R-HSA-5693616. Presynaptic phase of homologous DNA pairing and strand exchange.

Miscellaneous databases

ChiTaRSiXRCC2. human.
GeneWikiiXRCC2.
GenomeRNAii7516.
PROiO43543.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196584.
CleanExiHS_XRCC2.
GenevisibleiO43543. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013632. DNA_recomb/repair_Rad51_C.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
IPR030547. XRCC2.
[Graphical view]
PANTHERiPTHR22942:SF44. PTHR22942:SF44. 1 hit.
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXRCC2_HUMAN
AccessioniPrimary (citable) accession number: O43543
Secondary accession number(s): B2R925
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: June 1, 1998
Last modified: January 18, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.