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UniProtKB - O43526 (KCNQ2_HUMAN)

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Protein

Potassium voltage-gated channel subfamily KQT member 2

Gene

KCNQ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors.

Miscellaneous

Inclusion of isoform 6 in heteromultimers results in attenuation of potassium current. Prominent expression of isoform 6 in the developing brain may alter firing repertoires of immature neurons excitability to provide cues for proliferation rather than differentiation.
Mutagenesis experiments were carried out in Xenopus oocytes by coexpression of either KCNQ2(mut) and KCNQ3 at the ratio of 1:1, or of KCNQ2(mut), KCNQ2(wt) and KCNQ3 at the ratio of 1:1:2, to mimic the situation in a heterozygous patient with BFNC1 disease.

GO - Molecular functioni

  • ankyrin binding Source: BHF-UCL
  • potassium channel activity Source: ProtInc
  • voltage-gated potassium channel activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • nervous system development Source: ProtInc
  • potassium ion transport Source: ProtInc
Complete GO annotation...

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1296072. Voltage gated Potassium channels.
R-HSA-445095. Interaction between L1 and Ankyrins.
SIGNORiO43526.

Protein family/group databases

TCDBi1.A.1.15.2. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily KQT member 2
Alternative name(s):
KQT-like 2
Neuroblastoma-specific potassium channel subunit alpha KvLQT2
Voltage-gated potassium channel subunit Kv7.2
Gene namesi
Name:KCNQ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:6296. KCNQ2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei92 – 112Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini113 – 122ExtracellularSequence analysis10
Transmembranei123 – 143Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini144 – 166CytoplasmicSequence analysisAdd BLAST23
Transmembranei167 – 187Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini188 – 195ExtracellularSequence analysis8
Transmembranei196 – 218Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST23
Topological domaini219 – 231CytoplasmicSequence analysisAdd BLAST13
Transmembranei232 – 252Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini253 – 264ExtracellularSequence analysisAdd BLAST12
Intramembranei265 – 285Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini286 – 291ExtracellularSequence analysis6
Transmembranei292 – 312Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini313 – 872CytoplasmicSequence analysisAdd BLAST560

GO - Cellular componenti

  • axon initial segment Source: BHF-UCL
  • integral component of membrane Source: GO_Central
  • node of Ranvier Source: BHF-UCL
  • plasma membrane Source: BHF-UCL
  • voltage-gated potassium channel complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Seizures, benign familial neonatal 1 (BFNS1)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by clusters of seizures occurring in the first days of life. Most patients have spontaneous remission by 12 months of age and show normal psychomotor development. Some rare cases manifest an atypical severe phenotype associated with epileptic encephalopathy and psychomotor retardation. The disorder is distinguished from benign familial infantile seizures by an earlier age at onset. In some patients, neonatal convulsions are followed later in life by myokymia, a benign condition characterized by spontaneous involuntary contractions of skeletal muscles fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Some patients may have isolated myokymia.
See also OMIM:121200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026987207R → W in BFNS1; phenotype manifestations include myokymia in some patients; leads to a shift of voltage-dependent activation of the channel and a dramatic slowing of activation upon depolarization. 1 PublicationCorresponds to variant dbSNP:rs74315391Ensembl.1
Natural variantiVAR_026988208M → V in BFNS1; minor effect on maximal current but clearly exhibits a faster rate of deactivation. 1 PublicationCorresponds to variant dbSNP:rs118192201Ensembl.1
Natural variantiVAR_010929214R → W in BFNS1. 1 PublicationCorresponds to variant dbSNP:rs28939684Ensembl.1
Natural variantiVAR_026989228H → Q in BFNS1. 1 PublicationCorresponds to variant dbSNP:rs118192204Ensembl.1
Natural variantiVAR_026990243L → F in BFNS1. 1 PublicationCorresponds to variant dbSNP:rs118192205Ensembl.1
Natural variantiVAR_010930284Y → C in BFNS1; 30%-60% reduction of wt current in heteromeric channels. 3 PublicationsCorresponds to variant dbSNP:rs28939683Ensembl.1
Natural variantiVAR_010931306A → T in BFNS1; 20%-40% reduction of wt current in heteromeric channels. 3 PublicationsCorresponds to variant dbSNP:rs74315390Ensembl.1
Natural variantiVAR_026992333R → Q in BFNS1; moderate effect; less than 50% reduction in current compared with wt heteromeric channels. 1 PublicationCorresponds to variant dbSNP:rs118192216Ensembl.1
Natural variantiVAR_026993554K → N in BFNS1 and EIEE7; decreases the voltage-dependence of the channel. 1 PublicationCorresponds to variant dbSNP:rs267607198Ensembl.1
Epileptic encephalopathy, early infantile, 7 (EIEE7)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant seizure disorder characterized by infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities.
See also OMIM:613720
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078638196A → V in EIEE7. 1 Publication1
Natural variantiVAR_078639201R → H in EIEE7; with infantile spasms. 1 Publication1
Natural variantiVAR_026991247S → W in EIEE7; reduces channel currents by more than 50% in homomeric channels. 1 PublicationCorresponds to variant dbSNP:rs74315392Ensembl.1
Natural variantiVAR_078207266D → E in EIEE7; patient also manifests dyskinesia. 1 Publication1
Natural variantiVAR_078208268L → F in EIEE7. 1 Publication1
Natural variantiVAR_078209291R → S in EIEE7. 1 Publication1
Natural variantiVAR_078210294A → V in EIEE7. 1 Publication1
Natural variantiVAR_078211301G → S in EIEE7. 1 Publication1
Natural variantiVAR_078640306A → V in EIEE7; unknown pathological significance. 1 Publication1
Natural variantiVAR_026993554K → N in BFNS1 and EIEE7; decreases the voltage-dependence of the channel. 1 PublicationCorresponds to variant dbSNP:rs267607198Ensembl.1
Natural variantiVAR_078212581R → Q in EIEE7. 1 PublicationCorresponds to variant dbSNP:rs118192235Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi52S → E: 40% increase in potassium current amplitude. Ratio of 1:1. 1 Publication1
Mutagenesisi52S → Q: Decrease of PKA stimulation. Ratio of 1:1. 1 Publication1
Mutagenesisi217T → A: No effect on current or expression. 1 Publication1
Mutagenesisi217T → D: Abolishes currents without reducing channel protein expression. 1 Publication1
Mutagenesisi279G → S: More than 50% reduction of wt heteromeric current. Ratio of 1:1 and 1:1:2. 1 Publication1

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

DisGeNETi3785.
MalaCardsiKCNQ2.
MIMi121200. phenotype.
613720. phenotype.
OpenTargetsiENSG00000075043.
Orphaneti306. Benign familial infantile epilepsy.
1949. Benign familial neonatal seizures.
140927. Benign familial neonatal-infantile seizures.
1934. Early infantile epileptic encephalopathy.
PharmGKBiPA30074.

Chemistry databases

ChEMBLiCHEMBL2476.
DrugBankiDB00321. Amitriptyline.
DB00586. Diclofenac.
DB04953. Ezogabine.
DB06089. ICA-105665.
DB00939. Meclofenamic acid.
GuidetoPHARMACOLOGYi561.

Polymorphism and mutation databases

BioMutaiKCNQ2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540301 – 872Potassium voltage-gated channel subfamily KQT member 2Add BLAST872

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei52Phosphoserine; by PKA1 Publication1
Modified residuei217Phosphothreonine1 Publication1
Modified residuei466PhosphoserineBy similarity1
Modified residuei468PhosphoserineBy similarity1
Modified residuei472PhosphoserineBy similarity1
Modified residuei476PhosphoserineBy similarity1
Modified residuei478PhosphoserineBy similarity1
Modified residuei507PhosphoserineBy similarity1
Modified residuei672PhosphoserineBy similarity1
Modified residuei801PhosphoserineBy similarity1
Modified residuei803PhosphoserineBy similarity1

Post-translational modificationi

In Xenopus oocytes KCNQ2/KCNQ3 heteromeric current can be increased by intracellular cyclic AMP, an effect that depends on phosphorylation of Ser-52 in the N-terminal region.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO43526.
PeptideAtlasiO43526.
PRIDEiO43526.

PTM databases

iPTMnetiO43526.
PhosphoSitePlusiO43526.

Expressioni

Tissue specificityi

In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal chord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors.1 Publication

Gene expression databases

BgeeiENSG00000075043.
CleanExiHS_KCNQ2.
ExpressionAtlasiO43526. baseline and differential.
GenevisibleiO43526. HS.

Organism-specific databases

HPAiHPA016642.
HPA057112.

Interactioni

Subunit structurei

Heteromultimer with KCNQ3. May associate with KCNE2.

GO - Molecular functioni

  • ankyrin binding Source: BHF-UCL
Complete GO annotation...

Protein-protein interaction databases

BioGridi109986. 6 interactors.
IntActiO43526. 1 interactor.
MINTiMINT-8402812.
STRINGi9606.ENSP00000352035.

Chemistry databases

BindingDBiO43526.

Structurei

Secondary structure

1872
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi535 – 556Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5J03X-ray2.00A530-557[»]
ProteinModelPortaliO43526.
SMRiO43526.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi277 – 282Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1419. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00550000074513.
HOVERGENiHBG059014.
InParanoidiO43526.
KOiK04927.
OMAiVTVPMYS.
OrthoDBiEOG091G02ZT.
PhylomeDBiO43526.
TreeFamiTF315186.

Family and domain databases

InterProiView protein in InterPro
IPR020969. Ankyrin-G_BS.
IPR005821. Ion_trans_dom.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR003947. K_chnl_volt-dep_KCNQ2.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiView protein in Pfam
PF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
PF11956. KCNQC3-Ank-G_bd. 1 hit.
PRINTSiPR00169. KCHANNEL.
PR01461. KCNQ2CHANNEL.
PR01459. KCNQCHANNEL.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: O43526-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQKSRNGGV YPGPSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR 
        60         70         80         90        100
GSILSKPRAG GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF 
       110        120        130        140        150
LLVFSCLVLS VFSTIKEYEK SSEGALYILE IVTIVVFGVE YFVRIWAAGC 
       160        170        180        190        200
CCRYRGWRGR LKFARKPFCV IDIMVLIASI AVLAAGSQGN VFATSALRSL 
       210        220        230        240        250
RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF LCLILASFLV 
       260        270        280        290        300
YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 
       310        320        330        340        350
GVSFFALPAG ILGSGFALKV QEQHRQKHFE KRRNPAAGLI QSAWRFYATN 
       360        370        380        390        400
LSRTDLHSTW QYYERTVTVP MYSSQTQTYG ASRLIPPLNQ LELLRNLKSK 
       410        420        430        440        450
SGLAFRKDPP PEPSPSKGSP CRGPLCGCCP GRSSQKVSLK DRVFSSPRGV 
       460        470        480        490        500
AAKGKGSPQA QTVRRSPSAD QSLEDSPSKV PKSWSFGDRS RARQAFRIKG 
       510        520        530        540        550
AASRQNSEEA SLPGEDIVDD KSCPCEFVTE DLTPGLKVSI RAVCVMRFLV 
       560        570        580        590        600
SKRKFKESLR PYDVMDVIEQ YSAGHLDMLS RIKSLQSRVD QIVGRGPAIT 
       610        620        630        640        650
DKDRTKGPAE AELPEDPSMM GRLGKVEKQV LSMEKKLDFL VNIYMQRMGI 
       660        670        680        690        700
PPTETEAYFG AKEPEPAPPY HSPEDSREHV DRHGCIVKIV RSSSSTGQKN 
       710        720        730        740        750
FSAPPAAPPV QCPPSTSWQP QSHPRQGHGT SPVGDHGSLV RIPPPPAHER 
       760        770        780        790        800
SLSAYGGGNR ASMEFLRQED TPGCRPPEGN LRDSDTSISI PSVDHEELER 
       810        820        830        840        850
SFSGFSISQS KENLDALNSC YAAVAPCAKV RPYIAEGESD TDSDLCTPCG 
       860        870 
PPPRSATGEG PFGDVGWAGP RK
Length:872
Mass (Da):95,848
Last modified:June 1, 2001 - v2
Checksum:i22E8A0880A27B58C
GO
Isoform 2 (identifier: O43526-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-434: Missing.

Show »
Length:854
Mass (Da):94,100
Checksum:iCF3F5EC2E23E21FC
GO
Isoform 3 (identifier: O43526-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-382: Missing.
     417-434: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:844
Mass (Da):93,089
Checksum:i5228E1B8C3D8C17F
GO
Isoform 4 (identifier: O43526-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     417-446: Missing.
     509-509: Missing.

Show »
Length:841
Mass (Da):92,596
Checksum:i065E37AF63726B10
GO
Isoform 5 (identifier: O43526-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     310-320: Missing.
     417-434: Missing.

Show »
Length:843
Mass (Da):93,057
Checksum:iAF6F5146789F4167
GO
Isoform 6 (identifier: O43526-6) [UniParc]FASTAAdd to basket
Also known as: HNSPC

The sequence of this isoform differs from the canonical sequence as follows:
     373-393: SSQTQTYGASRLIPPLNQLEL → RYRRRAPATKQLFHFLFSICS
     394-872: Missing.

Show »
Length:393
Mass (Da):44,261
Checksum:i9415BC4FC2F84675
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti699K → E in AAD16988 (PubMed:9836639).Curated1
Sequence conflicti854R → C in AAD16988 (PubMed:9836639).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078638196A → V in EIEE7. 1 Publication1
Natural variantiVAR_078639201R → H in EIEE7; with infantile spasms. 1 Publication1
Natural variantiVAR_043819207R → Q Found in a patient with isolated myokymia; leads to a shift of voltage-dependent activation. 1 PublicationCorresponds to variant dbSNP:rs118192200Ensembl.1
Natural variantiVAR_026987207R → W in BFNS1; phenotype manifestations include myokymia in some patients; leads to a shift of voltage-dependent activation of the channel and a dramatic slowing of activation upon depolarization. 1 PublicationCorresponds to variant dbSNP:rs74315391Ensembl.1
Natural variantiVAR_026988208M → V in BFNS1; minor effect on maximal current but clearly exhibits a faster rate of deactivation. 1 PublicationCorresponds to variant dbSNP:rs118192201Ensembl.1
Natural variantiVAR_010929214R → W in BFNS1. 1 PublicationCorresponds to variant dbSNP:rs28939684Ensembl.1
Natural variantiVAR_026989228H → Q in BFNS1. 1 PublicationCorresponds to variant dbSNP:rs118192204Ensembl.1
Natural variantiVAR_026990243L → F in BFNS1. 1 PublicationCorresponds to variant dbSNP:rs118192205Ensembl.1
Natural variantiVAR_026991247S → W in EIEE7; reduces channel currents by more than 50% in homomeric channels. 1 PublicationCorresponds to variant dbSNP:rs74315392Ensembl.1
Natural variantiVAR_078207266D → E in EIEE7; patient also manifests dyskinesia. 1 Publication1
Natural variantiVAR_078208268L → F in EIEE7. 1 Publication1
Natural variantiVAR_010930284Y → C in BFNS1; 30%-60% reduction of wt current in heteromeric channels. 3 PublicationsCorresponds to variant dbSNP:rs28939683Ensembl.1
Natural variantiVAR_078209291R → S in EIEE7. 1 Publication1
Natural variantiVAR_078210294A → V in EIEE7. 1 Publication1
Natural variantiVAR_078211301G → S in EIEE7. 1 Publication1
Natural variantiVAR_010931306A → T in BFNS1; 20%-40% reduction of wt current in heteromeric channels. 3 PublicationsCorresponds to variant dbSNP:rs74315390Ensembl.1
Natural variantiVAR_078640306A → V in EIEE7; unknown pathological significance. 1 Publication1
Natural variantiVAR_026992333R → Q in BFNS1; moderate effect; less than 50% reduction in current compared with wt heteromeric channels. 1 PublicationCorresponds to variant dbSNP:rs118192216Ensembl.1
Natural variantiVAR_026993554K → N in BFNS1 and EIEE7; decreases the voltage-dependence of the channel. 1 PublicationCorresponds to variant dbSNP:rs267607198Ensembl.1
Natural variantiVAR_078212581R → Q in EIEE7. 1 PublicationCorresponds to variant dbSNP:rs118192235Ensembl.1
Natural variantiVAR_078213777P → S Found in a patient with continuous spikes and waves during sleep; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs748400155Ensembl.1
Natural variantiVAR_010932780N → T1 PublicationCorresponds to variant dbSNP:rs1801475Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000984310 – 320Missing in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_000986373 – 393SSQTQ…NQLEL → RYRRRAPATKQLFHFLFSIC S in isoform 6. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_000985373 – 382Missing in isoform 3. 1 Publication10
Alternative sequenceiVSP_000987394 – 872Missing in isoform 6. 2 PublicationsAdd BLAST479
Alternative sequenceiVSP_000989417 – 446Missing in isoform 4. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_000988417 – 434Missing in isoform 2, isoform 3 and isoform 5. 3 PublicationsAdd BLAST18
Alternative sequenceiVSP_000990509Missing in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82346 mRNA. Translation: BAA11557.1.
AF033348 mRNA. Translation: AAB97315.1.
Y15065 mRNA. Translation: CAA75348.1.
AF110020 mRNA. Translation: AAD16988.1.
AF074247 mRNA. Translation: AAC25921.1.
AL353658, AL121827, AL121829 Genomic DNA. Translation: CAH72958.1.
AL353658, AL121827, AL121829 Genomic DNA. Translation: CAH72959.1.
AL121827, AL121829, AL353658 Genomic DNA. Translation: CAI95054.1.
AL121829, AL121827, AL353658 Genomic DNA. Translation: CAI95740.1.
AL121829, AL121827, AL353658 Genomic DNA. Translation: CAI95744.1.
BC000699 mRNA. Translation: AAH00699.1.
CCDSiCCDS13518.1. [O43526-3]
CCDS13519.1. [O43526-2]
CCDS13520.1. [O43526-1]
CCDS13521.1. [O43526-6]
CCDS46629.1. [O43526-4]
PIRiJC5275.
RefSeqiNP_004509.2. NM_004518.5. [O43526-3]
NP_742104.1. NM_172106.2. [O43526-2]
NP_742105.1. NM_172107.3. [O43526-1]
NP_742106.1. NM_172108.4. [O43526-4]
NP_742107.1. NM_172109.2. [O43526-6]
UniGeneiHs.161851.
Hs.652468.

Genome annotation databases

EnsembliENST00000344425; ENSP00000345523; ENSG00000075043. [O43526-6]
ENST00000344462; ENSP00000339611; ENSG00000075043. [O43526-4]
ENST00000359125; ENSP00000352035; ENSG00000075043. [O43526-1]
ENST00000360480; ENSP00000353668; ENSG00000075043. [O43526-3]
ENST00000626839; ENSP00000486706; ENSG00000075043. [O43526-2]
GeneIDi3785.
KEGGihsa:3785.
UCSCiuc002yey.2. human. [O43526-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82346 mRNA. Translation: BAA11557.1.
AF033348 mRNA. Translation: AAB97315.1.
Y15065 mRNA. Translation: CAA75348.1.
AF110020 mRNA. Translation: AAD16988.1.
AF074247 mRNA. Translation: AAC25921.1.
AL353658, AL121827, AL121829 Genomic DNA. Translation: CAH72958.1.
AL353658, AL121827, AL121829 Genomic DNA. Translation: CAH72959.1.
AL121827, AL121829, AL353658 Genomic DNA. Translation: CAI95054.1.
AL121829, AL121827, AL353658 Genomic DNA. Translation: CAI95740.1.
AL121829, AL121827, AL353658 Genomic DNA. Translation: CAI95744.1.
BC000699 mRNA. Translation: AAH00699.1.
CCDSiCCDS13518.1. [O43526-3]
CCDS13519.1. [O43526-2]
CCDS13520.1. [O43526-1]
CCDS13521.1. [O43526-6]
CCDS46629.1. [O43526-4]
PIRiJC5275.
RefSeqiNP_004509.2. NM_004518.5. [O43526-3]
NP_742104.1. NM_172106.2. [O43526-2]
NP_742105.1. NM_172107.3. [O43526-1]
NP_742106.1. NM_172108.4. [O43526-4]
NP_742107.1. NM_172109.2. [O43526-6]
UniGeneiHs.161851.
Hs.652468.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5J03X-ray2.00A530-557[»]
ProteinModelPortaliO43526.
SMRiO43526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109986. 6 interactors.
IntActiO43526. 1 interactor.
MINTiMINT-8402812.
STRINGi9606.ENSP00000352035.

Chemistry databases

BindingDBiO43526.
ChEMBLiCHEMBL2476.
DrugBankiDB00321. Amitriptyline.
DB00586. Diclofenac.
DB04953. Ezogabine.
DB06089. ICA-105665.
DB00939. Meclofenamic acid.
GuidetoPHARMACOLOGYi561.

Protein family/group databases

TCDBi1.A.1.15.2. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiO43526.
PhosphoSitePlusiO43526.

Polymorphism and mutation databases

BioMutaiKCNQ2.

Proteomic databases

PaxDbiO43526.
PeptideAtlasiO43526.
PRIDEiO43526.

Protocols and materials databases

DNASUi3785.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344425; ENSP00000345523; ENSG00000075043. [O43526-6]
ENST00000344462; ENSP00000339611; ENSG00000075043. [O43526-4]
ENST00000359125; ENSP00000352035; ENSG00000075043. [O43526-1]
ENST00000360480; ENSP00000353668; ENSG00000075043. [O43526-3]
ENST00000626839; ENSP00000486706; ENSG00000075043. [O43526-2]
GeneIDi3785.
KEGGihsa:3785.
UCSCiuc002yey.2. human. [O43526-1]

Organism-specific databases

CTDi3785.
DisGeNETi3785.
GeneCardsiKCNQ2.
GeneReviewsiKCNQ2.
HGNCiHGNC:6296. KCNQ2.
HPAiHPA016642.
HPA057112.
MalaCardsiKCNQ2.
MIMi121200. phenotype.
602235. gene.
613720. phenotype.
neXtProtiNX_O43526.
OpenTargetsiENSG00000075043.
Orphaneti306. Benign familial infantile epilepsy.
1949. Benign familial neonatal seizures.
140927. Benign familial neonatal-infantile seizures.
1934. Early infantile epileptic encephalopathy.
PharmGKBiPA30074.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1419. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00550000074513.
HOVERGENiHBG059014.
InParanoidiO43526.
KOiK04927.
OMAiVTVPMYS.
OrthoDBiEOG091G02ZT.
PhylomeDBiO43526.
TreeFamiTF315186.

Enzyme and pathway databases

ReactomeiR-HSA-1296072. Voltage gated Potassium channels.
R-HSA-445095. Interaction between L1 and Ankyrins.
SIGNORiO43526.

Miscellaneous databases

ChiTaRSiKCNQ2. human.
GeneWikiiKvLQT2.
GenomeRNAii3785.
PROiPR:O43526.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075043.
CleanExiHS_KCNQ2.
ExpressionAtlasiO43526. baseline and differential.
GenevisibleiO43526. HS.

Family and domain databases

InterProiView protein in InterPro
IPR020969. Ankyrin-G_BS.
IPR005821. Ion_trans_dom.
IPR003937. K_chnl_volt-dep_KCNQ.
IPR003947. K_chnl_volt-dep_KCNQ2.
IPR013821. K_chnl_volt-dep_KCNQ_C.
IPR028325. VG_K_chnl.
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiView protein in Pfam
PF00520. Ion_trans. 1 hit.
PF03520. KCNQ_channel. 1 hit.
PF11956. KCNQC3-Ank-G_bd. 1 hit.
PRINTSiPR00169. KCHANNEL.
PR01461. KCNQ2CHANNEL.
PR01459. KCNQCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNQ2_HUMAN
AccessioniPrimary (citable) accession number: O43526
Secondary accession number(s): O43796
, O75580, O95845, Q4VXP4, Q4VXR6, Q5VYT8, Q96J59, Q99454
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.