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Reviewed, UniProtKB/Swiss-Prot O43521 (BIM_HUMAN)

Last modified July 22, 2008. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Bcl-2-like protein 11
Alternative name(s):
    Bcl2-interacting mediator of cell death
Gene names
Name: BCL2L11
Synonyms: BIM
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Induces apoptosis. Isoform BimL is more potent than isoform BimEL.

Subunit structure

Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including Mcl-1, Bcl-2, Bcl-X(L), BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK By similarity.

Subcellular location

Membrane; Peripheral membrane protein. Note= Associated with intracytoplasmic membranes By similarity.

Domain

The BH3 motif is required for Bcl-2 binding and cytotoxicity.

Ontologies

Keywords

   Biological processApoptosis
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical term3D-structure

Gene Ontology (GO)

   Biological processactivation of pro-apoptotic gene products

Inferred from Experiment. Source: Reactome

induction of apoptosis

Traceable author statement. Source: UniProtKB

   Cellular componentcytosol

Inferred from Experiment. Source: Reactome

membrane fraction Ref.1

Traceable author statement. Source: ProtInc

mitochondrial outer membrane

Inferred from Experiment. Source: Reactome

plasma membrane

Inferred from Experiment. Source: Reactome

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform BimEL (identifier: O43521-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform BimL (identifier: O43521-2)

The sequence of this isoform differs from the canonical sequence as follows:
     42-101: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 198198Bcl-2-like protein 11

Regions

Motif148 – 16215BH3

Amino acid modifications

Modified residue771Phosphoserine

Natural variations

Alternative sequence42 – 10160Missing in isoform BimL.

Secondary structure

... 198
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform BimEL [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: D75735E469CA6997

FASTA19822,171
        10         20         30         40         50         60 
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP 

        70         80         90        100        110        120 
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP 

       130        140        150        160        170        180 
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR 

       190 
MVILRLLRYI VRLVWRMH 

« Hide

Isoform BimL [UniParc].

Checksum: 8BB4AAE06CB080FA
Show »

13815,967

References

« Hide 'large scale' references
[1]"Bim: a novel member of the Bcl-2 family that promotes apoptosis."
O'Connor L., Strasser A., O'Reilly L.A., Hausmann G., Adams J.M., Cory S., Huang D.C.S.
EMBO J. 17:384-395(1998) [PubMed: 9430630] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BIMEL AND BIML), FUNCTION.
Tissue: Peripheral blood and Spleen.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BIMEL).
Tissue: Blood.
[3]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF032457 mRNA. Translation: AAC39593.1.
AF032458 mRNA. Translation: AAC39594.1.
BC033694 mRNA. Translation: AAH33694.1.
RefSeqNP_006529.1.
NP_619527.1.
UniGeneHs.469658

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2NL9X-ray1.55B141-166[»]
2VM6X-ray2.20B141-165[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:29185N.
IntActO43521.

PTM databases

PhosphoSiteO43521.

Genome annotation databases

EnsemblENSG00000153094. Homo sapiens. [Contig view]
GeneID10018.
KEGGhsa:10018.

Organism-specific databases

HGNCHGNC:994. BCL2L11.
HPACAB002616.
MIM603827. gene.
PharmGKBPA25305.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMO43521.
HOVERGENO43521.

Enzyme and pathway databases

ReactomeREACT_578. Apoptosis.

Gene expression databases

ArrayExpressO43521.
CleanExHS_BCL2L11.
GermOnlineENSG00000153094. Homo sapiens.

Family and domain databases

InterProIPR017288. Apoptosis_Bcl-2-like_11.
IPR014771. Apoptosis_Bim_N.
IPR000712. Bcl2_BH.
IPR015040. Bclx_interact.
[Graphical view]
PfamPF08945. Bclx_interact. 1 hit.
PF06773. Bim_N. 1 hit.
[Graphical view]
PIRSFPIRSF037827. Bcl-2-like_p11. 1 hit.
PROSITEPS01259. BH3. False negative.
[Graphical view]
ProDomO43521.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

LinkHubO43521.
SOURCESearch...
ProtoNetSearch...

Entry information

Entry nameBIM_HUMAN
AccessionPrimary (citable) accession number: O43521
Secondary accession number(s): O43522
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 1998
Last modified: July 22, 2008
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents