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Reviewed, UniProtKB/Swiss-Prot O43521 (B2L11_HUMAN)

Last modified November 3, 2009. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Bcl-2-like protein 11
      Short name=Bcl2-L-11
Alternative name(s):
    Bcl2-interacting mediator of cell death
Gene names
Name: BCL2L11
Synonyms: BIM
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis. Ref.1 Ref.2 Ref.3 Ref.4

Subunit structure

Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK By similarity.

Subcellular location

Endomembrane system; Peripheral membrane protein By similarity. Note: Associated with intracytoplasmic membranes By similarity.

Isoform BimEL: Mitochondrion. Ref.2 Ref.3

Isoform BimL: Mitochondrion. Ref.2 Ref.3

Isoform BimS: Mitochondrion. Ref.2 Ref.3

Isoform Bim-alpha1: Mitochondrion. Ref.2 Ref.3

Tissue specificity

Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. Ref.3

Domain

The BH3 motif is required for Bcl-2 binding and cytotoxicity.

Sequence similarities

Belongs to the Bcl-2 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentMembrane
Mitochondrion
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processactivation of pro-apoptotic gene products

Inferred from Experiment. Source: Reactome

induction of apoptosis by extracellular signals

Inferred from Experiment. Source: Reactome

   Cellular componentcytosol

Inferred from Experiment. Source: Reactome

extrinsic to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

mitochondrial outer membrane

Inferred from Experiment. Source: Reactome

plasma membrane

Inferred from Experiment. Source: Reactome

   Molecular functionprotein binding

Inferred from physical interaction. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 17 isoforms produced by alternative splicing. [Align] [Select]
Isoform BimEL (identifier: O43521-1)

Also known as: Bim(EL);

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform BimL (identifier: O43521-2)

Also known as: Bim(L);

The sequence of this isoform differs from the canonical sequence as follows:
     42-101: Missing.
Isoform BimS (identifier: O43521-3)

Also known as: BCL2-like 11 transcript variant 9; Bim(S);

The sequence of this isoform differs from the canonical sequence as follows:
     42-131: Missing.
Isoform Bim-alpha1 (identifier: O43521-4)

The sequence of this isoform differs from the canonical sequence as follows:
     167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → LEK
Isoform Bim-alpha2 (identifier: O43521-5)

The sequence of this isoform differs from the canonical sequence as follows:
     42-101: Missing.
     167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → LEK
Isoform Bim-alpha3 (identifier: O43521-6)

Also known as: BCL2-like 11 transcript variant 10;

The sequence of this isoform differs from the canonical sequence as follows:
     42-131: Missing.
     167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → LEK
Isoform Bim-alpha4 (identifier: O43521-7)

The sequence of this isoform differs from the canonical sequence as follows:
     42-131: Missing.
     167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → LAKLLASST
Isoform Bim-alpha5 (identifier: O43521-8)

The sequence of this isoform differs from the canonical sequence as follows:
     167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → MPLPPD
Isoform Bim-alpha6 (identifier: O43521-9)

The sequence of this isoform differs from the canonical sequence as follows:
     42-131: Missing.
     167-198: VFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH → MPLPPD
Isoform Bim-beta1 (identifier: O43521-10)

The sequence of this isoform differs from the canonical sequence as follows:
     133-135: SMR → NWD
     136-198: Missing.
Isoform Bim-beta2 (identifier: O43521-11)

The sequence of this isoform differs from the canonical sequence as follows:
     132-135: ASMR → GIFE
     136-198: Missing.
Isoform Bim-beta3 (identifier: O43521-12)

The sequence of this isoform differs from the canonical sequence as follows:
     42-75: GNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFAT → VSLCHPGWSALVRSWLTATSNSQVQAVLLPQPPK
Isoform Bim-beta4 (identifier: O43521-13)

The sequence of this isoform differs from the canonical sequence as follows:
     43-44: NP → IF
     45-198: Missing.
Isoform Bim-beta5 (identifier: O43521-14)

The sequence of this isoform differs from the canonical sequence as follows:
     132-140: ASMRQAEPA → VREIEEVVV
     141-198: Missing.
Isoform Bim-beta6 (identifier: O43521-15)

The sequence of this isoform differs from the canonical sequence as follows:
     42-101: Missing.
     132-135: ASMR → GIFE
     136-198: Missing.
Isoform Bim-beta7 (identifier: O43521-16)

The sequence of this isoform differs from the canonical sequence as follows:
     42-101: Missing.
     132-140: ASMRQAEPA → VREIEEVVV
     141-198: Missing.
Isoform Bim-gamma (identifier: O43521-17)

The sequence of this isoform differs from the canonical sequence as follows:
     42-101: Missing.
     132-198: ASMRQAEPAD...YIVRLVWRMH → VVILEDIGDL...TEQLNHKDFS

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198Bcl-2-like protein 11
PRO_0000143109

Regions

Motif148 – 16215BH3

Amino acid modifications

Modified residue771Phosphoserine Ref.10 Ref.11
Modified residue871Phosphoserine By similarity

Natural variations

Alternative sequence42 – 13190Missing in isoform BimS, isoform Bim-alpha3, isoform Bim-alpha6 and isoform Bim-alpha4.
VSP_035608
Alternative sequence42 – 10160Missing in isoform BimL, isoform Bim-alpha2, isoform Bim-gamma, isoform Bim-beta6 and isoform Bim-beta7.
VSP_000535
Alternative sequence42 – 7534GNPEG…GPFAT → VSLCHPGWSALVRSWLTATS NSQVQAVLLPQPPK in isoform Bim-beta3.
VSP_035609
Alternative sequence43 – 442NP → IF in isoform Bim-beta4.
VSP_035610
Alternative sequence45 – 198154Missing in isoform Bim-beta4.
VSP_035611
Alternative sequence132 – 19867ASMRQ…VWRMH → VVILEDIGDLSLCFGFIFTG LDLYGHHHSQDTEQLNHKDF S in isoform Bim-gamma.
VSP_035612
Alternative sequence132 – 1409ASMRQAEPA → VREIEEVVV in isoform Bim-beta5 and isoform Bim-beta7.
VSP_035613
Alternative sequence132 – 1354ASMR → GIFE in isoform Bim-beta2 and isoform Bim-beta6.
VSP_035614
Alternative sequence133 – 1353SMR → NWD in isoform Bim-beta1.
VSP_035615
Alternative sequence136 – 19863Missing in isoform Bim-beta1, isoform Bim-beta2 and isoform Bim-beta6.
VSP_035616
Alternative sequence141 – 19858Missing in isoform Bim-beta5 and isoform Bim-beta7.
VSP_035617
Alternative sequence167 – 19832VFLNN…VWRMH → LEK in isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3.
VSP_035620
Alternative sequence167 – 19832VFLNN…VWRMH → LAKLLASST in isoform Bim-alpha4.
VSP_035618
Alternative sequence167 – 19832VFLNN…VWRMH → MPLPPD in isoform Bim-alpha5 and isoform Bim-alpha6.
VSP_035619

Experimental info

Sequence conflict331P → L in BAF83066. Ref.6

Secondary structure

... 198
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform BimEL (Bim(EL)) [UniParc].

Last modified June 1, 1998. Version 1.
Checksum: D75735E469CA6997

FASTA19822,171
        10         20         30         40         50         60 
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP 

        70         80         90        100        110        120 
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP 

       130        140        150        160        170        180 
CQAFNHYLSA MASMRQAEPA DMRPEIWIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPR 

       190 
MVILRLLRYI VRLVWRMH 

« Hide

Isoform BimL (Bim(L)).

Checksum: 8BB4AAE06CB080FA
Show »

FASTA13815,967
Isoform BimS (BCL2-like 11 transcript variant 9) (Bim(S)).

Checksum: 60067208524D5BEA
Show »

FASTA10812,717
Isoform Bim-alpha1.

Checksum: E2E24D5697C955BA
Show »

FASTA16918,536
Isoform Bim-alpha2.

Checksum: 4335FA21C13B49AD
Show »

FASTA10912,332
Isoform Bim-alpha3 (BCL2-like 11 transcript variant 10).

Checksum: 3E03CCF2154A242C
Show »

FASTA799,081
Isoform Bim-alpha4.

Checksum: 7A6FD9AF07DA3E05
Show »

FASTA859,596
Isoform Bim-alpha5.

Checksum: D2F7FC06EE3CE697
Show »

FASTA17218,816
Isoform Bim-alpha6.

Checksum: 08678A7A0FBD4215
Show »

FASTA829,362
Isoform Bim-beta1.

Checksum: D208F1CB6D324539
Show »

FASTA13514,458
Isoform Bim-beta2.

Checksum: D3A245DECD324539
Show »

FASTA13514,418
Isoform Bim-beta3.

Checksum: A8FA866EBD5CF16E
Show »

FASTA19822,649
Isoform Bim-beta4.

Checksum: FA9541901CA32FD1
Show »

FASTA444,834
Isoform Bim-beta5.

Checksum: B7590CC04A98E081
Show »

FASTA14015,025
Isoform Bim-beta6.

Checksum: 7CFE6B5A5ED671F3
Show »

FASTA758,214
Isoform Bim-beta7.

Checksum: 6958582B30D7BCAF
Show »

FASTA808,821
Isoform Bim-gamma.

Checksum: 15E21254C12C239B
Show »

FASTA11212,412

References

« Hide 'large scale' references
[1]"Bim: a novel member of the Bcl-2 family that promotes apoptosis."
O'Connor L., Strasser A., O'Reilly L.A., Hausmann G., Adams J.M., Cory S., Huang D.C.S.
EMBO J. 17:384-395(1998) [PubMed: 9430630] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BIMEL AND BIML), FUNCTION.
Tissue: Peripheral blood and Spleen.
[2]"Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family."
Mami U., Miyashita T., Shikama Y., Tadokoro K., Yamada M.
FEBS Lett. 509:135-141(2001) [PubMed: 11734221] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BIM-ALPHA1; BIM-ALPHA2; BIM-BETA1; BIM-BETA2; BIM-BETA3 AND BIM-BETA4), FUNCTION (ISOFORMS BIM-ALPHA1 AND BIM-ALPHA2), SUBCELLULAR LOCATION.
[3]"Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim."
Liu J.-W., Chandra D., Tang S.H., Chopra D., Tang D.G.
Cancer Res. 62:2976-2981(2002) [PubMed: 12019181] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BIM-GAMMA), FUNCTION (ISOFORM BIM-GAMMA), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]"Over-expression of Bim alpha3, a novel isoform of human Bim, result in cell apoptosis."
Chen J.Z., Ji C.N., Gu S.H., Li J.X., Zhao E.P., Huang Y., Huang L., Ying K., Xie Y., Mao Y.M.
Int. J. Biochem. Cell Biol. 36:1554-1561(2004) [PubMed: 15147734] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BIMS AND BIM-ALPHA3), FUNCTION (ISOFORM BIM-ALPHA3).
[5]"Identification and characterization of BH3 domain protein Bim and its isoforms in human hepatocellular carcinomas."
Miao J., Chen G.G., Yun J.P., Chun S.Y., Zheng Z.Z., Ho R.L.K., Chak E.C., Xia N.S., Lai P.B.
Apoptosis 12:1691-1701(2007) [PubMed: 17503221] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BIM-ALPHA3; BIM-ALPHA4; BIM-ALPHA5; BIM-ALPHA6; BIM-BETA5; BIM-BETA6; BIM-BETA7).
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS BIMEL AND BIML).
Tissue: Teratocarcinoma and Tongue.
[7]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BIMEL).
Tissue: Blood.
[10]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, MASS SPECTROMETRY.
[11]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, MASS SPECTROMETRY.
[12]"Structural insights into the degradation of Mcl-1 induced by BH3 domains."
Czabotar P.E., Lee E.F., van Delft M.F., Day C.L., Smith B.J., Huang D.C.S., Fairlie W.D., Hinds M.G., Colman P.M.
Proc. Natl. Acad. Sci. U.S.A. 104:6217-6222(2007) [PubMed: 17389404] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 141-166 IN COMPLEX WITH MCL1.
[13]"Human BCL-2A1 in complex with BIM."
Structural genomics consortium (SGC)
Submitted (FEB-2008) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 141-165 IN COMPLEX WITH BCL2A1.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF032457 mRNA. Translation: AAC39593.1.
AF032458 mRNA. Translation: AAC39594.1.
AB071195 mRNA. Translation: BAB78589.1.
AB071196 mRNA. Translation: BAB78590.1.
AB071197 mRNA. Translation: BAB78591.1.
AB071198 mRNA. Translation: BAB78592.1.
AB071199 mRNA. Translation: BAB78593.1.
AB071200 mRNA. Translation: BAB78594.1.
AY352518 mRNA. Translation: AAQ62569.1.
AY305714 mRNA. Translation: AAQ82546.1.
AY305715 mRNA. Translation: AAQ82547.1.
AY423441 mRNA. Translation: AAQ99148.1.
AY423442 mRNA. Translation: AAQ99149.1.
AY423443 mRNA. Translation: AAQ99150.1.
AY428962 mRNA. Translation: AAR06908.1.
DQ849200 mRNA. Translation: ABI13589.1.
DQ849201 mRNA. Translation: ABI13590.1.
DQ849202 mRNA. Translation: ABI13591.1.
AK290377 mRNA. Translation: BAF83066.1.
AK291269 mRNA. Translation: BAF83958.1.
AC096670 Genomic DNA. Translation: AAY14797.1.
CH471237 Genomic DNA. Translation: EAW50365.1.
CH471237 Genomic DNA. Translation: EAW50367.1.
CH471237 Genomic DNA. Translation: EAW50369.1.
CH471237 Genomic DNA. Translation: EAW50370.1.
CH471237 Genomic DNA. Translation: EAW50371.1.
CH471237 Genomic DNA. Translation: EAW50372.1.
CH471237 Genomic DNA. Translation: EAW50373.1.
CH471237 Genomic DNA. Translation: EAW50374.1.
BC033694 mRNA. Translation: AAH33694.1.
IPIIPI00012853.
IPI00103743.
IPI00216585.
IPI00410159.
IPI00428840.
IPI00451139.
IPI00514401.
IPI00873921.
IPI00878323.
IPI00914559.
IPI00914560.
IPI00914563.
IPI00914586.
IPI00914592.
IPI00914600.
IPI00914670.
IPI00914677.
RefSeqNP_006529.1.
NP_619527.1.
NP_996885.1.
UniGeneHs.469658

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2K7WNMR-B145-164[»]
2NL9X-ray1.55B141-166[»]
2V6QX-ray2.70B141-166[»]
2VM6X-ray2.20B141-165[»]
3D7VX-ray2.03B141-166[»]
3FDLX-ray1.78B141-166[»]
3IO8X-ray2.30B/D141-166[»]
3IO9X-ray2.40B141-166[»]
ModBaseSearch...

Protein-protein interaction databases

DIPDIP:29185N.
IntActO43521. 24 interactions.
STRINGO43521.

PTM databases

PhosphoSiteO43521.

Proteomic databases

PRIDEO43521.

Genome annotation databases

EnsemblENST00000308659; ENSP00000309226; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000337565; ENSP00000338374; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000357682; ENSP00000350311; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000357757; ENSP00000350398; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000361493; ENSP00000354879; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000393252; ENSP00000376941; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000393253; ENSP00000376942; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000393256; ENSP00000376943; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000405953; ENSP00000384641; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000415458; ENSP00000393781; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000422765; ENSP00000408260; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000428038; ENSP00000396851; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000431217; ENSP00000394640; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000432179; ENSP00000411870; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000433098; ENSP00000401662; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000436733; ENSP00000403727; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000437029; ENSP00000412892; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000438054; ENSP00000389225; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000439718; ENSP00000411137; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000452033; ENSP00000403666; ENSG00000153094; Homo sapiens. [Genome view]
ENST00000452231; ENSP00000391292; ENSG00000153094; Homo sapiens. [Genome view]
GeneID10018.
KEGGhsa:10018.
UCSCuc002tgt.1. human.
uc002tgu.1. human.
uc002tgv.1. human.
uc002tgz.1. human.
uc002tha.1. human.
uc002thd.1. human.

Organism-specific databases

CTD10018.
GeneCardsGC02P111597.
HGNCHGNC:994. BCL2L11.
MIM603827. gene.
PharmGKBPA25305.
GenAtlasSearch...

Phylogenomic databases

HOGENOMO43521.
HOVERGENO43521.
OMAMVVILED.

Enzyme and pathway databases

Pathway_Interaction_DBfoxopathway. FoxO family signaling.
p75ntrpathway. p75(NTR)-mediated signaling.
ReactomeREACT_11061. Signalling by NGF.
REACT_578. Apoptosis.

Gene expression databases

ArrayExpressO43521.
BgeeO43521.
GenevestigatorO43521.
GermOnlineENSG00000153094. Homo sapiens.

Family and domain databases

InterProIPR017288. Apoptosis_Bcl-2-like_11.
IPR014771. Apoptosis_Bim_N.
IPR015040. Bcl-x_interacting.
IPR000712. Bcl2_BH.
[Graphical view]
PfamPF08945. Bclx_interact. 1 hit.
PF06773. Bim_N. 1 hit.
[Graphical view]
PIRSFPIRSF037827. Bcl-2-like_p11. 1 hit.
PROSITEPS01259. BH3. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio37849.
PMAP-CutDBO43521.
SOURCESearch...

Entry information

Entry nameB2L11_HUMAN
AccessionPrimary (citable) accession number: O43521
Secondary accession number(s): A8K2W2 expand/collapse secondary AC list , O43522, Q0MSE7, Q0MSE8, Q0MSE9, Q53R28, Q6JTU6, Q6T851, Q6TE14, Q6TE15, Q6TE16, Q6V402, Q8WYL6, Q8WYL7, Q8WYL8, Q8WYL9, Q8WYM0, Q8WYM1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 1998
Last modified: November 3, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents