Reviewed,
UniProtKB/Swiss-Prot O43508 (TNF12_HUMAN)
Last modified
November 25, 2008.
Version 78.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tumor necrosis factor ligand superfamily member 12 Alternative name(s): TNF-related weak inducer of apoptosis Short name=TWEAK APO3 ligand Cleaved into the following 2 chains: 1- Recommended name: Tumor necrosis factor ligand superfamily member 12, membrane form 2- Recommended name: Tumor necrosis factor ligand superfamily member 12, secreted form | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 249 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. |
| Subunit structure | Homotrimer Potential. Interacts with the angiogenic factor AGGF1/VG5Q. |
| Subcellular location | Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted. |
| Tissue specificity | Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. |
| Post-translational modification | The soluble form derives from the membrane form by proteolytic processing. |
| Sequence similarities | Belongs to the tumor necrosis factor family. |
| Sequence caution | The sequence AAH19047.1 differs from that shown. Reason: Frameshift at position 125. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 249 | 249 | Tumor necrosis factor ligand superfamily member 12, membrane form | PRO_0000034520 | |||||
| Chain | 94 – 249 | 156 | Tumor necrosis factor ligand superfamily member 12, secreted form | PRO_0000034521 | |||||
Regions | |||||||||
| Topological domain | 1 – 21 | 21 | Cytoplasmic Potential | ||||||
| Transmembrane | 22 – 42 | 21 | Signal-anchor for type II membrane protein Potential | ||||||
| Topological domain | 43 – 249 | 207 | Extracellular Potential | ||||||
Sites | |||||||||
| Site | 93 – 94 | 2 | Cleavage | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 139 | 1 | N-linked (GlcNAc...) | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis." Chicheportiche Y., Bourdon P.R., Xu H., Hsu Y.-M., Scott H., Hession C., Garcia I., Browning J.L. J. Biol. Chem. 272:32401-32410(1997) [PubMed: 9405449] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], N-TERMINUS OF SOLUBLE FORM. Tissue: Fetal liver and Tonsil. |
| [2] | "Identification of a ligand for the death-domain-containing receptor Apo3." Marsters S.A., Sheridan J.P., Pitti R.M., Brush J., Goddard A., Ashkenazi A. Curr. Biol. 8:525-528(1998) [PubMed: 9560343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal kidney. |
| [3] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tonsil. |
| [5] | "TWEAK induces angiogenesis and proliferation of endothelial cells." Lynch C.N., Wang Y.C., Lund J.K., Chen Y.-W., Leal J.A., Wiley S.R. J. Biol. Chem. 274:8455-8459(1999) [PubMed: 10085077] [Abstract] Cited for: FUNCTION. |
| [6] | "Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome." Tian X.-L., Kadaba R., You S.-A., Liu M., Timur A.A., Yang L., Chen Q., Szafranski P., Rao S., Wu L., Housman D.E., DiCorleto P.E., Driscoll D.J., Borrow J., Wang Q. Nature 427:640-645(2004) [PubMed: 14961121] [Abstract] Cited for: INTERACTION WITH AGGF1/VG5Q. |
| [7] | "TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor." Wiley S.R., Winkles J.A. Cytokine Growth Factor Rev. 14:241-249(2003) [PubMed: 12787562] [Abstract] Cited for: REVIEW. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF030099 mRNA. Translation: AAC51923.1. AF055872 mRNA. Translation: AAC39724.1. AY358870 mRNA. Translation: AAQ89229.1. BC019047 mRNA. Translation: AAH19047.1. Frameshift. | |
| RefSeq | NP_003800.1. |
| UniGene | Hs.54673 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000161955. Homo sapiens. [Contig view] |
| GeneID | 8742. |
| KEGG | hsa:8742. |
Organism-specific databases | |
| HGNC | HGNC:11927. TNFSF12. |
| MIM | 602695. gene. |
| PharmGKB | PA36620. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | O43508. |
Gene expression databases | |
| ArrayExpress | O43508. |
| GermOnline | ENSG00000161955. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR006052. TNF_family. IPR008983. Tumour_necrosis_fac-like. [Graphical view] |
| Gene3D | G3DSA:2.60.120.40. Tumour_necrosis_fac-like. 1 hit. |
| Pfam | PF00229. TNF. 1 hit. [Graphical view] |
| SMART | SM00207. TNF. 1 hit. [Graphical view] |
| PROSITE | PS00251. TNF_1. False negative. PS50049. TNF_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 32801. |
| SOURCE | Search... |
Entry information
| Entry name | TNF12_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O43508 Secondary accession number(s): Q8WUZ7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


