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O43502

- RA51C_HUMAN

UniProt

O43502 - RA51C_HUMAN

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Protein

DNA repair protein RAD51 homolog 3

Gene
RAD51C, RAD51L2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response to DNA damage suggesting an involvement in early stages of HR probably in the invasion step. Has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Participates in branch migration and HJ resolution and thus is important for processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex. Part of a PALB2-scaffolded HR complex containing BRCA2 and which is thought to play a role in DNA repair by HR. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.8 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi125 – 1328ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. crossover junction endodeoxyribonuclease activity Source: Ensembl
  3. DNA binding Source: ProtInc
  4. DNA-dependent ATPase activity Source: InterPro
  5. protein binding Source: IntAct

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. DNA catabolic process, endonucleolytic Source: GOC
  3. DNA recombination Source: UniProtKB
  4. DNA repair Source: UniProtKB
  5. double-strand break repair via homologous recombination Source: UniProtKB
  6. female meiosis sister chromatid cohesion Source: Ensembl
  7. male meiosis I Source: Ensembl
  8. positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
  9. reciprocal meiotic recombination Source: Ensembl
  10. sister chromatid cohesion Source: UniProtKB
  11. spermatogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_27271. Meiotic recombination.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD51 homolog 3
Short name:
R51H3
Alternative name(s):
RAD51 homolog C
RAD51-like protein 2
Gene namesi
Name:RAD51C
Synonyms:RAD51L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:9820. RAD51C.

Subcellular locationi

Nucleus. Cytoplasm. Cytoplasmperinuclear region. Mitochondrion
Note: DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA.5 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. mitochondrion Source: UniProtKB
  3. nucleoplasm Source: Reactome
  4. nucleus Source: UniProtKB
  5. perinuclear region of cytoplasm Source: UniProtKB
  6. Rad51B-Rad51C-Rad51D-XRCC2 complex Source: UniProtKB
  7. Rad51C-XRCC3 complex Source: UniProtKB
  8. replication fork Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Involvement in diseasei

Fanconi anemia complementation group O (FANCO) [MIM:613390]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti258 – 2581R → H in FANCO; possibly hypomorphic allele; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 Publications
VAR_064032
Breast-ovarian cancer, familial, 3 (BROVCA3) [MIM:613399]: A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate.
Note: The disease is caused by mutations affecting the gene represented in this entry.3 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti125 – 1251G → V in BROVCA3. 1 Publication
VAR_063838
Natural varianti138 – 1381L → F in BROVCA3; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 Publications
VAR_063840
Natural varianti162 – 1621G → E in BROVCA3. 1 Publication
Corresponds to variant rs35151472 [ dbSNP | Ensembl ].
VAR_068017
Natural varianti178 – 1781Q → P in BROVCA3. 1 Publication
VAR_068019
Natural varianti287 – 2871T → A in BROVCA3. 3 Publications
Corresponds to variant rs28363317 [ dbSNP | Ensembl ].
VAR_020520

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi131 – 1311K → A: Significant loss of function; abolishes Holliday junction resolution activity. 2 Publications
Mutagenesisi131 – 1311K → R: Partial loss of function. 2 Publications

Keywords - Diseasei

Disease mutation, Fanconi anemia

Organism-specific databases

MIMi613390. phenotype.
613399. phenotype.
Orphaneti84. Fanconi anemia.
145. Hereditary breast and ovarian cancer syndrome.
PharmGKBiPA34177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376DNA repair protein RAD51 homolog 3PRO_0000122941Add
BLAST

Proteomic databases

MaxQBiO43502.
PaxDbiO43502.
PRIDEiO43502.

PTM databases

PhosphoSiteiO43502.

Expressioni

Tissue specificityi

Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.

Inductioni

Stress-induced increase in the mitochondrial levels is seen.1 Publication

Gene expression databases

ArrayExpressiO43502.
BgeeiO43502.
CleanExiHS_RAD51C.
GenevestigatoriO43502.

Interactioni

Subunit structurei

Part of the Rad21 paralog protein complexes BCDX2 and CX3; the complexes have a ring-like structure arranged into a flat disc around a central channel. The BCDX2 complex consits of RAD51B, RAD51C, RAD51D and XRCC2; the CX3 complex consists of RAD51C and XRCC3. The BCDX2 subcomplex RAD51B:RAD51C interacts with RAD51. Interacts with SWSAP1; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.10 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PALB2Q86YC210EBI-2267048,EBI-1222653
RAD51Q066096EBI-2267048,EBI-297202
RAD51BO1531510EBI-2267048,EBI-2824089
RAD51DO757716EBI-2267048,EBI-1055693
SWSAP1Q6NVH72EBI-2267048,EBI-5281637
XRCC2O435432EBI-2267048,EBI-3918457
XRCC3O435427EBI-2267048,EBI-2849976

Protein-protein interaction databases

BioGridi111826. 10 interactions.
DIPiDIP-41247N.
IntActiO43502. 8 interactions.
MINTiMINT-204767.
STRINGi9606.ENSP00000336701.

Structurei

3D structure databases

ProteinModelPortaliO43502.
SMRiO43502. Positions 19-348.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 126126Required for Holliday junction resolution activityAdd
BLAST
Regioni79 – 13658Interaction with RAD51B, RAD51D and XRCC3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi366 – 3705Nuclear localization signal Reviewed prediction

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.

Phylogenomic databases

eggNOGiCOG0468.
HOGENOMiHOG000227426.
HOVERGENiHBG055764.
InParanoidiO43502.
KOiK10870.
OMAiTNQMTTR.
PhylomeDBiO43502.
TreeFamiTF101220.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43502-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV    50
GISKAEALET LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI 100
ITFCSALDDI LGGGVPLMKT TEICGAPGVG KTQLCMQLAV DVQIPECFGG 150
VAGEAVFIDT EGSFMVDRVV DLATACIQHL QLIAEKHKGE EHRKALEDFT 200
LDNILSHIYY FRCRDYTELL AQVYLLPDFL SEHSKVRLVI VDGIAFPFRH 250
DLDDLSLRTR LLNGLAQQMI SLANNHRLAV ILTNQMTTKI DRNQALLVPA 300
LGESWGHAAT IRLIFHWDRK QRLATLYKSP SQKECTVLFQ IKPQGFRDTV 350
VTSACSLQTE GSLSTRKRSR DPEEEL 376
Length:376
Mass (Da):42,190
Last modified:June 1, 1998 - v1
Checksum:i3AAADD3C1C0851E0
GO
Isoform 2 (identifier: O43502-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: C → W
     136-376: Missing.

Show »
Length:135
Mass (Da):14,883
Checksum:i56657E563509D90F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31G → R.1 Publication
VAR_063837
Natural varianti52 – 521I → L.1 Publication
VAR_068014
Natural varianti103 – 1031Missing.1 Publication
VAR_068015
Natural varianti114 – 1141G → V.1 Publication
VAR_068016
Natural varianti125 – 1251G → V in BROVCA3. 1 Publication
VAR_063838
Natural varianti126 – 1261A → T.2 Publications
Corresponds to variant rs61758784 [ dbSNP | Ensembl ].
VAR_063839
Natural varianti138 – 1381L → F in BROVCA3; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 Publications
VAR_063840
Natural varianti144 – 1441I → T.1 Publication
Corresponds to variant rs28363307 [ dbSNP | Ensembl ].
VAR_020518
Natural varianti159 – 1591D → N Reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 Publications
VAR_063841
Natural varianti162 – 1621G → E in BROVCA3. 1 Publication
Corresponds to variant rs35151472 [ dbSNP | Ensembl ].
VAR_068017
Natural varianti169 – 1691V → A.2 Publications
VAR_063842
Natural varianti175 – 1751A → T.1 Publication
VAR_068018
Natural varianti178 – 1781Q → P in BROVCA3. 1 Publication
VAR_068019
Natural varianti249 – 2491R → C.2 Publications
Corresponds to variant rs28363311 [ dbSNP | Ensembl ].
VAR_020519
Natural varianti258 – 2581R → H in FANCO; possibly hypomorphic allele; reduces interaction with BRCA2 and to a lesser extent with PALB2 and RAD51. 2 Publications
VAR_064032
Natural varianti262 – 2621L → V.1 Publication
Corresponds to variant rs149331537 [ dbSNP | Ensembl ].
VAR_068020
Natural varianti264 – 2641G → S.2 Publications
Corresponds to variant rs147241704 [ dbSNP | Ensembl ].
VAR_063843
Natural varianti264 – 2641G → V.1 Publication
VAR_063844
Natural varianti287 – 2871T → A in BROVCA3. 3 Publications
Corresponds to variant rs28363317 [ dbSNP | Ensembl ].
VAR_020520
Natural varianti366 – 3661R → Q.1 Publication
VAR_063845

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei135 – 1351C → W in isoform 2. VSP_043656
Alternative sequencei136 – 376241Missing in isoform 2. VSP_043657Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029669 mRNA. Translation: AAC39604.1.
AF029670 mRNA. Translation: AAC39605.1.
AY623112 Genomic DNA. Translation: AAT38108.1.
AC011195 Genomic DNA. No translation available.
AC025521 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94432.1.
BC107753 mRNA. Translation: AAI07754.1.
CCDSiCCDS11611.1. [O43502-1]
CCDS45745.1. [O43502-2]
RefSeqiNP_002867.1. NM_002876.3. [O43502-2]
NP_478123.1. NM_058216.2. [O43502-1]
UniGeneiHs.412587.

Genome annotation databases

EnsembliENST00000337432; ENSP00000336701; ENSG00000108384. [O43502-1]
ENST00000421782; ENSP00000391450; ENSG00000108384. [O43502-2]
GeneIDi5889.
KEGGihsa:5889.
UCSCiuc002iwt.1. human. [O43502-2]
uc002iwu.3. human. [O43502-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs
RAD51 homolog C (S.cerevisiae) (RAD51C)

Leiden Open Variation Database (LOVD)

RAD51 homolog C (S.cerevisiae) (RAD51C)

ZJU-CGGM and BGI-Shenzhen

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029669 mRNA. Translation: AAC39604.1 .
AF029670 mRNA. Translation: AAC39605.1 .
AY623112 Genomic DNA. Translation: AAT38108.1 .
AC011195 Genomic DNA. No translation available.
AC025521 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94432.1 .
BC107753 mRNA. Translation: AAI07754.1 .
CCDSi CCDS11611.1. [O43502-1 ]
CCDS45745.1. [O43502-2 ]
RefSeqi NP_002867.1. NM_002876.3. [O43502-2 ]
NP_478123.1. NM_058216.2. [O43502-1 ]
UniGenei Hs.412587.

3D structure databases

ProteinModelPortali O43502.
SMRi O43502. Positions 19-348.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111826. 10 interactions.
DIPi DIP-41247N.
IntActi O43502. 8 interactions.
MINTi MINT-204767.
STRINGi 9606.ENSP00000336701.

PTM databases

PhosphoSitei O43502.

Proteomic databases

MaxQBi O43502.
PaxDbi O43502.
PRIDEi O43502.

Protocols and materials databases

DNASUi 5889.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337432 ; ENSP00000336701 ; ENSG00000108384 . [O43502-1 ]
ENST00000421782 ; ENSP00000391450 ; ENSG00000108384 . [O43502-2 ]
GeneIDi 5889.
KEGGi hsa:5889.
UCSCi uc002iwt.1. human. [O43502-2 ]
uc002iwu.3. human. [O43502-1 ]

Organism-specific databases

CTDi 5889.
GeneCardsi GC17P056769.
GeneReviewsi RAD51C.
HGNCi HGNC:9820. RAD51C.
MIMi 602774. gene.
613390. phenotype.
613399. phenotype.
neXtProti NX_O43502.
Orphaneti 84. Fanconi anemia.
145. Hereditary breast and ovarian cancer syndrome.
PharmGKBi PA34177.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0468.
HOGENOMi HOG000227426.
HOVERGENi HBG055764.
InParanoidi O43502.
KOi K10870.
OMAi TNQMTTR.
PhylomeDBi O43502.
TreeFami TF101220.

Enzyme and pathway databases

Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_27271. Meiotic recombination.

Miscellaneous databases

GeneWikii RAD51C.
GenomeRNAii 5889.
NextBioi 22902.
PROi O43502.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43502.
Bgeei O43502.
CleanExi HS_RAD51C.
Genevestigatori O43502.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
[Graphical view ]
Pfami PF08423. Rad51. 1 hit.
[Graphical view ]
PIRSFi PIRSF005856. Rad51. 1 hit.
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50162. RECA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes."
    Dosanjh M.K., Collins D.W., Fan W., Lennon G.G., Albala J.S., Shen Z., Schild D.
    Nucleic Acids Res. 26:1179-1184(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. NIEHS SNPs program
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-144; CYS-249 AND ALA-287.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Identification and purification of two distinct complexes containing the five RAD51 paralogs."
    Masson J.Y., Tarsounas M.C., Stasiak A.Z., Stasiak A., Shah R., McIlwraith M.J., Benson F.E., West S.C.
    Genes Dev. 15:3296-3307(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE BCDX2 COMPLEX WITH RAD51B; RAD51D AND XRCC2, IDENTIFICATION IN THE CX3 COMPLEX WITH XRCC3.
  7. "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange."
    Sigurdsson S., Van Komen S., Bussen W., Schild D., Albala J.S., Sung P.
    Genes Dev. 15:3308-3318(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FIUNCTION, INTERACTION WITH RAD51B.
  8. "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51."
    Miller K.A., Yoshikawa D.M., McConnell I.R., Clark R., Schild D., Albala J.S.
    J. Biol. Chem. 277:8406-8411(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAD51B, SUBUNIT.
  9. "Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells."
    Wiese C., Collins D.W., Albala J.S., Thompson L.H., Kronenberg A., Schild D.
    Nucleic Acids Res. 30:1001-1008(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH RAD51B; RAD51D AND XRCC2.
  10. "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells."
    Liu N., Schild D., Thelen M.P., Thompson L.H.
    Nucleic Acids Res. 30:1009-1015(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH RAD51B; RAD51D AND XRCC2, INTERACTION WITH XRCC3.
  11. "Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro."
    Lio Y.-C., Mazin A.V., Kowalczykowski S.C., Chen D.J.
    J. Biol. Chem. 278:2469-2478(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAD51 AND RAD51B.
  12. "Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion."
    French C.A., Tambini C.E., Thacker J.
    J. Biol. Chem. 278:45445-45450(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-131.
  13. "Domain mapping of the Rad51 paralog protein complexes."
    Miller K.A., Sawicka D., Barsky D., Albala J.S.
    Nucleic Acids Res. 32:169-178(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAD51B; RAD51D AND XRCC3.
  14. "RAD51C is required for Holliday junction processing in mammalian cells."
    Liu Y., Masson J.Y., Shah R., O'Regan P., West S.C.
    Science 303:243-246(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF LYS-131.
  15. "Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51."
    Bennett B.T., Knight K.L.
    J. Cell. Biochem. 96:1095-1109(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  16. "Interplay between human DNA repair proteins at a unique double-strand break in vivo."
    Rodrigue A., Lafrance M., Gauthier M.C., McDonald D., Hendzel M., West S.C., Jasin M., Masson J.Y.
    EMBO J. 25:222-231(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH RAD51.
  17. "Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C."
    Gildemeister O.S., Sage J.M., Knight K.L.
    J. Biol. Chem. 284:31945-31952(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  18. "RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation."
    Badie S., Liao C., Thanasoula M., Barber P., Hill M.A., Tarsounas M.
    J. Cell Biol. 185:587-600(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  19. "Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome."
    Sage J.M., Gildemeister O.S., Knight K.L.
    J. Biol. Chem. 285:18984-18990(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
  20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  21. "hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair."
    Liu T., Wan L., Wu Y., Chen J., Huang J.
    J. Biol. Chem. 286:41758-41766(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SWSAP1.
  22. "The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy."
    Rodrigue A., Coulombe Y., Jacquet K., Gagne J.P., Roques C., Gobeil S., Poirier G., Masson J.Y.
    J. Cell Sci. 126:348-359(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN MITOTIC CELL PROGRESSION.
  23. "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway."
    Chun J., Buechelmaier E.S., Powell S.N.
    Mol. Cell. Biol. 33:387-395(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE BCDX2 COMPLEX, FUNCTION OF THE CX3 COMPLEX.
  24. "Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair."
    Park J.Y., Singh T.R., Nassar N., Zhang F., Freund M., Hanenberg H., Meetei A.R., Andreassen P.R.
    Oncogene 0:0-0(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BRCA2; RAD51 AND PALB2, IDENTIFICATION IN A PALB2-CONTAINING HR COMPLEX, CHARACTERIZATION OF VARIANT BROVCA3 PHE-138, CHARACTERIZATION OF VARIANT ASN-159, CHARACTERIZATION OF VARIANT FANCO HIS-258.
  25. "Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy."
    Compton S.A., Ozgur S., Griffith J.D.
    J. Biol. Chem. 285:13349-13356(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ELECTRON MICROSCOPY OF THE BCDX2 AND CX3 COMPLEXES, DNA-BINDING OF THE BCDX2 AND CX3 COMPLEXES.
  26. Cited for: VARIANT FANCO HIS-258, CHARACTERIZATION OF VARIANT FANCO HIS-258.
  27. Cited for: VARIANTS ARG-3; THR-126; ASN-159; ALA-169; SER-264; VAL-264; ALA-287 AND GLN-366, VARIANTS BROVCA3 VAL-125 AND PHE-138.
  28. Cited for: VARIANTS LEU-52; PHE-103 DEL; VAL-114; THR-126; ALA-169; THR-175; CYS-249; VAL-262 AND SER-264, VARIANTS BROVCA3 GLU-162; PRO-178 AND ALA-287.

Entry informationi

Entry nameiRA51C_HUMAN
AccessioniPrimary (citable) accession number: O43502
Secondary accession number(s): O43503, Q3B783
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: September 3, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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