O43502 (RA51C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA repair protein RAD51 homolog 3
Short name=R51H3

Alternative name(s):
RAD51 homolog C
RAD51-like protein 2

Gene names

Name:	RAD51C
Synonyms:	RAD51L2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. Ref.13 Ref.14 Ref.15 Ref.16
Subunit structure	Interacts with RAD51B and XRCC3. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Part of a complex with RAD51B and RAD51. Interacts with SWSAP1; involved in homologous recombination repair. Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.18
Subcellular location	Nucleus. Cytoplasm. Cytoplasm › perinuclear region. Mitochondrion. Note: DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA. Ref.12 Ref.13 Ref.14 Ref.15 Ref.16
Tissue specificity	Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and prostate.
Induction	Stress-induced increase in the mitochondrial levels is seen. Ref.16
Involvement in disease	Fanconi anemia complementation group O (FANCO) [MIM:613390]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.19 Familial breast-ovarian cancer 3 (BROVCA3) [MIM:613399]: A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.20 Ref.21
Sequence similarities	Belongs to the RecA family. RAD51 subfamily.

Ontologies

Keywords
Biological process	DNA damage DNA recombination DNA repair
Cellular component	Cytoplasm Mitochondrion Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Fanconi anemia
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA recombination Inferred from direct assay Ref.15. Source: UniProtKB DNA repair Inferred from direct assay Ref.15. Source: UniProtKB blood coagulation Traceable author statement. Source: Reactome female meiosis sister chromatid cohesion Inferred from electronic annotation. Source: Compara male meiosis I Inferred from electronic annotation. Source: Compara reciprocal meiotic recombination Inferred from electronic annotation. Source: Compara sister chromatid cohesion Inferred from sequence or structural similarity. Source: UniProtKB spermatogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	mitochondrion Inferred from direct assay Ref.16. Source: UniProtKB nucleoplasm Traceable author statement. Source: Reactome perinuclear region of cytoplasm Inferred from direct assay Ref.13. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Traceable author statement Ref.1. Source: ProtInc DNA-dependent ATPase activity Inferred from electronic annotation. Source: InterPro crossover junction endodeoxyribonuclease activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SWSAP1	Q6NVH7	2	EBI-2267048,EBI-5281637

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O43502-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43502-2)

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: C → W
     136-376: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	DNA repair protein RAD51 homolog 3		PRO_0000122941
Regions
	Nucleotide binding	125 – 132	8	ATP Potential
	Motif	366 – 370	5	Nuclear localization signal Potential
Natural variations
	Alternative sequence	135	1	C → W in isoform 2.		VSP_043656
	Alternative sequence	136 – 376	241	Missing in isoform 2.		VSP_043657
	Natural variant	3	1	G → R. Ref.20		VAR_063837
	Natural variant	52	1	I → L. Ref.21		VAR_068014
	Natural variant	103	1	Missing. Ref.21		VAR_068015
	Natural variant	114	1	G → V. Ref.21		VAR_068016
	Natural variant	125	1	G → V in BROVCA3. Ref.20		VAR_063838
	Natural variant	126	1	A → T. Ref.20 Ref.21 Corresponds to variant rs61758784 [ dbSNP | Ensembl ].		VAR_063839
	Natural variant	138	1	L → F in BROVCA3. Ref.20		VAR_063840
	Natural variant	144	1	I → T. Ref.2 Corresponds to variant rs28363307 [ dbSNP | Ensembl ].		VAR_020518
	Natural variant	159	1	D → N. Ref.20		VAR_063841
	Natural variant	162	1	G → E in BROVCA3. Ref.21 Corresponds to variant rs35151472 [ dbSNP | Ensembl ].		VAR_068017
	Natural variant	169	1	V → A. Ref.20 Ref.21		VAR_063842
	Natural variant	175	1	A → T. Ref.21		VAR_068018
	Natural variant	178	1	Q → P in BROVCA3. Ref.21		VAR_068019
	Natural variant	249	1	R → C. Ref.2 Ref.21 Corresponds to variant rs28363311 [ dbSNP | Ensembl ].		VAR_020519
	Natural variant	258	1	R → H in FANCO; possibly hypomorphic allele. Ref.19		VAR_064032
	Natural variant	262	1	L → V. Ref.21 Corresponds to variant rs149331537 [ dbSNP | Ensembl ].		VAR_068020
	Natural variant	264	1	G → S. Ref.20 Ref.21 Corresponds to variant rs147241704 [ dbSNP | Ensembl ].		VAR_063843
	Natural variant	264	1	G → V. Ref.20		VAR_063844
	Natural variant	287	1	T → A in BROVCA3. Ref.2 Ref.20 Ref.21 Corresponds to variant rs28363317 [ dbSNP | Ensembl ].		VAR_020520
	Natural variant	366	1	R → Q. Ref.20		VAR_063845
Experimental info
	Mutagenesis	131	1	K → A: Significant loss of function. Ref.12
	Mutagenesis	131	1	K → R: Partial loss of function. Ref.12

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 3AAADD3C1C0851E0	FASTA	376	42,190
	10 20 30 40 50 60 MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV GISKAEALET 70 80 90 100 110 120 LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI ITFCSALDDI LGGGVPLMKT 130 140 150 160 170 180 TEICGAPGVG KTQLCMQLAV DVQIPECFGG VAGEAVFIDT EGSFMVDRVV DLATACIQHL 190 200 210 220 230 240 QLIAEKHKGE EHRKALEDFT LDNILSHIYY FRCRDYTELL AQVYLLPDFL SEHSKVRLVI 250 260 270 280 290 300 VDGIAFPFRH DLDDLSLRTR LLNGLAQQMI SLANNHRLAV ILTNQMTTKI DRNQALLVPA 310 320 330 340 350 360 LGESWGHAAT IRLIFHWDRK QRLATLYKSP SQKECTVLFQ IKPQGFRDTV VTSACSLQTE 370 GSLSTRKRSR DPEEEL
	Isoform 2 [UniParc]. Checksum: 56657E563509D90F	FASTA	135	14,883
	10 20 30 40 50 60 MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV GISKAEALET 70 80 90 100 110 120 LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI ITFCSALDDI LGGGVPLMKT 130 TEICGAPGVG KTQLW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes." Dosanjh M.K., Collins D.W., Fan W., Lennon G.G., Albala J.S., Shen Z., Schild D. Nucleic Acids Res. 26:1179-1184(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	NIEHS SNPs program Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-144; CYS-249 AND ALA-287.
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]	"Identification and purification of two distinct complexes containing the five RAD51 paralogs." Masson J.Y., Tarsounas M.C., Stasiak A.Z., Stasiak A., Shah R., McIlwraith M.J., Benson F.E., West S.C. Genes Dev. 15:3296-3307(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A COMPLEX WITH RAD51B; RAD51D AND XRCC2.
[7]	"Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange." Sigurdsson S., Van Komen S., Bussen W., Schild D., Albala J.S., Sung P. Genes Dev. 15:3308-3318(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RAD51B.
[8]	"RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51." Miller K.A., Yoshikawa D.M., McConnell I.R., Clark R., Schild D., Albala J.S. J. Biol. Chem. 277:8406-8411(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A COMPLEX WITH RAD51B; RAD51D; XRCC2 AND XRCC3.
[9]	"Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells." Wiese C., Collins D.W., Albala J.S., Thompson L.H., Kronenberg A., Schild D. Nucleic Acids Res. 30:1001-1008(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A COMPLEX WITH RAD51B; RAD51D AND XRCC2.
[10]	"Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells." Liu N., Schild D., Thelen M.P., Thompson L.H. Nucleic Acids Res. 30:1009-1015(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A COMPLEX WITH RAD51B; RAD51D AND XRCC2, INTERACTION WITH XRCC3.
[11]	"Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro." Lio Y.-C., Mazin A.V., Kowalczykowski S.C., Chen D.J. J. Biol. Chem. 278:2469-2478(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A COMPLEX WITH RAD51 AND RAD51B.
[12]	"Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion." French C.A., Tambini C.E., Thacker J. J. Biol. Chem. 278:45445-45450(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-131.
[13]	"Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51." Bennett B.T., Knight K.L. J. Cell. Biochem. 96:1095-1109(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[14]	"Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C." Gildemeister O.S., Sage J.M., Knight K.L. J. Biol. Chem. 284:31945-31952(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[15]	"RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation." Badie S., Liao C., Thanasoula M., Barber P., Hill M.A., Tarsounas M. J. Cell Biol. 185:587-600(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[16]	"Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome." Sage J.M., Gildemeister O.S., Knight K.L. J. Biol. Chem. 285:18984-18990(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INDUCTION.
[17]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]	"hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair." Liu T., Wan L., Wu Y., Chen J., Huang J. J. Biol. Chem. 286:41758-41766(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SWSAP1.
[19]	"Mutation of the RAD51C gene in a Fanconi anemia-like disorder." Vaz F., Hanenberg H., Schuster B., Barker K., Wiek C., Erven V., Neveling K., Endt D., Kesterton I., Autore F., Fraternali F., Freund M., Hartmann L., Grimwade D., Roberts R.G., Schaal H., Mohammed S., Rahman N., Schindler D., Mathew C.G. Nat. Genet. 42:406-409(2010) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT FANCO HIS-258, CHARACTERIZATION OF VARIANT FANCO HIS-258.
[20]	"Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene." Meindl A., Hellebrand H., Wiek C., Erven V., Wappenschmidt B., Niederacher D., Freund M., Lichtner P., Hartmann L., Schaal H., Ramser J., Honisch E., Kubisch C., Wichmann H.E., Kast K., Deissler H., Engel C., Muller-Myhsok B. , Neveling K., Kiechle M., Mathew C.G., Schindler D., Schmutzler R.K., Hanenberg H. Nat. Genet. 42:410-414(2010) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ARG-3; THR-126; ASN-159; ALA-169; SER-264; VAL-264; ALA-287 AND GLN-366, VARIANTS BROVCA3 VAL-125 AND PHE-138.
[21]	"Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients." Kathleen Cuningham foundation consortium for research into familial breast cancer (kConFab) Thompson E.R., Boyle S.E., Johnson J., Ryland G.L., Sawyer S., Choong D.Y., Chenevix-Trench G., Trainer A.H., Lindeman G.J., Mitchell G., James P.A., Campbell I.G. Hum. Mutat. 33:95-99(2012) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS LEU-52; PHE-103 DEL; VAL-114; THR-126; ALA-169; THR-175; CYS-249; VAL-262 AND SER-264, VARIANTS BROVCA3 GLU-162; PRO-178 AND ALA-287.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

RAD51 homolog C (S.cerevisiae) (RAD51C)

Leiden Open Variation Database (LOVD)

RAD51 homolog C (S.cerevisiae) (RAD51C)

ZJU-CGGM and BGI-Shenzhen

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF029669 mRNA. Translation: AAC39604.1. AF029670 mRNA. Translation: AAC39605.1. AY623112 Genomic DNA. Translation: AAT38108.1. AC011195 Genomic DNA. No translation available. AC025521 Genomic DNA. No translation available. CH471109 Genomic DNA. Translation: EAW94432.1. BC107753 mRNA. Translation: AAI07754.1.
IPI	IPI00012829. IPI00040453.
RefSeq	NP_002867.1. NM_002876.2. NP_478123.1. NM_058216.1.
UniGene	Hs.412587.
3D structure databases
ProteinModelPortal	O43502.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43502. 1 interaction.
MINT	MINT-204767.
STRING	9606.ENSP00000336701.
PTM databases
PhosphoSite	O43502.
Proteomic databases
PaxDb	O43502.
PRIDE	O43502.
Protocols and materials databases
DNASU	5889.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000337432; ENSP00000336701; ENSG00000108384. ENST00000421782; ENSP00000391450; ENSG00000108384.
GeneID	5889.
KEGG	hsa:5889.
UCSC	uc002iwu.3. human.
Organism-specific databases
CTD	5889.
GeneCards	GC17P056769.
HGNC	HGNC:9820. RAD51C.
MIM	602774. gene. 613390. phenotype. 613399. phenotype.
neXtProt	NX_O43502.
Orphanet	84. Fanconi anemia. 145. Hereditary breast and ovarian cancer syndrome.
PharmGKB	PA34177.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0468.
HOGENOM	HOG000227426.
HOVERGEN	HBG055764.
InParanoid	O43502.
KO	K10870.
OMA	QRDLVSF.
OrthoDB	EOG4CRM09.
PhylomeDB	O43502.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	O43502.
Bgee	O43502.
CleanEx	HS_RAD51C.
Genevestigator	O43502.
GermOnline	ENSG00000108384. Homo sapiens.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR013632. DNA_recomb/repair_Rad51_C. IPR016467. DNA_recomb/repair_RecA-like. IPR020588. DNA_recomb_RecA/RadB_ATP-bd. [Graphical view]
Pfam	PF08423. Rad51. 1 hit. [Graphical view]
PIRSF	PIRSF005856. Rad51. 1 hit.
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS50162. RECA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5889.
NextBio	22902.
SOURCE	Search...

Entry information

Entry name

RA51C_HUMAN

Accession

Primary (citable) accession number: O43502
Secondary accession number(s): O43503, Q3B783

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	June 1, 1998
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.