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Reviewed, UniProtKB/Swiss-Prot O43497 (CAC1G_HUMAN)

Last modified January 19, 2010. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Voltage-dependent T-type calcium channel subunit alpha-1G
Alternative name(s):
    Voltage-gated calcium channel subunit alpha Cav3.1
    Cav3.1c
    NBR13
Gene names
Name: CACNA1G
Synonyms: KIAA1123
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length2377 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression.

Domain

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

The linker region between repeat III and IV probably play a role in the inactivation of the channel. The C-terminal part may be implicated in the anchoring of the protein to the membrane, this by interfering/restricting its lateral diffusion.

Post-translational modification

In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.

Sequence similarities

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

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Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Transmembrane
   LigandCalcium
   Molecular functionCalcium channel
Ionic channel
Voltage-gated channel
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcalcium ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

transmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular componentvoltage-gated calcium channel complex Ref.8

Traceable author statement. Source: ProtInc

   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

low voltage-gated calcium channel activity Ref.8

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Alternative products

This entry describes 14 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 5 (identifier: O43497-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: O43497-2)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.
Isoform 2 (identifier: O43497-3)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1587: NLMLDDVIASGSSASAASE → K
     1928-2020: Missing.
Isoform 3 (identifier: O43497-4)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
Isoform 4 (identifier: O43497-5)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.
     2156-2234: Missing.
Isoform 6 (identifier: O43497-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.
Isoform 7 (identifier: O43497-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1976-2020: Missing.
Isoform 8 (identifier: O43497-8)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1976-2020: Missing.
Isoform 9 (identifier: O43497-9)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1928-2020: Missing.
Isoform 10 (identifier: O43497-10)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1928-1975: Missing.
Isoform 11 (identifier: O43497-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1928-2020: Missing.
Isoform 12 (identifier: O43497-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1976-2020: Missing.
Isoform 13 (identifier: O43497-13)

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1587: NLMLDDVIASGSSASAASE → K
     1928-2020: Missing.
Isoform 14 (identifier: O43497-14)

The sequence of this isoform differs from the canonical sequence as follows:
     1475-1555: ALMSLFVLAS...HQEEEEARRR → VSPRLRGGAV...KDEETEAQRG
     1556-2377: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 23772377Voltage-dependent T-type calcium channel subunit alpha-1G
PRO_0000053952

Regions

Topological domain1 – 8080Cytoplasmic Potential
Transmembrane81 – 10121S1 of repeat I Potential
Topological domain102 – 11918Extracellular Potential
Transmembrane120 – 14122S2 of repeat I Potential
Topological domain142 – 1509Cytoplasmic Potential
Transmembrane151 – 17020S3 of repeat I Potential
Topological domain171 – 1755Extracellular Potential
Transmembrane176 – 19318S4 of repeat I Potential
Topological domain194 – 21320Cytoplasmic Potential
Transmembrane214 – 23421S5 of repeat I Potential
Topological domain235 – 370136Extracellular Potential
Transmembrane371 – 39525S6 of repeat I Potential
Topological domain396 – 743348Cytoplasmic Potential
Transmembrane744 – 76421S1 of repeat II Potential
Topological domain765 – 77713Extracellular Potential
Transmembrane778 – 79922S2 of repeat II Potential
Topological domain800 – 8056Cytoplasmic Potential
Transmembrane806 – 82419S3 of repeat II Potential
Topological domain825 – 8328Extracellular Potential
Transmembrane833 – 85624S4 of repeat II Potential
Topological domain857 – 86711Cytoplasmic Potential
Transmembrane868 – 88821S5 of repeat II Potential
Topological domain889 – 93951Extracellular Potential
Transmembrane940 – 96425S6 of repeat II Potential
Topological domain965 – 1272308Cytoplasmic Potential
Transmembrane1273 – 129523S1 of repeat III Potential
Topological domain1296 – 131318Extracellular Potential
Transmembrane1314 – 133421S2 of repeat III Potential
Topological domain1335 – 134410Cytoplasmic Potential
Transmembrane1345 – 136420S3 of repeat III Potential
Topological domain1365 – 137814Extracellular Potential
Transmembrane1379 – 140022S4 of repeat III Potential
Topological domain1401 – 141010Cytoplasmic Potential
Transmembrane1411 – 143424S5 of repeat III Potential
Topological domain1435 – 151177Extracellular Potential
Transmembrane1512 – 153726S6 of repeat III Potential
Topological domain1538 – 161073Cytoplasmic Potential
Transmembrane1611 – 163121S1 of repeat IV Potential
Topological domain1632 – 164514Extracellular Potential
Transmembrane1646 – 166722S2 of repeat IV Potential
Topological domain1668 – 16747Cytoplasmic Potential
Transmembrane1675 – 169319S3 of repeat IV Potential
Topological domain1694 – 170714Extracellular Potential
Transmembrane1708 – 173124S4 of repeat IV Potential
Topological domain1732 – 174514Cytoplasmic Potential
Transmembrane1746 – 176621S5 of repeat IV Potential
Topological domain1767 – 182660Extracellular Potential
Transmembrane1827 – 185428S6 of repeat IV Potential
Topological domain1855 – 2377523Cytoplasmic Potential
Repeat68 – 398331I
Repeat729 – 967239II
Repeat1263 – 1540278III
Repeat1596 – 1854259IV
Compositional bias290 – 2956Poly-Gly
Compositional bias496 – 50611Poly-His

Sites

Site3541Calcium ion selectivity and permeability By similarity
Site9241Calcium ion selectivity and permeability By similarity
Site14651Calcium ion selectivity and permeability By similarity
Site17701Calcium ion selectivity and permeability By similarity

Amino acid modifications

Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation2461N-linked (GlcNAc...) Potential
Glycosylation3061N-linked (GlcNAc...) Potential
Glycosylation3101N-linked (GlcNAc...) Potential
Glycosylation3221N-linked (GlcNAc...) Potential
Glycosylation14481N-linked (GlcNAc...) Potential
Glycosylation14511N-linked (GlcNAc...) Potential
Glycosylation16981N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence971 – 99323Missing in isoform 1, isoform 2, isoform 3, isoform 4, isoform 8, isoform 9 and isoform 10.
VSP_000940
Alternative sequence1475 – 155581ALMSL…EARRR → VSPRLRGGAVVKEAGGGTGP CLVIPADSGGGGLHEEISPS HPLLSNHQHVAKPSPSHSAP KSGPMGSLAVLKDEETEAQR G in isoform 14.
VSP_000941
Alternative sequence1556 – 2377822Missing in isoform 14.
VSP_000942
Alternative sequence1569 – 158719NLMLD…SAASE → K in isoform 2 and isoform 13.
VSP_000944
Alternative sequence1569 – 158618NLMLD…ASAAS → SKEKQMA in isoform 1, isoform 4, isoform 6, isoform 7 and isoform 8.
VSP_000943
Alternative sequence1928 – 202093Missing in isoform 1, isoform 2, isoform 4, isoform 6, isoform 9, isoform 11 and isoform 13.
VSP_000946
Alternative sequence1928 – 197548Missing in isoform 10.
VSP_000945
Alternative sequence1976 – 202045Missing in isoform 7, isoform 8 and isoform 12.
VSP_000947
Alternative sequence2156 – 223479Missing in isoform 4.
VSP_000948

Experimental info

Sequence conflict13451S → I Ref.8

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Sequences

Sequence LengthMass (Da)Tools
Isoform 5 [UniParc].

Last modified December 1, 2000. Version 3.
Checksum: 1C9F7C557D9D32DF

FASTA2,377262,472
        10         20         30         40         50         60 
MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 

        70         80         90        100        110        120 
FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 

       130        140        150        160        170        180 
DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 

       190        200        210        220        230        240 
TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 

       250        260        270        280        290        300 
CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 

       310        320        330        340        350        360 
DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 

       370        380        390        400        410        420 
YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 

       430        440        450        460        470        480 
STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 

       490        500        510        520        530        540 
SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 

       550        560        570        580        590        600 
ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 

       610        620        630        640        650        660 
TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 

       670        680        690        700        710        720 
ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 

       730        740        750        760        770        780 
EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 

       790        800        810        820        830        840 
VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 

       850        860        870        880        890        900 
VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 

       910        920        930        940        950        960 
PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 

       970        980        990       1000       1010       1020 
AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE SEPDFFSPSL DGDGDRKKCL 

      1030       1040       1050       1060       1070       1080 
ALVSLGEHPE LRKSLLPPLI IHTAATPMSL PKSTSTGLGE ALGPASRRTS SSGSAEPGAA 

      1090       1100       1110       1120       1130       1140 
HEMKSPPSAR SSPHSPWSAA SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ 

      1150       1160       1170       1180       1190       1200 
DEEESSEEER ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN 

      1210       1220       1230       1240       1250       1260 
GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE RDSWSAYIFP 

      1270       1280       1290       1300       1310       1320 
PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI DPHSAERIFL TLSNYIFTAV 

      1330       1340       1350       1360       1370       1380 
FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD GLLVLISVID ILVSMVSDSG TKILGMLRVL 

      1390       1400       1410       1420       1430       1440 
RLLRTLRPLR VISRAQGLKL VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV 

      1450       1460       1470       1480       1490       1500 
CQGEDTRNIT NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG 

      1510       1520       1530       1540       1550       1560 
VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EARRREEKRL 

      1570       1580       1590       1600       1610       1620 
RRLEKKRRNL MLDDVIASGS SASAASEAQC KPYYSDYSRF RLLVHHLCTS HYLDLFITGV 

      1630       1640       1650       1660       1670       1680 
IGLNVVTMAM EHYQQPQILD EALKICNYIF TVIFVLESVF KLVAFGFRRF FQDRWNQLDL 

      1690       1700       1710       1720       1730       1740 
AIVLLSIMGI TLEEIEVNAS LPINPTIIRI MRVLRIARVL KLLKMAVGMR ALLDTVMQAL 

      1750       1760       1770       1780       1790       1800 
PQVGNLGLLF MLLFFIFAAL GVELFGDLEC DETHPCEGLG RHATFRNFGM AFLTLFRVST 

      1810       1820       1830       1840       1850       1860 
GDNWNGIMKD TLRDCDQEST CYNTVISPIY FVSFVLTAQF VLVNVVIAVL MKHLEESNKE 

      1870       1880       1890       1900       1910       1920 
AKEEAELEAE LELEMKTLSP QPHSPLGSPF LWPGVEGPDS PDSPKPGALH PAAHARSASH 

      1930       1940       1950       1960       1970       1980 
FSLEHPTDRQ LFDTISLLIQ GSLEWELKLM DELAGPGGQP SAFPSAPSLG GSDPQIPLAE 

      1990       2000       2010       2020       2030       2040 
MEALSLTSEI VSEPSCSLAL TDDSLPDDMH TLLLSALESN MQPHPTELPG PDLLTVRKSG 

      2050       2060       2070       2080       2090       2100 
VSRTHSLPND SYMCRHGSTA EGPLGHRGWG LPKAQSGSVL SVHSQPADTS YILQLPKDAP 

      2110       2120       2130       2140       2150       2160 
HLLQPHSAPT WGTIPKLPPP GRSPLAQRPL RRQAAIRTDS LDVQGLGSRE DLLAEVSGPS 

      2170       2180       2190       2200       2210       2220 
PPLARAYSFW GQSSTQAQQH SRSHSKISKH MTPPAPCPGP EPNWGKGPPE TRSSLELDTE 

      2230       2240       2250       2260       2270       2280 
LSWISGDLLP PGGQEEPPSP RDLKKCYSVE AQSCQRRPTS WLDEQRRHSI AVSCLDSGSQ 

      2290       2300       2310       2320       2330       2340 
PHLGTDPSNL GGQPLGGPGS RPKKKLSPPS ITIDPPESQG PRTPPSPGIC LRRRAPSSDS 

      2350       2360       2370 
KDPLASGPPD SMAASPSPKK DVLSLSGLSS DPADLDP

« Hide

Isoform 1.

Checksum: ACDCB167AA5DF18F
Show »

FASTA2,250249,333
Isoform 2.

Checksum: 74FA50071A5F9FBD
Show »

FASTA2,243248,529
Isoform 3.

Checksum: 2F13189AF179C9E2
Show »

FASTA2,354260,029
Isoform 4.

Checksum: 1C5BEDD83C1C8FB7
Show »

FASTA2,171240,920
Isoform 6.

Checksum: BBE93AF4CCAC8F8D
Show »

FASTA2,273251,776
Isoform 7.

Checksum: 2051A97223D0081D
Show »

FASTA2,321256,828
Isoform 8.

Checksum: EF51D26EC38F66F8
Show »

FASTA2,298254,386
Isoform 9.

Checksum: DCA090B5433D83E1
Show »

FASTA2,261250,221
Isoform 10.

Checksum: 943D153CFCC75CF8
Show »

FASTA2,306254,976
Isoform 11.

Checksum: FCB59420799A126E
Show »

FASTA2,284252,664
Isoform 12.

Checksum: 74F41CEA601E8CBC
Show »

FASTA2,332257,716
Isoform 13.

Checksum: 66E3563375ED61DA
Show »

FASTA2,266250,972
Isoform 14.

Checksum: 1219B12AD46561AC
Show »

FASTA1,555171,386

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References

« Hide 'large scale' references
[1]"Structure and alternative splicing of the gene encoding alpha1G, a human brain T calcium channel alpha1 subunit."
Mittman S., Guo J., Agnew W.S.
Neurosci. Lett. 274:143-146(1999) [PubMed: 10548410] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING (ISOFORMS 4 AND 5).
Tissue: Brain.
[2]"Molecular cloning and functional expression of ca(v)3.1c, a T-type calcium channel from human brain."
Cribbs L.L., Gomora J.C., Daud A.N., Lee J.-H., Perez-Reyes E.
FEBS Lett. 466:54-58(2000) [PubMed: 10648811] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"Molecular and functional properties of the human alpha1G subunit that forms T-type calcium channels."
Monteil A., Chemin J., Bourinet E., Mennessier G., Lory P., Nargeot J.
J. Biol. Chem. 275:6090-6100(2000) [PubMed: 10692398] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING (ISOFORMS 1-2 AND 6-13).
Tissue: Brain.
[4]Kishi F.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 14).
[5]"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
DNA Res. 6:329-336(1999) [PubMed: 10574461] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 550-2377 (ISOFORM 13).
Tissue: Brain.
[6]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract]
Cited for: SEQUENCE REVISION.
[7]"Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors."
Toyota M., Ho C., Ohe-Toyota M., Baylin S.B., Issa J.-P.J.
Cancer Res. 59:4535-4541(1999) [PubMed: 10493502] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), GENE STRUCTURE.
Tissue: Prostatic carcinoma.
[8]"Molecular characterization of a neuronal low-voltage-activated T-type calcium channel."
Perez-Reyes E., Cribbs L.L., Daud A., Lacerda A.E., Barclay J., Williamson M.P., Fox M., Rees M., Lee J.-H.
Nature 391:896-900(1998) [PubMed: 9495342] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1126-1444; 1778-1927 AND 2021-2312.
Tissue: Brain.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF134986 mRNA. Translation: AAF19347.1.
AF134985 mRNA. Translation: AAF19346.1.
AF227744 mRNA. Translation: AAF37689.1.
AF227745 mRNA. Translation: AAF37690.1.
AF227746 mRNA. Translation: AAF37691.1.
AF227747 mRNA. Translation: AAF37692.1.
AF227748 mRNA. Translation: AAF37693.1.
AF227749 mRNA. Translation: AAF37694.1.
AF227750 mRNA. Translation: AAF37695.1.
AF227751 mRNA. Translation: AAF37696.1.
AF124351 mRNA. Translation: AAD34352.1.
AB032949 mRNA. Translation: BAA86437.2.
AB012043 mRNA. Translation: BAA36409.1.
AF126965 mRNA. Translation: AAD29400.1.
AF126966 mRNA. Translation: AAD29401.1.
AF190860 mRNA. Translation: AAF35287.1.
AF029228 mRNA. Translation: AAD12731.1.
AF029229 mRNA. Translation: AAD12732.1.
IPIIPI00218687.
IPI00218688.
IPI00218689.
IPI00218690.
IPI00219390.
IPI00219391.
IPI00219393.
IPI00219394.
IPI00219395.
IPI00219396.
IPI00219397.
IPI00219398.
IPI00299037.
IPI00794872.
RefSeqNP_061496.2.
NP_938190.1.
NP_938191.1.
NP_938192.1.
NP_938193.1.
NP_938194.1.
NP_938196.1.
NP_938197.1.
NP_938198.1.
NP_938199.1.
NP_938200.1.
NP_938201.1.
NP_938202.1.
NP_938406.1.
NP_938407.1.
UniGeneHs.591169

3D structure databases

SMRO43497. Positions 737-969, 1271-1543.
ModBaseSearch...

Protein-protein interaction databases

IntActO43497. 1 interaction.
STRINGO43497.

PTM databases

PhosphoSiteO43497.

Proteomic databases

PRIDEO43497.

Genome annotation databases

EnsemblENST00000359106; ENSP00000352011; ENSG00000006283; Homo sapiens. [Genome view]
GeneID8913.
KEGGhsa:8913.
UCSCuc002iri.1. human.
uc002irk.1. human.
uc002irq.1. human.
uc002irw.1. human.

Organism-specific databases

CTD8913.
GeneCardsGC17P045993.
H-InvDBHIX0013983.
HGNCHGNC:1394. CACNA1G.
HPAHPA004714.
MIM604065. gene.
PharmGKBPA381.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG10127.
HOVERGENO43497.
InParanoidO43497.
OMAGSLEWEL.

Gene expression databases

ArrayExpressO43497.
BgeeO43497.
GenevestigatorO43497.
GermOnlineENSG00000006283. Homo sapiens.

Family and domain databases

InterProIPR005821. Ion_trans.
IPR005445. VDCC_T_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERPTHR10037:SF44. TVDCCAlpha1. 1 hit.
PfamPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.
ProtoNetSearch...

Other Resources

DrugBankDB00593. Ethosuximide.
DB04841. Flunarizine.
DB01202. Levetiracetam.
DB01388. Mibefradil.
DB01100. Pimozide.
DB00347. Trimethadione.
DB00661. Verapamil.
DB00909. Zonisamide.
NextBio33500.
SOURCESearch...

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Entry information

Entry nameCAC1G_HUMAN
AccessionPrimary (citable) accession number: O43497
Secondary accession number(s): O43498 expand/collapse secondary AC list , O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 1, 2000
Last modified: January 19, 2010
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents