O43497 (CAC1G_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent T-type calcium channel subunit alpha-1G

Alternative name(s):
Cav3.1c
NBR13
Voltage-gated calcium channel subunit alpha Cav3.1

Gene names

Name:	CACNA1G
Synonyms:	KIAA1123

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2377 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression.
Domain	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position. The linker region between repeat III and IV probably play a role in the inactivation of the channel. The C-terminal part may be implicated in the anchoring of the protein to the membrane, this by interfering/restricting its lateral diffusion.
Post-translational modification	In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome calcium ion import Inferred from direct assay PubMed 21084288. Source: BHF-UCL regulation of atrial cardiac muscle cell membrane depolarization Inferred from electronic annotation. Source: Compara regulation of heart rate Inferred from electronic annotation. Source: Compara regulation of membrane potential Inferred from direct assay PubMed 21084288. Source: BHF-UCL response to nickel cation Inferred from electronic annotation. Source: Compara synaptic transmission Inferred from electronic annotation. Source: Compara
Cellular_component	voltage-gated calcium channel complex Traceable author statement Ref.7. Source: ProtInc
Molecular_function	low voltage-gated calcium channel activity Inferred from direct assay PubMed 21084288. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 13 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 5 (identifier: O43497-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: O43497-2)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.

Isoform 2 (identifier: O43497-3)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1587: NLMLDDVIASGSSASAASE → K
     1928-2020: Missing.

Isoform 3 (identifier: O43497-4)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.

Isoform 4 (identifier: O43497-5)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.
     2156-2234: Missing.

Isoform 6 (identifier: O43497-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1928-2020: Missing.

Isoform 7 (identifier: O43497-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1976-2020: Missing.

Isoform 8 (identifier: O43497-8)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1569-1586: NLMLDDVIASGSSASAAS → SKEKQMA
     1976-2020: Missing.

Isoform 9 (identifier: O43497-9)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1928-2020: Missing.

Isoform 10 (identifier: O43497-10)

The sequence of this isoform differs from the canonical sequence as follows:
     971-993: Missing.
     1928-1975: Missing.

Isoform 11 (identifier: O43497-11)

The sequence of this isoform differs from the canonical sequence as follows:
     1928-2020: Missing.

Isoform 12 (identifier: O43497-12)

The sequence of this isoform differs from the canonical sequence as follows:
     1976-2020: Missing.

Isoform 13 (identifier: O43497-13)

The sequence of this isoform differs from the canonical sequence as follows:
     1569-1587: NLMLDDVIASGSSASAASE → K
     1928-2020: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2377	2377	Voltage-dependent T-type calcium channel subunit alpha-1G		PRO_0000053952
Regions
	Topological domain	1 – 80	80	Cytoplasmic Potential
	Transmembrane	81 – 101	21	Helical; Name=S1 of repeat I; Potential
	Topological domain	102 – 119	18	Extracellular Potential
	Transmembrane	120 – 141	22	Helical; Name=S2 of repeat I; Potential
	Topological domain	142 – 150	9	Cytoplasmic Potential
	Transmembrane	151 – 170	20	Helical; Name=S3 of repeat I; Potential
	Topological domain	171 – 175	5	Extracellular Potential
	Transmembrane	176 – 193	18	Helical; Name=S4 of repeat I; Potential
	Topological domain	194 – 213	20	Cytoplasmic Potential
	Transmembrane	214 – 234	21	Helical; Name=S5 of repeat I; Potential
	Topological domain	235 – 370	136	Extracellular Potential
	Transmembrane	371 – 395	25	Helical; Name=S6 of repeat I; Potential
	Topological domain	396 – 743	348	Cytoplasmic Potential
	Transmembrane	744 – 764	21	Helical; Name=S1 of repeat II; Potential
	Topological domain	765 – 777	13	Extracellular Potential
	Transmembrane	778 – 799	22	Helical; Name=S2 of repeat II; Potential
	Topological domain	800 – 805	6	Cytoplasmic Potential
	Transmembrane	806 – 824	19	Helical; Name=S3 of repeat II; Potential
	Topological domain	825 – 832	8	Extracellular Potential
	Transmembrane	833 – 856	24	Helical; Name=S4 of repeat II; Potential
	Topological domain	857 – 867	11	Cytoplasmic Potential
	Transmembrane	868 – 888	21	Helical; Name=S5 of repeat II; Potential
	Topological domain	889 – 939	51	Extracellular Potential
	Transmembrane	940 – 964	25	Helical; Name=S6 of repeat II; Potential
	Topological domain	965 – 1272	308	Cytoplasmic Potential
	Transmembrane	1273 – 1295	23	Helical; Name=S1 of repeat III; Potential
	Topological domain	1296 – 1313	18	Extracellular Potential
	Transmembrane	1314 – 1334	21	Helical; Name=S2 of repeat III; Potential
	Topological domain	1335 – 1344	10	Cytoplasmic Potential
	Transmembrane	1345 – 1364	20	Helical; Name=S3 of repeat III; Potential
	Topological domain	1365 – 1378	14	Extracellular Potential
	Transmembrane	1379 – 1400	22	Helical; Name=S4 of repeat III; Potential
	Topological domain	1401 – 1410	10	Cytoplasmic Potential
	Transmembrane	1411 – 1434	24	Helical; Name=S5 of repeat III; Potential
	Topological domain	1435 – 1511	77	Extracellular Potential
	Transmembrane	1512 – 1537	26	Helical; Name=S6 of repeat III; Potential
	Topological domain	1538 – 1610	73	Cytoplasmic Potential
	Transmembrane	1611 – 1631	21	Helical; Name=S1 of repeat IV; Potential
	Topological domain	1632 – 1645	14	Extracellular Potential
	Transmembrane	1646 – 1667	22	Helical; Name=S2 of repeat IV; Potential
	Topological domain	1668 – 1674	7	Cytoplasmic Potential
	Transmembrane	1675 – 1693	19	Helical; Name=S3 of repeat IV; Potential
	Topological domain	1694 – 1707	14	Extracellular Potential
	Transmembrane	1708 – 1731	24	Helical; Name=S4 of repeat IV; Potential
	Topological domain	1732 – 1745	14	Cytoplasmic Potential
	Transmembrane	1746 – 1766	21	Helical; Name=S5 of repeat IV; Potential
	Topological domain	1767 – 1826	60	Extracellular Potential
	Transmembrane	1827 – 1854	28	Helical; Name=S6 of repeat IV; Potential
	Topological domain	1855 – 2377	523	Cytoplasmic Potential
	Repeat	68 – 398	331	I
	Repeat	729 – 967	239	II
	Repeat	1263 – 1540	278	III
	Repeat	1596 – 1854	259	IV
	Compositional bias	290 – 295	6	Poly-Gly
	Compositional bias	496 – 506	11	Poly-His
Sites
	Site	354	1	Calcium ion selectivity and permeability By similarity
	Site	924	1	Calcium ion selectivity and permeability By similarity
	Site	1465	1	Calcium ion selectivity and permeability By similarity
	Site	1770	1	Calcium ion selectivity and permeability By similarity
Amino acid modifications
	Glycosylation	173	1	N-linked (GlcNAc...) Potential
	Glycosylation	246	1	N-linked (GlcNAc...) Potential
	Glycosylation	306	1	N-linked (GlcNAc...) Potential
	Glycosylation	310	1	N-linked (GlcNAc...) Potential
	Glycosylation	322	1	N-linked (GlcNAc...) Potential
	Glycosylation	1448	1	N-linked (GlcNAc...) Potential
	Glycosylation	1451	1	N-linked (GlcNAc...) Potential
	Glycosylation	1698	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	971 – 993	23	Missing in isoform 1, isoform 2, isoform 3, isoform 4, isoform 8, isoform 9 and isoform 10.		VSP_000940
	Alternative sequence	1569 – 1587	19	NLMLD…SAASE → K in isoform 2 and isoform 13.		VSP_000944
	Alternative sequence	1569 – 1586	18	NLMLD…ASAAS → SKEKQMA in isoform 1, isoform 4, isoform 6, isoform 7 and isoform 8.		VSP_000943
	Alternative sequence	1928 – 2020	93	Missing in isoform 1, isoform 2, isoform 4, isoform 6, isoform 9, isoform 11 and isoform 13.		VSP_000946
	Alternative sequence	1928 – 1975	48	Missing in isoform 10.		VSP_000945
	Alternative sequence	1976 – 2020	45	Missing in isoform 7, isoform 8 and isoform 12.		VSP_000947
	Alternative sequence	2156 – 2234	79	Missing in isoform 4.		VSP_000948
Experimental info
	Sequence conflict	1345	1	S → I in AAD12731. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 5 [UniParc]. Last modified December 1, 2000. Version 3. Checksum: 1C9F7C557D9D32DF	FASTA	2,377	262,472
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE SEPDFFSPSL DGDGDRKKCL 1030 1040 1050 1060 1070 1080 ALVSLGEHPE LRKSLLPPLI IHTAATPMSL PKSTSTGLGE ALGPASRRTS SSGSAEPGAA 1090 1100 1110 1120 1130 1140 HEMKSPPSAR SSPHSPWSAA SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ 1150 1160 1170 1180 1190 1200 DEEESSEEER ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN 1210 1220 1230 1240 1250 1260 GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE RDSWSAYIFP 1270 1280 1290 1300 1310 1320 PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI DPHSAERIFL TLSNYIFTAV 1330 1340 1350 1360 1370 1380 FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD GLLVLISVID ILVSMVSDSG TKILGMLRVL 1390 1400 1410 1420 1430 1440 RLLRTLRPLR VISRAQGLKL VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV 1450 1460 1470 1480 1490 1500 CQGEDTRNIT NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG 1510 1520 1530 1540 1550 1560 VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EARRREEKRL 1570 1580 1590 1600 1610 1620 RRLEKKRRNL MLDDVIASGS SASAASEAQC KPYYSDYSRF RLLVHHLCTS HYLDLFITGV 1630 1640 1650 1660 1670 1680 IGLNVVTMAM EHYQQPQILD EALKICNYIF TVIFVLESVF KLVAFGFRRF FQDRWNQLDL 1690 1700 1710 1720 1730 1740 AIVLLSIMGI TLEEIEVNAS LPINPTIIRI MRVLRIARVL KLLKMAVGMR ALLDTVMQAL 1750 1760 1770 1780 1790 1800 PQVGNLGLLF MLLFFIFAAL GVELFGDLEC DETHPCEGLG RHATFRNFGM AFLTLFRVST 1810 1820 1830 1840 1850 1860 GDNWNGIMKD TLRDCDQEST CYNTVISPIY FVSFVLTAQF VLVNVVIAVL MKHLEESNKE 1870 1880 1890 1900 1910 1920 AKEEAELEAE LELEMKTLSP QPHSPLGSPF LWPGVEGPDS PDSPKPGALH PAAHARSASH 1930 1940 1950 1960 1970 1980 FSLEHPTDRQ LFDTISLLIQ GSLEWELKLM DELAGPGGQP SAFPSAPSLG GSDPQIPLAE 1990 2000 2010 2020 2030 2040 MEALSLTSEI VSEPSCSLAL TDDSLPDDMH TLLLSALESN MQPHPTELPG PDLLTVRKSG 2050 2060 2070 2080 2090 2100 VSRTHSLPND SYMCRHGSTA EGPLGHRGWG LPKAQSGSVL SVHSQPADTS YILQLPKDAP 2110 2120 2130 2140 2150 2160 HLLQPHSAPT WGTIPKLPPP GRSPLAQRPL RRQAAIRTDS LDVQGLGSRE DLLAEVSGPS 2170 2180 2190 2200 2210 2220 PPLARAYSFW GQSSTQAQQH SRSHSKISKH MTPPAPCPGP EPNWGKGPPE TRSSLELDTE 2230 2240 2250 2260 2270 2280 LSWISGDLLP PGGQEEPPSP RDLKKCYSVE AQSCQRRPTS WLDEQRRHSI AVSCLDSGSQ 2290 2300 2310 2320 2330 2340 PHLGTDPSNL GGQPLGGPGS RPKKKLSPPS ITIDPPESQG PRTPPSPGIC LRRRAPSSDS 2350 2360 2370 KDPLASGPPD SMAASPSPKK DVLSLSGLSS DPADLDP
	Isoform 1 [UniParc]. Checksum: ACDCB167AA5DF18F	FASTA	2,250	249,333
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE GDANKSESEP DFFSPSLDGD GDRKKCLALV SLGEHPELRK SLLPPLIIHT 1030 1040 1050 1060 1070 1080 AATPMSLPKS TSTGLGEALG PASRRTSSSG SAEPGAAHEM KSPPSARSSP HSPWSAASSW 1090 1100 1110 1120 1130 1140 TSRRSSRNSL GRAPSLKRRS PSGERRSLLS GEGQESQDEE ESSEEERASP AGSDHRHRGS 1150 1160 1170 1180 1190 1200 LEREAKSSFD LPDTLQVPGL HRTASGRGSA SEHQDCNGKS ASGRLARALR PDDPPLDGDD 1210 1220 1230 1240 1250 1260 ADDEGNLSKG ERVRAWIRAR LPACCLERDS WSAYIFPPQS RFRLLCHRII THKMFDHVVL 1270 1280 1290 1300 1310 1320 VIIFLNCITI AMERPKIDPH SAERIFLTLS NYIFTAVFLA EMTVKVVALG WCFGEQAYLR 1330 1340 1350 1360 1370 1380 SSWNVLDGLL VLISVIDILV SMVSDSGTKI LGMLRVLRLL RTLRPLRVIS RAQGLKLVVE 1390 1400 1410 1420 1430 1440 TLMSSLKPIG NIVVICCAFF IIFGILGVQL FKGKFFVCQG EDTRNITNKS DCAEASYRWV 1450 1460 1470 1480 1490 1500 RHKYNFDNLG QALMSLFVLA SKDGWVDIMY DGLDAVGVDQ QPIMNHNPWM LLYFISFLLI 1510 1520 1530 1540 1550 1560 VAFFVLNMFV GVVVENFHKC RQHQEEEEAR RREEKRLRRL EKKRRSKEKQ MAEAQCKPYY 1570 1580 1590 1600 1610 1620 SDYSRFRLLV HHLCTSHYLD LFITGVIGLN VVTMAMEHYQ QPQILDEALK ICNYIFTVIF 1630 1640 1650 1660 1670 1680 VLESVFKLVA FGFRRFFQDR WNQLDLAIVL LSIMGITLEE IEVNASLPIN PTIIRIMRVL 1690 1700 1710 1720 1730 1740 RIARVLKLLK MAVGMRALLD TVMQALPQVG NLGLLFMLLF FIFAALGVEL FGDLECDETH 1750 1760 1770 1780 1790 1800 PCEGLGRHAT FRNFGMAFLT LFRVSTGDNW NGIMKDTLRD CDQESTCYNT VISPIYFVSF 1810 1820 1830 1840 1850 1860 VLTAQFVLVN VVIAVLMKHL EESNKEAKEE AELEAELELE MKTLSPQPHS PLGSPFLWPG 1870 1880 1890 1900 1910 1920 VEGPDSPDSP KPGALHPAAH ARSASHFSLE HPTMQPHPTE LPGPDLLTVR KSGVSRTHSL 1930 1940 1950 1960 1970 1980 PNDSYMCRHG STAEGPLGHR GWGLPKAQSG SVLSVHSQPA DTSYILQLPK DAPHLLQPHS 1990 2000 2010 2020 2030 2040 APTWGTIPKL PPPGRSPLAQ RPLRRQAAIR TDSLDVQGLG SREDLLAEVS GPSPPLARAY 2050 2060 2070 2080 2090 2100 SFWGQSSTQA QQHSRSHSKI SKHMTPPAPC PGPEPNWGKG PPETRSSLEL DTELSWISGD 2110 2120 2130 2140 2150 2160 LLPPGGQEEP PSPRDLKKCY SVEAQSCQRR PTSWLDEQRR HSIAVSCLDS GSQPHLGTDP 2170 2180 2190 2200 2210 2220 SNLGGQPLGG PGSRPKKKLS PPSITIDPPE SQGPRTPPSP GICLRRRAPS SDSKDPLASG 2230 2240 2250 PPDSMAASPS PKKDVLSLSG LSSDPADLDP
	Isoform 2 [UniParc]. Checksum: 74FA50071A5F9FBD	FASTA	2,243	248,529
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE GDANKSESEP DFFSPSLDGD GDRKKCLALV SLGEHPELRK SLLPPLIIHT 1030 1040 1050 1060 1070 1080 AATPMSLPKS TSTGLGEALG PASRRTSSSG SAEPGAAHEM KSPPSARSSP HSPWSAASSW 1090 1100 1110 1120 1130 1140 TSRRSSRNSL GRAPSLKRRS PSGERRSLLS GEGQESQDEE ESSEEERASP AGSDHRHRGS 1150 1160 1170 1180 1190 1200 LEREAKSSFD LPDTLQVPGL HRTASGRGSA SEHQDCNGKS ASGRLARALR PDDPPLDGDD 1210 1220 1230 1240 1250 1260 ADDEGNLSKG ERVRAWIRAR LPACCLERDS WSAYIFPPQS RFRLLCHRII THKMFDHVVL 1270 1280 1290 1300 1310 1320 VIIFLNCITI AMERPKIDPH SAERIFLTLS NYIFTAVFLA EMTVKVVALG WCFGEQAYLR 1330 1340 1350 1360 1370 1380 SSWNVLDGLL VLISVIDILV SMVSDSGTKI LGMLRVLRLL RTLRPLRVIS RAQGLKLVVE 1390 1400 1410 1420 1430 1440 TLMSSLKPIG NIVVICCAFF IIFGILGVQL FKGKFFVCQG EDTRNITNKS DCAEASYRWV 1450 1460 1470 1480 1490 1500 RHKYNFDNLG QALMSLFVLA SKDGWVDIMY DGLDAVGVDQ QPIMNHNPWM LLYFISFLLI 1510 1520 1530 1540 1550 1560 VAFFVLNMFV GVVVENFHKC RQHQEEEEAR RREEKRLRRL EKKRRKAQCK PYYSDYSRFR 1570 1580 1590 1600 1610 1620 LLVHHLCTSH YLDLFITGVI GLNVVTMAME HYQQPQILDE ALKICNYIFT VIFVLESVFK 1630 1640 1650 1660 1670 1680 LVAFGFRRFF QDRWNQLDLA IVLLSIMGIT LEEIEVNASL PINPTIIRIM RVLRIARVLK 1690 1700 1710 1720 1730 1740 LLKMAVGMRA LLDTVMQALP QVGNLGLLFM LLFFIFAALG VELFGDLECD ETHPCEGLGR 1750 1760 1770 1780 1790 1800 HATFRNFGMA FLTLFRVSTG DNWNGIMKDT LRDCDQESTC YNTVISPIYF VSFVLTAQFV 1810 1820 1830 1840 1850 1860 LVNVVIAVLM KHLEESNKEA KEEAELEAEL ELEMKTLSPQ PHSPLGSPFL WPGVEGPDSP 1870 1880 1890 1900 1910 1920 DSPKPGALHP AAHARSASHF SLEHPTMQPH PTELPGPDLL TVRKSGVSRT HSLPNDSYMC 1930 1940 1950 1960 1970 1980 RHGSTAEGPL GHRGWGLPKA QSGSVLSVHS QPADTSYILQ LPKDAPHLLQ PHSAPTWGTI 1990 2000 2010 2020 2030 2040 PKLPPPGRSP LAQRPLRRQA AIRTDSLDVQ GLGSREDLLA EVSGPSPPLA RAYSFWGQSS 2050 2060 2070 2080 2090 2100 TQAQQHSRSH SKISKHMTPP APCPGPEPNW GKGPPETRSS LELDTELSWI SGDLLPPGGQ 2110 2120 2130 2140 2150 2160 EEPPSPRDLK KCYSVEAQSC QRRPTSWLDE QRRHSIAVSC LDSGSQPHLG TDPSNLGGQP 2170 2180 2190 2200 2210 2220 LGGPGSRPKK KLSPPSITID PPESQGPRTP PSPGICLRRR APSSDSKDPL ASGPPDSMAA 2230 2240 SPSPKKDVLS LSGLSSDPAD LDP
	Isoform 3 [UniParc]. Checksum: 2F13189AF179C9E2	FASTA	2,354	260,029
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE GDANKSESEP DFFSPSLDGD GDRKKCLALV SLGEHPELRK SLLPPLIIHT 1030 1040 1050 1060 1070 1080 AATPMSLPKS TSTGLGEALG PASRRTSSSG SAEPGAAHEM KSPPSARSSP HSPWSAASSW 1090 1100 1110 1120 1130 1140 TSRRSSRNSL GRAPSLKRRS PSGERRSLLS GEGQESQDEE ESSEEERASP AGSDHRHRGS 1150 1160 1170 1180 1190 1200 LEREAKSSFD LPDTLQVPGL HRTASGRGSA SEHQDCNGKS ASGRLARALR PDDPPLDGDD 1210 1220 1230 1240 1250 1260 ADDEGNLSKG ERVRAWIRAR LPACCLERDS WSAYIFPPQS RFRLLCHRII THKMFDHVVL 1270 1280 1290 1300 1310 1320 VIIFLNCITI AMERPKIDPH SAERIFLTLS NYIFTAVFLA EMTVKVVALG WCFGEQAYLR 1330 1340 1350 1360 1370 1380 SSWNVLDGLL VLISVIDILV SMVSDSGTKI LGMLRVLRLL RTLRPLRVIS RAQGLKLVVE 1390 1400 1410 1420 1430 1440 TLMSSLKPIG NIVVICCAFF IIFGILGVQL FKGKFFVCQG EDTRNITNKS DCAEASYRWV 1450 1460 1470 1480 1490 1500 RHKYNFDNLG QALMSLFVLA SKDGWVDIMY DGLDAVGVDQ QPIMNHNPWM LLYFISFLLI 1510 1520 1530 1540 1550 1560 VAFFVLNMFV GVVVENFHKC RQHQEEEEAR RREEKRLRRL EKKRRNLMLD DVIASGSSAS 1570 1580 1590 1600 1610 1620 AASEAQCKPY YSDYSRFRLL VHHLCTSHYL DLFITGVIGL NVVTMAMEHY QQPQILDEAL 1630 1640 1650 1660 1670 1680 KICNYIFTVI FVLESVFKLV AFGFRRFFQD RWNQLDLAIV LLSIMGITLE EIEVNASLPI 1690 1700 1710 1720 1730 1740 NPTIIRIMRV LRIARVLKLL KMAVGMRALL DTVMQALPQV GNLGLLFMLL FFIFAALGVE 1750 1760 1770 1780 1790 1800 LFGDLECDET HPCEGLGRHA TFRNFGMAFL TLFRVSTGDN WNGIMKDTLR DCDQESTCYN 1810 1820 1830 1840 1850 1860 TVISPIYFVS FVLTAQFVLV NVVIAVLMKH LEESNKEAKE EAELEAELEL EMKTLSPQPH 1870 1880 1890 1900 1910 1920 SPLGSPFLWP GVEGPDSPDS PKPGALHPAA HARSASHFSL EHPTDRQLFD TISLLIQGSL 1930 1940 1950 1960 1970 1980 EWELKLMDEL AGPGGQPSAF PSAPSLGGSD PQIPLAEMEA LSLTSEIVSE PSCSLALTDD 1990 2000 2010 2020 2030 2040 SLPDDMHTLL LSALESNMQP HPTELPGPDL LTVRKSGVSR THSLPNDSYM CRHGSTAEGP 2050 2060 2070 2080 2090 2100 LGHRGWGLPK AQSGSVLSVH SQPADTSYIL QLPKDAPHLL QPHSAPTWGT IPKLPPPGRS 2110 2120 2130 2140 2150 2160 PLAQRPLRRQ AAIRTDSLDV QGLGSREDLL AEVSGPSPPL ARAYSFWGQS STQAQQHSRS 2170 2180 2190 2200 2210 2220 HSKISKHMTP PAPCPGPEPN WGKGPPETRS SLELDTELSW ISGDLLPPGG QEEPPSPRDL 2230 2240 2250 2260 2270 2280 KKCYSVEAQS CQRRPTSWLD EQRRHSIAVS CLDSGSQPHL GTDPSNLGGQ PLGGPGSRPK 2290 2300 2310 2320 2330 2340 KKLSPPSITI DPPESQGPRT PPSPGICLRR RAPSSDSKDP LASGPPDSMA ASPSPKKDVL 2350 SLSGLSSDPA DLDP
	Isoform 4 [UniParc]. Checksum: 1C5BEDD83C1C8FB7	FASTA	2,171	240,920
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE GDANKSESEP DFFSPSLDGD GDRKKCLALV SLGEHPELRK SLLPPLIIHT 1030 1040 1050 1060 1070 1080 AATPMSLPKS TSTGLGEALG PASRRTSSSG SAEPGAAHEM KSPPSARSSP HSPWSAASSW 1090 1100 1110 1120 1130 1140 TSRRSSRNSL GRAPSLKRRS PSGERRSLLS GEGQESQDEE ESSEEERASP AGSDHRHRGS 1150 1160 1170 1180 1190 1200 LEREAKSSFD LPDTLQVPGL HRTASGRGSA SEHQDCNGKS ASGRLARALR PDDPPLDGDD 1210 1220 1230 1240 1250 1260 ADDEGNLSKG ERVRAWIRAR LPACCLERDS WSAYIFPPQS RFRLLCHRII THKMFDHVVL 1270 1280 1290 1300 1310 1320 VIIFLNCITI AMERPKIDPH SAERIFLTLS NYIFTAVFLA EMTVKVVALG WCFGEQAYLR 1330 1340 1350 1360 1370 1380 SSWNVLDGLL VLISVIDILV SMVSDSGTKI LGMLRVLRLL RTLRPLRVIS RAQGLKLVVE 1390 1400 1410 1420 1430 1440 TLMSSLKPIG NIVVICCAFF IIFGILGVQL FKGKFFVCQG EDTRNITNKS DCAEASYRWV 1450 1460 1470 1480 1490 1500 RHKYNFDNLG QALMSLFVLA SKDGWVDIMY DGLDAVGVDQ QPIMNHNPWM LLYFISFLLI 1510 1520 1530 1540 1550 1560 VAFFVLNMFV GVVVENFHKC RQHQEEEEAR RREEKRLRRL EKKRRSKEKQ MAEAQCKPYY 1570 1580 1590 1600 1610 1620 SDYSRFRLLV HHLCTSHYLD LFITGVIGLN VVTMAMEHYQ QPQILDEALK ICNYIFTVIF 1630 1640 1650 1660 1670 1680 VLESVFKLVA FGFRRFFQDR WNQLDLAIVL LSIMGITLEE IEVNASLPIN PTIIRIMRVL 1690 1700 1710 1720 1730 1740 RIARVLKLLK MAVGMRALLD TVMQALPQVG NLGLLFMLLF FIFAALGVEL FGDLECDETH 1750 1760 1770 1780 1790 1800 PCEGLGRHAT FRNFGMAFLT LFRVSTGDNW NGIMKDTLRD CDQESTCYNT VISPIYFVSF 1810 1820 1830 1840 1850 1860 VLTAQFVLVN VVIAVLMKHL EESNKEAKEE AELEAELELE MKTLSPQPHS PLGSPFLWPG 1870 1880 1890 1900 1910 1920 VEGPDSPDSP KPGALHPAAH ARSASHFSLE HPTMQPHPTE LPGPDLLTVR KSGVSRTHSL 1930 1940 1950 1960 1970 1980 PNDSYMCRHG STAEGPLGHR GWGLPKAQSG SVLSVHSQPA DTSYILQLPK DAPHLLQPHS 1990 2000 2010 2020 2030 2040 APTWGTIPKL PPPGRSPLAQ RPLRRQAAIR TDSLDVQGLG SREDLLAEEE PPSPRDLKKC 2050 2060 2070 2080 2090 2100 YSVEAQSCQR RPTSWLDEQR RHSIAVSCLD SGSQPHLGTD PSNLGGQPLG GPGSRPKKKL 2110 2120 2130 2140 2150 2160 SPPSITIDPP ESQGPRTPPS PGICLRRRAP SSDSKDPLAS GPPDSMAASP SPKKDVLSLS 2170 GLSSDPADLD P
	Isoform 6 [UniParc]. Checksum: BBE93AF4CCAC8F8D	FASTA	2,273	251,776
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE SEPDFFSPSL DGDGDRKKCL 1030 1040 1050 1060 1070 1080 ALVSLGEHPE LRKSLLPPLI IHTAATPMSL PKSTSTGLGE ALGPASRRTS SSGSAEPGAA 1090 1100 1110 1120 1130 1140 HEMKSPPSAR SSPHSPWSAA SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ 1150 1160 1170 1180 1190 1200 DEEESSEEER ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN 1210 1220 1230 1240 1250 1260 GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE RDSWSAYIFP 1270 1280 1290 1300 1310 1320 PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI DPHSAERIFL TLSNYIFTAV 1330 1340 1350 1360 1370 1380 FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD GLLVLISVID ILVSMVSDSG TKILGMLRVL 1390 1400 1410 1420 1430 1440 RLLRTLRPLR VISRAQGLKL VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV 1450 1460 1470 1480 1490 1500 CQGEDTRNIT NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG 1510 1520 1530 1540 1550 1560 VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EARRREEKRL 1570 1580 1590 1600 1610 1620 RRLEKKRRSK EKQMAEAQCK PYYSDYSRFR LLVHHLCTSH YLDLFITGVI GLNVVTMAME 1630 1640 1650 1660 1670 1680 HYQQPQILDE ALKICNYIFT VIFVLESVFK LVAFGFRRFF QDRWNQLDLA IVLLSIMGIT 1690 1700 1710 1720 1730 1740 LEEIEVNASL PINPTIIRIM RVLRIARVLK LLKMAVGMRA LLDTVMQALP QVGNLGLLFM 1750 1760 1770 1780 1790 1800 LLFFIFAALG VELFGDLECD ETHPCEGLGR HATFRNFGMA FLTLFRVSTG DNWNGIMKDT 1810 1820 1830 1840 1850 1860 LRDCDQESTC YNTVISPIYF VSFVLTAQFV LVNVVIAVLM KHLEESNKEA KEEAELEAEL 1870 1880 1890 1900 1910 1920 ELEMKTLSPQ PHSPLGSPFL WPGVEGPDSP DSPKPGALHP AAHARSASHF SLEHPTMQPH 1930 1940 1950 1960 1970 1980 PTELPGPDLL TVRKSGVSRT HSLPNDSYMC RHGSTAEGPL GHRGWGLPKA QSGSVLSVHS 1990 2000 2010 2020 2030 2040 QPADTSYILQ LPKDAPHLLQ PHSAPTWGTI PKLPPPGRSP LAQRPLRRQA AIRTDSLDVQ 2050 2060 2070 2080 2090 2100 GLGSREDLLA EVSGPSPPLA RAYSFWGQSS TQAQQHSRSH SKISKHMTPP APCPGPEPNW 2110 2120 2130 2140 2150 2160 GKGPPETRSS LELDTELSWI SGDLLPPGGQ EEPPSPRDLK KCYSVEAQSC QRRPTSWLDE 2170 2180 2190 2200 2210 2220 QRRHSIAVSC LDSGSQPHLG TDPSNLGGQP LGGPGSRPKK KLSPPSITID PPESQGPRTP 2230 2240 2250 2260 2270 PSPGICLRRR APSSDSKDPL ASGPPDSMAA SPSPKKDVLS LSGLSSDPAD LDP
	Isoform 7 [UniParc]. Checksum: 2051A97223D0081D	FASTA	2,321	256,828
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE SEPDFFSPSL DGDGDRKKCL 1030 1040 1050 1060 1070 1080 ALVSLGEHPE LRKSLLPPLI IHTAATPMSL PKSTSTGLGE ALGPASRRTS SSGSAEPGAA 1090 1100 1110 1120 1130 1140 HEMKSPPSAR SSPHSPWSAA SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ 1150 1160 1170 1180 1190 1200 DEEESSEEER ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN 1210 1220 1230 1240 1250 1260 GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE RDSWSAYIFP 1270 1280 1290 1300 1310 1320 PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI DPHSAERIFL TLSNYIFTAV 1330 1340 1350 1360 1370 1380 FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD GLLVLISVID ILVSMVSDSG TKILGMLRVL 1390 1400 1410 1420 1430 1440 RLLRTLRPLR VISRAQGLKL VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV 1450 1460 1470 1480 1490 1500 CQGEDTRNIT NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG 1510 1520 1530 1540 1550 1560 VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EARRREEKRL 1570 1580 1590 1600 1610 1620 RRLEKKRRSK EKQMAEAQCK PYYSDYSRFR LLVHHLCTSH YLDLFITGVI GLNVVTMAME 1630 1640 1650 1660 1670 1680 HYQQPQILDE ALKICNYIFT VIFVLESVFK LVAFGFRRFF QDRWNQLDLA IVLLSIMGIT 1690 1700 1710 1720 1730 1740 LEEIEVNASL PINPTIIRIM RVLRIARVLK LLKMAVGMRA LLDTVMQALP QVGNLGLLFM 1750 1760 1770 1780 1790 1800 LLFFIFAALG VELFGDLECD ETHPCEGLGR HATFRNFGMA FLTLFRVSTG DNWNGIMKDT 1810 1820 1830 1840 1850 1860 LRDCDQESTC YNTVISPIYF VSFVLTAQFV LVNVVIAVLM KHLEESNKEA KEEAELEAEL 1870 1880 1890 1900 1910 1920 ELEMKTLSPQ PHSPLGSPFL WPGVEGPDSP DSPKPGALHP AAHARSASHF SLEHPTDRQL 1930 1940 1950 1960 1970 1980 FDTISLLIQG SLEWELKLMD ELAGPGGQPS AFPSAPSLGG SDPQMQPHPT ELPGPDLLTV 1990 2000 2010 2020 2030 2040 RKSGVSRTHS LPNDSYMCRH GSTAEGPLGH RGWGLPKAQS GSVLSVHSQP ADTSYILQLP 2050 2060 2070 2080 2090 2100 KDAPHLLQPH SAPTWGTIPK LPPPGRSPLA QRPLRRQAAI RTDSLDVQGL GSREDLLAEV 2110 2120 2130 2140 2150 2160 SGPSPPLARA YSFWGQSSTQ AQQHSRSHSK ISKHMTPPAP CPGPEPNWGK GPPETRSSLE 2170 2180 2190 2200 2210 2220 LDTELSWISG DLLPPGGQEE PPSPRDLKKC YSVEAQSCQR RPTSWLDEQR RHSIAVSCLD 2230 2240 2250 2260 2270 2280 SGSQPHLGTD PSNLGGQPLG GPGSRPKKKL SPPSITIDPP ESQGPRTPPS PGICLRRRAP 2290 2300 2310 2320 SSDSKDPLAS GPPDSMAASP SPKKDVLSLS GLSSDPADLD P
	Isoform 8 [UniParc]. Checksum: EF51D26EC38F66F8	FASTA	2,298	254,386
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE GDANKSESEP DFFSPSLDGD GDRKKCLALV SLGEHPELRK SLLPPLIIHT 1030 1040 1050 1060 1070 1080 AATPMSLPKS TSTGLGEALG PASRRTSSSG SAEPGAAHEM KSPPSARSSP HSPWSAASSW 1090 1100 1110 1120 1130 1140 TSRRSSRNSL GRAPSLKRRS PSGERRSLLS GEGQESQDEE ESSEEERASP AGSDHRHRGS 1150 1160 1170 1180 1190 1200 LEREAKSSFD LPDTLQVPGL HRTASGRGSA SEHQDCNGKS ASGRLARALR PDDPPLDGDD 1210 1220 1230 1240 1250 1260 ADDEGNLSKG ERVRAWIRAR LPACCLERDS WSAYIFPPQS RFRLLCHRII THKMFDHVVL 1270 1280 1290 1300 1310 1320 VIIFLNCITI AMERPKIDPH SAERIFLTLS NYIFTAVFLA EMTVKVVALG WCFGEQAYLR 1330 1340 1350 1360 1370 1380 SSWNVLDGLL VLISVIDILV SMVSDSGTKI LGMLRVLRLL RTLRPLRVIS RAQGLKLVVE 1390 1400 1410 1420 1430 1440 TLMSSLKPIG NIVVICCAFF IIFGILGVQL FKGKFFVCQG EDTRNITNKS DCAEASYRWV 1450 1460 1470 1480 1490 1500 RHKYNFDNLG QALMSLFVLA SKDGWVDIMY DGLDAVGVDQ QPIMNHNPWM LLYFISFLLI 1510 1520 1530 1540 1550 1560 VAFFVLNMFV GVVVENFHKC RQHQEEEEAR RREEKRLRRL EKKRRSKEKQ MAEAQCKPYY 1570 1580 1590 1600 1610 1620 SDYSRFRLLV HHLCTSHYLD LFITGVIGLN VVTMAMEHYQ QPQILDEALK ICNYIFTVIF 1630 1640 1650 1660 1670 1680 VLESVFKLVA FGFRRFFQDR WNQLDLAIVL LSIMGITLEE IEVNASLPIN PTIIRIMRVL 1690 1700 1710 1720 1730 1740 RIARVLKLLK MAVGMRALLD TVMQALPQVG NLGLLFMLLF FIFAALGVEL FGDLECDETH 1750 1760 1770 1780 1790 1800 PCEGLGRHAT FRNFGMAFLT LFRVSTGDNW NGIMKDTLRD CDQESTCYNT VISPIYFVSF 1810 1820 1830 1840 1850 1860 VLTAQFVLVN VVIAVLMKHL EESNKEAKEE AELEAELELE MKTLSPQPHS PLGSPFLWPG 1870 1880 1890 1900 1910 1920 VEGPDSPDSP KPGALHPAAH ARSASHFSLE HPTDRQLFDT ISLLIQGSLE WELKLMDELA 1930 1940 1950 1960 1970 1980 GPGGQPSAFP SAPSLGGSDP QMQPHPTELP GPDLLTVRKS GVSRTHSLPN DSYMCRHGST 1990 2000 2010 2020 2030 2040 AEGPLGHRGW GLPKAQSGSV LSVHSQPADT SYILQLPKDA PHLLQPHSAP TWGTIPKLPP 2050 2060 2070 2080 2090 2100 PGRSPLAQRP LRRQAAIRTD SLDVQGLGSR EDLLAEVSGP SPPLARAYSF WGQSSTQAQQ 2110 2120 2130 2140 2150 2160 HSRSHSKISK HMTPPAPCPG PEPNWGKGPP ETRSSLELDT ELSWISGDLL PPGGQEEPPS 2170 2180 2190 2200 2210 2220 PRDLKKCYSV EAQSCQRRPT SWLDEQRRHS IAVSCLDSGS QPHLGTDPSN LGGQPLGGPG 2230 2240 2250 2260 2270 2280 SRPKKKLSPP SITIDPPESQ GPRTPPSPGI CLRRRAPSSD SKDPLASGPP DSMAASPSPK 2290 KDVLSLSGLS SDPADLDP
	Isoform 9 [UniParc]. Checksum: DCA090B5433D83E1	FASTA	2,261	250,221
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE GDANKSESEP DFFSPSLDGD GDRKKCLALV SLGEHPELRK SLLPPLIIHT 1030 1040 1050 1060 1070 1080 AATPMSLPKS TSTGLGEALG PASRRTSSSG SAEPGAAHEM KSPPSARSSP HSPWSAASSW 1090 1100 1110 1120 1130 1140 TSRRSSRNSL GRAPSLKRRS PSGERRSLLS GEGQESQDEE ESSEEERASP AGSDHRHRGS 1150 1160 1170 1180 1190 1200 LEREAKSSFD LPDTLQVPGL HRTASGRGSA SEHQDCNGKS ASGRLARALR PDDPPLDGDD 1210 1220 1230 1240 1250 1260 ADDEGNLSKG ERVRAWIRAR LPACCLERDS WSAYIFPPQS RFRLLCHRII THKMFDHVVL 1270 1280 1290 1300 1310 1320 VIIFLNCITI AMERPKIDPH SAERIFLTLS NYIFTAVFLA EMTVKVVALG WCFGEQAYLR 1330 1340 1350 1360 1370 1380 SSWNVLDGLL VLISVIDILV SMVSDSGTKI LGMLRVLRLL RTLRPLRVIS RAQGLKLVVE 1390 1400 1410 1420 1430 1440 TLMSSLKPIG NIVVICCAFF IIFGILGVQL FKGKFFVCQG EDTRNITNKS DCAEASYRWV 1450 1460 1470 1480 1490 1500 RHKYNFDNLG QALMSLFVLA SKDGWVDIMY DGLDAVGVDQ QPIMNHNPWM LLYFISFLLI 1510 1520 1530 1540 1550 1560 VAFFVLNMFV GVVVENFHKC RQHQEEEEAR RREEKRLRRL EKKRRNLMLD DVIASGSSAS 1570 1580 1590 1600 1610 1620 AASEAQCKPY YSDYSRFRLL VHHLCTSHYL DLFITGVIGL NVVTMAMEHY QQPQILDEAL 1630 1640 1650 1660 1670 1680 KICNYIFTVI FVLESVFKLV AFGFRRFFQD RWNQLDLAIV LLSIMGITLE EIEVNASLPI 1690 1700 1710 1720 1730 1740 NPTIIRIMRV LRIARVLKLL KMAVGMRALL DTVMQALPQV GNLGLLFMLL FFIFAALGVE 1750 1760 1770 1780 1790 1800 LFGDLECDET HPCEGLGRHA TFRNFGMAFL TLFRVSTGDN WNGIMKDTLR DCDQESTCYN 1810 1820 1830 1840 1850 1860 TVISPIYFVS FVLTAQFVLV NVVIAVLMKH LEESNKEAKE EAELEAELEL EMKTLSPQPH 1870 1880 1890 1900 1910 1920 SPLGSPFLWP GVEGPDSPDS PKPGALHPAA HARSASHFSL EHPTMQPHPT ELPGPDLLTV 1930 1940 1950 1960 1970 1980 RKSGVSRTHS LPNDSYMCRH GSTAEGPLGH RGWGLPKAQS GSVLSVHSQP ADTSYILQLP 1990 2000 2010 2020 2030 2040 KDAPHLLQPH SAPTWGTIPK LPPPGRSPLA QRPLRRQAAI RTDSLDVQGL GSREDLLAEV 2050 2060 2070 2080 2090 2100 SGPSPPLARA YSFWGQSSTQ AQQHSRSHSK ISKHMTPPAP CPGPEPNWGK GPPETRSSLE 2110 2120 2130 2140 2150 2160 LDTELSWISG DLLPPGGQEE PPSPRDLKKC YSVEAQSCQR RPTSWLDEQR RHSIAVSCLD 2170 2180 2190 2200 2210 2220 SGSQPHLGTD PSNLGGQPLG GPGSRPKKKL SPPSITIDPP ESQGPRTPPS PGICLRRRAP 2230 2240 2250 2260 SSDSKDPLAS GPPDSMAASP SPKKDVLSLS GLSSDPADLD P
	Isoform 10 [UniParc]. Checksum: 943D153CFCC75CF8	FASTA	2,306	254,976
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE GDANKSESEP DFFSPSLDGD GDRKKCLALV SLGEHPELRK SLLPPLIIHT 1030 1040 1050 1060 1070 1080 AATPMSLPKS TSTGLGEALG PASRRTSSSG SAEPGAAHEM KSPPSARSSP HSPWSAASSW 1090 1100 1110 1120 1130 1140 TSRRSSRNSL GRAPSLKRRS PSGERRSLLS GEGQESQDEE ESSEEERASP AGSDHRHRGS 1150 1160 1170 1180 1190 1200 LEREAKSSFD LPDTLQVPGL HRTASGRGSA SEHQDCNGKS ASGRLARALR PDDPPLDGDD 1210 1220 1230 1240 1250 1260 ADDEGNLSKG ERVRAWIRAR LPACCLERDS WSAYIFPPQS RFRLLCHRII THKMFDHVVL 1270 1280 1290 1300 1310 1320 VIIFLNCITI AMERPKIDPH SAERIFLTLS NYIFTAVFLA EMTVKVVALG WCFGEQAYLR 1330 1340 1350 1360 1370 1380 SSWNVLDGLL VLISVIDILV SMVSDSGTKI LGMLRVLRLL RTLRPLRVIS RAQGLKLVVE 1390 1400 1410 1420 1430 1440 TLMSSLKPIG NIVVICCAFF IIFGILGVQL FKGKFFVCQG EDTRNITNKS DCAEASYRWV 1450 1460 1470 1480 1490 1500 RHKYNFDNLG QALMSLFVLA SKDGWVDIMY DGLDAVGVDQ QPIMNHNPWM LLYFISFLLI 1510 1520 1530 1540 1550 1560 VAFFVLNMFV GVVVENFHKC RQHQEEEEAR RREEKRLRRL EKKRRNLMLD DVIASGSSAS 1570 1580 1590 1600 1610 1620 AASEAQCKPY YSDYSRFRLL VHHLCTSHYL DLFITGVIGL NVVTMAMEHY QQPQILDEAL 1630 1640 1650 1660 1670 1680 KICNYIFTVI FVLESVFKLV AFGFRRFFQD RWNQLDLAIV LLSIMGITLE EIEVNASLPI 1690 1700 1710 1720 1730 1740 NPTIIRIMRV LRIARVLKLL KMAVGMRALL DTVMQALPQV GNLGLLFMLL FFIFAALGVE 1750 1760 1770 1780 1790 1800 LFGDLECDET HPCEGLGRHA TFRNFGMAFL TLFRVSTGDN WNGIMKDTLR DCDQESTCYN 1810 1820 1830 1840 1850 1860 TVISPIYFVS FVLTAQFVLV NVVIAVLMKH LEESNKEAKE EAELEAELEL EMKTLSPQPH 1870 1880 1890 1900 1910 1920 SPLGSPFLWP GVEGPDSPDS PKPGALHPAA HARSASHFSL EHPTIPLAEM EALSLTSEIV 1930 1940 1950 1960 1970 1980 SEPSCSLALT DDSLPDDMHT LLLSALESNM QPHPTELPGP DLLTVRKSGV SRTHSLPNDS 1990 2000 2010 2020 2030 2040 YMCRHGSTAE GPLGHRGWGL PKAQSGSVLS VHSQPADTSY ILQLPKDAPH LLQPHSAPTW 2050 2060 2070 2080 2090 2100 GTIPKLPPPG RSPLAQRPLR RQAAIRTDSL DVQGLGSRED LLAEVSGPSP PLARAYSFWG 2110 2120 2130 2140 2150 2160 QSSTQAQQHS RSHSKISKHM TPPAPCPGPE PNWGKGPPET RSSLELDTEL SWISGDLLPP 2170 2180 2190 2200 2210 2220 GGQEEPPSPR DLKKCYSVEA QSCQRRPTSW LDEQRRHSIA VSCLDSGSQP HLGTDPSNLG 2230 2240 2250 2260 2270 2280 GQPLGGPGSR PKKKLSPPSI TIDPPESQGP RTPPSPGICL RRRAPSSDSK DPLASGPPDS 2290 2300 MAASPSPKKD VLSLSGLSSD PADLDP
	Isoform 11 [UniParc]. Checksum: FCB59420799A126E	FASTA	2,284	252,664
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE SEPDFFSPSL DGDGDRKKCL 1030 1040 1050 1060 1070 1080 ALVSLGEHPE LRKSLLPPLI IHTAATPMSL PKSTSTGLGE ALGPASRRTS SSGSAEPGAA 1090 1100 1110 1120 1130 1140 HEMKSPPSAR SSPHSPWSAA SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ 1150 1160 1170 1180 1190 1200 DEEESSEEER ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN 1210 1220 1230 1240 1250 1260 GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE RDSWSAYIFP 1270 1280 1290 1300 1310 1320 PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI DPHSAERIFL TLSNYIFTAV 1330 1340 1350 1360 1370 1380 FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD GLLVLISVID ILVSMVSDSG TKILGMLRVL 1390 1400 1410 1420 1430 1440 RLLRTLRPLR VISRAQGLKL VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV 1450 1460 1470 1480 1490 1500 CQGEDTRNIT NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG 1510 1520 1530 1540 1550 1560 VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EARRREEKRL 1570 1580 1590 1600 1610 1620 RRLEKKRRNL MLDDVIASGS SASAASEAQC KPYYSDYSRF RLLVHHLCTS HYLDLFITGV 1630 1640 1650 1660 1670 1680 IGLNVVTMAM EHYQQPQILD EALKICNYIF TVIFVLESVF KLVAFGFRRF FQDRWNQLDL 1690 1700 1710 1720 1730 1740 AIVLLSIMGI TLEEIEVNAS LPINPTIIRI MRVLRIARVL KLLKMAVGMR ALLDTVMQAL 1750 1760 1770 1780 1790 1800 PQVGNLGLLF MLLFFIFAAL GVELFGDLEC DETHPCEGLG RHATFRNFGM AFLTLFRVST 1810 1820 1830 1840 1850 1860 GDNWNGIMKD TLRDCDQEST CYNTVISPIY FVSFVLTAQF VLVNVVIAVL MKHLEESNKE 1870 1880 1890 1900 1910 1920 AKEEAELEAE LELEMKTLSP QPHSPLGSPF LWPGVEGPDS PDSPKPGALH PAAHARSASH 1930 1940 1950 1960 1970 1980 FSLEHPTMQP HPTELPGPDL LTVRKSGVSR THSLPNDSYM CRHGSTAEGP LGHRGWGLPK 1990 2000 2010 2020 2030 2040 AQSGSVLSVH SQPADTSYIL QLPKDAPHLL QPHSAPTWGT IPKLPPPGRS PLAQRPLRRQ 2050 2060 2070 2080 2090 2100 AAIRTDSLDV QGLGSREDLL AEVSGPSPPL ARAYSFWGQS STQAQQHSRS HSKISKHMTP 2110 2120 2130 2140 2150 2160 PAPCPGPEPN WGKGPPETRS SLELDTELSW ISGDLLPPGG QEEPPSPRDL KKCYSVEAQS 2170 2180 2190 2200 2210 2220 CQRRPTSWLD EQRRHSIAVS CLDSGSQPHL GTDPSNLGGQ PLGGPGSRPK KKLSPPSITI 2230 2240 2250 2260 2270 2280 DPPESQGPRT PPSPGICLRR RAPSSDSKDP LASGPPDSMA ASPSPKKDVL SLSGLSSDPA DLDP
	Isoform 12 [UniParc]. Checksum: 74F41CEA601E8CBC	FASTA	2,332	257,716
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE SEPDFFSPSL DGDGDRKKCL 1030 1040 1050 1060 1070 1080 ALVSLGEHPE LRKSLLPPLI IHTAATPMSL PKSTSTGLGE ALGPASRRTS SSGSAEPGAA 1090 1100 1110 1120 1130 1140 HEMKSPPSAR SSPHSPWSAA SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ 1150 1160 1170 1180 1190 1200 DEEESSEEER ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN 1210 1220 1230 1240 1250 1260 GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE RDSWSAYIFP 1270 1280 1290 1300 1310 1320 PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI DPHSAERIFL TLSNYIFTAV 1330 1340 1350 1360 1370 1380 FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD GLLVLISVID ILVSMVSDSG TKILGMLRVL 1390 1400 1410 1420 1430 1440 RLLRTLRPLR VISRAQGLKL VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV 1450 1460 1470 1480 1490 1500 CQGEDTRNIT NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG 1510 1520 1530 1540 1550 1560 VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EARRREEKRL 1570 1580 1590 1600 1610 1620 RRLEKKRRNL MLDDVIASGS SASAASEAQC KPYYSDYSRF RLLVHHLCTS HYLDLFITGV 1630 1640 1650 1660 1670 1680 IGLNVVTMAM EHYQQPQILD EALKICNYIF TVIFVLESVF KLVAFGFRRF FQDRWNQLDL 1690 1700 1710 1720 1730 1740 AIVLLSIMGI TLEEIEVNAS LPINPTIIRI MRVLRIARVL KLLKMAVGMR ALLDTVMQAL 1750 1760 1770 1780 1790 1800 PQVGNLGLLF MLLFFIFAAL GVELFGDLEC DETHPCEGLG RHATFRNFGM AFLTLFRVST 1810 1820 1830 1840 1850 1860 GDNWNGIMKD TLRDCDQEST CYNTVISPIY FVSFVLTAQF VLVNVVIAVL MKHLEESNKE 1870 1880 1890 1900 1910 1920 AKEEAELEAE LELEMKTLSP QPHSPLGSPF LWPGVEGPDS PDSPKPGALH PAAHARSASH 1930 1940 1950 1960 1970 1980 FSLEHPTDRQ LFDTISLLIQ GSLEWELKLM DELAGPGGQP SAFPSAPSLG GSDPQMQPHP 1990 2000 2010 2020 2030 2040 TELPGPDLLT VRKSGVSRTH SLPNDSYMCR HGSTAEGPLG HRGWGLPKAQ SGSVLSVHSQ 2050 2060 2070 2080 2090 2100 PADTSYILQL PKDAPHLLQP HSAPTWGTIP KLPPPGRSPL AQRPLRRQAA IRTDSLDVQG 2110 2120 2130 2140 2150 2160 LGSREDLLAE VSGPSPPLAR AYSFWGQSST QAQQHSRSHS KISKHMTPPA PCPGPEPNWG 2170 2180 2190 2200 2210 2220 KGPPETRSSL ELDTELSWIS GDLLPPGGQE EPPSPRDLKK CYSVEAQSCQ RRPTSWLDEQ 2230 2240 2250 2260 2270 2280 RRHSIAVSCL DSGSQPHLGT DPSNLGGQPL GGPGSRPKKK LSPPSITIDP PESQGPRTPP 2290 2300 2310 2320 2330 SPGICLRRRA PSSDSKDPLA SGPPDSMAAS PSPKKDVLSL SGLSSDPADL DP
	Isoform 13 [UniParc]. Checksum: 66E3563375ED61DA	FASTA	2,266	250,972
	10 20 30 40 50 60 MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV 70 80 90 100 110 120 FFYLSQDSRP RSWCLRTVCN PWFERISMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 130 140 150 160 170 180 DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 190 200 210 220 230 240 TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 250 260 270 280 290 300 CFLPENFSLP LSVDLERYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG DGGGGPPCGL 310 320 330 340 350 360 DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 370 380 390 400 410 420 YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 430 440 450 460 470 480 STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS 490 500 510 520 530 540 SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP 550 560 570 580 590 600 ALSGAPPGGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 610 620 630 640 650 660 TLKEKALVEV AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG 670 680 690 700 710 720 ACGPDSCPYC ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA 730 740 750 760 770 780 EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 790 800 810 820 830 840 VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 850 860 870 880 890 900 VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 910 920 930 940 950 960 PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 970 980 990 1000 1010 1020 AILVEGFQAE EISKREDASG QLSCIQLPVD SQGGDANKSE SEPDFFSPSL DGDGDRKKCL 1030 1040 1050 1060 1070 1080 ALVSLGEHPE LRKSLLPPLI IHTAATPMSL PKSTSTGLGE ALGPASRRTS SSGSAEPGAA 1090 1100 1110 1120 1130 1140 HEMKSPPSAR SSPHSPWSAA SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ 1150 1160 1170 1180 1190 1200 DEEESSEEER ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN 1210 1220 1230 1240 1250 1260 GKSASGRLAR ALRPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE RDSWSAYIFP 1270 1280 1290 1300 1310 1320 PQSRFRLLCH RIITHKMFDH VVLVIIFLNC ITIAMERPKI DPHSAERIFL TLSNYIFTAV 1330 1340 1350 1360 1370 1380 FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD GLLVLISVID ILVSMVSDSG TKILGMLRVL 1390 1400 1410 1420 1430 1440 RLLRTLRPLR VISRAQGLKL VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV 1450 1460 1470 1480 1490 1500 CQGEDTRNIT NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG 1510 1520 1530 1540 1550 1560 VDQQPIMNHN PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EARRREEKRL 1570 1580 1590 1600 1610 1620 RRLEKKRRKA QCKPYYSDYS RFRLLVHHLC TSHYLDLFIT GVIGLNVVTM AMEHYQQPQI 1630 1640 1650 1660 1670 1680 LDEALKICNY IFTVIFVLES VFKLVAFGFR RFFQDRWNQL DLAIVLLSIM GITLEEIEVN 1690 1700 1710 1720 1730 1740 ASLPINPTII RIMRVLRIAR VLKLLKMAVG MRALLDTVMQ ALPQVGNLGL LFMLLFFIFA 1750 1760 1770 1780 1790 1800 ALGVELFGDL ECDETHPCEG LGRHATFRNF GMAFLTLFRV STGDNWNGIM KDTLRDCDQE 1810 1820 1830 1840 1850 1860 STCYNTVISP IYFVSFVLTA QFVLVNVVIA VLMKHLEESN KEAKEEAELE AELELEMKTL 1870 1880 1890 1900 1910 1920 SPQPHSPLGS PFLWPGVEGP DSPDSPKPGA LHPAAHARSA SHFSLEHPTM QPHPTELPGP 1930 1940 1950 1960 1970 1980 DLLTVRKSGV SRTHSLPNDS YMCRHGSTAE GPLGHRGWGL PKAQSGSVLS VHSQPADTSY 1990 2000 2010 2020 2030 2040 ILQLPKDAPH LLQPHSAPTW GTIPKLPPPG RSPLAQRPLR RQAAIRTDSL DVQGLGSRED 2050 2060 2070 2080 2090 2100 LLAEVSGPSP PLARAYSFWG QSSTQAQQHS RSHSKISKHM TPPAPCPGPE PNWGKGPPET 2110 2120 2130 2140 2150 2160 RSSLELDTEL SWISGDLLPP GGQEEPPSPR DLKKCYSVEA QSCQRRPTSW LDEQRRHSIA 2170 2180 2190 2200 2210 2220 VSCLDSGSQP HLGTDPSNLG GQPLGGPGSR PKKKLSPPSI TIDPPESQGP RTPPSPGICL 2230 2240 2250 2260 RRRAPSSDSK DPLASGPPDS MAASPSPKKD VLSLSGLSSD PADLDP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and alternative splicing of the gene encoding alpha1G, a human brain T calcium channel alpha1 subunit." Mittman S., Guo J., Agnew W.S. Neurosci. Lett. 274:143-146(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING (ISOFORMS 4 AND 5). Tissue: Brain.
[2]	"Molecular cloning and functional expression of ca(v)3.1c, a T-type calcium channel from human brain." Cribbs L.L., Gomora J.C., Daud A.N., Lee J.-H., Perez-Reyes E. FEBS Lett. 466:54-58(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[3]	"Molecular and functional properties of the human alpha1G subunit that forms T-type calcium channels." Monteil A., Chemin J., Bourinet E., Mennessier G., Lory P., Nargeot J. J. Biol. Chem. 275:6090-6100(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING (ISOFORMS 1-2 AND 6-13). Tissue: Brain.
[4]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 550-2377 (ISOFORM 13). Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[6]	"Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors." Toyota M., Ho C., Ohe-Toyota M., Baylin S.B., Issa J.-P.J. Cancer Res. 59:4535-4541(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), GENE STRUCTURE. Tissue: Prostatic carcinoma.
[7]	"Molecular characterization of a neuronal low-voltage-activated T-type calcium channel." Perez-Reyes E., Cribbs L.L., Daud A., Lacerda A.E., Barclay J., Williamson M.P., Fox M., Rees M., Lee J.-H. Nature 391:896-900(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1126-1444; 1778-1927 AND 2021-2312. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF134986 mRNA. Translation: AAF19347.1. AF134985 mRNA. Translation: AAF19346.1. AF227744 mRNA. Translation: AAF37689.1. AF227745 mRNA. Translation: AAF37690.1. AF227746 mRNA. Translation: AAF37691.1. AF227747 mRNA. Translation: AAF37692.1. AF227748 mRNA. Translation: AAF37693.1. AF227749 mRNA. Translation: AAF37694.1. AF227750 mRNA. Translation: AAF37695.1. AF227751 mRNA. Translation: AAF37696.1. AF124351 mRNA. Translation: AAD34352.1. AB032949 mRNA. Translation: BAA86437.2. AF126965 mRNA. Translation: AAD29400.1. AF126966 mRNA. Translation: AAD29401.1. AF190860 mRNA. Translation: AAF35287.1. AF029228 mRNA. Translation: AAD12731.1. AF029229 mRNA. Translation: AAD12732.1.
IPI	IPI00218687. IPI00218688. IPI00218689. IPI00218690. IPI00219390. IPI00219391. IPI00219393. IPI00219394. IPI00219395. IPI00219396. IPI00219397. IPI00219398. IPI00299037.
RefSeq	NP_001243253.1. NM_001256324.1. NP_001243254.1. NM_001256325.1. NP_001243255.1. NM_001256326.1. NP_001243256.1. NM_001256327.1. NP_001243257.1. NM_001256328.1. NP_001243258.1. NM_001256329.1. NP_001243259.1. NM_001256330.1. NP_001243260.1. NM_001256331.1. NP_001243261.1. NM_001256332.1. NP_001243262.1. NM_001256333.1. NP_001243263.1. NM_001256334.1. NP_001243288.1. NM_001256359.1. NP_001243289.1. NM_001256360.1. NP_001243290.1. NM_001256361.1. NP_061496.2. NM_018896.4. NP_938190.1. NM_198376.2. NP_938191.2. NM_198377.2. NP_938192.1. NM_198378.2. NP_938193.1. NM_198379.2. NP_938194.1. NM_198380.2. NP_938196.1. NM_198382.2. NP_938197.1. NM_198383.2. NP_938198.1. NM_198384.2. NP_938199.1. NM_198385.2. NP_938200.1. NM_198386.2. NP_938201.1. NM_198387.2. NP_938202.1. NM_198388.2. NP_938406.1. NM_198396.2.
UniGene	Hs.591169.
3D structure databases
ProteinModelPortal	O43497.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43497. 1 interaction.
MINT	MINT-2796172.
PTM databases
PhosphoSite	O43497.
Proteomic databases
PaxDb	O43497.
PRIDE	O43497.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000352832; ENSP00000339302; ENSG00000006283. ENST00000358244; ENSP00000350979; ENSG00000006283. ENST00000359106; ENSP00000352011; ENSG00000006283. ENST00000360761; ENSP00000353990; ENSG00000006283. ENST00000429973; ENSP00000414388; ENSG00000006283. ENST00000442258; ENSP00000409759; ENSG00000006283. ENST00000502264; ENSP00000425522; ENSG00000006283. ENST00000507510; ENSP00000423112; ENSG00000006283. ENST00000510115; ENSP00000427173; ENSG00000006283. ENST00000512389; ENSP00000426261; ENSG00000006283. ENST00000515165; ENSP00000426098; ENSG00000006283. ENST00000515765; ENSP00000426232; ENSG00000006283.
GeneID	8913.
KEGG	hsa:8913.
UCSC	uc002iri.1. human. uc002irq.1. human. uc002irw.1. human.
Organism-specific databases
CTD	8913.
GeneCards	GC17P048639.
HGNC	HGNC:1394. CACNA1G.
HPA	HPA004714.
MIM	604065. gene.
neXtProt	NX_O43497.
PharmGKB	PA381.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOVERGEN	HBG050764.
InParanoid	O43497.
KO	K04854.
OMA	QRCRILQ.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	O43497.
Bgee	O43497.
Genevestigator	O43497.
GermOnline	ENSG00000006283. Homo sapiens.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. IPR005445. VDCC_T_a1su. IPR002077. VDCCAlpha1. [Graphical view]
Pfam	PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01629. TVDCCALPHA1.
ProtoNet	Search...
Other
BindingDB	O43497.
ChEMBL	CHEMBL4641.
ChiTaRS	CACNA1G. human.
DrugBank	DB00593. Ethosuximide. DB04841. Flunarizine. DB01202. Levetiracetam. DB01388. Mibefradil. DB01100. Pimozide. DB00347. Trimethadione. DB00661. Verapamil. DB00909. Zonisamide.
GenomeRNAi	8913.
NextBio	33500.
SOURCE	Search...

Entry information

Entry name

CAC1G_HUMAN

Accession

Primary (citable) accession number: O43497
Secondary accession number(s): O43498 , O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.