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Protein

Band 4.1-like protein 2

Gene

EPB41L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Band 4.1-like protein 2
Alternative name(s):
Generally expressed protein 4.1
Short name:
4.1G
Gene namesi
Name:EPB41L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:3379. EPB41L2.

Subcellular locationi

GO - Cellular componenti

  • cell cortex region Source: UniProtKB
  • cell junction Source: HPA
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: HPA
  • plasma membrane Source: HPA
  • spectrin Source: ProtInc

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2037.
OpenTargetsiENSG00000079819.
PharmGKBiPA27812.

Polymorphism and mutation databases

BioMutaiEPB41L2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002193972 – 1005Band 4.1-like protein 2Add BLAST1004

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1 Publication1
Modified residuei7PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei89PhosphothreonineCombined sources1
Cross-linki144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei170PhosphoserineCombined sources1
Modified residuei208PhosphoserineBy similarity1
Modified residuei386PhosphoserineCombined sources1
Modified residuei402PhosphoserineBy similarity1
Modified residuei499PhosphoserineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Modified residuei562PhosphoserineCombined sources1
Modified residuei575PhosphoserineBy similarity1
Modified residuei598PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei623PhosphotyrosineBy similarity1
Modified residuei627PhosphoserineBy similarity1
Modified residuei647PhosphoserineCombined sources1
Modified residuei715PhosphoserineCombined sources1
Modified residuei718PhosphoserineCombined sources1
Modified residuei763PhosphothreonineBy similarity1
Modified residuei828PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43491.
MaxQBiO43491.
PaxDbiO43491.
PeptideAtlasiO43491.
PRIDEiO43491.
TopDownProteomicsiO43491-3. [O43491-3]

PTM databases

iPTMnetiO43491.
PhosphoSitePlusiO43491.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000079819.
CleanExiHS_EPB41L2.
ExpressionAtlasiO43491. baseline and differential.
GenevisibleiO43491. HS.

Organism-specific databases

HPAiHPA005730.
HPA006642.

Interactioni

Subunit structurei

Interacts with FCGR1A (PubMed:18023480). Interacts with TRPC4 (PubMed:16254212). Interacts (via CTD domain) with FKBP2 (By similarity). Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes anaphase-specific localization of NUMA1 in symmetrically dividing cells (PubMed:23870127).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108351. 50 interactors.
DIPiDIP-17034N.
IntActiO43491. 26 interactors.
MINTiMINT-5003841.
STRINGi9606.ENSP00000338481.

Structurei

3D structure databases

ProteinModelPortaliO43491.
SMRiO43491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 499FERMPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni502 – 610HydrophilicAdd BLAST109
Regioni611 – 676Spectrin--actin-bindingAdd BLAST66
Regioni855 – 1005C-terminal (CTD)Add BLAST151

Phylogenomic databases

eggNOGiKOG3527. Eukaryota.
ENOG410Y7NQ. LUCA.
GeneTreeiENSGT00760000118823.
HOGENOMiHOG000228841.
HOVERGENiHBG007777.
InParanoidiO43491.
KOiK06107.
OMAiISEFQFA.
OrthoDBiEOG091G00IL.
PhylomeDBiO43491.
TreeFamiTF351626.

Family and domain databases

CDDicd14473. FERM_B-lobe. 1 hit.
Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR008379. Band_4.1_C.
IPR019749. Band_41_domain.
IPR030546. E41L2.
IPR000798. Ez/rad/moesin-like.
IPR014847. FERM-adjacent.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_dom-like.
IPR007477. SAB_dom.
IPR029071. Ubiquitin-rel_dom.
PANTHERiPTHR23280:SF32. PTHR23280:SF32. 1 hit.
PfamiView protein in Pfam
PF05902. 4_1_CTD. 1 hit.
PF08736. FA. 1 hit.
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF04382. SAB. 1 hit.
PRINTSiPR00935. BAND41.
PR00661. ERMFAMILY.
SMARTiView protein in SMART
SM00295. B41. 1 hit.
SM01195. FA. 1 hit.
SM01196. FERM_C. 1 hit.
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43491-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTEVGSVSE VKKDSSQLGT DATKEKPKEV AENQQNQSSD PEEEKGSQPP
60 70 80 90 100
PAAESQSSLR RQKREKETSE SRGISRFIPP WLKKQKSYTL VVAKDGGDKK
110 120 130 140 150
EPTQAVVEEQ VLDKEEPLPE EQRQAKGDAE EMAQKKQEIK VEVKEEKPSV
160 170 180 190 200
SKEEKPSVSK VEMQPTELVS KEREEKVKET QEDKLEGGAA KRETKEVQTN
210 220 230 240 250
ELKAEKASQK VTKKTKTVQC KVTLLDGTEY SCDLEKHAKG QVLFDKVCEH
260 270 280 290 300
LNLLEKDYFG LLFQESPEQK NWLDPAKEIK RQLRNLPWLF TFNVKFYPPD
310 320 330 340 350
PSQLTEDITR YFLCLQLRQD IASGRLPCSF VTHALLGSYT LQAELGDYDP
360 370 380 390 400
EEHGSIDLSE FQFAPTQTKE LEEKVAELHK THRGLSPAQA DSQFLENAKR
410 420 430 440 450
LSMYGVDLHH AKDSEGVDIK LGVCANGLLI YKDRLRINRF AWPKILKISY
460 470 480 490 500
KRSNFYIKVR PAELEQFEST IGFKLPNHRA AKRLWKVCVE HHTFYRLVSP
510 520 530 540 550
EQPPKAKFLT LGSKFRYSGR TQAQTRQAST LIDRPAPHFE RTSSKRVSRS
560 570 580 590 600
LDGAPIGVMD QSLMKDFPGA AGEISAYGPG LVSIAVVQDG DGRREVRSPT
610 620 630 640 650
KAPHLQLIEG KKNSLRVEGD NIYVRHSNLM LEELDKAQED ILKHQASISE
660 670 680 690 700
LKRNFMESTP EPRPNEWEKR RITPLSLQTQ GSSHETLNIV EEKKRAEVGK
710 720 730 740 750
DERVITEEMN GKEISPGSGP GEIRKVEPVT QKDSTSLSSE SSSSSSESEE
760 770 780 790 800
EDVGEYRPHH RVTEGTIREE QEYEEEVEEE PRPAAKVVER EEAVPEASPV
810 820 830 840 850
TQAGASVITV ETVIQENVGA QKIPGEKSVH EGALKQDMGE EAEEEPQKVN
860 870 880 890 900
GEVSHVDIDV LPQIICCSEP PVVKTEMVTI SDASQRTEIS TKEVPIVQTE
910 920 930 940 950
TKTITYESPQ IDGGAGGDSG TLLTAQTITS ESVSTTTTTH ITKTVKGGIS
960 970 980 990 1000
ETRIEKRIVI TGDGDIDHDQ ALAQAIREAR EQHPDMSVTR VVVHKETELA

EEGED
Length:1,005
Mass (Da):112,588
Last modified:June 1, 1998 - v1
Checksum:iE86CB17488F6045F
GO
Isoform 2 (identifier: O43491-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     612-943: Missing.

Note: No experimental confirmation available.
Show »
Length:673
Mass (Da):76,053
Checksum:iFE88398B4AC18A0B
GO
Isoform 3 (identifier: O43491-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     612-869: Missing.

Note: No experimental confirmation available.
Show »
Length:747
Mass (Da):83,803
Checksum:iB5F08A014E5AD5A9
GO
Isoform 4 (identifier: O43491-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     612-681: Missing.
     787-869: Missing.

Note: No experimental confirmation available. Gene prediction based on cDNA data.
Show »
Length:852
Mass (Da):95,542
Checksum:iCACB03447C7ED78B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02014517Q → H. Corresponds to variant dbSNP:rs2297852Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042910612 – 943Missing in isoform 2. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_045090612 – 869Missing in isoform 3. 1 PublicationAdd BLAST258
Alternative sequenceiVSP_047181612 – 681Missing in isoform 4. CuratedAdd BLAST70
Alternative sequenceiVSP_047182787 – 869Missing in isoform 4. CuratedAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027299 mRNA. Translation: AAC16923.1.
AY047584 mRNA. Translation: AAK95850.1.
AK295124 mRNA. Translation: BAG58150.1.
CR749262 mRNA. Translation: CAH18118.1.
AL109938 Genomic DNA. No translation available.
AL357496 Genomic DNA. No translation available.
AL358943, AL355360 Genomic DNA. Translation: CAI20310.1.
AL590014 Genomic DNA. No translation available.
CH471051 Genomic DNA. Translation: EAW48062.1.
CCDSiCCDS47474.1. [O43491-2]
CCDS5141.1. [O43491-1]
CCDS56450.1. [O43491-4]
CCDS59037.1. [O43491-3]
RefSeqiNP_001129026.1. NM_001135554.1. [O43491-2]
NP_001129027.1. NM_001135555.3. [O43491-2]
NP_001239589.1. NM_001252660.1. [O43491-3]
NP_001422.1. NM_001431.3. [O43491-1]
XP_011533832.1. XM_011535530.1. [O43491-4]
XP_011533836.1. XM_011535534.1. [O43491-3]
XP_016865844.1. XM_017010355.1. [O43491-1]
XP_016865848.1. XM_017010359.1. [O43491-4]
XP_016865849.1. XM_017010360.1. [O43491-4]
XP_016865850.1. XM_017010361.1. [O43491-3]
XP_016865851.1. XM_017010362.1. [O43491-3]
UniGeneiHs.486470.
Hs.708219.

Genome annotation databases

EnsembliENST00000337057; ENSP00000338481; ENSG00000079819. [O43491-1]
ENST00000368128; ENSP00000357110; ENSG00000079819. [O43491-1]
ENST00000392427; ENSP00000376222; ENSG00000079819. [O43491-2]
ENST00000445890; ENSP00000402041; ENSG00000079819. [O43491-3]
ENST00000525271; ENSP00000432803; ENSG00000079819. [O43491-2]
ENST00000528282; ENSP00000434308; ENSG00000079819. [O43491-3]
ENST00000530481; ENSP00000434576; ENSG00000079819. [O43491-4]
GeneIDi2037.
KEGGihsa:2037.
UCSCiuc003qcg.2. human. [O43491-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiE41L2_HUMAN
AccessioniPrimary (citable) accession number: O43491
Secondary accession number(s): B4DHI8
, E9PPD9, Q5T4F0, Q68DV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 1998
Last modified: July 5, 2017
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot