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Protein

Band 4.1-like protein 2

Gene

EPB41L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCell cycle, Cell division, Mitosis, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Band 4.1-like protein 2
Alternative name(s):
Generally expressed protein 4.1
Short name:
4.1G
Gene namesi
Name:EPB41L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000079819.16
HGNCiHGNC:3379 EPB41L2
MIMi603237 gene
neXtProtiNX_O43491

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2037
OpenTargetsiENSG00000079819
PharmGKBiPA27812

Polymorphism and mutation databases

BioMutaiEPB41L2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002193972 – 1005Band 4.1-like protein 2Add BLAST1004

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineCombined sources1 Publication1
Modified residuei7PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei89PhosphothreonineCombined sources1
Cross-linki140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki144Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei170PhosphoserineCombined sources1
Modified residuei208PhosphoserineBy similarity1
Modified residuei386PhosphoserineCombined sources1
Modified residuei402PhosphoserineBy similarity1
Modified residuei499PhosphoserineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Modified residuei562PhosphoserineCombined sources1
Modified residuei575PhosphoserineBy similarity1
Modified residuei598PhosphoserineCombined sources1
Modified residuei614PhosphoserineCombined sources1
Modified residuei623PhosphotyrosineBy similarity1
Modified residuei627PhosphoserineBy similarity1
Modified residuei647PhosphoserineCombined sources1
Modified residuei715PhosphoserineCombined sources1
Modified residuei718PhosphoserineCombined sources1
Modified residuei763PhosphothreonineBy similarity1
Modified residuei828PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO43491
MaxQBiO43491
PaxDbiO43491
PeptideAtlasiO43491
PRIDEiO43491
TopDownProteomicsiO43491-3 [O43491-3]

PTM databases

iPTMnetiO43491
PhosphoSitePlusiO43491

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000079819
CleanExiHS_EPB41L2
ExpressionAtlasiO43491 baseline and differential
GenevisibleiO43491 HS

Organism-specific databases

HPAiHPA005730
HPA006642

Interactioni

Subunit structurei

Interacts with FCGR1A (PubMed:18023480). Interacts with TRPC4 (PubMed:16254212). Interacts (via CTD domain) with FKBP2 (By similarity). Interacts with NUMA1; this interaction is negatively regulated by CDK1 during metaphase and promotes anaphase-specific localization of NUMA1 in symmetrically dividing cells (PubMed:23870127).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108351, 54 interactors
DIPiDIP-17034N
IntActiO43491, 28 interactors
STRINGi9606.ENSP00000338481

Structurei

3D structure databases

ProteinModelPortaliO43491
SMRiO43491
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 499FERMPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni502 – 610HydrophilicAdd BLAST109
Regioni611 – 676Spectrin--actin-bindingAdd BLAST66
Regioni855 – 1005C-terminal (CTD)Add BLAST151

Phylogenomic databases

eggNOGiKOG3527 Eukaryota
ENOG410Y7NQ LUCA
GeneTreeiENSGT00760000118823
HOGENOMiHOG000228841
HOVERGENiHBG007777
InParanoidiO43491
KOiK06107
OMAiISEFQFA
OrthoDBiEOG091G00IL
PhylomeDBiO43491
TreeFamiTF351626

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR008379 Band_4.1_C
IPR019749 Band_41_domain
IPR030546 E41L2
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR007477 SAB_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR23280:SF17 PTHR23280:SF17, 2 hits
PfamiView protein in Pfam
PF05902 4_1_CTD, 1 hit
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF04382 SAB, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43491-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTEVGSVSE VKKDSSQLGT DATKEKPKEV AENQQNQSSD PEEEKGSQPP
60 70 80 90 100
PAAESQSSLR RQKREKETSE SRGISRFIPP WLKKQKSYTL VVAKDGGDKK
110 120 130 140 150
EPTQAVVEEQ VLDKEEPLPE EQRQAKGDAE EMAQKKQEIK VEVKEEKPSV
160 170 180 190 200
SKEEKPSVSK VEMQPTELVS KEREEKVKET QEDKLEGGAA KRETKEVQTN
210 220 230 240 250
ELKAEKASQK VTKKTKTVQC KVTLLDGTEY SCDLEKHAKG QVLFDKVCEH
260 270 280 290 300
LNLLEKDYFG LLFQESPEQK NWLDPAKEIK RQLRNLPWLF TFNVKFYPPD
310 320 330 340 350
PSQLTEDITR YFLCLQLRQD IASGRLPCSF VTHALLGSYT LQAELGDYDP
360 370 380 390 400
EEHGSIDLSE FQFAPTQTKE LEEKVAELHK THRGLSPAQA DSQFLENAKR
410 420 430 440 450
LSMYGVDLHH AKDSEGVDIK LGVCANGLLI YKDRLRINRF AWPKILKISY
460 470 480 490 500
KRSNFYIKVR PAELEQFEST IGFKLPNHRA AKRLWKVCVE HHTFYRLVSP
510 520 530 540 550
EQPPKAKFLT LGSKFRYSGR TQAQTRQAST LIDRPAPHFE RTSSKRVSRS
560 570 580 590 600
LDGAPIGVMD QSLMKDFPGA AGEISAYGPG LVSIAVVQDG DGRREVRSPT
610 620 630 640 650
KAPHLQLIEG KKNSLRVEGD NIYVRHSNLM LEELDKAQED ILKHQASISE
660 670 680 690 700
LKRNFMESTP EPRPNEWEKR RITPLSLQTQ GSSHETLNIV EEKKRAEVGK
710 720 730 740 750
DERVITEEMN GKEISPGSGP GEIRKVEPVT QKDSTSLSSE SSSSSSESEE
760 770 780 790 800
EDVGEYRPHH RVTEGTIREE QEYEEEVEEE PRPAAKVVER EEAVPEASPV
810 820 830 840 850
TQAGASVITV ETVIQENVGA QKIPGEKSVH EGALKQDMGE EAEEEPQKVN
860 870 880 890 900
GEVSHVDIDV LPQIICCSEP PVVKTEMVTI SDASQRTEIS TKEVPIVQTE
910 920 930 940 950
TKTITYESPQ IDGGAGGDSG TLLTAQTITS ESVSTTTTTH ITKTVKGGIS
960 970 980 990 1000
ETRIEKRIVI TGDGDIDHDQ ALAQAIREAR EQHPDMSVTR VVVHKETELA

EEGED
Length:1,005
Mass (Da):112,588
Last modified:June 1, 1998 - v1
Checksum:iE86CB17488F6045F
GO
Isoform 2 (identifier: O43491-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     612-943: Missing.

Note: No experimental confirmation available.
Show »
Length:673
Mass (Da):76,053
Checksum:iFE88398B4AC18A0B
GO
Isoform 3 (identifier: O43491-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     612-869: Missing.

Note: No experimental confirmation available.
Show »
Length:747
Mass (Da):83,803
Checksum:iB5F08A014E5AD5A9
GO
Isoform 4 (identifier: O43491-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     612-681: Missing.
     787-869: Missing.

Note: No experimental confirmation available. Gene prediction based on cDNA data.
Show »
Length:852
Mass (Da):95,542
Checksum:iCACB03447C7ED78B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02014517Q → H. Corresponds to variant dbSNP:rs2297852Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042910612 – 943Missing in isoform 2. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_045090612 – 869Missing in isoform 3. 1 PublicationAdd BLAST258
Alternative sequenceiVSP_047181612 – 681Missing in isoform 4. CuratedAdd BLAST70
Alternative sequenceiVSP_047182787 – 869Missing in isoform 4. CuratedAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027299 mRNA Translation: AAC16923.1
AY047584 mRNA Translation: AAK95850.1
AK295124 mRNA Translation: BAG58150.1
CR749262 mRNA Translation: CAH18118.1
AL109938 Genomic DNA No translation available.
AL357496 Genomic DNA No translation available.
AL355360 Genomic DNA No translation available.
AL358943 Genomic DNA No translation available.
AL590014 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48062.1
CCDSiCCDS47474.1 [O43491-2]
CCDS5141.1 [O43491-1]
CCDS56450.1 [O43491-4]
CCDS59037.1 [O43491-3]
RefSeqiNP_001129026.1, NM_001135554.1 [O43491-2]
NP_001129027.1, NM_001135555.3 [O43491-2]
NP_001239589.1, NM_001252660.1 [O43491-3]
NP_001422.1, NM_001431.3 [O43491-1]
XP_011533832.1, XM_011535530.1
XP_011533836.1, XM_011535534.1
XP_016865844.1, XM_017010355.1
XP_016865848.1, XM_017010359.1
XP_016865849.1, XM_017010360.1
XP_016865850.1, XM_017010361.1
XP_016865851.1, XM_017010362.1
UniGeneiHs.486470
Hs.708219

Genome annotation databases

EnsembliENST00000337057; ENSP00000338481; ENSG00000079819 [O43491-1]
ENST00000368128; ENSP00000357110; ENSG00000079819 [O43491-1]
ENST00000392427; ENSP00000376222; ENSG00000079819 [O43491-2]
ENST00000445890; ENSP00000402041; ENSG00000079819 [O43491-3]
ENST00000525271; ENSP00000432803; ENSG00000079819 [O43491-2]
ENST00000528282; ENSP00000434308; ENSG00000079819 [O43491-3]
ENST00000530481; ENSP00000434576; ENSG00000079819 [O43491-4]
GeneIDi2037
KEGGihsa:2037
UCSCiuc003qcg.2 human [O43491-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiE41L2_HUMAN
AccessioniPrimary (citable) accession number: O43491
Secondary accession number(s): B4DHI8
, E9PPD9, Q5T4F0, Q68DV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: June 1, 1998
Last modified: May 23, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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