ID MS18B_HUMAN Reviewed; 229 AA. AC O43482; Q96BX7; DT 03-APR-2002, integrated into UniProtKB/Swiss-Prot. DT 03-APR-2002, sequence version 2. DT 24-JAN-2024, entry version 170. DE RecName: Full=Protein Mis18-beta; DE AltName: Full=Cancer/testis antigen 86; DE Short=CT86; DE AltName: Full=Opa-interacting protein 5 {ECO:0000303|PubMed:9466265}; DE Short=OIP-5 {ECO:0000303|PubMed:9466265}; GN Name=OIP5 {ECO:0000303|PubMed:9466265}; Synonyms=MIS18B; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBUNIT. RX PubMed=9466265; DOI=10.1046/j.1365-2958.1998.00670.x; RA Williams J.M., Chen G.-C., Zhu L., Rest R.F.; RT "Using the yeast two-hybrid system to identify human epithelial cell RT proteins that bind gonococcal Opa proteins: intracellular gonococci bind RT pyruvate kinase via their Opa proteins and require host pyruvate for RT growth."; RL Mol. Microbiol. 27:171-186(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY, RP INTERACTION WITH MIS18A, AND IDENTIFICATION IN A COMPLEX CONTAINING MIS18A; RP MIS18B; MIS18BP1; RBBP7 AND RBBP4. RX PubMed=17199038; DOI=10.1016/j.devcel.2006.11.002; RA Fujita Y., Hayashi T., Kiyomitsu T., Toyoda Y., Kokubu A., Obuse C., RA Yanagida M.; RT "Priming of centromere for CENP-A recruitment by human hMis18alpha, RT hMis18beta, and M18BP1."; RL Dev. Cell 12:17-30(2007). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007; RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., RA Greff Z., Keri G., Stemmann O., Mann M.; RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the RT kinome across the cell cycle."; RL Mol. Cell 31:438-448(2008). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48; THR-221 AND SER-225, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-221 AND SER-225, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21406692; DOI=10.1126/scisignal.2001570; RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.; RT "System-wide temporal characterization of the proteome and phosphoproteome RT of human embryonic stem cell differentiation."; RL Sci. Signal. 4:RS3-RS3(2011). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; THR-221 AND SER-225, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [10] RP SUBUNIT, AND MUTAGENESIS OF VAL-77 AND TYR-172. RX PubMed=26921242; DOI=10.15252/embr.201541520; RA Subramanian L., Medina-Pritchard B., Barton R., Spiller F., RA Kulasegaran-Shylini R., Radaviciute G., Allshire R.C., RA Arockia Jeyaprakash A.; RT "Centromere localization and function of Mis18 requires Yippee-like domain- RT mediated oligomerization."; RL EMBO Rep. 17:496-507(2016). CC -!- FUNCTION: Required for recruitment of CENPA to centromeres and normal CC chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}. CC -!- SUBUNIT: Homodimer, and heterodimer with MIS18A (PubMed:17199038, CC PubMed:26921242). Identified in a complex containing MIS18A, CC OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4 (PubMed:17199038). Binds outer CC membrane protein OpaP from Neisseria gonorrhoeae (in vitro) CC (PubMed:9466265). {ECO:0000269|PubMed:17199038, CC ECO:0000269|PubMed:26921242, ECO:0000269|PubMed:9466265}. CC -!- INTERACTION: CC O43482; Q9NQ94: A1CF; NbExp=3; IntAct=EBI-536879, EBI-2809489; CC O43482; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-536879, EBI-11096309; CC O43482; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-536879, EBI-742038; CC O43482; P21549: AGXT; NbExp=3; IntAct=EBI-536879, EBI-727098; CC O43482; Q92870-2: APBB2; NbExp=3; IntAct=EBI-536879, EBI-21535880; CC O43482; O75934: BCAS2; NbExp=3; IntAct=EBI-536879, EBI-1050106; CC O43482; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-536879, EBI-745073; CC O43482; Q13515: BFSP2; NbExp=3; IntAct=EBI-536879, EBI-10229433; CC O43482; Q8TDH9: BLOC1S5; NbExp=3; IntAct=EBI-536879, EBI-465861; CC O43482; Q6P1W5: C1orf94; NbExp=6; IntAct=EBI-536879, EBI-946029; CC O43482; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-536879, EBI-11524851; CC O43482; O60826: CCDC22; NbExp=3; IntAct=EBI-536879, EBI-3943153; CC O43482; Q8N4L8: CCDC24; NbExp=5; IntAct=EBI-536879, EBI-1104933; CC O43482; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-536879, EBI-10175300; CC O43482; Q86X02: CDR2L; NbExp=3; IntAct=EBI-536879, EBI-11063830; CC O43482; Q96L14: CEP170P1; NbExp=3; IntAct=EBI-536879, EBI-743488; CC O43482; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-536879, EBI-11752486; CC O43482; Q8TCT0: CERK; NbExp=3; IntAct=EBI-536879, EBI-10274247; CC O43482; Q9Y6H1: CHCHD2; NbExp=3; IntAct=EBI-536879, EBI-2321769; CC O43482; Q9H1P6: CIMIP1; NbExp=3; IntAct=EBI-536879, EBI-12155483; CC O43482; P10606: COX5B; NbExp=3; IntAct=EBI-536879, EBI-1053725; CC O43482; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-536879, EBI-739773; CC O43482; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-536879, EBI-11962928; CC O43482; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-536879, EBI-9679045; CC O43482; Q96EV8: DTNBP1; NbExp=3; IntAct=EBI-536879, EBI-465804; CC O43482; Q86UW9: DTX2; NbExp=3; IntAct=EBI-536879, EBI-740376; CC O43482; Q9H596: DUSP21; NbExp=3; IntAct=EBI-536879, EBI-7357329; CC O43482; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-536879, EBI-743105; CC O43482; Q9NRA8: EIF4ENIF1; NbExp=3; IntAct=EBI-536879, EBI-301024; CC O43482; Q96DF8: ESS2; NbExp=3; IntAct=EBI-536879, EBI-3928124; CC O43482; Q9NYK6-3: EURL; NbExp=3; IntAct=EBI-536879, EBI-13371226; CC O43482; Q96MY7: FAM161B; NbExp=4; IntAct=EBI-536879, EBI-7225287; CC O43482; Q8WU58: FAM222B; NbExp=3; IntAct=EBI-536879, EBI-2807642; CC O43482; P22607: FGFR3; NbExp=3; IntAct=EBI-536879, EBI-348399; CC O43482; A1L4K1: FSD2; NbExp=3; IntAct=EBI-536879, EBI-5661036; CC O43482; Q8TAE8: GADD45GIP1; NbExp=3; IntAct=EBI-536879, EBI-372506; CC O43482; Q96CN9: GCC1; NbExp=3; IntAct=EBI-536879, EBI-746252; CC O43482; P55040: GEM; NbExp=3; IntAct=EBI-536879, EBI-744104; CC O43482; Q9BZE0: GLIS2; NbExp=3; IntAct=EBI-536879, EBI-7251368; CC O43482; O95872: GPANK1; NbExp=3; IntAct=EBI-536879, EBI-751540; CC O43482; Q13227: GPS2; NbExp=5; IntAct=EBI-536879, EBI-713355; CC O43482; Q14957: GRIN2C; NbExp=3; IntAct=EBI-536879, EBI-8285963; CC O43482; P28799: GRN; NbExp=3; IntAct=EBI-536879, EBI-747754; CC O43482; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-536879, EBI-11956675; CC O43482; O14964: HGS; NbExp=3; IntAct=EBI-536879, EBI-740220; CC O43482; P09067: HOXB5; NbExp=3; IntAct=EBI-536879, EBI-3893317; CC O43482; P17482: HOXB9; NbExp=3; IntAct=EBI-536879, EBI-745290; CC O43482; P31273: HOXC8; NbExp=3; IntAct=EBI-536879, EBI-1752118; CC O43482; P01112: HRAS; NbExp=3; IntAct=EBI-536879, EBI-350145; CC O43482; Q9ULV5-2: HSF4; NbExp=5; IntAct=EBI-536879, EBI-12056251; CC O43482; Q14005-2: IL16; NbExp=3; IntAct=EBI-536879, EBI-17178971; CC O43482; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-536879, EBI-2556193; CC O43482; O60333-2: KIF1B; NbExp=3; IntAct=EBI-536879, EBI-10975473; CC O43482; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-536879, EBI-8472129; CC O43482; O14901: KLF11; NbExp=3; IntAct=EBI-536879, EBI-948266; CC O43482; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-536879, EBI-6426443; CC O43482; Q9P2K6: KLHL42; NbExp=3; IntAct=EBI-536879, EBI-739890; CC O43482; Q9Y448: KNSTRN; NbExp=3; IntAct=EBI-536879, EBI-373334; CC O43482; P02533: KRT14; NbExp=3; IntAct=EBI-536879, EBI-702178; CC O43482; P19012: KRT15; NbExp=4; IntAct=EBI-536879, EBI-739566; CC O43482; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-536879, EBI-3044087; CC O43482; P12035: KRT3; NbExp=3; IntAct=EBI-536879, EBI-2430095; CC O43482; Q92764: KRT35; NbExp=3; IntAct=EBI-536879, EBI-1058674; CC O43482; O76014: KRT37; NbExp=3; IntAct=EBI-536879, EBI-1045716; CC O43482; Q6A162: KRT40; NbExp=3; IntAct=EBI-536879, EBI-10171697; CC O43482; P04259: KRT6B; NbExp=3; IntAct=EBI-536879, EBI-740907; CC O43482; O95678: KRT75; NbExp=5; IntAct=EBI-536879, EBI-2949715; CC O43482; Q14533: KRT81; NbExp=5; IntAct=EBI-536879, EBI-739648; CC O43482; P78385: KRT83; NbExp=3; IntAct=EBI-536879, EBI-10221390; CC O43482; O43790: KRT86; NbExp=3; IntAct=EBI-536879, EBI-9996498; CC O43482; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-536879, EBI-11953846; CC O43482; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-536879, EBI-1048945; CC O43482; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-536879, EBI-12805508; CC O43482; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-536879, EBI-726510; CC O43482; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-536879, EBI-394607; CC O43482; O14770-4: MEIS2; NbExp=3; IntAct=EBI-536879, EBI-8025850; CC O43482; Q5JXC2: MIIP; NbExp=3; IntAct=EBI-536879, EBI-2801965; CC O43482; Q9NYP9: MIS18A; NbExp=23; IntAct=EBI-536879, EBI-1104552; CC O43482; Q6P0N0: MIS18BP1; NbExp=4; IntAct=EBI-536879, EBI-9870821; CC O43482; Q8IVT2: MISP; NbExp=3; IntAct=EBI-536879, EBI-2555085; CC O43482; Q6PF18: MORN3; NbExp=3; IntAct=EBI-536879, EBI-9675802; CC O43482; Q9P2K5-2: MYEF2; NbExp=5; IntAct=EBI-536879, EBI-10318831; CC O43482; Q8NFW9: MYRIP; NbExp=3; IntAct=EBI-536879, EBI-1759414; CC O43482; O14561: NDUFAB1; NbExp=3; IntAct=EBI-536879, EBI-1246261; CC O43482; Q7Z6G3-2: NECAB2; NbExp=6; IntAct=EBI-536879, EBI-10172876; CC O43482; P07196: NEFL; NbExp=3; IntAct=EBI-536879, EBI-475646; CC O43482; Q7Z3B4: NUP54; NbExp=3; IntAct=EBI-536879, EBI-741048; CC O43482; Q9BVL2: NUP58; NbExp=3; IntAct=EBI-536879, EBI-2811583; CC O43482; P37198: NUP62; NbExp=6; IntAct=EBI-536879, EBI-347978; CC O43482; O43482: OIP5; NbExp=4; IntAct=EBI-536879, EBI-536879; CC O43482; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-536879, EBI-10181968; CC O43482; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-536879, EBI-11022007; CC O43482; Q8N4B1-4: PHETA1; NbExp=3; IntAct=EBI-536879, EBI-14131832; CC O43482; Q99697-2: PITX2; NbExp=3; IntAct=EBI-536879, EBI-12138495; CC O43482; Q9UPG8: PLAGL2; NbExp=3; IntAct=EBI-536879, EBI-2876622; CC O43482; P52435: POLR2J; NbExp=3; IntAct=EBI-536879, EBI-394753; CC O43482; P78424: POU6F2; NbExp=3; IntAct=EBI-536879, EBI-12029004; CC O43482; P60891: PRPS1; NbExp=3; IntAct=EBI-536879, EBI-749195; CC O43482; P0CG20: PRR35; NbExp=3; IntAct=EBI-536879, EBI-11986293; CC O43482; P20618: PSMB1; NbExp=3; IntAct=EBI-536879, EBI-372273; CC O43482; Q9ULW5: RAB26; NbExp=3; IntAct=EBI-536879, EBI-958239; CC O43482; Q9UJ41-4: RABGEF1; NbExp=3; IntAct=EBI-536879, EBI-14093916; CC O43482; P04049: RAF1; NbExp=4; IntAct=EBI-536879, EBI-365996; CC O43482; Q8N443: RIBC1; NbExp=3; IntAct=EBI-536879, EBI-10265323; CC O43482; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-536879, EBI-11984663; CC O43482; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-536879, EBI-6257312; CC O43482; Q8WXG8: S100Z; NbExp=3; IntAct=EBI-536879, EBI-12198403; CC O43482; Q7Z3H4: SAMD7; NbExp=3; IntAct=EBI-536879, EBI-12148649; CC O43482; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-536879, EBI-3957636; CC O43482; Q7Z5V6-2: SAXO4; NbExp=3; IntAct=EBI-536879, EBI-12000762; CC O43482; Q6ZSJ9: SHISA6; NbExp=6; IntAct=EBI-536879, EBI-12037847; CC O43482; P12757: SKIL; NbExp=3; IntAct=EBI-536879, EBI-2902468; CC O43482; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-536879, EBI-455078; CC O43482; Q9BV90: SNRNP25; NbExp=3; IntAct=EBI-536879, EBI-9675976; CC O43482; P14678-2: SNRPB; NbExp=3; IntAct=EBI-536879, EBI-372475; CC O43482; Q5JUK2: SOHLH1; NbExp=3; IntAct=EBI-536879, EBI-12288855; CC O43482; O60504: SORBS3; NbExp=3; IntAct=EBI-536879, EBI-741237; CC O43482; Q86W54-2: SPATA24; NbExp=3; IntAct=EBI-536879, EBI-12041693; CC O43482; Q8N865: SPMIP4; NbExp=3; IntAct=EBI-536879, EBI-10174456; CC O43482; Q9BXF9: TEKT3; NbExp=5; IntAct=EBI-536879, EBI-8644516; CC O43482; Q9BXU0: TEX12; NbExp=3; IntAct=EBI-536879, EBI-12090309; CC O43482; Q7Z6R9: TFAP2D; NbExp=5; IntAct=EBI-536879, EBI-11952651; CC O43482; Q9UBB9: TFIP11; NbExp=6; IntAct=EBI-536879, EBI-1105213; CC O43482; O60220: TIMM8A; NbExp=3; IntAct=EBI-536879, EBI-1049822; CC O43482; O43711: TLX3; NbExp=3; IntAct=EBI-536879, EBI-3939165; CC O43482; P06753: TPM3; NbExp=12; IntAct=EBI-536879, EBI-355607; CC O43482; Q5VU62: TPM3; NbExp=5; IntAct=EBI-536879, EBI-10184033; CC O43482; Q8N7U7-2: TPRX1; NbExp=5; IntAct=EBI-536879, EBI-14115717; CC O43482; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-536879, EBI-492476; CC O43482; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-536879, EBI-10259086; CC O43482; Q15654: TRIP6; NbExp=4; IntAct=EBI-536879, EBI-742327; CC O43482; Q12815: TROAP; NbExp=3; IntAct=EBI-536879, EBI-2349743; CC O43482; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-536879, EBI-739895; CC O43482; O75604: USP2; NbExp=3; IntAct=EBI-536879, EBI-743272; CC O43482; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-536879, EBI-11975223; CC O43482; O76024: WFS1; NbExp=3; IntAct=EBI-536879, EBI-720609; CC O43482; Q9BYJ9: YTHDF1; NbExp=3; IntAct=EBI-536879, EBI-1051237; CC O43482; Q15915: ZIC1; NbExp=5; IntAct=EBI-536879, EBI-11963196; CC O43482; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-536879, EBI-740727; CC O43482; Q8N720: ZNF655; NbExp=3; IntAct=EBI-536879, EBI-625509; CC O43482; Q9Y649; NbExp=3; IntAct=EBI-536879, EBI-25900580; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17199038}. Chromosome CC {ECO:0000269|PubMed:17199038}. Chromosome, centromere CC {ECO:0000269|PubMed:17199038}. Note=Associated with centromeres in CC interphase cells, from late anaphase to the G1 phase. Not detected on CC centromeres during earlier phases of mitosis. Associated with CC chromatin. CC -!- SIMILARITY: Belongs to the mis18 family. {ECO:0000255|PROSITE- CC ProRule:PRU01129}. CC -!- SEQUENCE CAUTION: CC Sequence=AAC39561.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF025441; AAC39561.1; ALT_INIT; mRNA. DR EMBL; BC015050; AAH15050.1; -; mRNA. DR CCDS; CCDS10074.1; -. DR RefSeq; NP_001304789.1; NM_001317860.1. DR RefSeq; NP_009211.1; NM_007280.1. DR PDB; 7SFY; X-ray; 2.50 A; C/F=188-229. DR PDBsum; 7SFY; -. DR AlphaFoldDB; O43482; -. DR SMR; O43482; -. DR BioGRID; 116467; 218. DR ComplexPortal; CPX-3272; Mis18 complex. DR CORUM; O43482; -. DR IntAct; O43482; 166. DR MINT; O43482; -. DR STRING; 9606.ENSP00000220514; -. DR iPTMnet; O43482; -. DR PhosphoSitePlus; O43482; -. DR BioMuta; OIP5; -. DR EPD; O43482; -. DR jPOST; O43482; -. DR MassIVE; O43482; -. DR MaxQB; O43482; -. DR PaxDb; 9606-ENSP00000220514; -. DR PeptideAtlas; O43482; -. DR ProteomicsDB; 48965; -. DR Pumba; O43482; -. DR Antibodypedia; 23263; 181 antibodies from 20 providers. DR DNASU; 11339; -. DR Ensembl; ENST00000220514.8; ENSP00000220514.3; ENSG00000104147.9. DR GeneID; 11339; -. DR KEGG; hsa:11339; -. DR MANE-Select; ENST00000220514.8; ENSP00000220514.3; NM_007280.2; NP_009211.1. DR UCSC; uc001znp.3; human. DR AGR; HGNC:20300; -. DR CTD; 11339; -. DR DisGeNET; 11339; -. DR GeneCards; OIP5; -. DR HGNC; HGNC:20300; OIP5. DR HPA; ENSG00000104147; Tissue enhanced (bone marrow, skeletal muscle, testis). DR MIM; 606020; gene. DR neXtProt; NX_O43482; -. DR OpenTargets; ENSG00000104147; -. DR PharmGKB; PA134887641; -. DR VEuPathDB; HostDB:ENSG00000104147; -. DR eggNOG; ENOG502S5R3; Eukaryota. DR GeneTree; ENSGT00940000154267; -. DR InParanoid; O43482; -. DR OMA; MDIHNVP; -. DR OrthoDB; 5314781at2759; -. DR PhylomeDB; O43482; -. DR TreeFam; TF330739; -. DR PathwayCommons; O43482; -. DR Reactome; R-HSA-606279; Deposition of new CENPA-containing nucleosomes at the centromere. DR SignaLink; O43482; -. DR BioGRID-ORCS; 11339; 633 hits in 1165 CRISPR screens. DR ChiTaRS; OIP5; human. DR GenomeRNAi; 11339; -. DR Pharos; O43482; Tbio. DR PRO; PR:O43482; -. DR Proteomes; UP000005640; Chromosome 15. DR RNAct; O43482; Protein. DR Bgee; ENSG00000104147; Expressed in oocyte and 121 other cell types or tissues. DR ExpressionAtlas; O43482; baseline and differential. DR GO; GO:0015030; C:Cajal body; IDA:MGI. DR GO; GO:0000785; C:chromatin; IDA:MGI. DR GO; GO:0010369; C:chromocenter; IEA:Ensembl. DR GO; GO:0000775; C:chromosome, centromeric region; IBA:GO_Central. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. DR GO; GO:0016607; C:nuclear speck; IDA:HPA. DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome. DR GO; GO:0005634; C:nucleus; IDA:MGI. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0007154; P:cell communication; NAS:UniProtKB. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0034080; P:CENP-A containing chromatin assembly; IBA:GO_Central. DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central. DR InterPro; IPR034752; Mis18. DR InterPro; IPR004910; Yippee/Mis18/Cereblon. DR PANTHER; PTHR16431; NEUROGENIC PROTEIN MASTERMIND; 1. DR PANTHER; PTHR16431:SF3; PROTEIN MIS18-BETA; 1. DR Pfam; PF03226; Yippee-Mis18; 1. DR PROSITE; PS51793; MIS18; 1. DR Genevisible; O43482; HS. PE 1: Evidence at protein level; KW 3D-structure; Cell cycle; Cell division; Centromere; Chromosome; KW Metal-binding; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Zinc. FT CHAIN 1..229 FT /note="Protein Mis18-beta" FT /id="PRO_0000058038" FT DOMAIN 75..174 FT /note="Mis18" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129" FT BINDING 80 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129" FT BINDING 83 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129" FT BINDING 137 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129" FT BINDING 140 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01129" FT MOD_RES 14 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 48 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:19690332" FT MOD_RES 221 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:19690332, FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163" FT MOD_RES 225 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:19690332, FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, FT ECO:0007744|PubMed:23186163" FT MUTAGEN 77 FT /note="V->E: Abolishes interaction with MIS18A; when FT associated with D-172." FT /evidence="ECO:0000269|PubMed:26921242" FT MUTAGEN 172 FT /note="Y->D: Abolishes interaction with MIS18A; when FT associated with E-77." FT /evidence="ECO:0000269|PubMed:26921242" FT HELIX 191..218 FT /evidence="ECO:0007829|PDB:7SFY" SQ SEQUENCE 229 AA; 24691 MW; 0EBD4006193A3106 CRC64; MAAQPLRHRS RCATPPRGDF CGGTERAIDQ ASFTTSMEWD TQVVKGSSPL GPAGLGAEEP AAGPQLPSWL QPERCAVFQC AQCHAVLADS VHLAWDLSRS LGAVVFSRVT NNVVLEAPFL VGIEGSLKGS TYNLLFCGSC GIPVGFHLYS THAALAALRG HFCLSSDKMV CYLLKTKAIV NASEMDIQNV PLSEKIAELK EKIVLTHNRL KSLMKILSEV TPDQSKPEN //