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Protein

Protein Mis18-beta

Gene

OIP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80ZincPROSITE-ProRule annotation1
Metal bindingi83ZincPROSITE-ProRule annotation1
Metal bindingi137ZincPROSITE-ProRule annotation1
Metal bindingi140ZincPROSITE-ProRule annotation1

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-606279. Deposition of new CENPA-containing nucleosomes at the centromere.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Mis18-beta
Alternative name(s):
Cancer/testis antigen 86
Short name:
CT86
Opa-interacting protein 51 Publication
Short name:
OIP-51 Publication
Gene namesi
Name:OIP51 Publication
Synonyms:MIS18B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000104147.8.
HGNCiHGNC:20300. OIP5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi77V → E: Abolishes interaction with MIS18A; when associated with D-172. 1 Publication1
Mutagenesisi172Y → D: Abolishes interaction with MIS18A; when associated with E-77. 1 Publication1

Organism-specific databases

DisGeNETi11339.
OpenTargetsiENSG00000104147.
PharmGKBiPA134887641.

Polymorphism and mutation databases

BioMutaiOIP5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000580381 – 229Protein Mis18-betaAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei221PhosphothreonineCombined sources1
Modified residuei225PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO43482.
MaxQBiO43482.
PaxDbiO43482.
PeptideAtlasiO43482.
PRIDEiO43482.

PTM databases

iPTMnetiO43482.
PhosphoSitePlusiO43482.

Expressioni

Gene expression databases

BgeeiENSG00000104147.
CleanExiHS_OIP5.
ExpressionAtlasiO43482. baseline and differential.
GenevisibleiO43482. HS.

Organism-specific databases

HPAiHPA052271.
HPA059602.

Interactioni

Subunit structurei

Homodimer, and heterodimer with MIS18A (PubMed:17199038, PubMed:26921242). Identified in a complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4 (PubMed:17199038). Binds outer membrane protein OpaP from Neisseria gonorrhoeae (in vitro) (PubMed:9466265).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi116467. 82 interactors.
CORUMiO43482.
IntActiO43482. 102 interactors.
MINTiMINT-8417709.
STRINGi9606.ENSP00000220514.

Structurei

3D structure databases

ProteinModelPortaliO43482.
SMRiO43482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 174Mis18PROSITE-ProRule annotationAdd BLAST100

Sequence similaritiesi

Belongs to the mis18 family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IZ6R. Eukaryota.
ENOG410YQ0W. LUCA.
GeneTreeiENSGT00390000007347.
HOGENOMiHOG000113655.
HOVERGENiHBG095583.
InParanoidiO43482.
KOiK11565.
OMAiFTTSMEW.
OrthoDBiEOG091G0KVE.
PhylomeDBiO43482.
TreeFamiTF330739.

Family and domain databases

InterProiView protein in InterPro
IPR034752. Mis18.
IPR004910. Yippee/Mis18/Cereblon.
PfamiView protein in Pfam
PF03226. Yippee-Mis18. 1 hit.
PROSITEiView protein in PROSITE
PS51793. MIS18. 1 hit.

Sequencei

Sequence statusi: Complete.

O43482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQPLRHRS RCATPPRGDF CGGTERAIDQ ASFTTSMEWD TQVVKGSSPL
60 70 80 90 100
GPAGLGAEEP AAGPQLPSWL QPERCAVFQC AQCHAVLADS VHLAWDLSRS
110 120 130 140 150
LGAVVFSRVT NNVVLEAPFL VGIEGSLKGS TYNLLFCGSC GIPVGFHLYS
160 170 180 190 200
THAALAALRG HFCLSSDKMV CYLLKTKAIV NASEMDIQNV PLSEKIAELK
210 220
EKIVLTHNRL KSLMKILSEV TPDQSKPEN
Length:229
Mass (Da):24,691
Last modified:April 3, 2002 - v2
Checksum:i0EBD4006193A3106
GO

Sequence cautioni

The sequence AAC39561 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025441 mRNA. Translation: AAC39561.1. Different initiation.
BC015050 mRNA. Translation: AAH15050.1.
CCDSiCCDS10074.1.
RefSeqiNP_001304789.1. NM_001317860.1.
NP_009211.1. NM_007280.1.
UniGeneiHs.661645.

Genome annotation databases

EnsembliENST00000220514; ENSP00000220514; ENSG00000104147.
GeneIDi11339.
KEGGihsa:11339.
UCSCiuc001znp.3. human.

Similar proteinsi

Entry informationi

Entry nameiMS18B_HUMAN
AccessioniPrimary (citable) accession number: O43482
Secondary accession number(s): Q96BX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: April 3, 2002
Last modified: November 22, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families