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O43474

- KLF4_HUMAN

UniProt

O43474 - KLF4_HUMAN

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Protein

Krueppel-like factor 4

Gene

KLF4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri430 – 45425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri490 – 51223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. core promoter proximal region sequence-specific DNA binding Source: BHF-UCL
  2. double-stranded DNA binding Source: Ensembl
  3. phosphatidylinositol 3-kinase regulator activity Source: Ensembl
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
  5. RNA polymerase II transcription factor binding Source: BHF-UCL
  6. RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
  7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. sequence-specific DNA binding transcription factor recruiting transcription factor activity Source: BHF-UCL
  9. transcription regulatory region DNA binding Source: UniProtKB
  10. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. cellular response to cycloheximide Source: Ensembl
  2. cellular response to growth factor stimulus Source: BHF-UCL
  3. cellular response to hydrogen peroxide Source: Ensembl
  4. cellular response to laminar fluid shear stress Source: BHF-UCL
  5. cellular response to peptide Source: Ensembl
  6. epidermal cell differentiation Source: Ensembl
  7. epidermis morphogenesis Source: Ensembl
  8. fat cell differentiation Source: BHF-UCL
  9. mesodermal cell fate determination Source: ProtInc
  10. negative regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
  11. negative regulation of cell proliferation Source: ProtInc
  12. negative regulation of chemokine (C-X-C motif) ligand 2 production Source: BHF-UCL
  13. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
  14. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  15. negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
  16. negative regulation of inflammatory response Source: BHF-UCL
  17. negative regulation of interleukin-8 biosynthetic process Source: BHF-UCL
  18. negative regulation of muscle hyperplasia Source: Ensembl
  19. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  20. negative regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
  21. negative regulation of protein kinase B signaling Source: Ensembl
  22. negative regulation of response to cytokine stimulus Source: BHF-UCL
  23. negative regulation of smooth muscle cell proliferation Source: Ensembl
  24. negative regulation of transcription, DNA-templated Source: UniProtKB
  25. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  26. positive regulation of cellular protein metabolic process Source: BHF-UCL
  27. positive regulation of hemoglobin biosynthetic process Source: BHF-UCL
  28. positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
  29. positive regulation of protein metabolic process Source: BHF-UCL
  30. positive regulation of transcription, DNA-templated Source: UniProtKB
  31. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  32. post-embryonic camera-type eye development Source: Ensembl
  33. post-embryonic hemopoiesis Source: BHF-UCL
  34. regulation of cell differentiation Source: UniProtKB
  35. response to retinoic acid Source: Ensembl
  36. stem cell maintenance Source: UniProtKB
  37. transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_19189. Synthesis, secretion, and deacylation of Ghrelin.
REACT_200812. Transcriptional regulation of pluripotent stem cells.
REACT_27161. Transcriptional regulation of white adipocyte differentiation.
SignaLinkiO43474.

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 4
Alternative name(s):
Epithelial zinc finger protein EZF
Gut-enriched krueppel-like factor
Gene namesi
Name:KLF4
Synonyms:EZF, GKLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:6348. KLF4.

Subcellular locationi

GO - Cellular componenti

  1. nuclear chromatin Source: BHF-UCL
  2. nucleus Source: HPA
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Biotechnological usei

POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.1 Publication

Organism-specific databases

PharmGKBiPA30138.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Krueppel-like factor 4PRO_0000047167Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki32 – 32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei254 – 2541Phosphoserine1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO43474.
PaxDbiO43474.
PRIDEiO43474.

PTM databases

PhosphoSiteiO43474.

Expressioni

Gene expression databases

BgeeiO43474.
CleanExiHS_KLF4.
ExpressionAtlasiO43474. baseline and differential.
GenevestigatoriO43474.

Organism-specific databases

HPAiHPA002926.

Interactioni

Subunit structurei

Interacts with POU5F1/OCT4 and SOX2 (By similarity). Interacts with MUC1 (via the C-terminal domain). Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP1Q133634EBI-7232405,EBI-908846

Protein-protein interaction databases

BioGridi114726. 22 interactions.
DIPiDIP-57667N.
IntActiO43474. 2 interactions.
MINTiMINT-7261942.
STRINGi9606.ENSP00000363804.

Structurei

3D structure databases

ProteinModelPortaliO43474.
SMRiO43474. Positions 427-513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni473 – 50432Interaction with target DNABy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi101 – 10999aaTAD

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi125 – 14925Ser-richAdd
BLAST
Compositional biasi179 – 415237Pro-richAdd
BLAST

Domaini

the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.1 Publication

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri430 – 45425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri460 – 48425C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri490 – 51223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118998.
HOVERGENiHBG006220.
InParanoidiO43474.
KOiK17846.
OMAiCTVGRPL.
PhylomeDBiO43474.
TreeFamiTF350556.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43474-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRQPPGESDM AVSDALLPSF STFASGPAGR EKTLRQAGAP NNRWREELSH
60 70 80 90 100
MKRLPPVLPG RPYDLAAATV ATDLESGGAG AACGGSNLAP LPRRETEEFN
110 120 130 140 150
DLLDLDFILS NSLTHPPESV AATVSSSASA SSSSSPSSSG PASAPSTCSF
160 170 180 190 200
TYPIRAGNDP GVAPGGTGGG LLYGRESAPP PTAPFNLADI NDVSPSGGFV
210 220 230 240 250
AELLRPELDP VYIPPQQPQP PGGGLMGKFV LKASLSAPGS EYGSPSVISV
260 270 280 290 300
SKGSPDGSHP VVVAPYNGGP PRTCPKIKQE AVSSCTHLGA GPPLSNGHRP
310 320 330 340 350
AAHDFPLGRQ LPSRTTPTLG LEEVLSSRDC HPALPLPPGF HPHPGPNYPS
360 370 380 390 400
FLPDQMQPQV PPLHYQGQSR GFVARAGEPC VCWPHFGTHG MMLTPPSSPL
410 420 430 440 450
ELMPPGSCMP EEPKPKRGRR SWPRKRTATH TCDYAGCGKT YTKSSHLKAH
460 470 480 490 500
LRTHTGEKPY HCDWDGCGWK FARSDELTRH YRKHTGHRPF QCQKCDRAFS
510
RSDHLALHMK RHF
Length:513
Mass (Da):54,671
Last modified:February 10, 2009 - v3
Checksum:i3B6113A3EF333935
GO
Isoform 2 (identifier: O43474-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-400: Missing.

Show »
Length:479
Mass (Da):51,076
Checksum:i039095BBF3E3F78D
GO
Isoform 3 (identifier: O43474-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.
     367-400: Missing.

Note: No experimental confirmation available.

Show »
Length:429
Mass (Da):45,639
Checksum:i99B86BE95A31F23D
GO
Isoform 4 (identifier: O43474-5) [UniParc]FASTAAdd to Basket

Also known as: 1a

The sequence of this isoform differs from the canonical sequence as follows:
     43-118: RWREELSHMK...LSNSLTHPPE → SSCHPVPACQ...VDGNSPAQMN
     119-513: Missing.

Show »
Length:118
Mass (Da):12,329
Checksum:i9E900F0852665920
GO
Isoform 5 (identifier: O43474-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-63: RWREELSHMKRLPPVLPGRPY → VRNLTTVTGTAVDGNSPAQMN
     64-513: Missing.

Show »
Length:63
Mass (Da):6,489
Checksum:i2A7B5BE789162A89
GO

Sequence cautioni

The sequence AAB48399.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC03462.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAD42165.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH29923.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH30811.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence ABG25917.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAG36271.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW59020.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence EAW59021.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 612GR → AG in AAC03462. (PubMed:9422764)Curated
Sequence conflicti77 – 771G → A in AAC03462. (PubMed:9422764)Curated
Sequence conflicti251 – 2511S → T in AAC03462. (PubMed:9422764)Curated
Sequence conflicti304 – 3041D → N in AAB48399. 1 PublicationCurated
Sequence conflicti329 – 3291D → E in AAB48399. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti315 – 3151T → S.1 Publication
Corresponds to variant rs1059913 [ dbSNP | Ensembl ].
VAR_059888
Natural varianti321 – 3211L → F.1 Publication
Corresponds to variant rs1059914 [ dbSNP | Ensembl ].
VAR_059889

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5050Missing in isoform 3. 1 PublicationVSP_040569Add
BLAST
Alternative sequencei43 – 11876RWREE…THPPE → SSCHPVPACQRSPSQRGEDD RGPGKGPPPTLVITRAAAKP TQRVPISRHTCEPTQVRNLT TVTGTAVDGNSPAQMN in isoform 4. 1 PublicationVSP_047470Add
BLAST
Alternative sequencei43 – 6321RWREE…PGRPY → VRNLTTVTGTAVDGNSPAQM N in isoform 5. 1 PublicationVSP_047471Add
BLAST
Alternative sequencei64 – 513450Missing in isoform 5. 1 PublicationVSP_047472Add
BLAST
Alternative sequencei119 – 513395Missing in isoform 4. 1 PublicationVSP_047473Add
BLAST
Alternative sequencei367 – 40034Missing in isoform 2 and isoform 3. 5 PublicationsVSP_036399Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022184 mRNA. Translation: AAC03462.1. Different initiation.
AF105036 mRNA. Translation: AAD42165.1. Different initiation.
HF546201 mRNA. Translation: CCO02787.1.
HF546202 mRNA. Translation: CCO02788.1.
U70663 mRNA. Translation: AAB48399.1. Different initiation.
AK095134 mRNA. Translation: BAG52991.1.
AK313489 mRNA. Translation: BAG36271.1. Different initiation.
DQ658241 Genomic DNA. Translation: ABG25917.1. Sequence problems.
AL360218 Genomic DNA. Translation: CAI12254.2.
CH471105 Genomic DNA. Translation: EAW59020.1. Sequence problems.
CH471105 Genomic DNA. Translation: EAW59021.1. Sequence problems.
BC029923 mRNA. Translation: AAH29923.1. Different initiation.
BC030811 mRNA. Translation: AAH30811.1. Different initiation.
CCDSiCCDS6770.2. [O43474-1]
RefSeqiNP_004226.3. NM_004235.4. [O43474-1]
XP_005252362.1. XM_005252305.1. [O43474-3]
UniGeneiHs.376206.

Genome annotation databases

EnsembliENST00000374672; ENSP00000363804; ENSG00000136826. [O43474-1]
GeneIDi9314.
KEGGihsa:9314.
UCSCiuc004bdf.2. human. [O43474-4]
uc004bdg.3. human. [O43474-1]
uc004bdh.3. human. [O43474-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022184 mRNA. Translation: AAC03462.1 . Different initiation.
AF105036 mRNA. Translation: AAD42165.1 . Different initiation.
HF546201 mRNA. Translation: CCO02787.1 .
HF546202 mRNA. Translation: CCO02788.1 .
U70663 mRNA. Translation: AAB48399.1 . Different initiation.
AK095134 mRNA. Translation: BAG52991.1 .
AK313489 mRNA. Translation: BAG36271.1 . Different initiation.
DQ658241 Genomic DNA. Translation: ABG25917.1 . Sequence problems.
AL360218 Genomic DNA. Translation: CAI12254.2 .
CH471105 Genomic DNA. Translation: EAW59020.1 . Sequence problems.
CH471105 Genomic DNA. Translation: EAW59021.1 . Sequence problems.
BC029923 mRNA. Translation: AAH29923.1 . Different initiation.
BC030811 mRNA. Translation: AAH30811.1 . Different initiation.
CCDSi CCDS6770.2. [O43474-1 ]
RefSeqi NP_004226.3. NM_004235.4. [O43474-1 ]
XP_005252362.1. XM_005252305.1. [O43474-3 ]
UniGenei Hs.376206.

3D structure databases

ProteinModelPortali O43474.
SMRi O43474. Positions 427-513.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114726. 22 interactions.
DIPi DIP-57667N.
IntActi O43474. 2 interactions.
MINTi MINT-7261942.
STRINGi 9606.ENSP00000363804.

PTM databases

PhosphoSitei O43474.

Proteomic databases

MaxQBi O43474.
PaxDbi O43474.
PRIDEi O43474.

Protocols and materials databases

DNASUi 9314.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374672 ; ENSP00000363804 ; ENSG00000136826 . [O43474-1 ]
GeneIDi 9314.
KEGGi hsa:9314.
UCSCi uc004bdf.2. human. [O43474-4 ]
uc004bdg.3. human. [O43474-1 ]
uc004bdh.3. human. [O43474-3 ]

Organism-specific databases

CTDi 9314.
GeneCardsi GC09M110247.
HGNCi HGNC:6348. KLF4.
HPAi HPA002926.
MIMi 602253. gene.
neXtProti NX_O43474.
PharmGKBi PA30138.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118998.
HOVERGENi HBG006220.
InParanoidi O43474.
KOi K17846.
OMAi CTVGRPL.
PhylomeDBi O43474.
TreeFami TF350556.

Enzyme and pathway databases

Reactomei REACT_19189. Synthesis, secretion, and deacylation of Ghrelin.
REACT_200812. Transcriptional regulation of pluripotent stem cells.
REACT_27161. Transcriptional regulation of white adipocyte differentiation.
SignaLinki O43474.

Miscellaneous databases

ChiTaRSi KLF4. human.
GeneWikii KLF4.
GenomeRNAii 9314.
NextBioi 34891.
PROi O43474.
SOURCEi Search...

Gene expression databases

Bgeei O43474.
CleanExi HS_KLF4.
ExpressionAtlasi O43474. baseline and differential.
Genevestigatori O43474.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains."
    Yet S.-F., McA'Nulty M.M., Folta S.C., Yen H.-W., Yoshizumi M., Hsieh C.-M., Layne M.D., Chin M.T., Wang H., Perrella M.A., Jain M.K., Lee M.-E.
    J. Biol. Chem. 273:1026-1031(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF."
    Foster K.W., Ren S., Louro I.D., Lobo-Ruppert S.M., McKie-Bell P., Grizzle W., Hayes M.R., Broker T.R., Chow L.T., Ruppert J.M.
    Cell Growth Differ. 10:423-434(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."
    Camacho-Vanegas O., Till J., Miranda-Lorenzo I., Ozturk B., Camacho S.C., Martignetti J.A.
    FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5), ALTERNATIVE SPLICING.
  4. Garrett-Sinha L.A., de Crombrugghe B.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS SER-315 AND PHE-321.
    Tissue: Placenta.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Substantia nigra and Tongue.
  6. SeattleSNPs variation discovery resource
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cervix and Lung.
  10. "Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene."
    Wei X., Xu H., Kufe D.
    Cancer Res. 67:1853-1858(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MUC1, FUNCTION.
  11. "Induction of pluripotent stem cells from adult human fibroblasts by defined factors."
    Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S.
    Cell 131:861-872(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: BIOTECHNOLOGY.
  12. "Nine-amino-acid transactivation domain: establishment and prediction utilities."
    Piskacek S., Gregor M., Nemethova M., Grabner M., Kovarik P., Piskacek M.
    Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
    Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
    Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-32.
    Tissue: Cervix carcinoma.
  15. "Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression."
    Zhang P., Andrianakos R., Yang Y., Liu C., Lu W.
    J. Biol. Chem. 285:9180-9189(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  17. "Cooperative transcriptional activation by Klf4, Meis2, and Pbx1."
    Bjerke G.A., Hyman-Walsh C., Wotton D.
    Mol. Cell. Biol. 31:3723-3733(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PBX1 AND MEIS2.
  18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKLF4_HUMAN
AccessioniPrimary (citable) accession number: O43474
Secondary accession number(s): B2R8S4
, B3KT79, L0R3I6, L0R4N5, P78338, Q5T3J8, Q5T3J9, Q8N717, Q9UNP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 10, 2009
Last modified: November 26, 2014
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3