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O43474

- KLF4_HUMAN

UniProt

O43474 - KLF4_HUMAN

Protein

Krueppel-like factor 4

Gene

KLF4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 3 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri430 – 45425C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri460 – 48425C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri490 – 51223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. core promoter proximal region sequence-specific DNA binding Source: BHF-UCL
    2. double-stranded DNA binding Source: Ensembl
    3. phosphatidylinositol 3-kinase regulator activity Source: Ensembl
    4. protein binding Source: IntAct
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
    6. RNA polymerase II transcription factor binding Source: BHF-UCL
    7. RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription Source: BHF-UCL
    8. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    9. sequence-specific DNA binding transcription factor recruiting transcription factor activity Source: BHF-UCL
    10. transcription regulatory region DNA binding Source: UniProtKB
    11. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to cycloheximide Source: Ensembl
    2. cellular response to growth factor stimulus Source: BHF-UCL
    3. cellular response to hydrogen peroxide Source: Ensembl
    4. cellular response to laminar fluid shear stress Source: BHF-UCL
    5. cellular response to peptide Source: Ensembl
    6. epidermal cell differentiation Source: Ensembl
    7. epidermis morphogenesis Source: Ensembl
    8. fat cell differentiation Source: BHF-UCL
    9. mesodermal cell fate determination Source: ProtInc
    10. negative regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
    11. negative regulation of cell proliferation Source: ProtInc
    12. negative regulation of chemokine (C-X-C motif) ligand 2 production Source: BHF-UCL
    13. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
    14. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
    15. negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
    16. negative regulation of inflammatory response Source: BHF-UCL
    17. negative regulation of interleukin-8 biosynthetic process Source: BHF-UCL
    18. negative regulation of muscle hyperplasia Source: Ensembl
    19. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
    20. negative regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    21. negative regulation of protein kinase B signaling Source: Ensembl
    22. negative regulation of response to cytokine stimulus Source: BHF-UCL
    23. negative regulation of smooth muscle cell proliferation Source: Ensembl
    24. negative regulation of transcription, DNA-templated Source: UniProtKB
    25. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    26. positive regulation of cellular protein metabolic process Source: BHF-UCL
    27. positive regulation of hemoglobin biosynthetic process Source: BHF-UCL
    28. positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
    29. positive regulation of protein metabolic process Source: BHF-UCL
    30. positive regulation of transcription, DNA-templated Source: UniProtKB
    31. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    32. post-embryonic camera-type eye development Source: Ensembl
    33. post-embryonic hemopoiesis Source: BHF-UCL
    34. regulation of cell differentiation Source: UniProtKB
    35. response to retinoic acid Source: Ensembl
    36. stem cell maintenance Source: UniProtKB
    37. transcription from RNA polymerase II promoter Source: BHF-UCL

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_19189. Synthesis, secretion, and deacylation of Ghrelin.
    REACT_200812. Transcriptional regulation of pluripotent stem cells.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinkiO43474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 4
    Alternative name(s):
    Epithelial zinc finger protein EZF
    Gut-enriched krueppel-like factor
    Gene namesi
    Name:KLF4
    Synonyms:EZF, GKLF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:6348. KLF4.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear chromatin Source: BHF-UCL
    2. nucleus Source: HPA
    3. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Biotechnological usei

    POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes.1 Publication

    Organism-specific databases

    PharmGKBiPA30138.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 513513Krueppel-like factor 4PRO_0000047167Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki32 – 32Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Modified residuei254 – 2541Phosphoserine1 Publication

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiO43474.
    PaxDbiO43474.
    PRIDEiO43474.

    PTM databases

    PhosphoSiteiO43474.

    Expressioni

    Gene expression databases

    ArrayExpressiO43474.
    BgeeiO43474.
    CleanExiHS_KLF4.
    GenevestigatoriO43474.

    Organism-specific databases

    HPAiHPA002926.

    Interactioni

    Subunit structurei

    Interacts with POU5F1/OCT4 and SOX2 By similarity. Interacts with MUC1 (via the C-terminal domain). Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTBP1Q133634EBI-7232405,EBI-908846

    Protein-protein interaction databases

    BioGridi114726. 21 interactions.
    DIPiDIP-57667N.
    IntActiO43474. 2 interactions.
    MINTiMINT-7261942.
    STRINGi9606.ENSP00000363804.

    Structurei

    3D structure databases

    ProteinModelPortaliO43474.
    SMRiO43474. Positions 427-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni473 – 50432Interaction with target DNABy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi101 – 10999aaTAD

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi125 – 14925Ser-richAdd
    BLAST
    Compositional biasi179 – 415237Pro-richAdd
    BLAST

    Domaini

    the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.1 Publication

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri430 – 45425C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri460 – 48425C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri490 – 51223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOVERGENiHBG006220.
    KOiK17846.
    OMAiCTVGRPL.
    PhylomeDBiO43474.
    TreeFamiTF350556.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43474-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRQPPGESDM AVSDALLPSF STFASGPAGR EKTLRQAGAP NNRWREELSH    50
    MKRLPPVLPG RPYDLAAATV ATDLESGGAG AACGGSNLAP LPRRETEEFN 100
    DLLDLDFILS NSLTHPPESV AATVSSSASA SSSSSPSSSG PASAPSTCSF 150
    TYPIRAGNDP GVAPGGTGGG LLYGRESAPP PTAPFNLADI NDVSPSGGFV 200
    AELLRPELDP VYIPPQQPQP PGGGLMGKFV LKASLSAPGS EYGSPSVISV 250
    SKGSPDGSHP VVVAPYNGGP PRTCPKIKQE AVSSCTHLGA GPPLSNGHRP 300
    AAHDFPLGRQ LPSRTTPTLG LEEVLSSRDC HPALPLPPGF HPHPGPNYPS 350
    FLPDQMQPQV PPLHYQGQSR GFVARAGEPC VCWPHFGTHG MMLTPPSSPL 400
    ELMPPGSCMP EEPKPKRGRR SWPRKRTATH TCDYAGCGKT YTKSSHLKAH 450
    LRTHTGEKPY HCDWDGCGWK FARSDELTRH YRKHTGHRPF QCQKCDRAFS 500
    RSDHLALHMK RHF 513
    Length:513
    Mass (Da):54,671
    Last modified:February 10, 2009 - v3
    Checksum:i3B6113A3EF333935
    GO
    Isoform 2 (identifier: O43474-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         367-400: Missing.

    Show »
    Length:479
    Mass (Da):51,076
    Checksum:i039095BBF3E3F78D
    GO
    Isoform 3 (identifier: O43474-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-50: Missing.
         367-400: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:429
    Mass (Da):45,639
    Checksum:i99B86BE95A31F23D
    GO
    Isoform 4 (identifier: O43474-5) [UniParc]FASTAAdd to Basket

    Also known as: 1a

    The sequence of this isoform differs from the canonical sequence as follows:
         43-118: RWREELSHMK...LSNSLTHPPE → SSCHPVPACQ...VDGNSPAQMN
         119-513: Missing.

    Show »
    Length:118
    Mass (Da):12,329
    Checksum:i9E900F0852665920
    GO
    Isoform 5 (identifier: O43474-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         43-63: RWREELSHMKRLPPVLPGRPY → VRNLTTVTGTAVDGNSPAQMN
         64-513: Missing.

    Show »
    Length:63
    Mass (Da):6,489
    Checksum:i2A7B5BE789162A89
    GO

    Sequence cautioni

    The sequence AAB48399.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAC03462.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAD42165.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH29923.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH30811.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAG36271.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence ABG25917.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EAW59020.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EAW59021.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 612GR → AG in AAC03462. (PubMed:9422764)Curated
    Sequence conflicti77 – 771G → A in AAC03462. (PubMed:9422764)Curated
    Sequence conflicti251 – 2511S → T in AAC03462. (PubMed:9422764)Curated
    Sequence conflicti304 – 3041D → N in AAB48399. 1 PublicationCurated
    Sequence conflicti329 – 3291D → E in AAB48399. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti315 – 3151T → S.1 Publication
    Corresponds to variant rs1059913 [ dbSNP | Ensembl ].
    VAR_059888
    Natural varianti321 – 3211L → F.1 Publication
    Corresponds to variant rs1059914 [ dbSNP | Ensembl ].
    VAR_059889

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5050Missing in isoform 3. 1 PublicationVSP_040569Add
    BLAST
    Alternative sequencei43 – 11876RWREE…THPPE → SSCHPVPACQRSPSQRGEDD RGPGKGPPPTLVITRAAAKP TQRVPISRHTCEPTQVRNLT TVTGTAVDGNSPAQMN in isoform 4. 1 PublicationVSP_047470Add
    BLAST
    Alternative sequencei43 – 6321RWREE…PGRPY → VRNLTTVTGTAVDGNSPAQM N in isoform 5. 1 PublicationVSP_047471Add
    BLAST
    Alternative sequencei64 – 513450Missing in isoform 5. 1 PublicationVSP_047472Add
    BLAST
    Alternative sequencei119 – 513395Missing in isoform 4. 1 PublicationVSP_047473Add
    BLAST
    Alternative sequencei367 – 40034Missing in isoform 2 and isoform 3. 5 PublicationsVSP_036399Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022184 mRNA. Translation: AAC03462.1. Different initiation.
    AF105036 mRNA. Translation: AAD42165.1. Different initiation.
    HF546201 mRNA. Translation: CCO02787.1.
    HF546202 mRNA. Translation: CCO02788.1.
    U70663 mRNA. Translation: AAB48399.1. Different initiation.
    AK095134 mRNA. Translation: BAG52991.1.
    AK313489 mRNA. Translation: BAG36271.1. Different initiation.
    DQ658241 Genomic DNA. Translation: ABG25917.1. Sequence problems.
    AL360218 Genomic DNA. Translation: CAI12254.2.
    CH471105 Genomic DNA. Translation: EAW59020.1. Sequence problems.
    CH471105 Genomic DNA. Translation: EAW59021.1. Sequence problems.
    BC029923 mRNA. Translation: AAH29923.1. Different initiation.
    BC030811 mRNA. Translation: AAH30811.1. Different initiation.
    CCDSiCCDS6770.2. [O43474-1]
    RefSeqiNP_004226.3. NM_004235.4. [O43474-1]
    XP_005252362.1. XM_005252305.1. [O43474-3]
    UniGeneiHs.376206.

    Genome annotation databases

    EnsembliENST00000374672; ENSP00000363804; ENSG00000136826. [O43474-1]
    GeneIDi9314.
    KEGGihsa:9314.
    UCSCiuc004bdf.2. human. [O43474-4]
    uc004bdg.3. human. [O43474-1]
    uc004bdh.3. human. [O43474-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF022184 mRNA. Translation: AAC03462.1 . Different initiation.
    AF105036 mRNA. Translation: AAD42165.1 . Different initiation.
    HF546201 mRNA. Translation: CCO02787.1 .
    HF546202 mRNA. Translation: CCO02788.1 .
    U70663 mRNA. Translation: AAB48399.1 . Different initiation.
    AK095134 mRNA. Translation: BAG52991.1 .
    AK313489 mRNA. Translation: BAG36271.1 . Different initiation.
    DQ658241 Genomic DNA. Translation: ABG25917.1 . Sequence problems.
    AL360218 Genomic DNA. Translation: CAI12254.2 .
    CH471105 Genomic DNA. Translation: EAW59020.1 . Sequence problems.
    CH471105 Genomic DNA. Translation: EAW59021.1 . Sequence problems.
    BC029923 mRNA. Translation: AAH29923.1 . Different initiation.
    BC030811 mRNA. Translation: AAH30811.1 . Different initiation.
    CCDSi CCDS6770.2. [O43474-1 ]
    RefSeqi NP_004226.3. NM_004235.4. [O43474-1 ]
    XP_005252362.1. XM_005252305.1. [O43474-3 ]
    UniGenei Hs.376206.

    3D structure databases

    ProteinModelPortali O43474.
    SMRi O43474. Positions 427-513.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114726. 21 interactions.
    DIPi DIP-57667N.
    IntActi O43474. 2 interactions.
    MINTi MINT-7261942.
    STRINGi 9606.ENSP00000363804.

    PTM databases

    PhosphoSitei O43474.

    Proteomic databases

    MaxQBi O43474.
    PaxDbi O43474.
    PRIDEi O43474.

    Protocols and materials databases

    DNASUi 9314.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374672 ; ENSP00000363804 ; ENSG00000136826 . [O43474-1 ]
    GeneIDi 9314.
    KEGGi hsa:9314.
    UCSCi uc004bdf.2. human. [O43474-4 ]
    uc004bdg.3. human. [O43474-1 ]
    uc004bdh.3. human. [O43474-3 ]

    Organism-specific databases

    CTDi 9314.
    GeneCardsi GC09M110247.
    HGNCi HGNC:6348. KLF4.
    HPAi HPA002926.
    MIMi 602253. gene.
    neXtProti NX_O43474.
    PharmGKBi PA30138.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOVERGENi HBG006220.
    KOi K17846.
    OMAi CTVGRPL.
    PhylomeDBi O43474.
    TreeFami TF350556.

    Enzyme and pathway databases

    Reactomei REACT_19189. Synthesis, secretion, and deacylation of Ghrelin.
    REACT_200812. Transcriptional regulation of pluripotent stem cells.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.
    SignaLinki O43474.

    Miscellaneous databases

    GeneWikii KLF4.
    GenomeRNAii 9314.
    NextBioi 34891.
    PROi O43474.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43474.
    Bgeei O43474.
    CleanExi HS_KLF4.
    Genevestigatori O43474.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains."
      Yet S.-F., McA'Nulty M.M., Folta S.C., Yen H.-W., Yoshizumi M., Hsieh C.-M., Layne M.D., Chin M.T., Wang H., Perrella M.A., Jain M.K., Lee M.-E.
      J. Biol. Chem. 273:1026-1031(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF."
      Foster K.W., Ren S., Louro I.D., Lobo-Ruppert S.M., McKie-Bell P., Grizzle W., Hayes M.R., Broker T.R., Chow L.T., Ruppert J.M.
      Cell Growth Differ. 10:423-434(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors."
      Camacho-Vanegas O., Till J., Miranda-Lorenzo I., Ozturk B., Camacho S.C., Martignetti J.A.
      FASEB J. 27:432-436(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5), ALTERNATIVE SPLICING.
    4. Garrett-Sinha L.A., de Crombrugghe B.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANTS SER-315 AND PHE-321.
      Tissue: Placenta.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Substantia nigra and Tongue.
    6. SeattleSNPs variation discovery resource
      Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cervix and Lung.
    10. "Human mucin 1 oncoprotein represses transcription of the p53 tumor suppressor gene."
      Wei X., Xu H., Kufe D.
      Cancer Res. 67:1853-1858(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MUC1, FUNCTION.
    11. "Induction of pluripotent stem cells from adult human fibroblasts by defined factors."
      Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S.
      Cell 131:861-872(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: BIOTECHNOLOGY.
    12. "Nine-amino-acid transactivation domain: establishment and prediction utilities."
      Piskacek S., Gregor M., Nemethova M., Grabner M., Kovarik P., Piskacek M.
      Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DOMAIN.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
      Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E., Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.
      Proteomics 8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-32.
      Tissue: Cervix carcinoma.
    15. "Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression."
      Zhang P., Andrianakos R., Yang Y., Liu C., Lu W.
      J. Biol. Chem. 285:9180-9189(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. "Cooperative transcriptional activation by Klf4, Meis2, and Pbx1."
      Bjerke G.A., Hyman-Walsh C., Wotton D.
      Mol. Cell. Biol. 31:3723-3733(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PBX1 AND MEIS2.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKLF4_HUMAN
    AccessioniPrimary (citable) accession number: O43474
    Secondary accession number(s): B2R8S4
    , B3KT79, L0R3I6, L0R4N5, P78338, Q5T3J8, Q5T3J9, Q8N717, Q9UNP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 137 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3