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O43448

- KCAB3_HUMAN

UniProt

O43448 - KCAB3_HUMAN

Protein

Voltage-gated potassium channel subunit beta-3

Gene

KCNAB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.1 Publication

    GO - Molecular functioni

    1. potassium channel regulator activity Source: ProtInc
    2. voltage-gated potassium channel activity Source: InterPro

    GO - Biological processi

    1. potassium ion transport Source: ProtInc
    2. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75770. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-gated potassium channel subunit beta-3
    Alternative name(s):
    K(+) channel subunit beta-3
    Kv-beta-3
    Gene namesi
    Name:KCNAB3
    Synonyms:KCNA3B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6230. KCNAB3.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: InterPro
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30024.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 404404Voltage-gated potassium channel subunit beta-3PRO_0000148750Add
    BLAST

    Proteomic databases

    PaxDbiO43448.
    PRIDEiO43448.

    PTM databases

    PhosphoSiteiO43448.

    Expressioni

    Tissue specificityi

    Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiO43448.
    BgeeiO43448.
    CleanExiHS_KCNAB3.
    GenevestigatoriO43448.

    Interactioni

    Subunit structurei

    Forms heteromultimeric complex with alpha subunits.

    Protein-protein interaction databases

    BioGridi114631. 3 interactions.
    STRINGi9606.ENSP00000302719.

    Structurei

    3D structure databases

    ProteinModelPortaliO43448.
    SMRiO43448. Positions 80-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0667.
    HOGENOMiHOG000250283.
    HOVERGENiHBG052216.
    InParanoidiO43448.
    KOiK04884.
    OMAiSSDWREW.
    OrthoDBiEOG71G9TR.
    PhylomeDBiO43448.
    TreeFamiTF324563.

    Family and domain databases

    Gene3Di3.20.20.100. 1 hit.
    InterProiIPR001395. Aldo/ket_red.
    IPR005983. K_chnl_volt-dep_bsu_KCNAB.
    IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
    IPR005402. K_chnl_volt-dep_bsu_KCNAB3.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view]
    PANTHERiPTHR11732. PTHR11732. 1 hit.
    PfamiPF00248. Aldo_ket_red. 1 hit.
    [Graphical view]
    PRINTSiPR01580. KCNAB3CHANEL.
    PR01577. KCNABCHANNEL.
    SUPFAMiSSF51430. SSF51430. 1 hit.
    TIGRFAMsiTIGR01293. Kv_beta. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O43448-1 [UniParc]FASTAAdd to Basket

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    MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPAGGGH GNPPGGGGSG    50
    PKARAALVPR PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT 100
    FGSQISDETA EDVLTVAYEH GVNLFDTAEV YAAGKAERTL GNILKSKGWR 150
    RSSYVITTKI FWGGQAETER GLSRKHIIEG LRGSLERLQL GYVDIVFANR 200
    SDPNCPMEEI VRAMTYVINQ GLALYWGTSR WGAAEIMEAY SMARQFNLIP 250
    PVCEQAEHHL FQREKVEMQL PELYHKIGVG SVTWYPLACG LITSKYDGRV 300
    PDTCRASIKG YQWLKDKVQS EDGKKQQAKV MDLLPVAHQL GCTVAQLAIA 350
    WCLRSEGVSS VLLGVSSAEQ LIEHLGALQV LSQLTPQTVM EIDGLLGNKP 400
    HSKK 404
    Length:404
    Mass (Da):43,670
    Last modified:February 20, 2007 - v2
    Checksum:i57C4FAD8D19D9EBB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571L → V in AAB92499. (PubMed:9857044)Curated
    Sequence conflicti60 – 601R → G in AAB92499. (PubMed:9857044)Curated
    Sequence conflicti65 – 651A → G in AAB92499. (PubMed:9857044)Curated
    Sequence conflicti68 – 681L → V in AAB92499. (PubMed:9857044)Curated
    Sequence conflicti86 – 883SGL → CGV in AAB92499. (PubMed:9857044)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016411 mRNA. Translation: AAB92499.1.
    BC096232 mRNA. Translation: AAH96232.1.
    BC096234 mRNA. Translation: AAH96234.1.
    BC099634 mRNA. Translation: AAH99634.1.
    CCDSiCCDS11124.1.
    RefSeqiNP_004723.2. NM_004732.3.
    UniGeneiHs.435074.

    Genome annotation databases

    EnsembliENST00000303790; ENSP00000302719; ENSG00000170049.
    GeneIDi9196.
    KEGGihsa:9196.
    UCSCiuc002gjm.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF016411 mRNA. Translation: AAB92499.1 .
    BC096232 mRNA. Translation: AAH96232.1 .
    BC096234 mRNA. Translation: AAH96234.1 .
    BC099634 mRNA. Translation: AAH99634.1 .
    CCDSi CCDS11124.1.
    RefSeqi NP_004723.2. NM_004732.3.
    UniGenei Hs.435074.

    3D structure databases

    ProteinModelPortali O43448.
    SMRi O43448. Positions 80-402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114631. 3 interactions.
    STRINGi 9606.ENSP00000302719.

    PTM databases

    PhosphoSitei O43448.

    Proteomic databases

    PaxDbi O43448.
    PRIDEi O43448.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303790 ; ENSP00000302719 ; ENSG00000170049 .
    GeneIDi 9196.
    KEGGi hsa:9196.
    UCSCi uc002gjm.2. human.

    Organism-specific databases

    CTDi 9196.
    GeneCardsi GC17M007825.
    H-InvDB HIX0173736.
    HGNCi HGNC:6230. KCNAB3.
    MIMi 604111. gene.
    neXtProti NX_O43448.
    PharmGKBi PA30024.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0667.
    HOGENOMi HOG000250283.
    HOVERGENi HBG052216.
    InParanoidi O43448.
    KOi K04884.
    OMAi SSDWREW.
    OrthoDBi EOG71G9TR.
    PhylomeDBi O43448.
    TreeFami TF324563.

    Enzyme and pathway databases

    Reactomei REACT_75770. Voltage gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNAB3.
    GenomeRNAii 9196.
    NextBioi 34475.
    PROi O43448.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43448.
    Bgeei O43448.
    CleanExi HS_KCNAB3.
    Genevestigatori O43448.

    Family and domain databases

    Gene3Di 3.20.20.100. 1 hit.
    InterProi IPR001395. Aldo/ket_red.
    IPR005983. K_chnl_volt-dep_bsu_KCNAB.
    IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
    IPR005402. K_chnl_volt-dep_bsu_KCNAB3.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view ]
    PANTHERi PTHR11732. PTHR11732. 1 hit.
    Pfami PF00248. Aldo_ket_red. 1 hit.
    [Graphical view ]
    PRINTSi PR01580. KCNAB3CHANEL.
    PR01577. KCNABCHANNEL.
    SUPFAMi SSF51430. SSF51430. 1 hit.
    TIGRFAMsi TIGR01293. Kv_beta. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel."
      Leicher T., Baehring R., Isbrandt D., Pongs O.
      J. Biol. Chem. 273:35095-35101(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiKCAB3_HUMAN
    AccessioniPrimary (citable) accession number: O43448
    Secondary accession number(s): Q4VAW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3