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Protein

Voltage-gated potassium channel subunit beta-3

Gene

KCNAB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.1 Publication

GO - Molecular functioni

  1. potassium channel regulator activity Source: ProtInc
  2. voltage-gated potassium channel activity Source: InterPro

GO - Biological processi

  1. potassium ion transport Source: ProtInc
  2. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-3
Alternative name(s):
K(+) channel subunit beta-3
Kv-beta-3
Gene namesi
Name:KCNAB3
Synonyms:KCNA3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6230. KCNAB3.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: InterPro
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30024.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Voltage-gated potassium channel subunit beta-3PRO_0000148750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei153 – 1531PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO43448.
PRIDEiO43448.

PTM databases

PhosphoSiteiO43448.

Expressioni

Tissue specificityi

Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle.1 Publication

Gene expression databases

BgeeiO43448.
CleanExiHS_KCNAB3.
ExpressionAtlasiO43448. baseline and differential.
GenevestigatoriO43448.

Interactioni

Subunit structurei

Forms heteromultimeric complex with alpha subunits.

Protein-protein interaction databases

BioGridi114631. 8 interactions.
STRINGi9606.ENSP00000302719.

Structurei

3D structure databases

ProteinModelPortaliO43448.
SMRiO43448. Positions 80-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0667.
GeneTreeiENSGT00550000074567.
HOGENOMiHOG000250283.
HOVERGENiHBG052216.
InParanoidiO43448.
KOiK04884.
OMAiWHSFGHV.
OrthoDBiEOG71G9TR.
PhylomeDBiO43448.
TreeFamiTF324563.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005402. K_chnl_volt-dep_bsu_KCNAB3.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR01580. KCNAB3CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMiSSF51430. SSF51430. 1 hit.
TIGRFAMsiTIGR01293. Kv_beta. 1 hit.

Sequencei

Sequence statusi: Complete.

O43448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPAGGGH GNPPGGGGSG
60 70 80 90 100
PKARAALVPR PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT
110 120 130 140 150
FGSQISDETA EDVLTVAYEH GVNLFDTAEV YAAGKAERTL GNILKSKGWR
160 170 180 190 200
RSSYVITTKI FWGGQAETER GLSRKHIIEG LRGSLERLQL GYVDIVFANR
210 220 230 240 250
SDPNCPMEEI VRAMTYVINQ GLALYWGTSR WGAAEIMEAY SMARQFNLIP
260 270 280 290 300
PVCEQAEHHL FQREKVEMQL PELYHKIGVG SVTWYPLACG LITSKYDGRV
310 320 330 340 350
PDTCRASIKG YQWLKDKVQS EDGKKQQAKV MDLLPVAHQL GCTVAQLAIA
360 370 380 390 400
WCLRSEGVSS VLLGVSSAEQ LIEHLGALQV LSQLTPQTVM EIDGLLGNKP

HSKK
Length:404
Mass (Da):43,670
Last modified:February 20, 2007 - v2
Checksum:i57C4FAD8D19D9EBB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571L → V in AAB92499 (PubMed:9857044).Curated
Sequence conflicti60 – 601R → G in AAB92499 (PubMed:9857044).Curated
Sequence conflicti65 – 651A → G in AAB92499 (PubMed:9857044).Curated
Sequence conflicti68 – 681L → V in AAB92499 (PubMed:9857044).Curated
Sequence conflicti86 – 883SGL → CGV in AAB92499 (PubMed:9857044).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016411 mRNA. Translation: AAB92499.1.
BC096232 mRNA. Translation: AAH96232.1.
BC096234 mRNA. Translation: AAH96234.1.
BC099634 mRNA. Translation: AAH99634.1.
CCDSiCCDS11124.1.
RefSeqiNP_004723.2. NM_004732.3.
UniGeneiHs.435074.

Genome annotation databases

EnsembliENST00000303790; ENSP00000302719; ENSG00000170049.
GeneIDi9196.
KEGGihsa:9196.
UCSCiuc002gjm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016411 mRNA. Translation: AAB92499.1.
BC096232 mRNA. Translation: AAH96232.1.
BC096234 mRNA. Translation: AAH96234.1.
BC099634 mRNA. Translation: AAH99634.1.
CCDSiCCDS11124.1.
RefSeqiNP_004723.2. NM_004732.3.
UniGeneiHs.435074.

3D structure databases

ProteinModelPortaliO43448.
SMRiO43448. Positions 80-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114631. 8 interactions.
STRINGi9606.ENSP00000302719.

PTM databases

PhosphoSiteiO43448.

Proteomic databases

PaxDbiO43448.
PRIDEiO43448.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303790; ENSP00000302719; ENSG00000170049.
GeneIDi9196.
KEGGihsa:9196.
UCSCiuc002gjm.2. human.

Organism-specific databases

CTDi9196.
GeneCardsiGC17M007825.
H-InvDBHIX0173736.
HGNCiHGNC:6230. KCNAB3.
MIMi604111. gene.
neXtProtiNX_O43448.
PharmGKBiPA30024.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0667.
GeneTreeiENSGT00550000074567.
HOGENOMiHOG000250283.
HOVERGENiHBG052216.
InParanoidiO43448.
KOiK04884.
OMAiWHSFGHV.
OrthoDBiEOG71G9TR.
PhylomeDBiO43448.
TreeFamiTF324563.

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikiiKCNAB3.
GenomeRNAii9196.
NextBioi34475.
PROiO43448.
SOURCEiSearch...

Gene expression databases

BgeeiO43448.
CleanExiHS_KCNAB3.
ExpressionAtlasiO43448. baseline and differential.
GenevestigatoriO43448.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005402. K_chnl_volt-dep_bsu_KCNAB3.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR01580. KCNAB3CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMiSSF51430. SSF51430. 1 hit.
TIGRFAMsiTIGR01293. Kv_beta. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel."
    Leicher T., Baehring R., Isbrandt D., Pongs O.
    J. Biol. Chem. 273:35095-35101(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKCAB3_HUMAN
AccessioniPrimary (citable) accession number: O43448
Secondary accession number(s): Q4VAW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: February 20, 2007
Last modified: March 4, 2015
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.