O43448 (KCAB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-gated potassium channel subunit beta-3

Alternative name(s):
K(+) channel subunit beta-3
Kv-beta-3

Gene names

Name:	KCNAB3
Synonyms:	KCNA3B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5. Ref.1
Subunit structure	Forms heteromultimeric complex with alpha subunits.
Subcellular location	Cytoplasm Potential.
Tissue specificity	Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle. Ref.1
Domain	Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit Probable.
Sequence similarities	Belongs to the shaker potassium channel beta subunit family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Cytoplasm
Ligand	Potassium
Molecular function	Ionic channel Voltage-gated channel
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	synaptic transmission Traceable author statement. Source: Reactome
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro plasma membrane Traceable author statement. Source: Reactome
Molecular function	potassium channel regulator activity Traceable author statement. Source: ProtInc voltage-gated potassium channel activity Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Voltage-gated potassium channel subunit beta-3		PRO_0000148750
Amino acid modifications
	Modified residue	184	1	Phosphoserine Ref.3
	Modified residue	315	1	N6-acetyllysine Ref.4
Experimental info
	Sequence conflict	57	1	L → V in AAB92499. Ref.1
	Sequence conflict	60	1	R → G in AAB92499. Ref.1
	Sequence conflict	65	1	A → G in AAB92499. Ref.1
	Sequence conflict	68	1	L → V in AAB92499. Ref.1
	Sequence conflict	86 – 88	3	SGL → CGV in AAB92499. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O43448 [UniParc]. Last modified February 20, 2007. Version 2. Checksum: 57C4FAD8D19D9EBB	FASTA	404	43,670
	10 20 30 40 50 60 MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPAGGGH GNPPGGGGSG PKARAALVPR 70 80 90 100 110 120 PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT FGSQISDETA EDVLTVAYEH 130 140 150 160 170 180 GVNLFDTAEV YAAGKAERTL GNILKSKGWR RSSYVITTKI FWGGQAETER GLSRKHIIEG 190 200 210 220 230 240 LRGSLERLQL GYVDIVFANR SDPNCPMEEI VRAMTYVINQ GLALYWGTSR WGAAEIMEAY 250 260 270 280 290 300 SMARQFNLIP PVCEQAEHHL FQREKVEMQL PELYHKIGVG SVTWYPLACG LITSKYDGRV 310 320 330 340 350 360 PDTCRASIKG YQWLKDKVQS EDGKKQQAKV MDLLPVAHQL GCTVAQLAIA WCLRSEGVSS 370 380 390 400 VLLGVSSAEQ LIEHLGALQV LSQLTPQTVM EIDGLLGNKP HSKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel." Leicher T., Baehring R., Isbrandt D., Pongs O. J. Biol. Chem. 273:35095-35101(1998) [PubMed: 9857044] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[4]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-315, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF016411 mRNA. Translation: AAB92499.1. BC096232 mRNA. Translation: AAH96232.1. BC096234 mRNA. Translation: AAH96234.1. BC099634 mRNA. Translation: AAH99634.1.
IPI	IPI00006204.
RefSeq	NP_004723.2. NM_004732.2.
UniGene	Hs.435074.
3D structure databases
ProteinModelPortal	O43448.
SMR	O43448. Positions 80-402.
ModBase	Search...
Protein-protein interaction databases
STRING	O43448.
PTM databases
PhosphoSite	O43448.
Proteomic databases
PRIDE	O43448.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000303790; ENSP00000302719; ENSG00000170049.
GeneID	9196.
KEGG	hsa:9196.
UCSC	uc002gjm.1. human.
Organism-specific databases
CTD	9196.
GeneCards	GC17M007825.
H-InvDB	HIX0039038.
HGNC	HGNC:6230. KCNAB3.
MIM	604111. gene.
neXtProt	NX_O43448.
PharmGKB	PA30024.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08392.
GeneTree	ENSGT00550000074567.
HOGENOM	HBG605727.
HOVERGEN	HBG052216.
InParanoid	O43448.
OMA	YEHGINL.
OrthoDB	EOG476K0F.
PhylomeDB	O43448.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	O43448.
Bgee	O43448.
CleanEx	HS_KCNAB3.
Genevestigator	O43448.
GermOnline	ENSG00000170049. Homo sapiens.
Family and domain databases
InterPro	IPR001395. Aldo/ket_red. IPR005983. K_chnl_volt-dep_bsu_KCNAB. IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel. IPR005402. K_chnl_volt-dep_bsu_KCNAB3. IPR023210. NADP_OxRdtase_dom. [Graphical view]
Gene3D	G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.
KO	K04884.
PANTHER	PTHR11732. Aldo/ket_red. 1 hit. PTHR11732:SF14. KCNAB_channel. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PRINTS	PR01580. KCNAB3CHANEL. PR01577. KCNABCHANNEL.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
TIGRFAMs	TIGR01293. Kv_beta. 1 hit.
ProtoNet	Search...
Other
NextBio	34475.
SOURCE	Search...

Entry information

Entry name

KCAB3_HUMAN

Accession

Primary (citable) accession number: O43448
Secondary accession number(s): Q4VAW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	February 20, 2007
Last modified:	January 25, 2012
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.