Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O43448

- KCAB3_HUMAN

UniProt

O43448 - KCAB3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Voltage-gated potassium channel subunit beta-3

Gene

KCNAB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.1 Publication

GO - Molecular functioni

  1. potassium channel regulator activity Source: ProtInc
  2. voltage-gated potassium channel activity Source: InterPro

GO - Biological processi

  1. potassium ion transport Source: ProtInc
  2. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75770. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-gated potassium channel subunit beta-3
Alternative name(s):
K(+) channel subunit beta-3
Kv-beta-3
Gene namesi
Name:KCNAB3
Synonyms:KCNA3B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6230. KCNAB3.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. integral component of membrane Source: InterPro
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30024.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Voltage-gated potassium channel subunit beta-3PRO_0000148750Add
BLAST

Proteomic databases

PaxDbiO43448.
PRIDEiO43448.

PTM databases

PhosphoSiteiO43448.

Expressioni

Tissue specificityi

Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle.1 Publication

Gene expression databases

BgeeiO43448.
CleanExiHS_KCNAB3.
ExpressionAtlasiO43448. baseline and differential.
GenevestigatoriO43448.

Interactioni

Subunit structurei

Forms heteromultimeric complex with alpha subunits.

Protein-protein interaction databases

BioGridi114631. 8 interactions.
STRINGi9606.ENSP00000302719.

Structurei

3D structure databases

ProteinModelPortaliO43448.
SMRiO43448. Positions 80-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit.Curated

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0667.
GeneTreeiENSGT00550000074567.
HOGENOMiHOG000250283.
HOVERGENiHBG052216.
InParanoidiO43448.
KOiK04884.
OMAiSSDWREW.
OrthoDBiEOG71G9TR.
PhylomeDBiO43448.
TreeFamiTF324563.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005402. K_chnl_volt-dep_bsu_KCNAB3.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR01580. KCNAB3CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMiSSF51430. SSF51430. 1 hit.
TIGRFAMsiTIGR01293. Kv_beta. 1 hit.

Sequencei

Sequence statusi: Complete.

O43448-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPAGGGH GNPPGGGGSG
60 70 80 90 100
PKARAALVPR PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT
110 120 130 140 150
FGSQISDETA EDVLTVAYEH GVNLFDTAEV YAAGKAERTL GNILKSKGWR
160 170 180 190 200
RSSYVITTKI FWGGQAETER GLSRKHIIEG LRGSLERLQL GYVDIVFANR
210 220 230 240 250
SDPNCPMEEI VRAMTYVINQ GLALYWGTSR WGAAEIMEAY SMARQFNLIP
260 270 280 290 300
PVCEQAEHHL FQREKVEMQL PELYHKIGVG SVTWYPLACG LITSKYDGRV
310 320 330 340 350
PDTCRASIKG YQWLKDKVQS EDGKKQQAKV MDLLPVAHQL GCTVAQLAIA
360 370 380 390 400
WCLRSEGVSS VLLGVSSAEQ LIEHLGALQV LSQLTPQTVM EIDGLLGNKP

HSKK
Length:404
Mass (Da):43,670
Last modified:February 20, 2007 - v2
Checksum:i57C4FAD8D19D9EBB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571L → V in AAB92499. (PubMed:9857044)Curated
Sequence conflicti60 – 601R → G in AAB92499. (PubMed:9857044)Curated
Sequence conflicti65 – 651A → G in AAB92499. (PubMed:9857044)Curated
Sequence conflicti68 – 681L → V in AAB92499. (PubMed:9857044)Curated
Sequence conflicti86 – 883SGL → CGV in AAB92499. (PubMed:9857044)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016411 mRNA. Translation: AAB92499.1.
BC096232 mRNA. Translation: AAH96232.1.
BC096234 mRNA. Translation: AAH96234.1.
BC099634 mRNA. Translation: AAH99634.1.
CCDSiCCDS11124.1.
RefSeqiNP_004723.2. NM_004732.3.
UniGeneiHs.435074.

Genome annotation databases

EnsembliENST00000303790; ENSP00000302719; ENSG00000170049.
GeneIDi9196.
KEGGihsa:9196.
UCSCiuc002gjm.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016411 mRNA. Translation: AAB92499.1 .
BC096232 mRNA. Translation: AAH96232.1 .
BC096234 mRNA. Translation: AAH96234.1 .
BC099634 mRNA. Translation: AAH99634.1 .
CCDSi CCDS11124.1.
RefSeqi NP_004723.2. NM_004732.3.
UniGenei Hs.435074.

3D structure databases

ProteinModelPortali O43448.
SMRi O43448. Positions 80-402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114631. 8 interactions.
STRINGi 9606.ENSP00000302719.

PTM databases

PhosphoSitei O43448.

Proteomic databases

PaxDbi O43448.
PRIDEi O43448.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303790 ; ENSP00000302719 ; ENSG00000170049 .
GeneIDi 9196.
KEGGi hsa:9196.
UCSCi uc002gjm.2. human.

Organism-specific databases

CTDi 9196.
GeneCardsi GC17M007825.
H-InvDB HIX0173736.
HGNCi HGNC:6230. KCNAB3.
MIMi 604111. gene.
neXtProti NX_O43448.
PharmGKBi PA30024.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0667.
GeneTreei ENSGT00550000074567.
HOGENOMi HOG000250283.
HOVERGENi HBG052216.
InParanoidi O43448.
KOi K04884.
OMAi SSDWREW.
OrthoDBi EOG71G9TR.
PhylomeDBi O43448.
TreeFami TF324563.

Enzyme and pathway databases

Reactomei REACT_75770. Voltage gated Potassium channels.

Miscellaneous databases

GeneWikii KCNAB3.
GenomeRNAii 9196.
NextBioi 34475.
PROi O43448.
SOURCEi Search...

Gene expression databases

Bgeei O43448.
CleanExi HS_KCNAB3.
ExpressionAtlasi O43448. baseline and differential.
Genevestigatori O43448.

Family and domain databases

Gene3Di 3.20.20.100. 1 hit.
InterProi IPR001395. Aldo/ket_red.
IPR005983. K_chnl_volt-dep_bsu_KCNAB.
IPR005399. K_chnl_volt-dep_bsu_KCNAB-rel.
IPR005402. K_chnl_volt-dep_bsu_KCNAB3.
IPR023210. NADP_OxRdtase_dom.
[Graphical view ]
PANTHERi PTHR11732. PTHR11732. 1 hit.
Pfami PF00248. Aldo_ket_red. 1 hit.
[Graphical view ]
PRINTSi PR01580. KCNAB3CHANEL.
PR01577. KCNABCHANNEL.
SUPFAMi SSF51430. SSF51430. 1 hit.
TIGRFAMsi TIGR01293. Kv_beta. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel."
    Leicher T., Baehring R., Isbrandt D., Pongs O.
    J. Biol. Chem. 273:35095-35101(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKCAB3_HUMAN
AccessioniPrimary (citable) accession number: O43448
Secondary accession number(s): Q4VAW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3