true2003-08-292024-01-24191MTG8R_HUMANEHT, a new member of the MTG8/ETO gene family, maps on 20q11 region and is deleted in acute myeloid leukemias.Fracchiolla N.S.Colombo G.Finelli P.Maiolo A.T.Neri A.1998Blood923481-3484NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)TISSUE SPECIFICITYThe AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.Kitabayashi I.Ida K.Morohoshi F.Yokoyama A.Mitsuhashi N.Shimizu K.Nomura N.Hayashi Y.Ohki M.doi:10.1128/mcb.18.2.8461998Mol. Cell. Biol.18846-858NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)TISSUE SPECIFICITYPHOSPHORYLATIONINTERACTION WITH AML1-MTG8/ETOLeukemiaStructure and expression pattern of a human MTG8/ETO family gene, MTGR1.Morohoshi F.Mitani S.Mitsuhashi N.Kitabayashi I.Takahashi E.Suzuki M.Munakata N.Ohki M.doi:10.1016/s0378-1119(99)00481-32000Gene241287-295NUCLEOTIDE SEQUENCE [GENOMIC DNA]ALTERNATIVE SPLICING (ISOFORM 2)TISSUE SPECIFICITYComplete sequencing and characterization of 21,243 full-length human cDNAs.Ota T.Suzuki Y.Nishikawa T.Otsuki T.Sugiyama T.Irie R.Wakamatsu A.Hayashi K.Sato H.Nagai K.Kimura K.Makita H.Sekine M.Obayashi M.Nishi T.Shibahara T.Tanaka T.Ishii S.Yamamoto J.Saito K.Kawai Y.Isono Y.Nakamura Y.Nagahari K.Murakami K.Yasuda T.Iwayanagi T.Wagatsuma M.Shiratori A.Sudo H.Hosoiri T.Kaku Y.Kodaira H.Kondo H.Sugawara M.Takahashi M.Kanda K.Yokoi T.Furuya T.Kikkawa E.Omura Y.Abe K.Kamihara K.Katsuta N.Sato K.Tanikawa M.Yamazaki M.Ninomiya K.Ishibashi T.Yamashita H.Murakawa K.Fujimori K.Tanai H.Kimata M.Watanabe M.Hiraoka S.Chiba Y.Ishida S.Ono Y.Takiguchi S.Watanabe S.Yosida M.Hotuta T.Kusano J.Kanehori K.Takahashi-Fujii A.Hara H.Tanase T.-O.Nomura Y.Togiya S.Komai F.Hara R.Takeuchi K.Arita M.Imose N.Musashino K.Yuuki H.Oshima A.Sasaki N.Aotsuka S.Yoshikawa Y.Matsunawa H.Ichihara T.Shiohata N.Sano S.Moriya S.Momiyama H.Satoh N.Takami S.Terashima Y.Suzuki O.Nakagawa S.Senoh A.Mizoguchi H.Goto Y.Shimizu F.Wakebe H.Hishigaki H.Watanabe T.Sugiyama A.Takemoto M.Kawakami B.Yamazaki M.'Watanabe K.Kumagai A.Itakura S.Fukuzumi Y.Fujimori Y.Komiyama M.Tashiro H.Tanigami A.Fujiwara T.Ono T.Yamada K.Fujii Y.Ozaki K.Hirao M.Ohmori Y.Kawabata A.Hikiji T.Kobatake N.Inagaki H.Ikema Y.Okamoto S.Okitani R.Kawakami T.Noguchi S.Itoh T.Shigeta K.Senba T.Matsumura K.Nakajima Y.Mizuno T.Morinaga M.Sasaki M.Togashi T.Oyama M.Hata H.Watanabe M.'Komatsu T.Mizushima-Sugano J.Satoh T.Shirai Y.Takahashi Y.Nakagawa K.Okumura K.Nagase T.Nomura N.Kikuchi H.Masuho Y.Yamashita R.Nakai K.Yada T.Nakamura Y.'Ohara O.Isogai T.Sugano S.doi:10.1038/ng12852004Nat. Genet.3640-45NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-532 (ISOFORM 5)BrainHippocampusThe DNA sequence and comparative analysis of human chromosome 20.Deloukas P.Matthews L.H.Ashurst J.L.Burton J.Gilbert J.G.R.Jones M.Stavrides G.Almeida J.P.Babbage A.K.Bagguley C.L.Bailey J.Barlow K.F.Bates K.N.Beard L.M.Beare D.M.Beasley O.P.Bird C.P.Blakey S.E.Bridgeman A.M.Brown A.J.Buck D.Burrill W.D.Butler A.P.Carder C.Carter N.P.Chapman J.C.Clamp M.Clark G.Clark L.N.Clark S.Y.Clee C.M.Clegg S.Cobley V.E.Collier R.E.Connor R.E.Corby N.R.Coulson A.Coville G.J.Deadman R.Dhami P.D.Dunn M.Ellington A.G.Frankland J.A.Fraser A.French L.Garner P.Grafham D.V.Griffiths C.Griffiths M.N.D.Gwilliam R.Hall R.E.Hammond S.Harley J.L.Heath P.D.Ho S.Holden J.L.Howden P.J.Huckle E.Hunt A.R.Hunt S.E.Jekosch K.Johnson C.M.Johnson D.Kay M.P.Kimberley A.M.King A.Knights A.Laird G.K.Lawlor S.Lehvaeslaiho M.H.Leversha M.A.Lloyd C.Lloyd D.M.Lovell J.D.Marsh V.L.Martin S.L.McConnachie L.J.McLay K.McMurray A.A.Milne S.A.Mistry D.Moore M.J.F.Mullikin J.C.Nickerson T.Oliver K.Parker A.Patel R.Pearce T.A.V.Peck A.I.Phillimore B.J.C.T.Prathalingam S.R.Plumb R.W.Ramsay H.Rice C.M.Ross M.T.Scott C.E.Sehra H.K.Shownkeen R.Sims S.Skuce C.D.Smith M.L.Soderlund C.Steward C.A.Sulston J.E.Swann R.M.Sycamore N.Taylor R.Tee L.Thomas D.W.Thorpe A.Tracey A.Tromans A.C.Vaudin M.Wall M.Wallis J.M.Whitehead S.L.Whittaker P.Willey D.L.Williams L.Williams S.A.Wilming L.Wray P.W.Hubbard T.Durbin R.M.Bentley D.R.Beck S.Rogers J.doi:10.1038/414865a2001Nature414865-871NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Mural R.J.Istrail S.Sutton G.G.Florea L.Halpern A.L.Mobarry C.M.Lippert R.Walenz B.Shatkay H.Dew I.Miller J.R.Flanigan M.J.Edwards N.J.Bolanos R.Fasulo D.Halldorsson B.V.Hannenhalli S.Turner R.Yooseph S.Lu F.Nusskern D.R.Shue B.C.Zheng X.H.Zhong F.Delcher A.L.Huson D.H.Kravitz S.A.Mouchard L.Reinert K.Remington K.A.Clark A.G.Waterman M.S.Eichler E.E.Adams M.D.Hunkapiller M.W.Myers E.W.Venter J.C.2005-09EMBL/GenBank/DDBJNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Teamdoi:10.1101/gr.25965042004Genome Res.142121-2127NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)EyeOvaryProstateCBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.Calabi F.Cilli V.doi:10.1006/geno.1998.54291998Genomics52332-341NUCLEOTIDE SEQUENCE [MRNA] OF 22-604 (ISOFORMS 1/4/5)ALTERNATIVE SPLICINGTISSUE SPECIFICITYFetal brainRetinaThe transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies.Hoogeveen A.T.Rossetti S.Stoyanova V.Schonkeren J.Fenaroli A.Schiaffonati L.van Unen L.Sacchi N.doi:10.1038/sj.onc.12058822002Oncogene216703-6712INTERACTION WITH CBFA2T3Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins.Lindberg S.R.Olsson A.Persson A.M.Olsson I.doi:10.1046/j.0902-4441.2003.00166.x2003Eur. J. Haematol.71439-447INTERACTION WITH RUNX1T1 AND CBFA2T3The ETO (MTG8) gene family.Davis J.N.McGhee L.Meyers S.doi:10.1016/s0378-1119(02)01172-12003Gene3031-10REVIEWThe MTG proteins: chromatin repression players with a passion for networking.Rossetti S.Hoogeveen A.T.Sacchi N.doi:10.1016/j.ygeno.2004.02.0112004Genomics841-9REVIEWThe tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity.Liu Y.Cheney M.D.Gaudet J.J.Chruszcz M.Lukasik S.M.Sugiyama D.Lary J.Cole J.Dauter Z.Minor W.Speck N.A.Bushweller J.H.doi:10.1016/j.ccr.2006.03.0122006Cancer Cell9249-260INTERACTION WITH AML1-MTG8/ETOQuantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.Mayya V.Lundgren D.H.Hwang S.-I.Rezaul K.Wu L.Eng J.K.Rodionov V.Han D.K.doi:10.1126/scisignal.20000072009Sci. Signal.2RA46IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Leukemic T-cellCBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia.Guastadisegni M.C.Lonoce A.Impera L.Di Terlizzi F.Fugazza G.Aliano S.Grasso R.Cluzeau T.Raynaud S.Rocchi M.Storlazzi C.T.doi:10.1038/leu.2010.1062010Leukemia241516-1519CHROMOSOMAL TRANSLOCATION WITH RUNX1Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.Olsen J.V.Vermeulen M.Santamaria A.Kumar C.Miller M.L.Jensen L.J.Gnad F.Cox J.Jensen T.S.Nigg E.A.Brunak S.Mann M.doi:10.1126/scisignal.20004752010Sci. Signal.3RA3IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Cervix carcinomaSystem-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.Rigbolt K.T.Prokhorova T.A.Akimov V.Henningsen J.Johansen P.T.Kratchmarova I.Kassem M.Mann M.Olsen J.V.Blagoev B.doi:10.1126/scisignal.20015702011Sci. Signal.4RS3IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.Barrett C.W.Smith J.J.Lu L.C.Markham N.Stengel K.R.Short S.P.Zhang B.Hunt A.A.Fingleton B.M.Carnahan R.H.Engel M.E.Chen X.Beauchamp R.D.Wilson K.T.Hiebert S.W.Reynolds A.B.Williams C.S.doi:10.1371/journal.pone.00512052012PLoS ONE7E51205FUNCTIONToward a comprehensive characterization of a human cancer cell phosphoproteome.Zhou H.Di Palma S.Preisinger C.Peng M.Polat A.N.Heck A.J.Mohammed S.doi:10.1021/pr300630k2013J. Proteome Res.12260-271PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33; SER-264; SER-409 AND SER-577IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]ErythroleukemiaAn enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y.Song C.Cheng K.Dong M.Wang F.Huang J.Sun D.Wang L.Ye M.Zou H.doi:10.1016/j.jprot.2013.11.0142014J. Proteomics96253-262IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]LiverPAX5 alterations in genetically unclassified childhood Precursor B-cell acute lymphoblastic leukaemia.Stasevich I.Inglott S.Austin N.Chatters S.Chalker J.Addy D.Dryden C.Ancliff P.Ford A.Williams O.Kempski H.doi:10.1111/bjh.135432015Br. J. Haematol.171263-272CHROMOSOMAL TRANSLOCATION WITH PAX5Co-repressor CBFA2T2 regulates pluripotency and germline development.Tu S.Narendra V.Yamaji M.Vidal S.E.Rojas L.A.Wang X.Kim S.Y.Garcia B.A.Tuschl T.Stadtfeld M.Reinberg D.doi:10.1038/nature180042016Nature534387-390FUNCTIONINTERACTION WITH PRDM14Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.Hendriks I.A.Lyon D.Young C.Jensen L.J.Vertegaal A.C.Nielsen M.L.doi:10.1038/nsmb.33662017Nat. Struct. Mol. Biol.24325-336SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-38 AND LYS-449IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Different initiation.4439311 antibodies from 33 providershumanCBFA2T2Low tissue specificitygeneEukaryotaSpecification of primordial germ cells17 hits in 1158 CRISPR screenshumanTbioProteinExpressed in buccal mucosa cell and 206 other cell types or tissuesbaseline and differentialTAFH/NHR1 domainCBFA2T1/2/3MTGR1NHR2TAFH/NHR1_dom_sfTAFH_NHR1Znf_MYNDMTG8 ETO EIGHT TWENTY ONE PROTEINPROTEIN CBFA2T2NHR2TAFHzf-MYNDETOFAMILYMTGR1PROTEINTAFHHIT/MYND zinc finger-likeTAFH domain-likeTAFHZF_MYND_1ZF_MYND_2HSProtein CBFA2T2ETO homologous on chromosome 20MTG8-like proteinMTG8-related protein 1Myeloid translocation-related protein 1p85CBFA2T2EHTMTGR1Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity).Homooligomer. Homotetramerization is mediated by nervy homology region 2 (By similarity). Can interact with RUNX1T1/CBFA2T1 and CBFA2T3/MTG16; heterotetramerization between members of the CBFA2T family is proposed (PubMed:12242670, PubMed:14703694, PubMed:16616331). Forms a heterooligomer with the AML1-MTG8/ETO fusion protein (PubMed:9447981). Interacts with PRDM14 (PubMed:27281218). Interacts with RBPJ, GFI1, TCF4. Interacts with TAL1 and CBFA2T3/MTG16; the heteromer with CBFA2T3/MTG16 may function in repression of TAL1 (By similarity).Ubiquitously expressed in fetal and adult tissues. Highly expressed in adult brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus.Nervy homology region 2 (NHR2) mediates homo- and possibly heterotypic oligomerization by forming a four-helix bundle tetrameric structure.A chromosomal aberration involving CBFA2T2 is found in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL). Translocation t(9;20)(p13;q11) with PAX5.A chromosomal aberration involving CBFA2T2 is found in acute myeloid leukemia. Translocation t(20;21)(q11;q22) with RUNX1/AML1.Belongs to the CBFA2T family.Extended N-terminus.Protein CBFA2T2671331604TAFH113208MYND-type507543Disordered25105Interaction with PRDM14107215Disordered229265Nervy homology region 2 (NHR2)331377Disordered397427Nervy homology region 3 (NHR3)435484Disordered547451491Pro residues4560Polar residues64Basic and acidic residues233254Polar residues403Polar residues570510518521527531539Breakpoint for translocation to form RUNX1-CBFA2T2 in acute myeloid leukemia2021Phosphoserine33Phosphoserine264Phosphoserine409Phosphoserine577Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)449In isoform 2 and isoform 3.29In isoform 5.MVGVPGAAAFQLIn isoform 4.MGFHHVGQARLELLTSGDLPALASQRAGITIn isoform 3.SCIIHLKSMGVASRHEYFSGTLQMPAHPVRNSTLENLWVDCSRSLRSTVLPFP240292In isoform 3.293H31V26612false4false3false12false3false3false3false3false3false3false3false6false3false3false3false3false3MDFIPDP1PRDM14TCP1BAG4CEP83KIFC3KRTAP13-2MAGEA6PHAF1PRDM6SIKE1SORBS3TCF4ZC2HC1A1998-06-011671334963c031021ace92fcbb15165b3e705f1MTGR1bMAKESGISLKEIQVLARQWKVGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAIDTNGL2MTGR1aEHTMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAIDTNGL3MPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPESCIIHLKSMGVASRHEYFSGTLQMPAHPVRNSTLENLWVDCSRSLRSTVLPFP4MGFHHVGQARLELLTSGDLPALASQRAGITVGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAIDTNGL5MVGVPGAAAFQLGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAIDTNGLtruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetruetrue