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Protein

Eukaryotic translation initiation factor 4 gamma 3

Gene

EIF4G3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA cap binding Source: ProtInc
  • translation factor activity, RNA binding Source: ProtInc
  • translation initiation factor activity Source: UniProtKB-KW

GO - Biological processi

  • regulation of translational initiation Source: ProtInc
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Host-virus interaction, Protein biosynthesis, Translation regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075151-MONOMER.
ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
SIGNORiO43432.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4 gamma 3
Short name:
eIF-4-gamma 3
Short name:
eIF-4G 3
Short name:
eIF4G 3
Alternative name(s):
eIF-4-gamma II
Short name:
eIF4GII
Gene namesi
Name:EIF4G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3298. EIF4G3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • eukaryotic translation initiation factor 4F complex Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi756R → D: Reduces binding to EIF4A; when associated with D-759 and D-764. 1 Publication1
Mutagenesisi759R → D: Reduces binding to EIF4A; when associated with D-756 and D-764. 1 Publication1
Mutagenesisi764K → D: Reduces binding to EIF4A; when associated with D-756 and D-759. 1 Publication1
Mutagenesisi814R → D: Reduces binding to EIF4A; when associated with D-820. 1 Publication1
Mutagenesisi820K → D: Reduces binding to EIF4A; when associated with D-814. 1 Publication1
Mutagenesisi834 – 835RK → DD: Reduces binding to IRES. 1 Publication2

Organism-specific databases

DisGeNETi8672.
OpenTargetsiENSG00000075151.
PharmGKBiPA27724.

Polymorphism and mutation databases

BioMutaiEIF4G3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133291 – 1585Eukaryotic translation initiation factor 4 gamma 3Add BLAST1585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei168PhosphothreonineBy similarity1
Modified residuei230PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1
Modified residuei441PhosphoserineBy similarity1
Modified residuei495PhosphoserineCombined sources1
Modified residuei1156Phosphoserine; by CaMK11 Publication1
Modified residuei1218PhosphoserineCombined sources1
Modified residuei1409PhosphoserineCombined sources1

Post-translational modificationi

Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei699 – 700Cleavage; by enterovirus/rhinovirus protease 2A2
Sitei700 – 701Cleavage; by foot-and-mouth disease virus leader protease2

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO43432.
MaxQBiO43432.
PaxDbiO43432.
PeptideAtlasiO43432.
PRIDEiO43432.

PTM databases

iPTMnetiO43432.
PhosphoSitePlusiO43432.

Miscellaneous databases

PMAP-CutDBO43432.

Expressioni

Gene expression databases

BgeeiENSG00000075151.
CleanExiHS_EIF4G3.
ExpressionAtlasiO43432. baseline and differential.
GenevisibleiO43432. HS.

Organism-specific databases

HPAiHPA025031.
HPA025039.
HPA025041.

Interactioni

Subunit structurei

Interacts with EIF4A, EIF4E, eIF3 and PABPC1. Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA (By similarity).By similarity

Protein-protein interaction databases

BioGridi114220. 38 interactors.
DIPiDIP-33245N.
IntActiO43432. 14 interactors.
MINTiMINT-85560.
STRINGi9606.ENSP00000364073.

Structurei

Secondary structure

11585
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi746 – 762Combined sources17
Helixi770 – 777Combined sources8
Helixi785 – 801Combined sources17
Helixi803 – 805Combined sources3
Helixi806 – 816Combined sources11
Helixi833 – 848Combined sources16
Helixi885 – 900Combined sources16
Turni901 – 903Combined sources3
Helixi907 – 919Combined sources13
Helixi923 – 940Combined sources18
Turni943 – 945Combined sources3
Helixi946 – 961Combined sources16
Helixi967 – 981Combined sources15
Turni982 – 984Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HU3X-ray2.37A745-1003[»]
ProteinModelPortaliO43432.
SMRiO43432.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43432.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati745 – 783HEAT 1Add BLAST39
Domaini755 – 983MIF4GPROSITE-ProRule annotationAdd BLAST229
Repeati784 – 831HEAT 2Add BLAST48
Repeati832 – 905HEAT 3Add BLAST74
Repeati906 – 944HEAT 4Add BLAST39
Repeati945 – 984HEAT 5Add BLAST40
Domaini1221 – 1343MIPROSITE-ProRule annotationAdd BLAST123
Domaini1416 – 1585W2PROSITE-ProRule annotationAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni134 – 162PABPC1-bindingAdd BLAST29
Regioni619 – 630EIF4E-bindingBy similarityAdd BLAST12
Regioni699 – 1019eIF3/EIF4A-bindingBy similarityAdd BLAST321
Regioni1433 – 1585EIF4A-bindingBy similarityAdd BLAST153
Regioni1571 – 1585Necessary but not sufficient for MKNK1-bindingBy similarityAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili447 – 475Sequence analysisAdd BLAST29
Coiled coili994 – 1023Sequence analysisAdd BLAST30

Sequence similaritiesi

Contains 5 HEAT repeats.Curated
Contains 1 MI domain.PROSITE-ProRule annotation
Contains 1 MIF4G domain.Curated
Contains 1 W2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0401. Eukaryota.
ENOG410XS4P. LUCA.
GeneTreeiENSGT00530000063038.
HOGENOMiHOG000231658.
HOVERGENiHBG052083.
InParanoidiO43432.
KOiK03260.
PhylomeDBiO43432.
TreeFamiTF101527.

Family and domain databases

Gene3Di1.25.40.180. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43432-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSQPQTRSP FFQRPQIQPP RATIPNSSPS IRPGAQTPTA VYQANQHIMM
60 70 80 90 100
VNHLPMPYPV PQGPQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG
110 120 130 140 150
PGDFPNAYGT PFYPSQPVYQ SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG
160 170 180 190 200
GKDITEEIMS GGGSRNPTPP IGRPTSTPTP PQQLPSQVPE HSPVVYGTVE
210 220 230 240 250
SAHLAASTPV TAASDQKQEE KPKPDPVLKS PSPVLRLVLS GEKKEQEGQT
260 270 280 290 300
SETTAIVSIA ELPLPPSPTT VSSVARSTIA APTSSALSSQ PIFTTAIDDR
310 320 330 340 350
CELSSPREDT IPIPSLTSCT ETSDPLPTNE NDDDICKKPC SVAPNDIPLV
360 370 380 390 400
SSTNLINEIN GVSEKLSATE SIVEIVKQEV LPLTLELEIL ENPPEEMKLE
410 420 430 440 450
CIPAPITPST VPSFPPTPPT PPASPPHTPV IVPAAATTVS SPSAAITVQR
460 470 480 490 500
VLEEDESIRT CLSEDAKEIQ NKIEVEADGQ TEEILDSQNL NSRRSPVPAQ
510 520 530 540 550
IAITVPKTWK KPKDRTRTTE EMLEAELELK AEEELSIDKV LESEQDKMSQ
560 570 580 590 600
GFHPERDPSD LKKVKAVEEN GEEAEPVRNG AESVSEGEGI DANSGSTDSS
610 620 630 640 650
GDGVTFPFKP ESWKPTDTEG KKQYDREFLL DFQFMPACIQ KPEGLPPISD
660 670 680 690 700
VVLDKINQPK LPMRTLDPRI LPRGPDFTPA FADFGRQTPG GRGVPLLNVG
710 720 730 740 750
SRRSQPGQRR EPRKIITVSV KEDVHLKKAE NAWKPSQKRD SQADDPENIK
760 770 780 790 800
TQELFRKVRS ILNKLTPQMF NQLMKQVSGL TVDTEERLKG VIDLVFEKAI
810 820 830 840 850
DEPSFSVAYA NMCRCLVTLK VPMADKPGNT VNFRKLLLNR CQKEFEKDKA
860 870 880 890 900
DDDVFEKKQK ELEAASAPEE RTRLHDELEE AKDKARRRSI GNIKFIGELF
910 920 930 940 950
KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL DFEKAKPRMD
960 970 980 990 1000
QYFNQMEKIV KERKTSSRIR FMLQDVIDLR LCNWVSRRAD QGPKTIEQIH
1010 1020 1030 1040 1050
KEAKIEEQEE QRKVQQLMTK EKRRPGVQRV DEGGWNTVQG AKNSRVLDPS
1060 1070 1080 1090 1100
KFLKITKPTI DEKIQLVPKA QLGSWGKGSS GGAKASETDA LRSSASSLNR
1110 1120 1130 1140 1150
FSALQPPAPS GSTPSTPVEF DSRRTLTSRG SMGREKNDKP LPSATARPNT
1160 1170 1180 1190 1200
FMRGGSSKDL LDNQSQEEQR REMLETVKQL TGGVDVERNS TEAERNKTRE
1210 1220 1230 1240 1250
SAKPEISAMS AHDKAALSEE ELERKSKSII DEFLHINDFK EAMQCVEELN
1260 1270 1280 1290 1300
AQGLLHVFVR VGVESTLERS QITRDHMGQL LYQLVQSEKL SKQDFFKGFS
1310 1320 1330 1340 1350
ETLELADDMA IDIPHIWLYL AELVTPMLKE GGISMRELTI EFSKPLLPVG
1360 1370 1380 1390 1400
RAGVLLSEIL HLLCKQMSHK KVGALWREAD LSWKDFLPEG EDVHNFLLEQ
1410 1420 1430 1440 1450
KLDFIESDSP CSSEALSKKE LSAEELYKRL EKLIIEDKAN DEQIFDWVEA
1460 1470 1480 1490 1500
NLDEIQMSSP TFLRALMTAV CKAAIIADSS TFRVDTAVIK QRVPILLKYL
1510 1520 1530 1540 1550
DSDTEKELQA LYALQASIVK LDQPANLLRM FFDCLYDEEV ISEDAFYKWE
1560 1570 1580
SSKDPAEQNG KGVALKSVTA FFTWLREAEE ESEDN
Length:1,585
Mass (Da):176,652
Last modified:March 1, 2001 - v2
Checksum:iEA483139373DCA5C
GO
Isoform 2 (identifier: O43432-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: F → FAAGPRPPHHQF
     499-504: AQIAIT → ETSNEC
     505-1585: Missing.

Note: No experimental confirmation available.
Show »
Length:515
Mass (Da):55,227
Checksum:i0B4E961F10F62EA0
GO
Isoform 3 (identifier: O43432-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-10: P → PGGFRPIQ
     182-182: Missing.

Note: No experimental confirmation available.
Show »
Length:1,591
Mass (Da):177,280
Checksum:iA6A4BEC78E05CC92
GO
Isoform 4 (identifier: O43432-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-498: Missing.

Note: No experimental confirmation available.
Show »
Length:1,305
Mass (Da):146,871
Checksum:iEDF74715CD55642D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159M → I in AAH30578 (PubMed:15489334).Curated1
Sequence conflicti333D → G in AAH30578 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048924378Q → R.Corresponds to variant rs35731992dbSNPEnsembl.1
Natural variantiVAR_034009496P → A.Corresponds to variant rs35176330dbSNPEnsembl.1
Natural variantiVAR_0489251185D → E.Corresponds to variant rs2230572dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04344710P → PGGFRPIQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_01048711F → FAAGPRPPHHQF in isoform 2. 1 Publication1
Alternative sequenceiVSP_043448182Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_054502219 – 498Missing in isoform 4. 1 PublicationAdd BLAST280
Alternative sequenceiVSP_010488499 – 504AQIAIT → ETSNEC in isoform 2. 1 Publication6
Alternative sequenceiVSP_010489505 – 1585Missing in isoform 2. 1 PublicationAdd BLAST1081

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012072 mRNA. Translation: AAC02903.2.
AL031005 Genomic DNA. No translation available.
AL358392, AL606477, AL627311 Genomic DNA. Translation: CAI12155.1.
AL606477, AL358392, AL627311 Genomic DNA. Translation: CAI12534.1.
AL627311, AL358392, AL606477 Genomic DNA. Translation: CAI14553.1.
AL672037 Genomic DNA. No translation available.
CH471134 Genomic DNA. Translation: EAW94956.1.
BC030578 mRNA. Translation: AAH30578.1.
BC094683 mRNA. Translation: AAH94683.1.
BC136643 mRNA. Translation: AAI36644.1.
Z34918 mRNA. Translation: CAA84397.1.
CCDSiCCDS214.1. [O43432-1]
CCDS55580.1. [O43432-3]
CCDS59192.1. [O43432-2]
PIRiS49172.
RefSeqiNP_001185730.1. NM_001198801.1.
NP_001185731.1. NM_001198802.1. [O43432-3]
NP_001185732.1. NM_001198803.2. [O43432-2]
NP_003751.2. NM_003760.4. [O43432-1]
XP_016858189.1. XM_017002700.1. [O43432-1]
XP_016858197.1. XM_017002708.1. [O43432-4]
XP_016858201.1. XM_017002712.1. [O43432-2]
UniGeneiHs.467084.
Hs.732241.

Genome annotation databases

EnsembliENST00000264211; ENSP00000264211; ENSG00000075151. [O43432-1]
ENST00000356916; ENSP00000349386; ENSG00000075151. [O43432-2]
ENST00000374935; ENSP00000364071; ENSG00000075151. [O43432-4]
ENST00000602326; ENSP00000473510; ENSG00000075151. [O43432-3]
GeneIDi8672.
KEGGihsa:8672.
UCSCiuc001bee.4. human. [O43432-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF012072 mRNA. Translation: AAC02903.2.
AL031005 Genomic DNA. No translation available.
AL358392, AL606477, AL627311 Genomic DNA. Translation: CAI12155.1.
AL606477, AL358392, AL627311 Genomic DNA. Translation: CAI12534.1.
AL627311, AL358392, AL606477 Genomic DNA. Translation: CAI14553.1.
AL672037 Genomic DNA. No translation available.
CH471134 Genomic DNA. Translation: EAW94956.1.
BC030578 mRNA. Translation: AAH30578.1.
BC094683 mRNA. Translation: AAH94683.1.
BC136643 mRNA. Translation: AAI36644.1.
Z34918 mRNA. Translation: CAA84397.1.
CCDSiCCDS214.1. [O43432-1]
CCDS55580.1. [O43432-3]
CCDS59192.1. [O43432-2]
PIRiS49172.
RefSeqiNP_001185730.1. NM_001198801.1.
NP_001185731.1. NM_001198802.1. [O43432-3]
NP_001185732.1. NM_001198803.2. [O43432-2]
NP_003751.2. NM_003760.4. [O43432-1]
XP_016858189.1. XM_017002700.1. [O43432-1]
XP_016858197.1. XM_017002708.1. [O43432-4]
XP_016858201.1. XM_017002712.1. [O43432-2]
UniGeneiHs.467084.
Hs.732241.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HU3X-ray2.37A745-1003[»]
ProteinModelPortaliO43432.
SMRiO43432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114220. 38 interactors.
DIPiDIP-33245N.
IntActiO43432. 14 interactors.
MINTiMINT-85560.
STRINGi9606.ENSP00000364073.

PTM databases

iPTMnetiO43432.
PhosphoSitePlusiO43432.

Polymorphism and mutation databases

BioMutaiEIF4G3.

Proteomic databases

EPDiO43432.
MaxQBiO43432.
PaxDbiO43432.
PeptideAtlasiO43432.
PRIDEiO43432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264211; ENSP00000264211; ENSG00000075151. [O43432-1]
ENST00000356916; ENSP00000349386; ENSG00000075151. [O43432-2]
ENST00000374935; ENSP00000364071; ENSG00000075151. [O43432-4]
ENST00000602326; ENSP00000473510; ENSG00000075151. [O43432-3]
GeneIDi8672.
KEGGihsa:8672.
UCSCiuc001bee.4. human. [O43432-1]

Organism-specific databases

CTDi8672.
DisGeNETi8672.
GeneCardsiEIF4G3.
HGNCiHGNC:3298. EIF4G3.
HPAiHPA025031.
HPA025039.
HPA025041.
MIMi603929. gene.
neXtProtiNX_O43432.
OpenTargetsiENSG00000075151.
PharmGKBiPA27724.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0401. Eukaryota.
ENOG410XS4P. LUCA.
GeneTreeiENSGT00530000063038.
HOGENOMiHOG000231658.
HOVERGENiHBG052083.
InParanoidiO43432.
KOiK03260.
PhylomeDBiO43432.
TreeFamiTF101527.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075151-MONOMER.
ReactomeiR-HSA-1169408. ISG15 antiviral mechanism.
SIGNORiO43432.

Miscellaneous databases

ChiTaRSiEIF4G3. human.
EvolutionaryTraceiO43432.
GeneWikiiEIF4G3.
GenomeRNAii8672.
PMAP-CutDBO43432.
PROiO43432.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075151.
CleanExiHS_EIF4G3.
ExpressionAtlasiO43432. baseline and differential.
GenevisibleiO43432. HS.

Family and domain databases

Gene3Di1.25.40.180. 3 hits.
InterProiIPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR016021. MIF4-like.
IPR003890. MIF4G-like_typ-3.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02847. MA3. 1 hit.
PF02854. MIF4G. 1 hit.
PF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
PROSITEiPS51366. MI. 1 hit.
PS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIF4G3_HUMAN
AccessioniPrimary (citable) accession number: O43432
Secondary accession number(s): B9EGQ7
, Q15597, Q504Z1, Q5SWC3, Q8NEN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.