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Protein

Acidic fibroblast growth factor intracellular-binding protein

Gene

FIBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in mitogenic function of FGF1.

GO - Molecular functioni

  • fibroblast growth factor binding Source: MGI

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: ProtInc
  • platelet aggregation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiO43427.

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic fibroblast growth factor intracellular-binding protein
Short name:
aFGF intracellular-binding protein
Alternative name(s):
FGF-1 intracellular-binding protein
Gene namesi
Name:FIBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:3705. FIBP.

Subcellular locationi

GO - Cellular componenti

  • endomembrane system Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • membrane Source: MGI
  • mitochondrion Source: ProtInc
  • nucleoplasm Source: HPA
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28145.

Polymorphism and mutation databases

BioMutaiFIBP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 364363Acidic fibroblast growth factor intracellular-binding proteinPRO_0000087237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiO43427.
PaxDbiO43427.
PRIDEiO43427.

PTM databases

PhosphoSiteiO43427.

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney.

Gene expression databases

BgeeiO43427.
CleanExiHS_FIBP.
ExpressionAtlasiO43427. baseline and differential.
GenevisibleiO43427. HS.

Organism-specific databases

HPAiHPA011729.

Interactioni

Subunit structurei

Binds to internalized FGF1; this interaction is increased in the presence of CSNKB, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.

Protein-protein interaction databases

BioGridi114603. 18 interactions.
IntActiO43427. 3 interactions.
MINTiMINT-1376383.
STRINGi9606.ENSP00000344572.

Structurei

3D structure databases

ProteinModelPortaliO43427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG70779.
GeneTreeiENSGT00390000015815.
HOGENOMiHOG000234336.
HOVERGENiHBG005728.
InParanoidiO43427.
OMAiQVDDMDV.
OrthoDBiEOG754HQB.
PhylomeDBiO43427.
TreeFamiTF323763.

Family and domain databases

InterProiIPR008614. FIBP.
[Graphical view]
PANTHERiPTHR13223. PTHR13223. 1 hit.
PfamiPF05427. FIBP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: O43427-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSELDIFVG NTTLIDEDVY RLWLDGYSVT DAVALRVRSG ILEQTGATAA
60 70 80 90 100
VLQSDTMDHY RTFHMLERLL HAPPKLLHQL IFQIPPSRQA LLIERYYAFD
110 120 130 140 150
EAFVREVLGK KLSKGTKKDL DDISTKTGIT LKSCRRQFDN FKRVFKVVEE
160 170 180 190 200
MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA NNRFETGKKK LQYLSFGDFA
210 220 230 240 250
FCAELMIQNW TLGAVGEAPT DPDSQMDDMD MDLDKEFLQD LKELKVLVAD
260 270 280 290 300
KDLLDLHKSL VCTALRGKLG VFSEMEANFK NLSRGLVNVA AKLTHNKDVR
310 320 330 340 350
DLFVDLVEKF VEPCRSDHWP LSDVRFFLNQ YSASVHSLDG FRHQALWDRY
360
MGTLRGCLLR LYHD
Length:364
Mass (Da):41,878
Last modified:April 27, 2001 - v3
Checksum:i7E9A05908760FF45
GO
Isoform Short (identifier: O43427-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-222: Missing.

Show »
Length:357
Mass (Da):41,210
Checksum:i259F5181185CB0ED
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521R → W.
Corresponds to variant rs11559154 [ dbSNP | Ensembl ].
VAR_050991
Natural varianti351 – 3511M → V.1 Publication
Corresponds to variant rs2231893 [ dbSNP | Ensembl ].
VAR_050992
Natural varianti359 – 3591L → R.1 Publication
Corresponds to variant rs36080962 [ dbSNP | Ensembl ].
VAR_060711

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei216 – 2227Missing in isoform Short. 5 PublicationsVSP_004250

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010187 mRNA. Translation: AAC97140.2.
AF171944 mRNA. Translation: AAD51694.1.
AF171945 mRNA. Translation: AAD51695.1.
AF171946 mRNA. Translation: AAD51696.1.
AF250391 mRNA. Translation: AAG01396.1.
AF250392 Genomic DNA. Translation: AAG01397.1.
CR456749 mRNA. Translation: CAG33030.1.
AK289562 mRNA. Translation: BAF82251.1.
DQ388430 Genomic DNA. Translation: ABD48957.1.
CH471076 Genomic DNA. Translation: EAW74465.1.
CH471076 Genomic DNA. Translation: EAW74466.1.
BC014388 mRNA. Translation: AAH14388.1.
BC017448 mRNA. Translation: AAH17448.1.
CCDSiCCDS8118.1. [O43427-2]
CCDS8119.1. [O43427-1]
RefSeqiNP_004205.2. NM_004214.4. [O43427-2]
NP_942600.1. NM_198897.1. [O43427-1]
UniGeneiHs.7768.

Genome annotation databases

EnsembliENST00000338369; ENSP00000344572; ENSG00000172500. [O43427-1]
ENST00000357519; ENSP00000350124; ENSG00000172500. [O43427-2]
GeneIDi9158.
KEGGihsa:9158.
UCSCiuc001ogd.3. human. [O43427-1]
uc001oge.3. human. [O43427-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010187 mRNA. Translation: AAC97140.2.
AF171944 mRNA. Translation: AAD51694.1.
AF171945 mRNA. Translation: AAD51695.1.
AF171946 mRNA. Translation: AAD51696.1.
AF250391 mRNA. Translation: AAG01396.1.
AF250392 Genomic DNA. Translation: AAG01397.1.
CR456749 mRNA. Translation: CAG33030.1.
AK289562 mRNA. Translation: BAF82251.1.
DQ388430 Genomic DNA. Translation: ABD48957.1.
CH471076 Genomic DNA. Translation: EAW74465.1.
CH471076 Genomic DNA. Translation: EAW74466.1.
BC014388 mRNA. Translation: AAH14388.1.
BC017448 mRNA. Translation: AAH17448.1.
CCDSiCCDS8118.1. [O43427-2]
CCDS8119.1. [O43427-1]
RefSeqiNP_004205.2. NM_004214.4. [O43427-2]
NP_942600.1. NM_198897.1. [O43427-1]
UniGeneiHs.7768.

3D structure databases

ProteinModelPortaliO43427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114603. 18 interactions.
IntActiO43427. 3 interactions.
MINTiMINT-1376383.
STRINGi9606.ENSP00000344572.

PTM databases

PhosphoSiteiO43427.

Polymorphism and mutation databases

BioMutaiFIBP.

Proteomic databases

MaxQBiO43427.
PaxDbiO43427.
PRIDEiO43427.

Protocols and materials databases

DNASUi9158.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338369; ENSP00000344572; ENSG00000172500. [O43427-1]
ENST00000357519; ENSP00000350124; ENSG00000172500. [O43427-2]
GeneIDi9158.
KEGGihsa:9158.
UCSCiuc001ogd.3. human. [O43427-1]
uc001oge.3. human. [O43427-2]

Organism-specific databases

CTDi9158.
GeneCardsiGC11M065651.
HGNCiHGNC:3705. FIBP.
HPAiHPA011729.
MIMi608296. gene.
neXtProtiNX_O43427.
PharmGKBiPA28145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG70779.
GeneTreeiENSGT00390000015815.
HOGENOMiHOG000234336.
HOVERGENiHBG005728.
InParanoidiO43427.
OMAiQVDDMDV.
OrthoDBiEOG754HQB.
PhylomeDBiO43427.
TreeFamiTF323763.

Enzyme and pathway databases

SignaLinkiO43427.

Miscellaneous databases

GeneWikiiFIBP.
GenomeRNAii9158.
NextBioi34357.
PROiO43427.
SOURCEiSearch...

Gene expression databases

BgeeiO43427.
CleanExiHS_FIBP.
ExpressionAtlasiO43427. baseline and differential.
GenevisibleiO43427. HS.

Family and domain databases

InterProiIPR008614. FIBP.
[Graphical view]
PANTHERiPTHR13223. PTHR13223. 1 hit.
PfamiPF05427. FIBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor."
    Kolpakova E., Wiedlocha A., Stenmark H., Klingenberg O., Falnes P.O., Olsnes S.
    Biochem. J. 336:213-222(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Tissue: Mammary cancer.
  2. Imamura T., Loupatov A.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Tissue: Heart, Mammary cancer and Umbilical vein endothelial cell.
  3. "Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein."
    Kolpakova E., Frengen E., Stokke T., Olsnes S.
    Biochem. J. 352:629-635(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM LONG).
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
    Tissue: Cerebellum.
  6. NIEHS SNPs program
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-351 AND ARG-359.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
    Tissue: Brain and Placenta.
  9. "Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor."
    Skjerpen C.S., Wesche J., Olsnes S.
    J. Biol. Chem. 277:23864-23871(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGF1.
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFIBP_HUMAN
AccessioniPrimary (citable) accession number: O43427
Secondary accession number(s): A8K0J7
, Q27Q85, Q6IBQ3, Q9HD65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: June 24, 2015
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.