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O43427

- FIBP_HUMAN

UniProt

O43427 - FIBP_HUMAN

Protein

Acidic fibroblast growth factor intracellular-binding protein

Gene

FIBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    May be involved in mitogenic function of FGF1.

    GO - Molecular functioni

    1. fibroblast growth factor binding Source: MGI

    GO - Biological processi

    1. fibroblast growth factor receptor signaling pathway Source: ProtInc

    Enzyme and pathway databases

    SignaLinkiO43427.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acidic fibroblast growth factor intracellular-binding protein
    Short name:
    aFGF intracellular-binding protein
    Alternative name(s):
    FGF-1 intracellular-binding protein
    Gene namesi
    Name:FIBP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:3705. FIBP.

    Subcellular locationi

    Nucleus. Endomembrane system; Peripheral membrane protein
    Note: Also associated with cytoplasmic membranes, particularly of mitochondria.

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. extracellular vesicular exosome Source: UniProt
    3. membrane Source: MGI
    4. mitochondrion Source: ProtInc
    5. nucleus Source: MGI

    Keywords - Cellular componenti

    Membrane, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28145.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 364363Acidic fibroblast growth factor intracellular-binding proteinPRO_0000087237Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylthreonine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiO43427.
    PaxDbiO43427.
    PRIDEiO43427.

    PTM databases

    PhosphoSiteiO43427.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, skeletal muscle and pancreas. Expressed at lower levels in brain. Also found in placenta, liver and kidney.

    Gene expression databases

    ArrayExpressiO43427.
    BgeeiO43427.
    CleanExiHS_FIBP.
    GenevestigatoriO43427.

    Organism-specific databases

    HPAiHPA011729.

    Interactioni

    Subunit structurei

    Binds to internalized FGF1; this interaction is increased in the presence of CSNKB, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.

    Protein-protein interaction databases

    BioGridi114603. 12 interactions.
    IntActiO43427. 3 interactions.
    MINTiMINT-1376383.
    STRINGi9606.ENSP00000344572.

    Structurei

    3D structure databases

    ProteinModelPortaliO43427.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG70779.
    HOGENOMiHOG000234336.
    HOVERGENiHBG005728.
    InParanoidiO43427.
    OMAiQVDDMDV.
    OrthoDBiEOG754HQB.
    PhylomeDBiO43427.
    TreeFamiTF323763.

    Family and domain databases

    InterProiIPR008614. FIBP.
    [Graphical view]
    PANTHERiPTHR13223. PTHR13223. 1 hit.
    PfamiPF05427. FIBP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: O43427-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTSELDIFVG NTTLIDEDVY RLWLDGYSVT DAVALRVRSG ILEQTGATAA    50
    VLQSDTMDHY RTFHMLERLL HAPPKLLHQL IFQIPPSRQA LLIERYYAFD 100
    EAFVREVLGK KLSKGTKKDL DDISTKTGIT LKSCRRQFDN FKRVFKVVEE 150
    MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA NNRFETGKKK LQYLSFGDFA 200
    FCAELMIQNW TLGAVGEAPT DPDSQMDDMD MDLDKEFLQD LKELKVLVAD 250
    KDLLDLHKSL VCTALRGKLG VFSEMEANFK NLSRGLVNVA AKLTHNKDVR 300
    DLFVDLVEKF VEPCRSDHWP LSDVRFFLNQ YSASVHSLDG FRHQALWDRY 350
    MGTLRGCLLR LYHD 364
    Length:364
    Mass (Da):41,878
    Last modified:April 27, 2001 - v3
    Checksum:i7E9A05908760FF45
    GO
    Isoform Short (identifier: O43427-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         216-222: Missing.

    Show »
    Length:357
    Mass (Da):41,210
    Checksum:i259F5181185CB0ED
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti152 – 1521R → W.
    Corresponds to variant rs11559154 [ dbSNP | Ensembl ].
    VAR_050991
    Natural varianti351 – 3511M → V.1 Publication
    Corresponds to variant rs2231893 [ dbSNP | Ensembl ].
    VAR_050992
    Natural varianti359 – 3591L → R.1 Publication
    Corresponds to variant rs36080962 [ dbSNP | Ensembl ].
    VAR_060711

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei216 – 2227Missing in isoform Short. 5 PublicationsVSP_004250

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF010187 mRNA. Translation: AAC97140.2.
    AF171944 mRNA. Translation: AAD51694.1.
    AF171945 mRNA. Translation: AAD51695.1.
    AF171946 mRNA. Translation: AAD51696.1.
    AF250391 mRNA. Translation: AAG01396.1.
    AF250392 Genomic DNA. Translation: AAG01397.1.
    CR456749 mRNA. Translation: CAG33030.1.
    AK289562 mRNA. Translation: BAF82251.1.
    DQ388430 Genomic DNA. Translation: ABD48957.1.
    CH471076 Genomic DNA. Translation: EAW74465.1.
    CH471076 Genomic DNA. Translation: EAW74466.1.
    BC014388 mRNA. Translation: AAH14388.1.
    BC017448 mRNA. Translation: AAH17448.1.
    CCDSiCCDS8118.1. [O43427-2]
    CCDS8119.1. [O43427-1]
    RefSeqiNP_004205.2. NM_004214.4. [O43427-2]
    NP_942600.1. NM_198897.1. [O43427-1]
    UniGeneiHs.7768.

    Genome annotation databases

    EnsembliENST00000338369; ENSP00000344572; ENSG00000172500. [O43427-1]
    ENST00000357519; ENSP00000350124; ENSG00000172500. [O43427-2]
    GeneIDi9158.
    KEGGihsa:9158.
    UCSCiuc001ogd.3. human. [O43427-1]
    uc001oge.3. human. [O43427-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF010187 mRNA. Translation: AAC97140.2 .
    AF171944 mRNA. Translation: AAD51694.1 .
    AF171945 mRNA. Translation: AAD51695.1 .
    AF171946 mRNA. Translation: AAD51696.1 .
    AF250391 mRNA. Translation: AAG01396.1 .
    AF250392 Genomic DNA. Translation: AAG01397.1 .
    CR456749 mRNA. Translation: CAG33030.1 .
    AK289562 mRNA. Translation: BAF82251.1 .
    DQ388430 Genomic DNA. Translation: ABD48957.1 .
    CH471076 Genomic DNA. Translation: EAW74465.1 .
    CH471076 Genomic DNA. Translation: EAW74466.1 .
    BC014388 mRNA. Translation: AAH14388.1 .
    BC017448 mRNA. Translation: AAH17448.1 .
    CCDSi CCDS8118.1. [O43427-2 ]
    CCDS8119.1. [O43427-1 ]
    RefSeqi NP_004205.2. NM_004214.4. [O43427-2 ]
    NP_942600.1. NM_198897.1. [O43427-1 ]
    UniGenei Hs.7768.

    3D structure databases

    ProteinModelPortali O43427.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114603. 12 interactions.
    IntActi O43427. 3 interactions.
    MINTi MINT-1376383.
    STRINGi 9606.ENSP00000344572.

    PTM databases

    PhosphoSitei O43427.

    Proteomic databases

    MaxQBi O43427.
    PaxDbi O43427.
    PRIDEi O43427.

    Protocols and materials databases

    DNASUi 9158.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338369 ; ENSP00000344572 ; ENSG00000172500 . [O43427-1 ]
    ENST00000357519 ; ENSP00000350124 ; ENSG00000172500 . [O43427-2 ]
    GeneIDi 9158.
    KEGGi hsa:9158.
    UCSCi uc001ogd.3. human. [O43427-1 ]
    uc001oge.3. human. [O43427-2 ]

    Organism-specific databases

    CTDi 9158.
    GeneCardsi GC11M065651.
    HGNCi HGNC:3705. FIBP.
    HPAi HPA011729.
    MIMi 608296. gene.
    neXtProti NX_O43427.
    PharmGKBi PA28145.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70779.
    HOGENOMi HOG000234336.
    HOVERGENi HBG005728.
    InParanoidi O43427.
    OMAi QVDDMDV.
    OrthoDBi EOG754HQB.
    PhylomeDBi O43427.
    TreeFami TF323763.

    Enzyme and pathway databases

    SignaLinki O43427.

    Miscellaneous databases

    GeneWikii FIBP.
    GenomeRNAii 9158.
    NextBioi 34357.
    PROi O43427.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43427.
    Bgeei O43427.
    CleanExi HS_FIBP.
    Genevestigatori O43427.

    Family and domain databases

    InterProi IPR008614. FIBP.
    [Graphical view ]
    PANTHERi PTHR13223. PTHR13223. 1 hit.
    Pfami PF05427. FIBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor."
      Kolpakova E., Wiedlocha A., Stenmark H., Klingenberg O., Falnes P.O., Olsnes S.
      Biochem. J. 336:213-222(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
      Tissue: Mammary cancer.
    2. Imamura T., Loupatov A.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
      Tissue: Heart, Mammary cancer and Umbilical vein endothelial cell.
    3. "Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein."
      Kolpakova E., Frengen E., Stokke T., Olsnes S.
      Biochem. J. 352:629-635(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM LONG).
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
      Tissue: Cerebellum.
    6. NIEHS SNPs program
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-351 AND ARG-359.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
      Tissue: Brain and Placenta.
    9. "Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor."
      Skjerpen C.S., Wesche J., Olsnes S.
      J. Biol. Chem. 277:23864-23871(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGF1.
    10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFIBP_HUMAN
    AccessioniPrimary (citable) accession number: O43427
    Secondary accession number(s): A8K0J7
    , Q27Q85, Q6IBQ3, Q9HD65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3