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Protein

Synaptojanin-1

Gene

SYNJ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inositol 5-phosphatase which has a role in clathrin-mediated endocytosis.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.

GO - Molecular functioni

GO - Biological processi

  • inositol phosphate dephosphorylation Source: ParkinsonsUK-UCL
  • inositol phosphate metabolic process Source: Reactome
  • learning Source: ParkinsonsUK-UCL
  • neurotransmitter transport Source: ParkinsonsUK-UCL
  • phosphatidylinositol biosynthetic process Source: Reactome
  • phosphatidylinositol dephosphorylation Source: ParkinsonsUK-UCL
  • phosphatidylinositol metabolic process Source: ParkinsonsUK-UCL
  • positive regulation of endosome organization Source: ParkinsonsUK-UCL
  • synaptic vesicle endocytosis Source: ParkinsonsUK-UCL
  • synaptic vesicle priming Source: ParkinsonsUK-UCL
  • synaptic vesicle transport Source: ParkinsonsUK-UCL
  • synaptic vesicle uncoating Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS08354-MONOMER.
ZFISH:HS08354-MONOMER.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
R-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-HSA-8856828. Clathrin-mediated endocytosis.
SIGNORiO43426.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptojanin-1 (EC:3.1.3.36)
Alternative name(s):
Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1
Gene namesi
Name:SYNJ1
Synonyms:KIAA0910
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:11503. SYNJ1.

Subcellular locationi

GO - Cellular componenti

  • clathrin coat of coated pit Source: BHF-UCL
  • cytosol Source: ParkinsonsUK-UCL
  • membrane coat Source: ParkinsonsUK-UCL
  • presynapse Source: ParkinsonsUK-UCL
  • synaptic membrane Source: BHF-UCL
  • terminal bouton Source: ParkinsonsUK-UCL
  • vesicle membrane Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Parkinson disease 20, early-onset (PARK20)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn early-onset form of Parkinson disease, a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK20 is characterized by young adult-onset of parkinsonism. Additional features may include seizures, cognitive decline, abnormal eye movements, and dystonia.
See also OMIM:615530
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070905219R → Q in PARK20; impairs the phosphatase activity of the enzyme toward phosphatidylinositol-3-phosphate and phosphatidylinositol-4-phosphate. 2 Publications1
Natural variantiVAR_0709061383S → R in PARK20; unknown pathological significance; the patient also carries a heterozygous PINK1 truncating mutation. 1 Publication1

Keywords - Diseasei

Disease mutation, Neurodegeneration, Parkinson disease, Parkinsonism

Organism-specific databases

DisGeNETi8867.
MalaCardsiSYNJ1.
MIMi615530. phenotype.
OpenTargetsiENSG00000159082.
Orphaneti391411. Atypical juvenile parkinsonism.
PharmGKBiPA36285.

Polymorphism and mutation databases

BioMutaiSYNJ1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097301 – 1573Synaptojanin-1Add BLAST1573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei820PhosphoserineBy similarity1
Modified residuei830PhosphoserineCombined sources1
Modified residuei1053PhosphoserineBy similarity1
Modified residuei1150PhosphoserineBy similarity1
Modified residuei1178PhosphoserineBy similarity1
Modified residuei1201Omega-N-methylarginineBy similarity1
Modified residuei1220PhosphothreonineCombined sources1
Modified residuei1292PhosphoserineCombined sources1
Modified residuei1318PhosphoserineCombined sources1
Modified residuei1345PhosphoserineCombined sources1
Modified residuei1349PhosphothreonineBy similarity1
Modified residuei1551PhosphoserineCombined sources1
Modified residuei1565PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiO43426.
MaxQBiO43426.
PaxDbiO43426.
PeptideAtlasiO43426.
PRIDEiO43426.

PTM databases

DEPODiO43426.
iPTMnetiO43426.
PhosphoSitePlusiO43426.

Expressioni

Tissue specificityi

Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals.

Gene expression databases

BgeeiENSG00000159082.
CleanExiHS_SYNJ1.
ExpressionAtlasiO43426. baseline and differential.
GenevisibleiO43426. HS.

Organism-specific databases

HPAiHPA011916.

Interactioni

Subunit structurei

Interacts with ASH/GRB2. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Binds AMPH, SH3GL1, SH3GL2 and SH3GL3. Interacts with MYO1E (via SH3 domain).By similarity2 Publications

Protein-protein interaction databases

BioGridi114388. 16 interactors.
IntActiO43426. 6 interactors.
MINTiMINT-109209.
STRINGi9606.ENSP00000409667.

Structurei

Secondary structure

11573
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi895 – 901Combined sources7
Turni905 – 907Combined sources3
Helixi912 – 923Combined sources12
Beta strandi928 – 933Combined sources6
Beta strandi935 – 944Combined sources10
Helixi945 – 950Combined sources6
Helixi951 – 954Combined sources4
Beta strandi962 – 968Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W80X-ray1.90P1477-1488[»]
Q1458-1469[»]
2DNRNMR-A894-971[»]
2VJ0X-ray1.60P1477-1488[»]
ProteinModelPortaliO43426.
SMRiO43426.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43426.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 442SACPROSITE-ProRule annotationAdd BLAST324
Domaini902 – 971RRMPROSITE-ProRule annotationAdd BLAST70
Repeati1396 – 139813
Repeati1406 – 140823
Repeati1417 – 141933

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni500 – 899CatalyticSequence analysisAdd BLAST400
Regioni1396 – 14193 X 3 AA repeats of N-P-FAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi900 – 1573Pro-richAdd BLAST674
Compositional biasi1033 – 1036Poly-Ser4
Compositional biasi1108 – 1113Poly-Pro6
Compositional biasi1126 – 1129Poly-Pro4
Compositional biasi1485 – 1488Poly-Glu4
Compositional biasi1538 – 1544Poly-Pro7

Domaini

Binds to EPS15 (a clathrin coat-associated protein) via a C-terminal domain containing three Asn-Pro-Phe (NPF) repeats.By similarity
The C-terminal proline-rich region mediates binding to a variety of SH3 domain-containing proteins including AMPH, SH3GL1, SH3GL2, SH3GL3 and GRB2.

Sequence similaritiesi

Belongs to the synaptojanin family.Curated
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.Curated
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation
Contains 1 SAC domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0566. Eukaryota.
COG5329. LUCA.
COG5411. LUCA.
GeneTreeiENSGT00760000119075.
HOGENOMiHOG000007937.
HOVERGENiHBG079225.
InParanoidiO43426.
KOiK20279.
PhylomeDBiO43426.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
3.60.10.10. 1 hit.
InterProiIPR015047. DUF1866.
IPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR002013. SAC_dom.
[Graphical view]
PfamiPF08952. DUF1866. 1 hit.
PF03372. Exo_endo_phos. 1 hit.
PF02383. Syja_N. 1 hit.
[Graphical view]
SMARTiSM01165. DUF1866. 1 hit.
SM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF56219. SSF56219. 2 hits.
PROSITEiPS50102. RRM. 1 hit.
PS50275. SAC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43426-1) [UniParc]FASTAAdd to basket
Also known as: Synaptojanin-170

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFSKGFRIY HKLDPPPFSL IVETRHKEEC LMFESGAVAV LSSAEKEAIK
60 70 80 90 100
GTYSKVLDAY GLLGVLRLNL GDTMLHYLVL VTGCMSVGKI QESEVFRVTS
110 120 130 140 150
TEFISLRIDS SDEDRISEVR KVLNSGNFYF AWSASGISLD LSLNAHRSMQ
160 170 180 190 200
EQTTDNRFFW NQSLHLHLKH YGVNCDDWLL RLMCGGVEIR TIYAAHKQAK
210 220 230 240 250
ACLISRLSCE RAGTRFNVRG TNDDGHVANF VETEQVVYLD DSVSSFIQIR
260 270 280 290 300
GSVPLFWEQP GLQVGSHRVR MSRGFEANAP AFDRHFRTLK NLYGKQIIVN
310 320 330 340 350
LLGSKEGEHM LSKAFQSHLK ASEHAADIQM VNFDYHQMVK GGKAEKLHSV
360 370 380 390 400
LKPQVQKFLD YGFFYFNGSE VQRCQSGTVR TNCLDCLDRT NSVQAFLGLE
410 420 430 440 450
MLAKQLEALG LAEKPQLVTR FQEVFRSMWS VNGDSISKIY AGTGALEGKA
460 470 480 490 500
KLKDGARSVT RTIQNNFFDS SKQEAIDVLL LGNTLNSDLA DKARALLTTG
510 520 530 540 550
SLRVSEQTLQ SASSKVLKSM CENFYKYSKP KKIRVCVGTW NVNGGKQFRS
560 570 580 590 600
IAFKNQTLTD WLLDAPKLAG IQEFQDKRSK PTDIFAIGFE EMVELNAGNI
610 620 630 640 650
VSASTTNQKL WAVELQKTIS RDNKYVLLAS EQLVGVCLFV FIRPQHAPFI
660 670 680 690 700
RDVAVDTVKT GMGGATGNKG AVAIRMLFHT TSLCFVCSHF AAGQSQVKER
710 720 730 740 750
NEDFIEIARK LSFPMGRMLF SHDYVFWCGD FNYRIDLPNE EVKELIRQQN
760 770 780 790 800
WDSLIAGDQL INQKNAGQVF RGFLEGKVTF APTYKYDLFS DDYDTSEKCR
810 820 830 840 850
TPAWTDRVLW RRRKWPFDRS AEDLDLLNAS FQDESKILYT WTPGTLLHYG
860 870 880 890 900
RAELKTSDHR PVVALIDIDI FEVEAEERQN IYKEVIAVQG PPDGTVLVSI
910 920 930 940 950
KSSLPENNFF DDALIDELLQ QFASFGEVIL IRFVEDKMWV TFLEGSSALN
960 970 980 990 1000
VLSLNGKELL NRTITIALKS PDWIKNLEEE MSLEKISIAL PSSTSSTLLG
1010 1020 1030 1040 1050
EDAEVAADFD MEGDVDDYSA EVEELLPQHL QPSSSSGLGT SPSSSPRTSP
1060 1070 1080 1090 1100
CQSPTISEGP VPSLPIRPSR APSRTPGPPS AQSSPIDAQP ATPLPQKDPA
1110 1120 1130 1140 1150
QPLEPKRPPP PRPVAPPTRP APPQRPPPPS GARSPAPTRK EFGGIGAPPS
1160 1170 1180 1190 1200
PGVARREMEA PKSPGTTRKD NIGRSQPSPQ AGLAGPGPAG YSTARPTIPP
1210 1220 1230 1240 1250
RAGVISAPQS HARASAGRLT PESQSKTSET SKGSTFLPEP LKPQAAFPPQ
1260 1270 1280 1290 1300
SSLPPPAQRL QEPLVPVAAP MPQSGPQPNL ETPPQPPPRS RSSHSLPSEA
1310 1320 1330 1340 1350
SSQPQVKTNG ISDGKRESPL KIDPFEDLSF NLLAVSKAQL SVQTSPVPTP
1360 1370 1380 1390 1400
DPKRLIQLPS ATQSNVLSSV SCMPTMPPIP ARSQSQENMR SSPNPFITGL
1410 1420 1430 1440 1450
TRTNPFSDRT AAPGNPFRAK SEESEATSWF SKEEPVTISP FPSLQPLGHN
1460 1470 1480 1490 1500
KSRASSSLDG FKDSFDLQGQ STLKISNPKG WVTFEEEEDF GVKGKSKSAC
1510 1520 1530 1540 1550
SDLLGNQPSS FSGSNLTLND DWNKGTNVSF CVLPSRRPPP PPVPLLPPGT
1560 1570
SPPVDPFTTL ASKASPTLDF TER
Length:1,573
Mass (Da):173,103
Last modified:November 25, 2008 - v2
Checksum:iD50B249B1EBFFC18
GO
Isoform 2 (identifier: O43426-2) [UniParc]FASTAAdd to basket
Also known as: Synaptojanin-145

The sequence of this isoform differs from the canonical sequence as follows:
     1306-1311: VKTNGI → QEQPSG
     1312-1573: Missing.

Show »
Length:1,311
Mass (Da):144,859
Checksum:i26F2B693F03D2617
GO
Isoform 3 (identifier: O43426-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1144-1159: Missing.
     1306-1311: VKTNGI → QEQPSG
     1312-1573: Missing.

Show »
Length:1,295
Mass (Da):143,254
Checksum:iF082833051AB7F69
GO
Isoform 4 (identifier: O43426-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-451: K → KAGK
     504-511: Missing.
     525-1573: Missing.

Show »
Length:519
Mass (Da):58,068
Checksum:i9B1ECB57B0D071C9
GO

Sequence cautioni

The sequence BAA74933 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1093 – 1108Missing in BAA74933 (PubMed:9428629).CuratedAdd BLAST16
Sequence conflicti1366V → VNT in AAC51922 (PubMed:9428629).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070905219R → Q in PARK20; impairs the phosphatase activity of the enzyme toward phosphatidylinositol-3-phosphate and phosphatidylinositol-4-phosphate. 2 Publications1
Natural variantiVAR_047308295K → R.1 PublicationCorresponds to variant rs2254562dbSNPEnsembl.1
Natural variantiVAR_0473091366V → A.Corresponds to variant rs9980589dbSNPEnsembl.1
Natural variantiVAR_0709061383S → R in PARK20; unknown pathological significance; the patient also carries a heterozygous PINK1 truncating mutation. 1 Publication1
Natural variantiVAR_0593571508P → L.Corresponds to variant rs2230767dbSNPEnsembl.1
Natural variantiVAR_0473101545L → P.Corresponds to variant rs2230767dbSNPEnsembl.1
Natural variantiVAR_0496031547P → L.Corresponds to variant rs2230767dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035709451K → KAGK in isoform 4. 1 Publication1
Alternative sequenceiVSP_035710504 – 511Missing in isoform 4. 1 Publication8
Alternative sequenceiVSP_035711525 – 1573Missing in isoform 4. 1 PublicationAdd BLAST1049
Alternative sequenceiVSP_0415781144 – 1159Missing in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_0026821306 – 1311VKTNGI → QEQPSG in isoform 2 and isoform 3. 2 Publications6
Alternative sequenceiVSP_0026831312 – 1573Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST262

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009039 mRNA. Translation: AAC51921.1.
AF009040 mRNA. Translation: AAC51922.1.
AB020717 mRNA. Translation: BAA74933.2. Different initiation.
AP000275 Genomic DNA. No translation available.
AP000276 Genomic DNA. No translation available.
AP000277 Genomic DNA. No translation available.
AP000278 Genomic DNA. No translation available.
AP000279 Genomic DNA. No translation available.
BC098395 mRNA. Translation: AAH98395.1.
CCDSiCCDS54483.1. [O43426-4]
RefSeqiNP_001153774.1. NM_001160302.1. [O43426-4]
NP_001153778.1. NM_001160306.1.
NP_003886.3. NM_003895.3.
NP_982271.2. NM_203446.2.
XP_016883989.1. XM_017028500.1. [O43426-2]
UniGeneiHs.473632.

Genome annotation databases

EnsembliENST00000357345; ENSP00000349903; ENSG00000159082. [O43426-4]
GeneIDi8867.
KEGGihsa:8867.
UCSCiuc002yqf.2. human. [O43426-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009039 mRNA. Translation: AAC51921.1.
AF009040 mRNA. Translation: AAC51922.1.
AB020717 mRNA. Translation: BAA74933.2. Different initiation.
AP000275 Genomic DNA. No translation available.
AP000276 Genomic DNA. No translation available.
AP000277 Genomic DNA. No translation available.
AP000278 Genomic DNA. No translation available.
AP000279 Genomic DNA. No translation available.
BC098395 mRNA. Translation: AAH98395.1.
CCDSiCCDS54483.1. [O43426-4]
RefSeqiNP_001153774.1. NM_001160302.1. [O43426-4]
NP_001153778.1. NM_001160306.1.
NP_003886.3. NM_003895.3.
NP_982271.2. NM_203446.2.
XP_016883989.1. XM_017028500.1. [O43426-2]
UniGeneiHs.473632.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W80X-ray1.90P1477-1488[»]
Q1458-1469[»]
2DNRNMR-A894-971[»]
2VJ0X-ray1.60P1477-1488[»]
ProteinModelPortaliO43426.
SMRiO43426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114388. 16 interactors.
IntActiO43426. 6 interactors.
MINTiMINT-109209.
STRINGi9606.ENSP00000409667.

PTM databases

DEPODiO43426.
iPTMnetiO43426.
PhosphoSitePlusiO43426.

Polymorphism and mutation databases

BioMutaiSYNJ1.

Proteomic databases

EPDiO43426.
MaxQBiO43426.
PaxDbiO43426.
PeptideAtlasiO43426.
PRIDEiO43426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357345; ENSP00000349903; ENSG00000159082. [O43426-4]
GeneIDi8867.
KEGGihsa:8867.
UCSCiuc002yqf.2. human. [O43426-1]

Organism-specific databases

CTDi8867.
DisGeNETi8867.
GeneCardsiSYNJ1.
HGNCiHGNC:11503. SYNJ1.
HPAiHPA011916.
MalaCardsiSYNJ1.
MIMi604297. gene.
615530. phenotype.
neXtProtiNX_O43426.
OpenTargetsiENSG00000159082.
Orphaneti391411. Atypical juvenile parkinsonism.
PharmGKBiPA36285.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0566. Eukaryota.
COG5329. LUCA.
COG5411. LUCA.
GeneTreeiENSGT00760000119075.
HOGENOMiHOG000007937.
HOVERGENiHBG079225.
InParanoidiO43426.
KOiK20279.
PhylomeDBiO43426.

Enzyme and pathway databases

BioCyciMetaCyc:HS08354-MONOMER.
ZFISH:HS08354-MONOMER.
ReactomeiR-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-1855183. Synthesis of IP2, IP, and Ins in the cytosol.
R-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-HSA-8856828. Clathrin-mediated endocytosis.
SIGNORiO43426.

Miscellaneous databases

ChiTaRSiSYNJ1. human.
EvolutionaryTraceiO43426.
GenomeRNAii8867.
PROiO43426.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159082.
CleanExiHS_SYNJ1.
ExpressionAtlasiO43426. baseline and differential.
GenevisibleiO43426. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
3.60.10.10. 1 hit.
InterProiIPR015047. DUF1866.
IPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR002013. SAC_dom.
[Graphical view]
PfamiPF08952. DUF1866. 1 hit.
PF03372. Exo_endo_phos. 1 hit.
PF02383. Syja_N. 1 hit.
[Graphical view]
SMARTiSM01165. DUF1866. 1 hit.
SM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF56219. SSF56219. 2 hits.
PROSITEiPS50102. RRM. 1 hit.
PS50275. SAC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYNJ1_HUMAN
AccessioniPrimary (citable) accession number: O43426
Secondary accession number(s): O43425, O94984, Q4KMR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 167 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.