O43426 (SYNJ1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptojanin-1
EC=3.1.3.36

Alternative name(s):
Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1

Gene names

Name:	SYNJ1
Synonyms:	KIAA0910

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1573 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inositol 5-phosphatase which has a role in clathrin-mediated endocytosis.
Catalytic activity	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Subunit structure	Interacts with ASH/GRB2 By similarity. Binds AMPH, SH3GL1, SH3GL2 and SH3GL3. Interacts with MYO1E (via SH3 domain). Ref.6 Ref.7
Subcellular location	Cytoplasm By similarity.
Tissue specificity	Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals.
Domain	Binds to EPS15 (a clathrin coat-associated protein) via a C-terminal domain containing three Asn-Pro-Phe (NPF) repeats By similarity. The C-terminal proline-rich region mediates binding to a variety of SH3 domain-containing proteins including AMPH, SH3GL1, SH3GL2, SH3GL3 and GRB2.
Sequence similarities	Belongs to the synaptojanin family. In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. Contains 1 RRM (RNA recognition motif) domain. Contains 1 SAC domain.
Sequence caution	The sequence BAA74933.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	RNA-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylinositol biosynthetic process Traceable author statement. Source: Reactome phosphatidylinositol phosphorylation Inferred from electronic annotation. Source: InterPro small molecule metabolic process Traceable author statement. Source: Reactome synaptic vesicle endocytosis Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW inositol-polyphosphate 5-phosphatase activity Traceable author statement Ref.1. Source: ProtInc nucleotide binding Inferred from electronic annotation. Source: InterPro phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O43426-1)

Also known as: Synaptojanin-170;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43426-2)

Also known as: Synaptojanin-145;

The sequence of this isoform differs from the canonical sequence as follows:
     1306-1311: VKTNGI → QEQPSG
     1312-1573: Missing.

Isoform 3 (identifier: O43426-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1144-1159: Missing.
     1306-1311: VKTNGI → QEQPSG
     1312-1573: Missing.

Isoform 4 (identifier: O43426-5)

The sequence of this isoform differs from the canonical sequence as follows:
     451-451: K → KAGK
     504-511: Missing.
     525-1573: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1573

1573

Synaptojanin-1

PRO_0000209730

Regions

Domain

119 – 442

324

SAC

Domain

902 – 971

70

RRM

Repeat

1396 – 1398

3

1

Repeat

1406 – 1408

3

2

Repeat

1417 – 1419

3

3

Region

500 – 899

400

Catalytic Potential

Region

1396 – 1419

24

3 X 3 AA repeats of N-P-F

Compositional bias

900 – 1573

674

Pro-rich

Compositional bias

1033 – 1036

4

Poly-Ser

Compositional bias

1108 – 1113

6

Poly-Pro

Compositional bias

1126 – 1129

4

Poly-Pro

Compositional bias

1485 – 1488

4

Poly-Glu

Compositional bias

1538 – 1544

7

Poly-Pro

Amino acid modifications

Modified residue

784

1

Phosphotyrosine By similarity

Modified residue

786

1

Phosphotyrosine By similarity

Modified residue

830

1

Phosphoserine Ref.8 Ref.9

Modified residue

1048

1

Phosphothreonine By similarity

Modified residue

1053

1

Phosphoserine By similarity

Modified residue

1084

1

Phosphoserine By similarity

Modified residue

1150

1

Phosphoserine By similarity

Modified residue

1220

1

Phosphothreonine Ref.8

Modified residue

1318

1

Phosphoserine Ref.10

Modified residue

1345

1

Phosphoserine By similarity

Modified residue

1349

1

Phosphothreonine By similarity

Modified residue

1551

1

Phosphoserine Ref.8

Modified residue

1565

1

Phosphoserine Ref.8

Natural variations

Alternative sequence

451

1

K → KAGK in isoform 4.

VSP_035709

Alternative sequence

504 – 511

8

Missing in isoform 4.

VSP_035710

Alternative sequence

525 – 1573

1049

Missing in isoform 4.

VSP_035711

Alternative sequence

1144 – 1159

16

Missing in isoform 3.

VSP_041578

Alternative sequence

1306 – 1311

6

VKTNGI → QEQPSG in isoform 2 and isoform 3.

VSP_002682

Alternative sequence

1312 – 1573

262

Missing in isoform 2 and isoform 3.

VSP_002683

Natural variant

295

1

K → R. Ref.1
Corresponds to variant rs2254562 [ dbSNP | Ensembl ].

VAR_047308

Natural variant

1366

1

V → A.
Corresponds to variant rs9980589 [ dbSNP | Ensembl ].

VAR_047309

Natural variant

1508

1

P → L.
Corresponds to variant rs2230767 [ dbSNP | Ensembl ].

VAR_059357

Natural variant

1545

1

L → P.
Corresponds to variant rs2230767 [ dbSNP | Ensembl ].

VAR_047310

Natural variant

1547

1

P → L.
Corresponds to variant rs2230767 [ dbSNP | Ensembl ].

VAR_049603

Experimental info

Sequence conflict

1093 – 1108

16

Missing in BAA74933. Ref.1

Sequence conflict

1366

1

V → VNT in AAC51922. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1573

Helix Strand Turn

Details...

Beta strand

895 – 901

7

Turn

905 – 907

3

Helix

912 – 923

12

Beta strand

928 – 933

6

Beta strand

935 – 944

10

Helix

945 – 950

6

Helix

951 – 954

4

Beta strand

962 – 968

7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Synaptojanin-170) [UniParc]. Last modified November 25, 2008. Version 2. Checksum: D50B249B1EBFFC18	FASTA	1,573	173,103
	10 20 30 40 50 60 MAFSKGFRIY HKLDPPPFSL IVETRHKEEC LMFESGAVAV LSSAEKEAIK GTYSKVLDAY 70 80 90 100 110 120 GLLGVLRLNL GDTMLHYLVL VTGCMSVGKI QESEVFRVTS TEFISLRIDS SDEDRISEVR 130 140 150 160 170 180 KVLNSGNFYF AWSASGISLD LSLNAHRSMQ EQTTDNRFFW NQSLHLHLKH YGVNCDDWLL 190 200 210 220 230 240 RLMCGGVEIR TIYAAHKQAK ACLISRLSCE RAGTRFNVRG TNDDGHVANF VETEQVVYLD 250 260 270 280 290 300 DSVSSFIQIR GSVPLFWEQP GLQVGSHRVR MSRGFEANAP AFDRHFRTLK NLYGKQIIVN 310 320 330 340 350 360 LLGSKEGEHM LSKAFQSHLK ASEHAADIQM VNFDYHQMVK GGKAEKLHSV LKPQVQKFLD 370 380 390 400 410 420 YGFFYFNGSE VQRCQSGTVR TNCLDCLDRT NSVQAFLGLE MLAKQLEALG LAEKPQLVTR 430 440 450 460 470 480 FQEVFRSMWS VNGDSISKIY AGTGALEGKA KLKDGARSVT RTIQNNFFDS SKQEAIDVLL 490 500 510 520 530 540 LGNTLNSDLA DKARALLTTG SLRVSEQTLQ SASSKVLKSM CENFYKYSKP KKIRVCVGTW 550 560 570 580 590 600 NVNGGKQFRS IAFKNQTLTD WLLDAPKLAG IQEFQDKRSK PTDIFAIGFE EMVELNAGNI 610 620 630 640 650 660 VSASTTNQKL WAVELQKTIS RDNKYVLLAS EQLVGVCLFV FIRPQHAPFI RDVAVDTVKT 670 680 690 700 710 720 GMGGATGNKG AVAIRMLFHT TSLCFVCSHF AAGQSQVKER NEDFIEIARK LSFPMGRMLF 730 740 750 760 770 780 SHDYVFWCGD FNYRIDLPNE EVKELIRQQN WDSLIAGDQL INQKNAGQVF RGFLEGKVTF 790 800 810 820 830 840 APTYKYDLFS DDYDTSEKCR TPAWTDRVLW RRRKWPFDRS AEDLDLLNAS FQDESKILYT 850 860 870 880 890 900 WTPGTLLHYG RAELKTSDHR PVVALIDIDI FEVEAEERQN IYKEVIAVQG PPDGTVLVSI 910 920 930 940 950 960 KSSLPENNFF DDALIDELLQ QFASFGEVIL IRFVEDKMWV TFLEGSSALN VLSLNGKELL 970 980 990 1000 1010 1020 NRTITIALKS PDWIKNLEEE MSLEKISIAL PSSTSSTLLG EDAEVAADFD MEGDVDDYSA 1030 1040 1050 1060 1070 1080 EVEELLPQHL QPSSSSGLGT SPSSSPRTSP CQSPTISEGP VPSLPIRPSR APSRTPGPPS 1090 1100 1110 1120 1130 1140 AQSSPIDAQP ATPLPQKDPA QPLEPKRPPP PRPVAPPTRP APPQRPPPPS GARSPAPTRK 1150 1160 1170 1180 1190 1200 EFGGIGAPPS PGVARREMEA PKSPGTTRKD NIGRSQPSPQ AGLAGPGPAG YSTARPTIPP 1210 1220 1230 1240 1250 1260 RAGVISAPQS HARASAGRLT PESQSKTSET SKGSTFLPEP LKPQAAFPPQ SSLPPPAQRL 1270 1280 1290 1300 1310 1320 QEPLVPVAAP MPQSGPQPNL ETPPQPPPRS RSSHSLPSEA SSQPQVKTNG ISDGKRESPL 1330 1340 1350 1360 1370 1380 KIDPFEDLSF NLLAVSKAQL SVQTSPVPTP DPKRLIQLPS ATQSNVLSSV SCMPTMPPIP 1390 1400 1410 1420 1430 1440 ARSQSQENMR SSPNPFITGL TRTNPFSDRT AAPGNPFRAK SEESEATSWF SKEEPVTISP 1450 1460 1470 1480 1490 1500 FPSLQPLGHN KSRASSSLDG FKDSFDLQGQ STLKISNPKG WVTFEEEEDF GVKGKSKSAC 1510 1520 1530 1540 1550 1560 SDLLGNQPSS FSGSNLTLND DWNKGTNVSF CVLPSRRPPP PPVPLLPPGT SPPVDPFTTL 1570 ASKASPTLDF TER
	Isoform 2 (Synaptojanin-145) [UniParc]. Checksum: 26F2B693F03D2617	FASTA	1,311	144,859
	10 20 30 40 50 60 MAFSKGFRIY HKLDPPPFSL IVETRHKEEC LMFESGAVAV LSSAEKEAIK GTYSKVLDAY 70 80 90 100 110 120 GLLGVLRLNL GDTMLHYLVL VTGCMSVGKI QESEVFRVTS TEFISLRIDS SDEDRISEVR 130 140 150 160 170 180 KVLNSGNFYF AWSASGISLD LSLNAHRSMQ EQTTDNRFFW NQSLHLHLKH YGVNCDDWLL 190 200 210 220 230 240 RLMCGGVEIR TIYAAHKQAK ACLISRLSCE RAGTRFNVRG TNDDGHVANF VETEQVVYLD 250 260 270 280 290 300 DSVSSFIQIR GSVPLFWEQP GLQVGSHRVR MSRGFEANAP AFDRHFRTLK NLYGKQIIVN 310 320 330 340 350 360 LLGSKEGEHM LSKAFQSHLK ASEHAADIQM VNFDYHQMVK GGKAEKLHSV LKPQVQKFLD 370 380 390 400 410 420 YGFFYFNGSE VQRCQSGTVR TNCLDCLDRT NSVQAFLGLE MLAKQLEALG LAEKPQLVTR 430 440 450 460 470 480 FQEVFRSMWS VNGDSISKIY AGTGALEGKA KLKDGARSVT RTIQNNFFDS SKQEAIDVLL 490 500 510 520 530 540 LGNTLNSDLA DKARALLTTG SLRVSEQTLQ SASSKVLKSM CENFYKYSKP KKIRVCVGTW 550 560 570 580 590 600 NVNGGKQFRS IAFKNQTLTD WLLDAPKLAG IQEFQDKRSK PTDIFAIGFE EMVELNAGNI 610 620 630 640 650 660 VSASTTNQKL WAVELQKTIS RDNKYVLLAS EQLVGVCLFV FIRPQHAPFI RDVAVDTVKT 670 680 690 700 710 720 GMGGATGNKG AVAIRMLFHT TSLCFVCSHF AAGQSQVKER NEDFIEIARK LSFPMGRMLF 730 740 750 760 770 780 SHDYVFWCGD FNYRIDLPNE EVKELIRQQN WDSLIAGDQL INQKNAGQVF RGFLEGKVTF 790 800 810 820 830 840 APTYKYDLFS DDYDTSEKCR TPAWTDRVLW RRRKWPFDRS AEDLDLLNAS FQDESKILYT 850 860 870 880 890 900 WTPGTLLHYG RAELKTSDHR PVVALIDIDI FEVEAEERQN IYKEVIAVQG PPDGTVLVSI 910 920 930 940 950 960 KSSLPENNFF DDALIDELLQ QFASFGEVIL IRFVEDKMWV TFLEGSSALN VLSLNGKELL 970 980 990 1000 1010 1020 NRTITIALKS PDWIKNLEEE MSLEKISIAL PSSTSSTLLG EDAEVAADFD MEGDVDDYSA 1030 1040 1050 1060 1070 1080 EVEELLPQHL QPSSSSGLGT SPSSSPRTSP CQSPTISEGP VPSLPIRPSR APSRTPGPPS 1090 1100 1110 1120 1130 1140 AQSSPIDAQP ATPLPQKDPA QPLEPKRPPP PRPVAPPTRP APPQRPPPPS GARSPAPTRK 1150 1160 1170 1180 1190 1200 EFGGIGAPPS PGVARREMEA PKSPGTTRKD NIGRSQPSPQ AGLAGPGPAG YSTARPTIPP 1210 1220 1230 1240 1250 1260 RAGVISAPQS HARASAGRLT PESQSKTSET SKGSTFLPEP LKPQAAFPPQ SSLPPPAQRL 1270 1280 1290 1300 1310 QEPLVPVAAP MPQSGPQPNL ETPPQPPPRS RSSHSLPSEA SSQPQQEQPS G
	Isoform 3 [UniParc]. Checksum: F082833051AB7F69	FASTA	1,295	143,254
	10 20 30 40 50 60 MAFSKGFRIY HKLDPPPFSL IVETRHKEEC LMFESGAVAV LSSAEKEAIK GTYSKVLDAY 70 80 90 100 110 120 GLLGVLRLNL GDTMLHYLVL VTGCMSVGKI QESEVFRVTS TEFISLRIDS SDEDRISEVR 130 140 150 160 170 180 KVLNSGNFYF AWSASGISLD LSLNAHRSMQ EQTTDNRFFW NQSLHLHLKH YGVNCDDWLL 190 200 210 220 230 240 RLMCGGVEIR TIYAAHKQAK ACLISRLSCE RAGTRFNVRG TNDDGHVANF VETEQVVYLD 250 260 270 280 290 300 DSVSSFIQIR GSVPLFWEQP GLQVGSHRVR MSRGFEANAP AFDRHFRTLK NLYGKQIIVN 310 320 330 340 350 360 LLGSKEGEHM LSKAFQSHLK ASEHAADIQM VNFDYHQMVK GGKAEKLHSV LKPQVQKFLD 370 380 390 400 410 420 YGFFYFNGSE VQRCQSGTVR TNCLDCLDRT NSVQAFLGLE MLAKQLEALG LAEKPQLVTR 430 440 450 460 470 480 FQEVFRSMWS VNGDSISKIY AGTGALEGKA KLKDGARSVT RTIQNNFFDS SKQEAIDVLL 490 500 510 520 530 540 LGNTLNSDLA DKARALLTTG SLRVSEQTLQ SASSKVLKSM CENFYKYSKP KKIRVCVGTW 550 560 570 580 590 600 NVNGGKQFRS IAFKNQTLTD WLLDAPKLAG IQEFQDKRSK PTDIFAIGFE EMVELNAGNI 610 620 630 640 650 660 VSASTTNQKL WAVELQKTIS RDNKYVLLAS EQLVGVCLFV FIRPQHAPFI RDVAVDTVKT 670 680 690 700 710 720 GMGGATGNKG AVAIRMLFHT TSLCFVCSHF AAGQSQVKER NEDFIEIARK LSFPMGRMLF 730 740 750 760 770 780 SHDYVFWCGD FNYRIDLPNE EVKELIRQQN WDSLIAGDQL INQKNAGQVF RGFLEGKVTF 790 800 810 820 830 840 APTYKYDLFS DDYDTSEKCR TPAWTDRVLW RRRKWPFDRS AEDLDLLNAS FQDESKILYT 850 860 870 880 890 900 WTPGTLLHYG RAELKTSDHR PVVALIDIDI FEVEAEERQN IYKEVIAVQG PPDGTVLVSI 910 920 930 940 950 960 KSSLPENNFF DDALIDELLQ QFASFGEVIL IRFVEDKMWV TFLEGSSALN VLSLNGKELL 970 980 990 1000 1010 1020 NRTITIALKS PDWIKNLEEE MSLEKISIAL PSSTSSTLLG EDAEVAADFD MEGDVDDYSA 1030 1040 1050 1060 1070 1080 EVEELLPQHL QPSSSSGLGT SPSSSPRTSP CQSPTISEGP VPSLPIRPSR APSRTPGPPS 1090 1100 1110 1120 1130 1140 AQSSPIDAQP ATPLPQKDPA QPLEPKRPPP PRPVAPPTRP APPQRPPPPS GARSPAPTRK 1150 1160 1170 1180 1190 1200 EFGAPKSPGT TRKDNIGRSQ PSPQAGLAGP GPAGYSTARP TIPPRAGVIS APQSHARASA 1210 1220 1230 1240 1250 1260 GRLTPESQSK TSETSKGSTF LPEPLKPQAA FPPQSSLPPP AQRLQEPLVP VAAPMPQSGP 1270 1280 1290 QPNLETPPQP PPRSRSSHSL PSEASSQPQQ EQPSG
	Isoform 4 [UniParc]. Checksum: 9B1ECB57B0D071C9	FASTA	519	58,068
	10 20 30 40 50 60 MAFSKGFRIY HKLDPPPFSL IVETRHKEEC LMFESGAVAV LSSAEKEAIK GTYSKVLDAY 70 80 90 100 110 120 GLLGVLRLNL GDTMLHYLVL VTGCMSVGKI QESEVFRVTS TEFISLRIDS SDEDRISEVR 130 140 150 160 170 180 KVLNSGNFYF AWSASGISLD LSLNAHRSMQ EQTTDNRFFW NQSLHLHLKH YGVNCDDWLL 190 200 210 220 230 240 RLMCGGVEIR TIYAAHKQAK ACLISRLSCE RAGTRFNVRG TNDDGHVANF VETEQVVYLD 250 260 270 280 290 300 DSVSSFIQIR GSVPLFWEQP GLQVGSHRVR MSRGFEANAP AFDRHFRTLK NLYGKQIIVN 310 320 330 340 350 360 LLGSKEGEHM LSKAFQSHLK ASEHAADIQM VNFDYHQMVK GGKAEKLHSV LKPQVQKFLD 370 380 390 400 410 420 YGFFYFNGSE VQRCQSGTVR TNCLDCLDRT NSVQAFLGLE MLAKQLEALG LAEKPQLVTR 430 440 450 460 470 480 FQEVFRSMWS VNGDSISKIY AGTGALEGKA KAGKLKDGAR SVTRTIQNNF FDSSKQEAID 490 500 510 VLLLGNTLNS DLADKARALL TTGSLRASSK VLKSMCENF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15." Haffner C., Takei K., Chen H., Ringstad N., Hudson A., Butler M.H., Salcini A.E., Di Fiore P.P., De Camilli P. FEBS Lett. 419:175-180(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-295. Tissue: Cerebellum.
[2]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[3]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[4]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Placenta.
[6]	"The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity." Cestra G., Castagnoli L., Dente L., Minenkova O., Petrelli A., Migone N., Hoffmueller U., Schneider-Mergener J., Cesareni G. J. Biol. Chem. 274:32001-32007(1999) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AMPH; SH3GL1; SH3GL2 AND SH3GL3.
[7]	"Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis." Krendel M., Osterweil E.K., Mooseker M.S. FEBS Lett. 581:644-650(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MYO1E.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-830; THR-1220; SER-1551 AND SER-1565, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-830, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1318, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Solution structure of RNA binding domain in synaptojanin 1." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 894-971.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF009039 mRNA. Translation: AAC51921.1.
AF009040 mRNA. Translation: AAC51922.1.
AB020717 mRNA. Translation: BAA74933.2. Different initiation.
AP000275 Genomic DNA. No translation available.
AP000276 Genomic DNA. No translation available.
AP000277 Genomic DNA. No translation available.
AP000278 Genomic DNA. No translation available.
AP000279 Genomic DNA. No translation available.
BC098395 mRNA. Translation: AAH98395.1.

IPI

IPI00012441.
IPI00333134.
IPI00386631.
IPI00658095.

RefSeq

NP_001153774.1. NM_001160302.1.
NP_001153778.1. NM_001160306.1.
NP_003886.3. NM_003895.3.
NP_982271.2. NM_203446.2.

UniGene

Hs.473632.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1W80	X-ray	1.90	P	1477-1488	[»]
			Q	1458-1469	[»]
2DNR	NMR	-	A	894-971	[»]
2VJ0	X-ray	1.60	P	1477-1488	[»]

ProteinModelPortal

O43426.

ModBase

Search...

Protein-protein interaction databases

IntAct

O43426. 3 interactions.

MINT

MINT-109209.

STRING

9606.ENSP00000322234.

PTM databases

PhosphoSite

O43426.

Proteomic databases

PaxDb

O43426.

PRIDE

O43426.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000322229; ENSP00000322234; ENSG00000159082.
ENST00000357345; ENSP00000349903; ENSG00000159082.

GeneID

8867.

KEGG

hsa:8867.

UCSC

uc002yqf.2. human.
uc002yqg.2. human.

Organism-specific databases

CTD

8867.

GeneCards

GC21M033997.

HGNC

HGNC:11503. SYNJ1.

HPA

HPA011916.

MIM

604297. gene.

neXtProt

NX_O43426.

PharmGKB

PA36285.

HUGE

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GenAtlas

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Phylogenomic databases

eggNOG

COG5411.

HOGENOM

HOG000007937.

HOVERGEN

HBG079225.

InParanoid

O43426.

KO

K01099.

Enzyme and pathway databases

BioCyc

MetaCyc:HS08354-MONOMER.

Pathway_Interaction_DB

ephbfwdpathway. EPHB forward signaling.

Reactome

REACT_111217. Metabolism.

Gene expression databases

ArrayExpress

O43426.

Bgee

O43426.

CleanEx

HS_SYNJ1.

Genevestigator

O43426.

GermOnline

ENSG00000159082. Homo sapiens.

Family and domain databases

Gene3D

3.30.70.330. 1 hit.

InterPro

IPR015047. DUF1866.
IPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR002013. Syja_N.
[Graphical view]

Pfam

PF08952. DUF1866. 1 hit.
PF03372. Exo_endo_phos. 1 hit.
PF02383. Syja_N. 1 hit.
[Graphical view]

SMART

SM00128. IPPc. 1 hit.
[Graphical view]

SUPFAM

SSF56219. Exo_endo_phos. 1 hit.

PROSITE

PS50102. RRM. 1 hit.
PS50275. SAC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

O43426.

GenomeRNAi

8867.

NextBio

33289.

SOURCE

Search...

Entry information

Entry name

SYNJ1_HUMAN

Accession

Primary (citable) accession number: O43426
Secondary accession number(s): O43425, O94984, Q4KMR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 133 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.