Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O43424

- GRID2_HUMAN

UniProt

O43424 - GRID2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glutamate receptor ionotropic, delta-2

Gene

GRID2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

GO - Molecular functioni

  1. extracellular-glutamate-gated ion channel activity Source: RefGenome
  2. glutamate receptor activity Source: ProtInc
  3. ionotropic glutamate receptor activity Source: RefGenome
  4. PDZ domain binding Source: BHF-UCL
  5. scaffold protein binding Source: BHF-UCL

GO - Biological processi

  1. cellular protein localization Source: BHF-UCL
  2. cerebellar granule cell differentiation Source: BHF-UCL
  3. glutamate receptor signaling pathway Source: ProtInc
  4. heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
  5. ionotropic glutamate receptor signaling pathway Source: RefGenome
  6. ion transmembrane transport Source: RefGenome
  7. prepulse inhibition Source: BHF-UCL
  8. regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
  9. regulation of neuron apoptotic process Source: BHF-UCL
  10. regulation of neuron projection development Source: Ensembl
  11. synaptic transmission, glutamatergic Source: BHF-UCL
  12. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, delta-2
Short name:
GluD2
Short name:
GluR delta-2 subunit
Gene namesi
Name:GRID2
Synonyms:GLURD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:4576. GRID2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 566543ExtracellularSequence AnalysisAdd
BLAST
Transmembranei567 – 58721HelicalSequence AnalysisAdd
BLAST
Topological domaini588 – 63548CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei636 – 65621HelicalSequence AnalysisAdd
BLAST
Topological domaini657 – 830174ExtracellularSequence AnalysisAdd
BLAST
Transmembranei831 – 85121HelicalSequence AnalysisAdd
BLAST
Topological domaini852 – 1007156CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. dendrite Source: RefGenome
  3. dendritic spine Source: BHF-UCL
  4. integral component of plasma membrane Source: ProtInc
  5. ionotropic glutamate receptor complex Source: BHF-UCL
  6. plasma membrane Source: BHF-UCL
  7. postsynaptic membrane Source: RefGenome
  8. synapse Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

Orphaneti363432. Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency.
PharmGKBiPA28971.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 1007984Glutamate receptor ionotropic, delta-2PRO_0000011564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO43424.
PaxDbiO43424.
PRIDEiO43424.

PTM databases

PhosphoSiteiO43424.

Expressioni

Gene expression databases

BgeeiO43424.
CleanExiHS_GRID2.
ExpressionAtlasiO43424. baseline and differential.
GenevestigatoriO43424.

Interactioni

Subunit structurei

Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2. Interacts with EML2 (By similarity). Interacts with CBLN1 and CBLN2, but not with CBLN4. CBLN1-binding is calcium-independent (By similarity).By similarity

Protein-protein interaction databases

BioGridi109152. 7 interactions.
MINTiMINT-257823.
STRINGi9606.ENSP00000282020.

Structurei

3D structure databases

ProteinModelPortaliO43424.
SMRiO43424. Positions 27-857.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni921 – 99171Interaction with AP4M1By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1005 – 10073PDZ-bindingBy similarity

Domaini

The PDZ-binding motif mediates interaction with GOPC.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG276334.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000264260.
HOVERGENiHBG051840.
InParanoidiO43424.
KOiK05207.
OMAiHGNYAFV.
OrthoDBiEOG7KQ20V.
PhylomeDBiO43424.
TreeFamiTF352434.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43424-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVFPFLLVL SVWWSRTWDS ANADSIIHIG AIFDESAKKD DEVFRTAVGD
60 70 80 90 100
LNQNEEILQT EKITFSVTFV DGNNPFQAVQ EACELMNQGI LALVSSIGCT
110 120 130 140 150
SAGSLQSLAD AMHIPHLFIQ RSTAGTPRSG CGLTRSNRND DYTLSVRPPV
160 170 180 190 200
YLHDVILRVV TEYAWQKFII FYDSEYDIRG IQEFLDKVSQ QGMDVALQKV
210 220 230 240 250
ENNINKMITT LFDTMRIEEL NRYRDTLRRA ILVMNPATAK SFITEVVETN
260 270 280 290 300
LVAFDCHWII INEEINDVDV QELVRRSIGR LTIIRQTFPV PQNISQRCFR
310 320 330 340 350
GNHRISSTLC DPKDPFAQNM EISNLYIYDT VLLLANAFHK KLEDRKWHSM
360 370 380 390 400
ASLSCIRKNS KPWQGGRSML ETIKKGGVSG LTGELEFGEN GGNPNVHFEI
410 420 430 440 450
LGTNYGEELG RGVRKLGCWN PVTGLNGSLT DKKLENNMRG VVLRVVTVLE
460 470 480 490 500
EPFVMVSENV LGKPKKYQGF SIDVLDALSN YLGFNYEIYV APDHKYGSPQ
510 520 530 540 550
EDGTWNGLVG ELVFKRADIG ISALTITPDR ENVVDFTTRY MDYSVGVLLR
560 570 580 590 600
RAEKTVDMFA CLAPFDLSLW ACIAGTVLLV GLLVYLLNWL NPPRLQMGSM
610 620 630 640 650
TSTTLYNSMW FVYGSFVQQG GEVPYTTLAT RMMMGAWWLF ALIVISSYTA
660 670 680 690 700
NLAAFLTITR IESSIQSLQD LSKQTEIPYG TVLDSAVYEH VRMKGLNPFE
710 720 730 740 750
RDSMYSQMWR MINRSNGSEN NVLESQAGIQ KVKYGNYAFV WDAAVLEYVA
760 770 780 790 800
INDPDCSFYT IGNTVADRGY GIALQHGSPY RDVFSQRILE LQQNGDMDIL
810 820 830 840 850
KHKWWPKNGQ CDLYSSVDTK QKGGALDIKS FAGVFCILAA GIVLSCFIAM
860 870 880 890 900
LETWWNKRKG SRVPSKEDDK EIDLEHLHRR VNSLCTDDDS PHKQFSTSSI
910 920 930 940 950
DLTPLDIDTL PTRQALEQIS DFRNTHITTT TFIPEQIQTL SRTLSAKAAS
960 970 980 990 1000
GFTFGNVPEH RTGPFRHRAP NGGFFRSPIK TMSSIPYQPT PTLGLNLGND

PDRGTSI
Length:1,007
Mass (Da):113,356
Last modified:May 5, 2009 - v2
Checksum:i8EF938AB7F1D6D26
GO
Isoform 2 (identifier: O43424-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-176: Missing.

Show »
Length:912
Mass (Da):102,822
Checksum:iA82226A9B772131B
GO

Sequence cautioni

The sequence BAD92555.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61F → L in AAC39579. (PubMed:9465309)Curated
Sequence conflicti6 – 61F → L in AAH99652. (PubMed:15489334)Curated
Sequence conflicti6 – 61F → L in AAH99653. (PubMed:15489334)Curated
Sequence conflicti6 – 61F → L in AAH99654. (PubMed:15489334)Curated
Sequence conflicti8 – 81L → F in AAH99652. (PubMed:15489334)Curated
Sequence conflicti290 – 2901V → I in AAC39579. (PubMed:9465309)Curated
Sequence conflicti462 – 4621G → C in AAC39579. (PubMed:9465309)Curated
Sequence conflicti557 – 5571D → E in AAH99652. (PubMed:15489334)Curated
Sequence conflicti752 – 7521N → Y in AAC39579. (PubMed:9465309)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681T → M.1 Publication
Corresponds to variant rs34144324 [ dbSNP | Ensembl ].
VAR_055016
Natural varianti209 – 2091T → N in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035697
Natural varianti398 – 3981F → S.
Corresponds to variant rs34796082 [ dbSNP | Ensembl ].
VAR_055017
Natural varianti490 – 4901V → I.
Corresponds to variant rs10034345 [ dbSNP | Ensembl ].
VAR_055018

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei82 – 17695Missing in isoform 2. 1 PublicationVSP_054704Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009014 mRNA. Translation: AAC39579.1.
AB209318 mRNA. Translation: BAD92555.1. Different initiation.
AC020699 Genomic DNA. No translation available.
AC022317 Genomic DNA. No translation available.
AC093596 Genomic DNA. No translation available.
AC093733 Genomic DNA. No translation available.
AC095059 Genomic DNA. No translation available.
AC096769 Genomic DNA. No translation available.
AC104077 Genomic DNA. No translation available.
AC105315 Genomic DNA. No translation available.
AC105452 Genomic DNA. No translation available.
AC108158 Genomic DNA. No translation available.
AC110800 Genomic DNA. No translation available.
AC112695 Genomic DNA. No translation available.
AC115111 Genomic DNA. No translation available.
AC115537 Genomic DNA. No translation available.
BC099652 mRNA. Translation: AAH99652.1.
BC099653 mRNA. Translation: AAH99653.1.
BC099654 mRNA. Translation: AAH99654.1.
CCDSiCCDS3637.1. [O43424-1]
CCDS68758.1. [O43424-2]
RefSeqiNP_001273767.1. NM_001286838.1. [O43424-2]
NP_001501.2. NM_001510.3. [O43424-1]
UniGeneiHs.162727.
Hs.480281.

Genome annotation databases

EnsembliENST00000282020; ENSP00000282020; ENSG00000152208. [O43424-1]
ENST00000510992; ENSP00000421257; ENSG00000152208. [O43424-2]
GeneIDi2895.
KEGGihsa:2895.
UCSCiuc011cdt.2. human. [O43424-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009014 mRNA. Translation: AAC39579.1 .
AB209318 mRNA. Translation: BAD92555.1 . Different initiation.
AC020699 Genomic DNA. No translation available.
AC022317 Genomic DNA. No translation available.
AC093596 Genomic DNA. No translation available.
AC093733 Genomic DNA. No translation available.
AC095059 Genomic DNA. No translation available.
AC096769 Genomic DNA. No translation available.
AC104077 Genomic DNA. No translation available.
AC105315 Genomic DNA. No translation available.
AC105452 Genomic DNA. No translation available.
AC108158 Genomic DNA. No translation available.
AC110800 Genomic DNA. No translation available.
AC112695 Genomic DNA. No translation available.
AC115111 Genomic DNA. No translation available.
AC115537 Genomic DNA. No translation available.
BC099652 mRNA. Translation: AAH99652.1 .
BC099653 mRNA. Translation: AAH99653.1 .
BC099654 mRNA. Translation: AAH99654.1 .
CCDSi CCDS3637.1. [O43424-1 ]
CCDS68758.1. [O43424-2 ]
RefSeqi NP_001273767.1. NM_001286838.1. [O43424-2 ]
NP_001501.2. NM_001510.3. [O43424-1 ]
UniGenei Hs.162727.
Hs.480281.

3D structure databases

ProteinModelPortali O43424.
SMRi O43424. Positions 27-857.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109152. 7 interactions.
MINTi MINT-257823.
STRINGi 9606.ENSP00000282020.

Chemistry

GuidetoPHARMACOLOGYi 449.

PTM databases

PhosphoSitei O43424.

Proteomic databases

MaxQBi O43424.
PaxDbi O43424.
PRIDEi O43424.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000282020 ; ENSP00000282020 ; ENSG00000152208 . [O43424-1 ]
ENST00000510992 ; ENSP00000421257 ; ENSG00000152208 . [O43424-2 ]
GeneIDi 2895.
KEGGi hsa:2895.
UCSCi uc011cdt.2. human. [O43424-1 ]

Organism-specific databases

CTDi 2895.
GeneCardsi GC04P093225.
H-InvDB HIX0031353.
HGNCi HGNC:4576. GRID2.
MIMi 602368. gene.
neXtProti NX_O43424.
Orphaneti 363432. Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency.
PharmGKBi PA28971.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276334.
GeneTreei ENSGT00760000118920.
HOGENOMi HOG000264260.
HOVERGENi HBG051840.
InParanoidi O43424.
KOi K05207.
OMAi HGNYAFV.
OrthoDBi EOG7KQ20V.
PhylomeDBi O43424.
TreeFami TF352434.

Miscellaneous databases

ChiTaRSi GRID2. human.
GeneWikii GRID2.
GenomeRNAii 2895.
NextBioi 11455.
PROi O43424.
SOURCEi Search...

Gene expression databases

Bgeei O43424.
CleanExi HS_GRID2.
ExpressionAtlasi O43424. baseline and differential.
Genevestigatori O43424.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view ]
PRINTSi PR00177. NMDARECEPTOR.
SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22."
    Hu W., Zuo J., De Jager P.L., Heintz N.
    Genomics 47:143-145(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Cerebellum.
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-68.
    Tissue: Brain.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-209.

Entry informationi

Entry nameiGRID2_HUMAN
AccessioniPrimary (citable) accession number: O43424
Secondary accession number(s): E9PH24
, Q4KKU8, Q4KKU9, Q4KKV0, Q59FZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 5, 2009
Last modified: November 26, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3