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Protein

Glutamate receptor ionotropic, delta-2

Gene

GRID2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, delta-2
Short name:
GluD2
Short name:
GluR delta-2 subunit
Gene namesi
Name:GRID2
Synonyms:GLURD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4576. GRID2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 566ExtracellularSequence analysisAdd BLAST543
Transmembranei567 – 587HelicalSequence analysisAdd BLAST21
Topological domaini588 – 635CytoplasmicSequence analysisAdd BLAST48
Transmembranei636 – 656HelicalSequence analysisAdd BLAST21
Topological domaini657 – 830ExtracellularSequence analysisAdd BLAST174
Transmembranei831 – 851HelicalSequence analysisAdd BLAST21
Topological domaini852 – 1007CytoplasmicSequence analysisAdd BLAST156

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Spinocerebellar ataxia, autosomal recessive, 18 (SCAR18)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSpinocerebellar ataxia defines a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR18 features include progressive cerebellar atrophy, delayed psychomotor development, severely impaired gait, ocular movement abnormalities, and intellectual disability.
See also OMIM:616204
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074166654A → D in SCAR18. 1 Publication1
Natural variantiVAR_074167654A → T in SCAR18. 1 Publication1
Natural variantiVAR_074168656L → V in SCAR18. 1 Publication1

Keywords - Diseasei

Neurodegeneration

Organism-specific databases

DisGeNETi2895.
MalaCardsiGRID2.
MIMi616204. phenotype.
OpenTargetsiENSG00000152208.
Orphaneti363432. Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency.
PharmGKBiPA28971.

Polymorphism and mutation databases

BioMutaiGRID2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001156424 – 1007Glutamate receptor ionotropic, delta-2Add BLAST984

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi293N-linked (GlcNAc...)Sequence analysis1
Glycosylationi426N-linked (GlcNAc...)Sequence analysis1
Modified residuei883PhosphoserineBy similarity1
Modified residuei886PhosphothreonineBy similarity1
Modified residuei890PhosphoserineBy similarity1
Modified residuei1006PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO43424.
PaxDbiO43424.
PeptideAtlasiO43424.
PRIDEiO43424.

PTM databases

iPTMnetiO43424.
PhosphoSitePlusiO43424.

Expressioni

Gene expression databases

BgeeiENSG00000152208.
CleanExiHS_GRID2.
ExpressionAtlasiO43424. baseline and differential.
GenevisibleiO43424. HS.

Organism-specific databases

HPAiHPA056253.
HPA058538.

Interactioni

Subunit structurei

Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2. Interacts with EML2 (By similarity). Interacts with CBLN1 and CBLN2, but not with CBLN4. CBLN1-binding is calcium-independent (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109152. 7 interactors.
MINTiMINT-257823.
STRINGi9606.ENSP00000282020.

Structurei

Secondary structure

11007
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 34Combined sources8
Helixi38 – 53Combined sources16
Beta strandi63 – 70Combined sources8
Helixi75 – 88Combined sources14
Beta strandi93 – 97Combined sources5
Helixi99 – 112Combined sources14
Beta strandi116 – 120Combined sources5
Beta strandi137 – 139Combined sources3
Beta strandi143 – 145Combined sources3
Helixi152 – 162Combined sources11
Beta strandi167 – 172Combined sources6
Helixi178 – 181Combined sources4
Helixi182 – 190Combined sources9
Beta strandi194 – 199Combined sources6
Helixi204 – 214Combined sources11
Helixi217 – 226Combined sources10
Beta strandi229 – 234Combined sources6
Helixi236 – 248Combined sources13
Beta strandi257 – 261Combined sources5
Helixi267 – 276Combined sources10
Beta strandi279 – 287Combined sources9
Helixi294 – 297Combined sources4
Beta strandi298 – 300Combined sources3
Helixi307 – 310Combined sources4
Helixi315 – 318Combined sources4
Helixi322 – 343Combined sources22
Beta strandi355 – 357Combined sources3
Helixi366 – 374Combined sources9
Beta strandi377 – 380Combined sources4
Beta strandi383 – 386Combined sources4
Beta strandi397 – 402Combined sources6
Beta strandi414 – 420Combined sources7
Turni421 – 423Combined sources3
Beta strandi424 – 427Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KC8X-ray1.75A24-440[»]
5KCAX-ray3.10A24-440[»]
ProteinModelPortaliO43424.
SMRiO43424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni921 – 991Interaction with AP4M1By similarityAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1005 – 1007PDZ-bindingBy similarity3

Domaini

The PDZ-binding motif mediates interaction with GOPC.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISR9. Eukaryota.
ENOG410YYDD. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000264260.
HOVERGENiHBG051840.
InParanoidiO43424.
KOiK05207.
OMAiHGNYAFV.
OrthoDBiEOG091G010L.
PhylomeDBiO43424.
TreeFamiTF352434.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43424-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVFPFLLVL SVWWSRTWDS ANADSIIHIG AIFDESAKKD DEVFRTAVGD
60 70 80 90 100
LNQNEEILQT EKITFSVTFV DGNNPFQAVQ EACELMNQGI LALVSSIGCT
110 120 130 140 150
SAGSLQSLAD AMHIPHLFIQ RSTAGTPRSG CGLTRSNRND DYTLSVRPPV
160 170 180 190 200
YLHDVILRVV TEYAWQKFII FYDSEYDIRG IQEFLDKVSQ QGMDVALQKV
210 220 230 240 250
ENNINKMITT LFDTMRIEEL NRYRDTLRRA ILVMNPATAK SFITEVVETN
260 270 280 290 300
LVAFDCHWII INEEINDVDV QELVRRSIGR LTIIRQTFPV PQNISQRCFR
310 320 330 340 350
GNHRISSTLC DPKDPFAQNM EISNLYIYDT VLLLANAFHK KLEDRKWHSM
360 370 380 390 400
ASLSCIRKNS KPWQGGRSML ETIKKGGVSG LTGELEFGEN GGNPNVHFEI
410 420 430 440 450
LGTNYGEELG RGVRKLGCWN PVTGLNGSLT DKKLENNMRG VVLRVVTVLE
460 470 480 490 500
EPFVMVSENV LGKPKKYQGF SIDVLDALSN YLGFNYEIYV APDHKYGSPQ
510 520 530 540 550
EDGTWNGLVG ELVFKRADIG ISALTITPDR ENVVDFTTRY MDYSVGVLLR
560 570 580 590 600
RAEKTVDMFA CLAPFDLSLW ACIAGTVLLV GLLVYLLNWL NPPRLQMGSM
610 620 630 640 650
TSTTLYNSMW FVYGSFVQQG GEVPYTTLAT RMMMGAWWLF ALIVISSYTA
660 670 680 690 700
NLAAFLTITR IESSIQSLQD LSKQTEIPYG TVLDSAVYEH VRMKGLNPFE
710 720 730 740 750
RDSMYSQMWR MINRSNGSEN NVLESQAGIQ KVKYGNYAFV WDAAVLEYVA
760 770 780 790 800
INDPDCSFYT IGNTVADRGY GIALQHGSPY RDVFSQRILE LQQNGDMDIL
810 820 830 840 850
KHKWWPKNGQ CDLYSSVDTK QKGGALDIKS FAGVFCILAA GIVLSCFIAM
860 870 880 890 900
LETWWNKRKG SRVPSKEDDK EIDLEHLHRR VNSLCTDDDS PHKQFSTSSI
910 920 930 940 950
DLTPLDIDTL PTRQALEQIS DFRNTHITTT TFIPEQIQTL SRTLSAKAAS
960 970 980 990 1000
GFTFGNVPEH RTGPFRHRAP NGGFFRSPIK TMSSIPYQPT PTLGLNLGND

PDRGTSI
Length:1,007
Mass (Da):113,356
Last modified:May 5, 2009 - v2
Checksum:i8EF938AB7F1D6D26
GO
Isoform 2 (identifier: O43424-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-176: Missing.

Show »
Length:912
Mass (Da):102,822
Checksum:iA82226A9B772131B
GO

Sequence cautioni

The sequence BAD92555 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6F → L in AAC39579 (PubMed:9465309).Curated1
Sequence conflicti6F → L in AAH99652 (PubMed:15489334).Curated1
Sequence conflicti6F → L in AAH99653 (PubMed:15489334).Curated1
Sequence conflicti6F → L in AAH99654 (PubMed:15489334).Curated1
Sequence conflicti8L → F in AAH99652 (PubMed:15489334).Curated1
Sequence conflicti290V → I in AAC39579 (PubMed:9465309).Curated1
Sequence conflicti462G → C in AAC39579 (PubMed:9465309).Curated1
Sequence conflicti557D → E in AAH99652 (PubMed:15489334).Curated1
Sequence conflicti752N → Y in AAC39579 (PubMed:9465309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05501668T → M.1 PublicationCorresponds to variant rs34144324dbSNPEnsembl.1
Natural variantiVAR_035697209T → N in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_055017398F → S.Corresponds to variant rs34796082dbSNPEnsembl.1
Natural variantiVAR_055018490V → I.Corresponds to variant rs10034345dbSNPEnsembl.1
Natural variantiVAR_074166654A → D in SCAR18. 1 Publication1
Natural variantiVAR_074167654A → T in SCAR18. 1 Publication1
Natural variantiVAR_074168656L → V in SCAR18. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05470482 – 176Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009014 mRNA. Translation: AAC39579.1.
AB209318 mRNA. Translation: BAD92555.1. Different initiation.
AC020699 Genomic DNA. No translation available.
AC022317 Genomic DNA. No translation available.
AC093596 Genomic DNA. No translation available.
AC093733 Genomic DNA. No translation available.
AC095059 Genomic DNA. No translation available.
AC096769 Genomic DNA. No translation available.
AC104077 Genomic DNA. No translation available.
AC105315 Genomic DNA. No translation available.
AC105452 Genomic DNA. No translation available.
AC108158 Genomic DNA. No translation available.
AC110800 Genomic DNA. No translation available.
AC112695 Genomic DNA. No translation available.
AC115111 Genomic DNA. No translation available.
AC115537 Genomic DNA. No translation available.
BC099652 mRNA. Translation: AAH99652.1.
BC099653 mRNA. Translation: AAH99653.1.
BC099654 mRNA. Translation: AAH99654.1.
CCDSiCCDS3637.1. [O43424-1]
CCDS68758.1. [O43424-2]
RefSeqiNP_001273767.1. NM_001286838.1. [O43424-2]
NP_001501.2. NM_001510.3. [O43424-1]
UniGeneiHs.162727.
Hs.480281.

Genome annotation databases

EnsembliENST00000282020; ENSP00000282020; ENSG00000152208. [O43424-1]
ENST00000510992; ENSP00000421257; ENSG00000152208. [O43424-2]
GeneIDi2895.
KEGGihsa:2895.
UCSCiuc011cdt.4. human. [O43424-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009014 mRNA. Translation: AAC39579.1.
AB209318 mRNA. Translation: BAD92555.1. Different initiation.
AC020699 Genomic DNA. No translation available.
AC022317 Genomic DNA. No translation available.
AC093596 Genomic DNA. No translation available.
AC093733 Genomic DNA. No translation available.
AC095059 Genomic DNA. No translation available.
AC096769 Genomic DNA. No translation available.
AC104077 Genomic DNA. No translation available.
AC105315 Genomic DNA. No translation available.
AC105452 Genomic DNA. No translation available.
AC108158 Genomic DNA. No translation available.
AC110800 Genomic DNA. No translation available.
AC112695 Genomic DNA. No translation available.
AC115111 Genomic DNA. No translation available.
AC115537 Genomic DNA. No translation available.
BC099652 mRNA. Translation: AAH99652.1.
BC099653 mRNA. Translation: AAH99653.1.
BC099654 mRNA. Translation: AAH99654.1.
CCDSiCCDS3637.1. [O43424-1]
CCDS68758.1. [O43424-2]
RefSeqiNP_001273767.1. NM_001286838.1. [O43424-2]
NP_001501.2. NM_001510.3. [O43424-1]
UniGeneiHs.162727.
Hs.480281.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KC8X-ray1.75A24-440[»]
5KCAX-ray3.10A24-440[»]
ProteinModelPortaliO43424.
SMRiO43424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109152. 7 interactors.
MINTiMINT-257823.
STRINGi9606.ENSP00000282020.

PTM databases

iPTMnetiO43424.
PhosphoSitePlusiO43424.

Polymorphism and mutation databases

BioMutaiGRID2.

Proteomic databases

MaxQBiO43424.
PaxDbiO43424.
PeptideAtlasiO43424.
PRIDEiO43424.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282020; ENSP00000282020; ENSG00000152208. [O43424-1]
ENST00000510992; ENSP00000421257; ENSG00000152208. [O43424-2]
GeneIDi2895.
KEGGihsa:2895.
UCSCiuc011cdt.4. human. [O43424-1]

Organism-specific databases

CTDi2895.
DisGeNETi2895.
GeneCardsiGRID2.
H-InvDBHIX0031353.
HGNCiHGNC:4576. GRID2.
HPAiHPA056253.
HPA058538.
MalaCardsiGRID2.
MIMi602368. gene.
616204. phenotype.
neXtProtiNX_O43424.
OpenTargetsiENSG00000152208.
Orphaneti363432. Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency.
PharmGKBiPA28971.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISR9. Eukaryota.
ENOG410YYDD. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000264260.
HOVERGENiHBG051840.
InParanoidiO43424.
KOiK05207.
OMAiHGNYAFV.
OrthoDBiEOG091G010L.
PhylomeDBiO43424.
TreeFamiTF352434.

Miscellaneous databases

ChiTaRSiGRID2. human.
GeneWikiiGRID2.
GenomeRNAii2895.
PROiO43424.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152208.
CleanExiHS_GRID2.
ExpressionAtlasiO43424. baseline and differential.
GenevisibleiO43424. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGRID2_HUMAN
AccessioniPrimary (citable) accession number: O43424
Secondary accession number(s): E9PH24
, Q4KKU8, Q4KKU9, Q4KKV0, Q59FZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.