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O43424 (GRID2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate receptor ionotropic, delta-2

Short name=GluD2
Short name=GluR delta-2 subunit
Gene names
Name:GRID2
Synonyms:GLURD2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1007 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Subunit structure

Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2 By similarity. Interacts with CBLN1 and CBLN2, but not with CBLN4. CBLN1-binding is calcium-independent By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Cell junctionsynapsepostsynaptic cell membrane; Multi-pass membrane protein By similarity.

Domain

The PDZ-binding motif mediates interaction with GOPC By similarity.

Sequence similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily. [View classification]

Sequence caution

The sequence BAD92555.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentCell junction
Cell membrane
Membrane
Postsynaptic cell membrane
Synapse
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionIon channel
Ligand-gated ion channel
Receptor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular protein localization

Inferred from sequence or structural similarity. Source: BHF-UCL

cerebellar granule cell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

glutamate receptor signaling pathway

Traceable author statement Ref.1. Source: ProtInc

heterophilic cell-cell adhesion

Inferred from sequence or structural similarity. Source: BHF-UCL

ion transmembrane transport

Inferred from Biological aspect of Ancestor. Source: RefGenome

ionotropic glutamate receptor signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

prepulse inhibition

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of excitatory postsynaptic membrane potential

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of neuron apoptotic process

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of neuron projection development

Inferred from electronic annotation. Source: Ensembl

synaptic transmission, glutamatergic

Inferred from sequence or structural similarity. Source: BHF-UCL

transport

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentcell junction

Inferred from electronic annotation. Source: UniProtKB-KW

dendrite

Inferred from Biological aspect of Ancestor. Source: RefGenome

dendritic spine

Inferred from sequence or structural similarity. Source: BHF-UCL

integral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

ionotropic glutamate receptor complex

Inferred from sequence or structural similarity. Source: BHF-UCL

plasma membrane

Inferred from sequence or structural similarity. Source: BHF-UCL

postsynaptic membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

synapse

Inferred from sequence or structural similarity. Source: BHF-UCL

   Molecular_functionPDZ domain binding

Inferred from sequence or structural similarity. Source: BHF-UCL

extracellular-glutamate-gated ion channel activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

glutamate receptor activity

Traceable author statement Ref.1. Source: ProtInc

ionotropic glutamate receptor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

scaffold protein binding

Inferred from sequence or structural similarity. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 1007984Glutamate receptor ionotropic, delta-2
PRO_0000011564

Regions

Topological domain24 – 566543Extracellular Potential
Transmembrane567 – 58721Helical; Potential
Topological domain588 – 63548Cytoplasmic Potential
Transmembrane636 – 65621Helical; Potential
Topological domain657 – 830174Extracellular Potential
Transmembrane831 – 85121Helical; Potential
Topological domain852 – 1007156Cytoplasmic Potential
Region921 – 99171Interaction with AP4M1 By similarity
Motif1005 – 10073PDZ-binding By similarity

Amino acid modifications

Glycosylation2931N-linked (GlcNAc...) Potential
Glycosylation4261N-linked (GlcNAc...) Potential

Natural variations

Natural variant681T → M. Ref.2
Corresponds to variant rs34144324 [ dbSNP | Ensembl ].
VAR_055016
Natural variant2091T → N in a colorectal cancer sample; somatic mutation. Ref.5
VAR_035697
Natural variant3981F → S.
Corresponds to variant rs34796082 [ dbSNP | Ensembl ].
VAR_055017
Natural variant4901V → I.
Corresponds to variant rs10034345 [ dbSNP | Ensembl ].
VAR_055018

Experimental info

Sequence conflict61F → L in AAC39579. Ref.1
Sequence conflict61F → L in AAH99652. Ref.4
Sequence conflict61F → L in AAH99653. Ref.4
Sequence conflict81L → F in AAH99652. Ref.4
Sequence conflict2901V → I in AAC39579. Ref.1
Sequence conflict4621G → C in AAC39579. Ref.1
Sequence conflict5571D → E in AAH99652. Ref.4
Sequence conflict7521N → Y in AAC39579. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O43424 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 8EF938AB7F1D6D26

FASTA1,007113,356
        10         20         30         40         50         60 
MEVFPFLLVL SVWWSRTWDS ANADSIIHIG AIFDESAKKD DEVFRTAVGD LNQNEEILQT 

        70         80         90        100        110        120 
EKITFSVTFV DGNNPFQAVQ EACELMNQGI LALVSSIGCT SAGSLQSLAD AMHIPHLFIQ 

       130        140        150        160        170        180 
RSTAGTPRSG CGLTRSNRND DYTLSVRPPV YLHDVILRVV TEYAWQKFII FYDSEYDIRG 

       190        200        210        220        230        240 
IQEFLDKVSQ QGMDVALQKV ENNINKMITT LFDTMRIEEL NRYRDTLRRA ILVMNPATAK 

       250        260        270        280        290        300 
SFITEVVETN LVAFDCHWII INEEINDVDV QELVRRSIGR LTIIRQTFPV PQNISQRCFR 

       310        320        330        340        350        360 
GNHRISSTLC DPKDPFAQNM EISNLYIYDT VLLLANAFHK KLEDRKWHSM ASLSCIRKNS 

       370        380        390        400        410        420 
KPWQGGRSML ETIKKGGVSG LTGELEFGEN GGNPNVHFEI LGTNYGEELG RGVRKLGCWN 

       430        440        450        460        470        480 
PVTGLNGSLT DKKLENNMRG VVLRVVTVLE EPFVMVSENV LGKPKKYQGF SIDVLDALSN 

       490        500        510        520        530        540 
YLGFNYEIYV APDHKYGSPQ EDGTWNGLVG ELVFKRADIG ISALTITPDR ENVVDFTTRY 

       550        560        570        580        590        600 
MDYSVGVLLR RAEKTVDMFA CLAPFDLSLW ACIAGTVLLV GLLVYLLNWL NPPRLQMGSM 

       610        620        630        640        650        660 
TSTTLYNSMW FVYGSFVQQG GEVPYTTLAT RMMMGAWWLF ALIVISSYTA NLAAFLTITR 

       670        680        690        700        710        720 
IESSIQSLQD LSKQTEIPYG TVLDSAVYEH VRMKGLNPFE RDSMYSQMWR MINRSNGSEN 

       730        740        750        760        770        780 
NVLESQAGIQ KVKYGNYAFV WDAAVLEYVA INDPDCSFYT IGNTVADRGY GIALQHGSPY 

       790        800        810        820        830        840 
RDVFSQRILE LQQNGDMDIL KHKWWPKNGQ CDLYSSVDTK QKGGALDIKS FAGVFCILAA 

       850        860        870        880        890        900 
GIVLSCFIAM LETWWNKRKG SRVPSKEDDK EIDLEHLHRR VNSLCTDDDS PHKQFSTSSI 

       910        920        930        940        950        960 
DLTPLDIDTL PTRQALEQIS DFRNTHITTT TFIPEQIQTL SRTLSAKAAS GFTFGNVPEH 

       970        980        990       1000 
RTGPFRHRAP NGGFFRSPIK TMSSIPYQPT PTLGLNLGND PDRGTSI 

« Hide

References

« Hide 'large scale' references
[1]"The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22."
Hu W., Zuo J., De Jager P.L., Heintz N.
Genomics 47:143-145(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cerebellum.
[2]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-68.
Tissue: Brain.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-209.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF009014 mRNA. Translation: AAC39579.1.
AB209318 mRNA. Translation: BAD92555.1. Different initiation.
AC022317 Genomic DNA. No translation available.
AC093596 Genomic DNA. No translation available.
AC093733 Genomic DNA. No translation available.
AC096769 Genomic DNA. No translation available.
AC104077 Genomic DNA. No translation available.
AC105315 Genomic DNA. No translation available.
AC105452 Genomic DNA. No translation available.
AC112695 Genomic DNA. No translation available.
AC115111 Genomic DNA. No translation available.
BC099652 mRNA. Translation: AAH99652.1.
BC099653 mRNA. Translation: AAH99653.1.
RefSeqNP_001273767.1. NM_001286838.1.
NP_001501.2. NM_001510.3.
UniGeneHs.162727.
Hs.480281.

3D structure databases

ProteinModelPortalO43424.
SMRO43424. Positions 26-856.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109152. 7 interactions.
MINTMINT-257823.
STRING9606.ENSP00000282020.

Chemistry

DrugBankDB00142. L-Glutamic Acid.

PTM databases

PhosphoSiteO43424.

Proteomic databases

PaxDbO43424.
PRIDEO43424.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000282020; ENSP00000282020; ENSG00000152208.
GeneID2895.
KEGGhsa:2895.
UCSCuc011cdt.2. human.

Organism-specific databases

CTD2895.
GeneCardsGC04P093225.
H-InvDBHIX0031353.
HGNCHGNC:4576. GRID2.
MIM602368. gene.
neXtProtNX_O43424.
Orphanet363432. Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency.
PharmGKBPA28971.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG276334.
HOGENOMHOG000264260.
HOVERGENHBG051840.
InParanoidO43424.
KOK05207.
OMAIKKGGVN.
OrthoDBEOG7KQ20V.
PhylomeDBO43424.
TreeFamTF352434.

Gene expression databases

ArrayExpressO43424.
BgeeO43424.
CleanExHS_GRID2.
GenevestigatorO43424.

Family and domain databases

InterProIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu_rcpt_Glu/Gly-bd.
IPR001320. Iontro_glu_rcpt.
IPR001508. NMDA_rcpt.
IPR028082. Peripla_BP_I.
IPR001638. SBP_bac_3.
[Graphical view]
PfamPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF00497. SBP_bac_3. 1 hit.
[Graphical view]
PRINTSPR00177. NMDARECEPTOR.
SMARTSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMSSF53822. SSF53822. 1 hit.
ProtoNetSearch...

Other

GeneWikiGRID2.
GenomeRNAi2895.
NextBio11455.
PROO43424.
SOURCESearch...

Entry information

Entry nameGRID2_HUMAN
AccessionPrimary (citable) accession number: O43424
Secondary accession number(s): Q4KKU9, Q4KKV0, Q59FZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM