O43424 (GRID2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate receptor ionotropic, delta-2
Short name=GluD2
Short name=GluR delta-2 subunit

Gene names

Name:	GRID2
Synonyms:	GLURD2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1007 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.
Subunit structure	Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2 By similarity. Interacts with CBLN1 and CBLN2, but not with CBLN4. CBLN1-binding is calcium-independent By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein By similarity.
Domain	The PDZ-binding motif mediates interaction with GOPC By similarity.
Sequence similarities	Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily. [View classification]
Sequence caution	The sequence BAD92555.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ion channel Ligand-gated ion channel Receptor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular protein localization Inferred from sequence or structural similarity. Source: BHF-UCL ionotropic glutamate receptor signaling pathway Inferred from electronic annotation. Source: GOC prepulse inhibition Inferred from sequence or structural similarity. Source: BHF-UCL regulation of excitatory postsynaptic membrane potential Inferred from sequence or structural similarity. Source: BHF-UCL regulation of neuron apoptotic process Inferred from sequence or structural similarity. Source: BHF-UCL synaptic transmission, glutamatergic Inferred from sequence or structural similarity. Source: BHF-UCL transport Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW dendritic spine Inferred from sequence or structural similarity. Source: BHF-UCL ionotropic glutamate receptor complex Inferred from sequence or structural similarity. Source: BHF-UCL outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell synapse Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular_function	PDZ domain binding Inferred from sequence or structural similarity. Source: BHF-UCL extracellular-glutamate-gated ion channel activity Inferred from electronic annotation. Source: InterPro glutamate receptor activity Traceable author statement Ref.1. Source: ProtInc ionotropic glutamate receptor activity Inferred from electronic annotation. Source: InterPro scaffold protein binding Inferred from sequence or structural similarity. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 1007	984	Glutamate receptor ionotropic, delta-2		PRO_0000011564
Regions
	Topological domain	24 – 566	543	Extracellular Potential
	Transmembrane	567 – 587	21	Helical; Potential
	Topological domain	588 – 635	48	Cytoplasmic Potential
	Transmembrane	636 – 656	21	Helical; Potential
	Topological domain	657 – 830	174	Extracellular Potential
	Transmembrane	831 – 851	21	Helical; Potential
	Topological domain	852 – 1007	156	Cytoplasmic Potential
	Region	921 – 991	71	Interaction with AP4M1 By similarity
	Motif	1005 – 1007	3	PDZ-binding By similarity
Amino acid modifications
	Glycosylation	293	1	N-linked (GlcNAc...) Potential
	Glycosylation	426	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	68	1	T → M. Ref.2 Corresponds to variant rs34144324 [ dbSNP | Ensembl ].		VAR_055016
	Natural variant	209	1	T → N in a colorectal cancer sample; somatic mutation. Ref.5		VAR_035697
	Natural variant	398	1	F → S. Corresponds to variant rs34796082 [ dbSNP | Ensembl ].		VAR_055017
	Natural variant	490	1	V → I. Corresponds to variant rs10034345 [ dbSNP | Ensembl ].		VAR_055018
Experimental info
	Sequence conflict	6	1	F → L in AAC39579. Ref.1
	Sequence conflict	6	1	F → L in AAH99652. Ref.4
	Sequence conflict	6	1	F → L in AAH99653. Ref.4
	Sequence conflict	8	1	L → F in AAH99652. Ref.4
	Sequence conflict	290	1	V → I in AAC39579. Ref.1
	Sequence conflict	462	1	G → C in AAC39579. Ref.1
	Sequence conflict	557	1	D → E in AAH99652. Ref.4
	Sequence conflict	752	1	N → Y in AAC39579. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O43424 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 8EF938AB7F1D6D26	FASTA	1,007	113,356
	10 20 30 40 50 60 MEVFPFLLVL SVWWSRTWDS ANADSIIHIG AIFDESAKKD DEVFRTAVGD LNQNEEILQT 70 80 90 100 110 120 EKITFSVTFV DGNNPFQAVQ EACELMNQGI LALVSSIGCT SAGSLQSLAD AMHIPHLFIQ 130 140 150 160 170 180 RSTAGTPRSG CGLTRSNRND DYTLSVRPPV YLHDVILRVV TEYAWQKFII FYDSEYDIRG 190 200 210 220 230 240 IQEFLDKVSQ QGMDVALQKV ENNINKMITT LFDTMRIEEL NRYRDTLRRA ILVMNPATAK 250 260 270 280 290 300 SFITEVVETN LVAFDCHWII INEEINDVDV QELVRRSIGR LTIIRQTFPV PQNISQRCFR 310 320 330 340 350 360 GNHRISSTLC DPKDPFAQNM EISNLYIYDT VLLLANAFHK KLEDRKWHSM ASLSCIRKNS 370 380 390 400 410 420 KPWQGGRSML ETIKKGGVSG LTGELEFGEN GGNPNVHFEI LGTNYGEELG RGVRKLGCWN 430 440 450 460 470 480 PVTGLNGSLT DKKLENNMRG VVLRVVTVLE EPFVMVSENV LGKPKKYQGF SIDVLDALSN 490 500 510 520 530 540 YLGFNYEIYV APDHKYGSPQ EDGTWNGLVG ELVFKRADIG ISALTITPDR ENVVDFTTRY 550 560 570 580 590 600 MDYSVGVLLR RAEKTVDMFA CLAPFDLSLW ACIAGTVLLV GLLVYLLNWL NPPRLQMGSM 610 620 630 640 650 660 TSTTLYNSMW FVYGSFVQQG GEVPYTTLAT RMMMGAWWLF ALIVISSYTA NLAAFLTITR 670 680 690 700 710 720 IESSIQSLQD LSKQTEIPYG TVLDSAVYEH VRMKGLNPFE RDSMYSQMWR MINRSNGSEN 730 740 750 760 770 780 NVLESQAGIQ KVKYGNYAFV WDAAVLEYVA INDPDCSFYT IGNTVADRGY GIALQHGSPY 790 800 810 820 830 840 RDVFSQRILE LQQNGDMDIL KHKWWPKNGQ CDLYSSVDTK QKGGALDIKS FAGVFCILAA 850 860 870 880 890 900 GIVLSCFIAM LETWWNKRKG SRVPSKEDDK EIDLEHLHRR VNSLCTDDDS PHKQFSTSSI 910 920 930 940 950 960 DLTPLDIDTL PTRQALEQIS DFRNTHITTT TFIPEQIQTL SRTLSAKAAS GFTFGNVPEH 970 980 990 1000 RTGPFRHRAP NGGFFRSPIK TMSSIPYQPT PTLGLNLGND PDRGTSI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22." Hu W., Zuo J., De Jager P.L., Heintz N. Genomics 47:143-145(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cerebellum.
[2]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT MET-68. Tissue: Brain.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-209.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF009014 mRNA. Translation: AAC39579.1. AB209318 mRNA. Translation: BAD92555.1. Different initiation. AC022317 Genomic DNA. No translation available. AC093596 Genomic DNA. No translation available. AC093733 Genomic DNA. No translation available. AC096769 Genomic DNA. No translation available. AC104077 Genomic DNA. No translation available. AC105315 Genomic DNA. No translation available. AC105452 Genomic DNA. No translation available. AC112695 Genomic DNA. No translation available. AC115111 Genomic DNA. No translation available. BC099652 mRNA. Translation: AAH99652.1. BC099653 mRNA. Translation: AAH99653.1.
IPI	IPI00747494.
RefSeq	NP_001501.2. NM_001510.2.
UniGene	Hs.480281.
3D structure databases
ProteinModelPortal	O43424.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-257823.
STRING	9606.ENSP00000282020.
PTM databases
PhosphoSite	O43424.
Proteomic databases
PaxDb	O43424.
PRIDE	O43424.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000282020; ENSP00000282020; ENSG00000152208.
GeneID	2895.
KEGG	hsa:2895.
UCSC	uc011cdt.2. human.
Organism-specific databases
CTD	2895.
GeneCards	GC04P093225.
H-InvDB	HIX0031353.
HGNC	HGNC:4576. GRID2.
MIM	602368. gene.
neXtProt	NX_O43424.
PharmGKB	PA28971.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG276334.
HOGENOM	HOG000264260.
HOVERGEN	HBG051840.
InParanoid	O43424.
KO	K05207.
OMA	CSFYTVG.
OrthoDB	EOG4SBDX4.
PhylomeDB	O43424.
Gene expression databases
ArrayExpress	O43424.
Bgee	O43424.
CleanEx	HS_GRID2.
Genevestigator	O43424.
Family and domain databases
InterPro	IPR001828. ANF_lig-bd_rcpt. IPR019594. Glu_rcpt_Glu/Gly-bd. IPR001320. Iontro_glu_rcpt. IPR001508. NMDA_rcpt. IPR001638. SBP_bac_3. [Graphical view]
Pfam	PF01094. ANF_receptor. 1 hit. PF00060. Lig_chan. 1 hit. PF00497. SBP_bac_3. 1 hit. [Graphical view]
PRINTS	PR00177. NMDARECEPTOR.
SMART	SM00918. Lig_chan-Glu_bd. 1 hit. SM00079. PBPe. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00142. L-Glutamic Acid.
GenomeRNAi	2895.
NextBio	11455.
SOURCE	Search...

Entry information

Entry name

GRID2_HUMAN

Accession

Primary (citable) accession number: O43424
Secondary accession number(s): Q4KKU9, Q4KKV0, Q59FZ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	May 5, 2009
Last modified:	May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.