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O43424

- GRID2_HUMAN

UniProt

O43424 - GRID2_HUMAN

Protein

Glutamate receptor ionotropic, delta-2

Gene

GRID2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    Functioni

    Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

    GO - Molecular functioni

    1. extracellular-glutamate-gated ion channel activity Source: RefGenome
    2. glutamate receptor activity Source: ProtInc
    3. ionotropic glutamate receptor activity Source: RefGenome
    4. PDZ domain binding Source: BHF-UCL
    5. scaffold protein binding Source: BHF-UCL

    GO - Biological processi

    1. cellular protein localization Source: BHF-UCL
    2. cerebellar granule cell differentiation Source: BHF-UCL
    3. glutamate receptor signaling pathway Source: ProtInc
    4. heterophilic cell-cell adhesion Source: BHF-UCL
    5. ionotropic glutamate receptor signaling pathway Source: RefGenome
    6. ion transmembrane transport Source: RefGenome
    7. prepulse inhibition Source: BHF-UCL
    8. regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
    9. regulation of neuron apoptotic process Source: BHF-UCL
    10. regulation of neuron projection development Source: Ensembl
    11. synaptic transmission, glutamatergic Source: BHF-UCL
    12. transport Source: ProtInc

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate receptor ionotropic, delta-2
    Short name:
    GluD2
    Short name:
    GluR delta-2 subunit
    Gene namesi
    Name:GRID2
    Synonyms:GLURD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:4576. GRID2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. dendrite Source: RefGenome
    3. dendritic spine Source: BHF-UCL
    4. integral component of plasma membrane Source: ProtInc
    5. ionotropic glutamate receptor complex Source: BHF-UCL
    6. plasma membrane Source: BHF-UCL
    7. postsynaptic membrane Source: RefGenome
    8. synapse Source: BHF-UCL

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti363432. Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency.
    PharmGKBiPA28971.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 1007984Glutamate receptor ionotropic, delta-2PRO_0000011564Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO43424.
    PaxDbiO43424.
    PRIDEiO43424.

    PTM databases

    PhosphoSiteiO43424.

    Expressioni

    Gene expression databases

    ArrayExpressiO43424.
    BgeeiO43424.
    CleanExiHS_GRID2.
    GenevestigatoriO43424.

    Interactioni

    Subunit structurei

    Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2. Interacts with EML2 By similarity. Interacts with CBLN1 and CBLN2, but not with CBLN4. CBLN1-binding is calcium-independent By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109152. 7 interactions.
    MINTiMINT-257823.
    STRINGi9606.ENSP00000282020.

    Structurei

    3D structure databases

    ProteinModelPortaliO43424.
    SMRiO43424. Positions 26-426, 441-806.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 566543ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini588 – 63548CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini657 – 830174ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini852 – 1007156CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei567 – 58721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei636 – 65621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei831 – 85121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni921 – 99171Interaction with AP4M1By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1005 – 10073PDZ-bindingBy similarity

    Domaini

    The PDZ-binding motif mediates interaction with GOPC.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG276334.
    HOGENOMiHOG000264260.
    HOVERGENiHBG051840.
    InParanoidiO43424.
    KOiK05207.
    OMAiHGNYAFV.
    OrthoDBiEOG7KQ20V.
    PhylomeDBiO43424.
    TreeFamiTF352434.

    Family and domain databases

    InterProiIPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    IPR001638. SBP_bac_3.
    [Graphical view]
    PfamiPF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view]
    PRINTSiPR00177. NMDARECEPTOR.
    SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43424-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEVFPFLLVL SVWWSRTWDS ANADSIIHIG AIFDESAKKD DEVFRTAVGD     50
    LNQNEEILQT EKITFSVTFV DGNNPFQAVQ EACELMNQGI LALVSSIGCT 100
    SAGSLQSLAD AMHIPHLFIQ RSTAGTPRSG CGLTRSNRND DYTLSVRPPV 150
    YLHDVILRVV TEYAWQKFII FYDSEYDIRG IQEFLDKVSQ QGMDVALQKV 200
    ENNINKMITT LFDTMRIEEL NRYRDTLRRA ILVMNPATAK SFITEVVETN 250
    LVAFDCHWII INEEINDVDV QELVRRSIGR LTIIRQTFPV PQNISQRCFR 300
    GNHRISSTLC DPKDPFAQNM EISNLYIYDT VLLLANAFHK KLEDRKWHSM 350
    ASLSCIRKNS KPWQGGRSML ETIKKGGVSG LTGELEFGEN GGNPNVHFEI 400
    LGTNYGEELG RGVRKLGCWN PVTGLNGSLT DKKLENNMRG VVLRVVTVLE 450
    EPFVMVSENV LGKPKKYQGF SIDVLDALSN YLGFNYEIYV APDHKYGSPQ 500
    EDGTWNGLVG ELVFKRADIG ISALTITPDR ENVVDFTTRY MDYSVGVLLR 550
    RAEKTVDMFA CLAPFDLSLW ACIAGTVLLV GLLVYLLNWL NPPRLQMGSM 600
    TSTTLYNSMW FVYGSFVQQG GEVPYTTLAT RMMMGAWWLF ALIVISSYTA 650
    NLAAFLTITR IESSIQSLQD LSKQTEIPYG TVLDSAVYEH VRMKGLNPFE 700
    RDSMYSQMWR MINRSNGSEN NVLESQAGIQ KVKYGNYAFV WDAAVLEYVA 750
    INDPDCSFYT IGNTVADRGY GIALQHGSPY RDVFSQRILE LQQNGDMDIL 800
    KHKWWPKNGQ CDLYSSVDTK QKGGALDIKS FAGVFCILAA GIVLSCFIAM 850
    LETWWNKRKG SRVPSKEDDK EIDLEHLHRR VNSLCTDDDS PHKQFSTSSI 900
    DLTPLDIDTL PTRQALEQIS DFRNTHITTT TFIPEQIQTL SRTLSAKAAS 950
    GFTFGNVPEH RTGPFRHRAP NGGFFRSPIK TMSSIPYQPT PTLGLNLGND 1000
    PDRGTSI 1007
    Length:1,007
    Mass (Da):113,356
    Last modified:May 5, 2009 - v2
    Checksum:i8EF938AB7F1D6D26
    GO
    Isoform 2 (identifier: O43424-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         82-176: Missing.

    Show »
    Length:912
    Mass (Da):102,822
    Checksum:iA82226A9B772131B
    GO

    Sequence cautioni

    The sequence BAD92555.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61F → L in AAC39579. (PubMed:9465309)Curated
    Sequence conflicti6 – 61F → L in AAH99652. (PubMed:15489334)Curated
    Sequence conflicti6 – 61F → L in AAH99653. (PubMed:15489334)Curated
    Sequence conflicti6 – 61F → L in AAH99654. (PubMed:15489334)Curated
    Sequence conflicti8 – 81L → F in AAH99652. (PubMed:15489334)Curated
    Sequence conflicti290 – 2901V → I in AAC39579. (PubMed:9465309)Curated
    Sequence conflicti462 – 4621G → C in AAC39579. (PubMed:9465309)Curated
    Sequence conflicti557 – 5571D → E in AAH99652. (PubMed:15489334)Curated
    Sequence conflicti752 – 7521N → Y in AAC39579. (PubMed:9465309)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681T → M.1 Publication
    Corresponds to variant rs34144324 [ dbSNP | Ensembl ].
    VAR_055016
    Natural varianti209 – 2091T → N in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035697
    Natural varianti398 – 3981F → S.
    Corresponds to variant rs34796082 [ dbSNP | Ensembl ].
    VAR_055017
    Natural varianti490 – 4901V → I.
    Corresponds to variant rs10034345 [ dbSNP | Ensembl ].
    VAR_055018

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei82 – 17695Missing in isoform 2. 1 PublicationVSP_054704Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF009014 mRNA. Translation: AAC39579.1.
    AB209318 mRNA. Translation: BAD92555.1. Different initiation.
    AC020699 Genomic DNA. No translation available.
    AC022317 Genomic DNA. No translation available.
    AC093596 Genomic DNA. No translation available.
    AC093733 Genomic DNA. No translation available.
    AC095059 Genomic DNA. No translation available.
    AC096769 Genomic DNA. No translation available.
    AC104077 Genomic DNA. No translation available.
    AC105315 Genomic DNA. No translation available.
    AC105452 Genomic DNA. No translation available.
    AC108158 Genomic DNA. No translation available.
    AC110800 Genomic DNA. No translation available.
    AC112695 Genomic DNA. No translation available.
    AC115111 Genomic DNA. No translation available.
    AC115537 Genomic DNA. No translation available.
    BC099652 mRNA. Translation: AAH99652.1.
    BC099653 mRNA. Translation: AAH99653.1.
    BC099654 mRNA. Translation: AAH99654.1.
    CCDSiCCDS3637.1. [O43424-1]
    CCDS68758.1. [O43424-2]
    RefSeqiNP_001273767.1. NM_001286838.1. [O43424-2]
    NP_001501.2. NM_001510.3. [O43424-1]
    UniGeneiHs.162727.
    Hs.480281.

    Genome annotation databases

    EnsembliENST00000282020; ENSP00000282020; ENSG00000152208. [O43424-1]
    ENST00000510992; ENSP00000421257; ENSG00000152208. [O43424-2]
    GeneIDi2895.
    KEGGihsa:2895.
    UCSCiuc011cdt.2. human. [O43424-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF009014 mRNA. Translation: AAC39579.1 .
    AB209318 mRNA. Translation: BAD92555.1 . Different initiation.
    AC020699 Genomic DNA. No translation available.
    AC022317 Genomic DNA. No translation available.
    AC093596 Genomic DNA. No translation available.
    AC093733 Genomic DNA. No translation available.
    AC095059 Genomic DNA. No translation available.
    AC096769 Genomic DNA. No translation available.
    AC104077 Genomic DNA. No translation available.
    AC105315 Genomic DNA. No translation available.
    AC105452 Genomic DNA. No translation available.
    AC108158 Genomic DNA. No translation available.
    AC110800 Genomic DNA. No translation available.
    AC112695 Genomic DNA. No translation available.
    AC115111 Genomic DNA. No translation available.
    AC115537 Genomic DNA. No translation available.
    BC099652 mRNA. Translation: AAH99652.1 .
    BC099653 mRNA. Translation: AAH99653.1 .
    BC099654 mRNA. Translation: AAH99654.1 .
    CCDSi CCDS3637.1. [O43424-1 ]
    CCDS68758.1. [O43424-2 ]
    RefSeqi NP_001273767.1. NM_001286838.1. [O43424-2 ]
    NP_001501.2. NM_001510.3. [O43424-1 ]
    UniGenei Hs.162727.
    Hs.480281.

    3D structure databases

    ProteinModelPortali O43424.
    SMRi O43424. Positions 26-426, 441-806.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109152. 7 interactions.
    MINTi MINT-257823.
    STRINGi 9606.ENSP00000282020.

    Chemistry

    DrugBanki DB00142. L-Glutamic Acid.
    GuidetoPHARMACOLOGYi 449.

    PTM databases

    PhosphoSitei O43424.

    Proteomic databases

    MaxQBi O43424.
    PaxDbi O43424.
    PRIDEi O43424.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282020 ; ENSP00000282020 ; ENSG00000152208 . [O43424-1 ]
    ENST00000510992 ; ENSP00000421257 ; ENSG00000152208 . [O43424-2 ]
    GeneIDi 2895.
    KEGGi hsa:2895.
    UCSCi uc011cdt.2. human. [O43424-1 ]

    Organism-specific databases

    CTDi 2895.
    GeneCardsi GC04P093225.
    H-InvDB HIX0031353.
    HGNCi HGNC:4576. GRID2.
    MIMi 602368. gene.
    neXtProti NX_O43424.
    Orphaneti 363432. Autosomal recessive congenital cerebellar ataxia due to GRID2 deficiency.
    PharmGKBi PA28971.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG276334.
    HOGENOMi HOG000264260.
    HOVERGENi HBG051840.
    InParanoidi O43424.
    KOi K05207.
    OMAi HGNYAFV.
    OrthoDBi EOG7KQ20V.
    PhylomeDBi O43424.
    TreeFami TF352434.

    Miscellaneous databases

    GeneWikii GRID2.
    GenomeRNAii 2895.
    NextBioi 11455.
    PROi O43424.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43424.
    Bgeei O43424.
    CleanExi HS_GRID2.
    Genevestigatori O43424.

    Family and domain databases

    InterProi IPR001828. ANF_lig-bd_rcpt.
    IPR019594. Glu_rcpt_Glu/Gly-bd.
    IPR001320. Iontro_glu_rcpt.
    IPR001508. NMDA_rcpt.
    IPR028082. Peripla_BP_I.
    IPR001638. SBP_bac_3.
    [Graphical view ]
    Pfami PF01094. ANF_receptor. 1 hit.
    PF00060. Lig_chan. 1 hit.
    PF00497. SBP_bac_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00177. NMDARECEPTOR.
    SMARTi SM00918. Lig_chan-Glu_bd. 1 hit.
    SM00079. PBPe. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22."
      Hu W., Zuo J., De Jager P.L., Heintz N.
      Genomics 47:143-145(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Cerebellum.
    2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-68.
      Tissue: Brain.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-209.

    Entry informationi

    Entry nameiGRID2_HUMAN
    AccessioniPrimary (citable) accession number: O43424
    Secondary accession number(s): E9PH24
    , Q4KKU8, Q4KKU9, Q4KKV0, Q59FZ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3