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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member C

Gene

ANP32C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member C
Alternative name(s):
Phosphoprotein 32-related protein 1
Tumorigenic protein pp32r1
Gene namesi
Name:ANP32C
Synonyms:PP32R1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:16675. ANP32C.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24813.

Polymorphism and mutation databases

BioMutaiANP32C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Acidic leucine-rich nuclear phosphoprotein 32 family member CPRO_0000137597Add
BLAST

Proteomic databases

EPDiO43423.
PRIDEiO43423.

PTM databases

iPTMnetiO43423.
PhosphoSiteiO43423.

Expressioni

Tissue specificityi

Expressed in activated stem cells, such as mobilized CD34+ cells and cord blood CD34+ cells, but not in resting bone marrow CD34+ cells. Expressed in a variety of neoplastic cell lines, mainly in prostatic adenocarcinoma cell lines. Not expressed in normal prostatic tissue.2 Publications

Gene expression databases

CleanExiHS_ANP32C.

Interactioni

Protein-protein interaction databases

BioGridi117067. 2 interactions.
IntActiO43423. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliO43423.
SMRiO43423. Positions 1-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati44 – 6320LRR 1Add
BLAST
Repeati64 – 8421LRR 2Add
BLAST
Repeati85 – 10723LRR 3Add
BLAST
Repeati111 – 13424LRR 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi157 – 22872Asp/Glu-rich (highly acidic)Add
BLAST

Sequence similaritiesi

Belongs to the ANP32 family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiO43423.
KOiK18646.
PhylomeDBiO43423.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O43423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMGRRIHSE LRNRAPSDVK ELALDNSRSN EGKLEALTDE FEELEFLSKI
60 70 80 90 100
NGGLTSISDL PKLKLRKLEL RVSGGLEVLA EKCPNLTHLY LSGNKIKDLS
110 120 130 140 150
TIEPLKQLEN LKSLDLFNCE VTNLNDYGEN VFKLLLQLTY LDSCYWDHKE
160 170 180 190 200
APYSDIEDHV EGLDDEEEGE HEEEYDEDAQ VVEDEEGEEE EEEGEEEDVS
210 220 230
GGDEEDEEGY NDGEVDGEED EEELGEEERG QKRK
Length:234
Mass (Da):26,762
Last modified:June 1, 1998 - v1
Checksum:i2515D9678EACC5C2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231A → V.1 Publication
Corresponds to variant rs2288674 [ dbSNP | Ensembl ].
VAR_026702
Natural varianti71 – 711R → K.1 Publication
Corresponds to variant rs2288675 [ dbSNP | Ensembl ].
VAR_020419
Natural varianti105 – 1051L → P.
Corresponds to variant rs17008716 [ dbSNP | Ensembl ].
VAR_048314
Natural varianti140 – 1401Y → H.1 Publication
VAR_026703
Natural varianti204 – 2041E → G.
Corresponds to variant rs2288676 [ dbSNP | Ensembl ].
VAR_020420

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008216 Genomic DNA. Translation: AAD12746.1.
AC105250 Genomic DNA. Translation: AAY40978.1.
CH471056 Genomic DNA. Translation: EAX04832.1.
RefSeqiNP_036535.1. NM_012403.1.
UniGeneiHs.661161.

Genome annotation databases

GeneIDi23520.
KEGGihsa:23520.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008216 Genomic DNA. Translation: AAD12746.1.
AC105250 Genomic DNA. Translation: AAY40978.1.
CH471056 Genomic DNA. Translation: EAX04832.1.
RefSeqiNP_036535.1. NM_012403.1.
UniGeneiHs.661161.

3D structure databases

ProteinModelPortaliO43423.
SMRiO43423. Positions 1-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117067. 2 interactions.
IntActiO43423. 3 interactions.

PTM databases

iPTMnetiO43423.
PhosphoSiteiO43423.

Polymorphism and mutation databases

BioMutaiANP32C.

Proteomic databases

EPDiO43423.
PRIDEiO43423.

Protocols and materials databases

DNASUi23520.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23520.
KEGGihsa:23520.

Organism-specific databases

CTDi23520.
GeneCardsiANP32C.
HGNCiHGNC:16675. ANP32C.
MIMi606877. gene.
neXtProtiNX_O43423.
PharmGKBiPA24813.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000007361.
HOVERGENiHBG053102.
InParanoidiO43423.
KOiK18646.
PhylomeDBiO43423.

Miscellaneous databases

GeneWikiiANP32C.
GenomeRNAii23520.
NextBioi45969.
PROiO43423.
SOURCEiSearch...

Gene expression databases

CleanExiHS_ANP32C.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Modulation of oncogenic potential by alternative gene use in human prostate cancer."
    Kadkol S.S., Brody J.R., Pevsner J., Bai J., Pasternack G.R.
    Nat. Med. 5:275-279(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Identification of a functional mutation in pp32r1 (ANP32C)."
    Kochevar G.J., Brody J.R., Kadkol S.S., Murphy K.M., Pasternack G.R.
    Hum. Mutat. 23:546-551(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-23; LYS-71 AND HIS-140, TISSUE SPECIFICITY.
  5. "The Anp32 family of proteins containing leucine-rich repeats."
    Matilla A., Radrizzani M.
    Cerebellum 4:7-18(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiAN32C_HUMAN
AccessioniPrimary (citable) accession number: O43423
Secondary accession number(s): Q4W5F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The His-140 polymorphism is uncertain. It has been found in prostatic cell line without corresponding normal tissue sample. Cells transfected with this variant expressed at least twice as much proteins than native cells.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.