O43423 (AN32C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member C

Alternative name(s):
Phosphoprotein 32-related protein 1
Tumorigenic protein pp32r1

Gene names

Name:	ANP32C
Synonyms:	PP32R1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Expressed in activated stem cells, such as mobilized CD34+ cells and cord blood CD34+ cells, but not in resting bone marrow CD34+ cells. Expressed in a variety of neoplastic cell lines, mainly in prostatic adenocarcinoma cell lines. Not expressed in normal protastic tissue. Ref.1 Ref.5
Sequence similarities	Belongs to the ANP32 family. Contains 4 LRR (leucine-rich) repeats.
Caution	The His-140 polymorphism is uncertain. It has been found in prostatic cell line without corresponding normal tissue sample. Cells transfected with this variant expressed at least twice as much proteins than native cells.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 234	234	Acidic leucine-rich nuclear phosphoprotein 32 family member C		PRO_0000137597
Regions
	Repeat	44 – 63	20	LRR 1
	Repeat	64 – 84	21	LRR 2
	Repeat	85 – 107	23	LRR 3
	Repeat	111 – 134	24	LRR 4
	Compositional bias	157 – 228	72	Asp/Glu-rich (highly acidic)
Natural variations
	Natural variant	23	1	A → V. Ref.5 Corresponds to variant rs2288674 [ dbSNP | Ensembl ].		VAR_026702
	Natural variant	71	1	R → K. Ref.5 Corresponds to variant rs2288675 [ dbSNP | Ensembl ].		VAR_020419
	Natural variant	105	1	L → P. Corresponds to variant rs17008716 [ dbSNP | Ensembl ].		VAR_048314
	Natural variant	140	1	Y → H. Ref.5		VAR_026703
	Natural variant	204	1	E → G. Corresponds to variant rs2288676 [ dbSNP | Ensembl ].		VAR_020420

Sequences

	Sequence		Length	Mass (Da)
	O43423 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 2515D9678EACC5C2	FASTA	234	26,762
	10 20 30 40 50 60 MEMGRRIHSE LRNRAPSDVK ELALDNSRSN EGKLEALTDE FEELEFLSKI NGGLTSISDL 70 80 90 100 110 120 PKLKLRKLEL RVSGGLEVLA EKCPNLTHLY LSGNKIKDLS TIEPLKQLEN LKSLDLFNCE 130 140 150 160 170 180 VTNLNDYGEN VFKLLLQLTY LDSCYWDHKE APYSDIEDHV EGLDDEEEGE HEEEYDEDAQ 190 200 210 220 230 VVEDEEGEEE EEEGEEEDVS GGDEEDEEGY NDGEVDGEED EEELGEEERG QKRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Modulation of oncogenic potential by alternative gene use in human prostate cancer." Kadkol S.S., Brody J.R., Pevsner J., Bai J., Pasternack G.R. Nat. Med. 5:275-279(1999) [PubMed: 10086381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]	Erratum Kadkol S.S., Brody J.R., Pevsner J., Bai J., Pasternack G.R. Nat. Med. 5:1087-1087(1999) [PubMed: 10471270] [Abstract]
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Identification of a functional mutation in pp32r1 (ANP32C)." Kochevar G.J., Brody J.R., Kadkol S.S., Murphy K.M., Pasternack G.R. Hum. Mutat. 23:546-551(2004) [PubMed: 15146458] [Abstract] Cited for: VARIANTS VAL-23; LYS-71 AND HIS-140, TISSUE SPECIFICITY.
[6]	"The Anp32 family of proteins containing leucine-rich repeats." Matilla A., Radrizzani M. Cerebellum 4:7-18(2005) [PubMed: 15895553] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF008216 Genomic DNA. Translation: AAD12746.1. AC105250 Genomic DNA. Translation: AAY40978.1. CH471056 Genomic DNA. Translation: EAX04832.1.
IPI	IPI00018262.
RefSeq	NP_036535.1. NM_012403.1.
UniGene	Hs.661161.
3D structure databases
ProteinModelPortal	O43423.
SMR	O43423. Positions 1-142.
ModBase	Search...
Protein-protein interaction databases
STRING	O43423.
PTM databases
PhosphoSite	O43423.
Proteomic databases
PRIDE	O43423.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330241; ENSP00000329250; ENSG00000184701.
GeneID	23520.
KEGG	hsa:23520.
UCSC	uc003iqt.1. human.
Organism-specific databases
CTD	23520.
GeneCards	GC04M165118.
HGNC	HGNC:16675. ANP32C.
MIM	606877. gene.
neXtProt	NX_O43423.
PharmGKB	PA24813.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14917.
GeneTree	ENSGT00560000077130.
HOGENOM	HBG747960.
HOVERGEN	HBG053102.
InParanoid	O43423.
OMA	MGRRIHS.
OrthoDB	EOG4ZW5CD.
PhylomeDB	O43423.
Gene expression databases
ArrayExpress	O43423.
CleanEx	HS_ANP32C.
Genevestigator	O43423.
GermOnline	ENSG00000184701. Homo sapiens.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. [Graphical view]
PROSITE	PS51450. LRR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	45969.
SOURCE	Search...

Entry information

Entry name

AN32C_HUMAN

Accession

Primary (citable) accession number: O43423
Secondary accession number(s): Q4W5F9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	June 1, 1998
Last modified:	January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.