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Protein

Acidic leucine-rich nuclear phosphoprotein 32 family member C

Gene

ANP32C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

The His-140 polymorphism is uncertain. It has been found in prostatic cell line without corresponding normal tissue sample. Cells transfected with this variant expressed at least twice as much proteins than native cells.Curated

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member C
Alternative name(s):
Phosphoprotein 32-related protein 1
Tumorigenic protein pp32r1
Gene namesi
Name:ANP32C
Synonyms:PP32R1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:16675 ANP32C
MIMi606877 gene
neXtProtiNX_O43423

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi23520
PharmGKBiPA24813

Polymorphism and mutation databases

BioMutaiANP32C

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375971 – 234Acidic leucine-rich nuclear phosphoprotein 32 family member CAdd BLAST234

Proteomic databases

EPDiO43423
MaxQBiO43423
PeptideAtlasiO43423
PRIDEiO43423
ProteomicsDBi48935

PTM databases

iPTMnetiO43423
PhosphoSitePlusiO43423

Expressioni

Tissue specificityi

Expressed in activated stem cells, such as mobilized CD34+ cells and cord blood CD34+ cells, but not in resting bone marrow CD34+ cells. Expressed in a variety of neoplastic cell lines, mainly in prostatic adenocarcinoma cell lines. Not expressed in normal prostatic tissue.2 Publications

Gene expression databases

CleanExiHS_ANP32C

Organism-specific databases

HPAiHPA063133
HPA067561

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117067, 5 interactors
IntActiO43423, 4 interactors
MINTiO43423

Structurei

3D structure databases

ProteinModelPortaliO43423
SMRiO43423
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati44 – 63LRR 1Add BLAST20
Repeati64 – 84LRR 2Add BLAST21
Repeati85 – 107LRR 3Add BLAST23
Repeati111 – 134LRR 4Add BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi157 – 228Asp/Glu-rich (highly acidic)Add BLAST72

Sequence similaritiesi

Belongs to the ANP32 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

HOGENOMiHOG000007361
HOVERGENiHBG053102
InParanoidiO43423
KOiK18646
PhylomeDBiO43423

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
PROSITEiView protein in PROSITE
PS51450 LRR, 3 hits

Sequencei

Sequence statusi: Complete.

O43423-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMGRRIHSE LRNRAPSDVK ELALDNSRSN EGKLEALTDE FEELEFLSKI
60 70 80 90 100
NGGLTSISDL PKLKLRKLEL RVSGGLEVLA EKCPNLTHLY LSGNKIKDLS
110 120 130 140 150
TIEPLKQLEN LKSLDLFNCE VTNLNDYGEN VFKLLLQLTY LDSCYWDHKE
160 170 180 190 200
APYSDIEDHV EGLDDEEEGE HEEEYDEDAQ VVEDEEGEEE EEEGEEEDVS
210 220 230
GGDEEDEEGY NDGEVDGEED EEELGEEERG QKRK
Length:234
Mass (Da):26,762
Last modified:June 1, 1998 - v1
Checksum:i2515D9678EACC5C2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02670223A → V1 PublicationCorresponds to variant dbSNP:rs2288674Ensembl.1
Natural variantiVAR_02041971R → K1 PublicationCorresponds to variant dbSNP:rs2288675Ensembl.1
Natural variantiVAR_048314105L → P. Corresponds to variant dbSNP:rs17008716Ensembl.1
Natural variantiVAR_026703140Y → H1 Publication1
Natural variantiVAR_020420204E → G. Corresponds to variant dbSNP:rs2288676Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF008216 Genomic DNA Translation: AAD12746.1
AC105250 Genomic DNA Translation: AAY40978.1
CH471056 Genomic DNA Translation: EAX04832.1
RefSeqiNP_036535.1, NM_012403.1
UniGeneiHs.661161

Genome annotation databases

GeneIDi23520
KEGGihsa:23520

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAN32C_HUMAN
AccessioniPrimary (citable) accession number: O43423
Secondary accession number(s): Q4W5F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 1998
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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