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O43422

- P52K_HUMAN

UniProt

O43422 - P52K_HUMAN

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Protein

52 kDa repressor of the inhibitor of the protein kinase

Gene

PRKRIR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8686THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of cell proliferation Source: ProtInc
  2. response to stress Source: ProtInc
  3. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
52 kDa repressor of the inhibitor of the protein kinase
Short name:
p52rIPK
Alternative name(s):
58 kDa interferon-induced protein kinase-interacting protein
Short name:
p58IPK-interacting protein
Death-associated protein 4
THAP domain-containing protein 0
Gene namesi
Name:PRKRIR
Synonyms:DAP4, P52RIPK, THAP0
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9440. PRKRIR.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33781.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 76176152 kDa repressor of the inhibitor of the protein kinasePRO_0000068634Add
BLAST

Proteomic databases

MaxQBiO43422.
PaxDbiO43422.
PRIDEiO43422.

PTM databases

PhosphoSiteiO43422.

Expressioni

Gene expression databases

BgeeiO43422.
CleanExiHS_PRKRIR.
ExpressionAtlasiO43422. baseline and differential.
GenevestigatoriO43422.

Organism-specific databases

HPAiHPA008758.

Interactioni

Subunit structurei

Interacts with P58IPK, probably sequestring it.

Protein-protein interaction databases

BioGridi111598. 14 interactions.
IntActiO43422. 3 interactions.
MINTiMINT-1531238.
STRINGi9606.ENSP00000260045.

Structurei

3D structure databases

ProteinModelPortaliO43422.
SMRiO43422. Positions 1-97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8686THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG145047.
GeneTreeiENSGT00530000063516.
HOGENOMiHOG000013127.
HOVERGENiHBG007908.
InParanoidiO43422.
OMAiKFRRAQH.
PhylomeDBiO43422.
TreeFamiTF330114.

Family and domain databases

InterProiIPR025398. DUF4371.
IPR008906. HATC_dom_C.
IPR012337. RNaseH-like_dom.
IPR006612. Znf_C2CH.
[Graphical view]
PfamiPF05699. Dimer_Tnp_hAT. 1 hit.
PF14291. DUF4371. 1 hit.
PF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: O43422-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNFCAAPNC TRKSTQSDLA FFRFPRDPAR CQKWVENCRR ADLEDKTPDQ
60 70 80 90 100
LNKHYRLCAK HFETSMICRT SPYRTVLRDN AIPTIFDLTS HLNNPHSRHR
110 120 130 140 150
KRIKELSEDE IRTLKQKKID ETSEQEQKHK ETNNSNAQNP SEEEGEGQDE
160 170 180 190 200
DILPLTLEEK ENKEYLKSLF EILILMGKQN IPLDGHEADE IPEGLFTPDN
210 220 230 240 250
FQALLECRIN SGEEVLRKRF ETTAVNTLFC SKTQQRQMLE ICESCIREET
260 270 280 290 300
LREVRDSHFF SIITDDVVDI AGEEHLPVLV RFVDESHNLR EEFIGFLPYE
310 320 330 340 350
ADAEILAVKF HTMITEKWGL NMEYCRGQAY IVSSGFSSKM KVVASRLLEK
360 370 380 390 400
YPQAIYTLCS SCALNMWLAK SVPVMGVSVA LGTIEEVCSF FHRSPQLLLE
410 420 430 440 450
LDNVISVLFQ NSKERGKELK EICHSQWTGR HDAFEILVEL LQALVLCLDG
460 470 480 490 500
INSDTNIRWN NYIAGRAFVL CSAVSDFDFI VTIVVLKNVL SFTRAFGKNL
510 520 530 540 550
QGQTSDVFFA AGSLTAVLHS LNEVMENIEV YHEFWFEEAT NLATKLDIQM
560 570 580 590 600
KLPGKFRRAH QGNLESQLTS ESYYKETLSV PTVEHIIQEL KDIFSEQHLK
610 620 630 640 650
ALKCLSLVPS VMGQLKFNTS EEHHADMYRS DLPNPDTLSA ELHCWRIKWK
660 670 680 690 700
HRGKDIELPS TIYEALHLPD IKFFPNVYAL LKVLCILPVM KVENERYENG
710 720 730 740 750
RKRLKAYLRN TLTDQRSSNL ALLNINFDIK HDLDLMVDTY IKLYTSKSEL
760
PTDNSETVEN T
Length:761
Mass (Da):87,704
Last modified:January 11, 2001 - v2
Checksum:i88809CFE52399C13
GO
Isoform Short (identifier: O43422-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     489-492: VLSF → EIKI
     493-761: Missing.

Note: No experimental confirmation available.

Show »
Length:492
Mass (Da):56,656
Checksum:iE0CC8E2C5DD93215
GO

Sequence cautioni

The sequence AAH21992.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB43226.1 differs from that shown. Reason: Frameshift at position 471. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti157 – 1571L → W(PubMed:17974005)Curated
Sequence conflicti738 – 7381D → V(PubMed:17974005)Curated
Sequence conflicti754 – 7541N → K(PubMed:17974005)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei489 – 4924VLSF → EIKI in isoform Short. 1 PublicationVSP_004355
Alternative sequencei493 – 761269Missing in isoform Short. 1 PublicationVSP_004356Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007393 mRNA. Translation: AAC39564.1.
AF081567 mRNA. Translation: AAG01570.1.
AK291843 mRNA. Translation: BAF84532.1.
CH471076 Genomic DNA. Translation: EAW74993.1.
BC021992 mRNA. Translation: AAH21992.1. Different initiation.
BC117138 mRNA. Translation: AAI17139.1.
BC117140 mRNA. Translation: AAI17141.1.
AL049970 mRNA. Translation: CAB43226.1. Frameshift.
CCDSiCCDS8243.1. [O43422-1]
RefSeqiNP_004696.2. NM_004705.2. [O43422-1]
UniGeneiHs.503315.

Genome annotation databases

EnsembliENST00000260045; ENSP00000260045; ENSG00000137492. [O43422-1]
GeneIDi5612.
KEGGihsa:5612.
UCSCiuc001oxh.1. human. [O43422-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007393 mRNA. Translation: AAC39564.1 .
AF081567 mRNA. Translation: AAG01570.1 .
AK291843 mRNA. Translation: BAF84532.1 .
CH471076 Genomic DNA. Translation: EAW74993.1 .
BC021992 mRNA. Translation: AAH21992.1 . Different initiation.
BC117138 mRNA. Translation: AAI17139.1 .
BC117140 mRNA. Translation: AAI17141.1 .
AL049970 mRNA. Translation: CAB43226.1 . Frameshift.
CCDSi CCDS8243.1. [O43422-1 ]
RefSeqi NP_004696.2. NM_004705.2. [O43422-1 ]
UniGenei Hs.503315.

3D structure databases

ProteinModelPortali O43422.
SMRi O43422. Positions 1-97.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111598. 14 interactions.
IntActi O43422. 3 interactions.
MINTi MINT-1531238.
STRINGi 9606.ENSP00000260045.

PTM databases

PhosphoSitei O43422.

Proteomic databases

MaxQBi O43422.
PaxDbi O43422.
PRIDEi O43422.

Protocols and materials databases

DNASUi 5612.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260045 ; ENSP00000260045 ; ENSG00000137492 . [O43422-1 ]
GeneIDi 5612.
KEGGi hsa:5612.
UCSCi uc001oxh.1. human. [O43422-1 ]

Organism-specific databases

CTDi 5612.
GeneCardsi GC11M076061.
HGNCi HGNC:9440. PRKRIR.
HPAi HPA008758.
MIMi 607374. gene.
neXtProti NX_O43422.
PharmGKBi PA33781.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145047.
GeneTreei ENSGT00530000063516.
HOGENOMi HOG000013127.
HOVERGENi HBG007908.
InParanoidi O43422.
OMAi KFRRAQH.
PhylomeDBi O43422.
TreeFami TF330114.

Miscellaneous databases

ChiTaRSi PRKRIR. human.
GeneWikii PRKRIR.
GenomeRNAii 5612.
NextBioi 21814.
PROi O43422.
SOURCEi Search...

Gene expression databases

Bgeei O43422.
CleanExi HS_PRKRIR.
ExpressionAtlasi O43422. baseline and differential.
Genevestigatori O43422.

Family and domain databases

InterProi IPR025398. DUF4371.
IPR008906. HATC_dom_C.
IPR012337. RNaseH-like_dom.
IPR006612. Znf_C2CH.
[Graphical view ]
Pfami PF05699. Dimer_Tnp_hAT. 1 hit.
PF14291. DUF4371. 1 hit.
PF05485. THAP. 1 hit.
[Graphical view ]
SMARTi SM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 2 hits.
PROSITEi PS50950. ZF_THAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK."
    Gale M.J. Jr., Blakely C.M., Hopkins D.A., Melville M.W., Wambach M., Romano P.R., Katze M.G.
    Mol. Cell. Biol. 18:859-871(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
  2. Barzilay G., Kimchi A.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Tissue: Brain and Prostate.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 157-761 (ISOFORM LONG).
    Tissue: Brain.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiP52K_HUMAN
AccessioniPrimary (citable) accession number: O43422
Secondary accession number(s): A8K728
, Q17RY9, Q8WTW1, Q9Y3Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 11, 2001
Last modified: November 26, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3