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O43414

- ERI3_HUMAN

UniProt

O43414 - ERI3_HUMAN

Protein

ERI1 exoribonuclease 3

Gene

ERI3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi150 – 1501Magnesium 1By similarity
    Metal bindingi150 – 1501Magnesium 2By similarity
    Active sitei152 – 1521Proton acceptorSequence Analysis
    Metal bindingi152 – 1521Magnesium 1By similarity
    Binding sitei152 – 1521AMPBy similarity
    Metal bindingi249 – 2491Magnesium 2By similarity
    Active sitei307 – 3071Proton acceptorSequence Analysis
    Binding sitei307 – 3071AMPBy similarity
    Metal bindingi312 – 3121Magnesium 1By similarity

    GO - Molecular functioni

    1. exonuclease activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. poly(A) RNA binding Source: UniProtKB

    Keywords - Molecular functioni

    Exonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ERI1 exoribonuclease 3 (EC:3.1.-.-)
    Alternative name(s):
    Prion interactor 1
    Prion protein-interacting protein
    Gene namesi
    Name:ERI3
    Synonyms:PINT1, PRNPIP, PRNPIP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:17276. ERI3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164719272.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 337337ERI1 exoribonuclease 3PRO_0000317626Add
    BLAST

    Proteomic databases

    MaxQBiO43414.
    PaxDbiO43414.
    PRIDEiO43414.

    PTM databases

    PhosphoSiteiO43414.

    Expressioni

    Gene expression databases

    ArrayExpressiO43414.
    BgeeiO43414.
    CleanExiHS_ERI3.
    GenevestigatoriO43414.

    Organism-specific databases

    HPAiHPA027147.
    HPA029895.
    HPA056253.
    HPA058538.

    Interactioni

    Subunit structurei

    Interacts with PRNP.By similarity

    Protein-protein interaction databases

    BioGridi122498. 4 interactions.
    STRINGi9606.ENSP00000361331.

    Structurei

    Secondary structure

    1
    337
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi144 – 1496
    Beta strandi165 – 17410
    Turni175 – 1773
    Beta strandi180 – 1878
    Beta strandi191 – 1933
    Helixi198 – 2047
    Helixi208 – 2114
    Helixi217 – 23014
    Turni231 – 2344
    Beta strandi240 – 2478
    Helixi248 – 2514
    Helixi253 – 2619
    Helixi267 – 2693
    Beta strandi272 – 2743
    Helixi275 – 2839
    Turni288 – 2903
    Helixi291 – 2977
    Helixi309 – 32517

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2XRIX-ray2.15A137-337[»]
    ProteinModelPortaliO43414.
    SMRiO43414. Positions 136-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43414.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini146 – 320175ExonucleaseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 exonuclease domain.Curated

    Phylogenomic databases

    eggNOGiCOG5018.
    HOVERGENiHBG108293.
    PhylomeDBiO43414.
    TreeFamiTF313449.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    InterProiIPR006055. Exonuclease.
    IPR013520. Exonuclease_RNaseT/DNA_pol3.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF00929. RNase_T. 1 hit.
    [Graphical view]
    SMARTiSM00479. EXOIII. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43414-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATASPAADG GRGRPWEGGL VSWPPAPPLT LPWTWMGPSW GQHPGHWGFP    50
    ALTEPSASPA AGLGIFEVRR VLDASGCSML APLQTGAARF SSYLLSRARK 100
    VLGSHLFSPC GVPEFCSIST RKLAAHGFGA SMAAMVSFPP QRYHYFLVLD 150
    FEATCDKPQI HPQEIIEFPI LKLNGRTMEI ESTFHMYVQP VVHPQLTPFC 200
    TELTGIIQAM VDGQPSLQQV LERVDEWMAK EGLLDPNVKS IFVTCGDWDL 250
    KVMLPGQCQY LGLPVADYFK QWINLKKAYS FAMGCWPKNG LLDMNKGLSL 300
    QHIGRPHSGI DDCKNIANIM KTLAYRGFIF KQTSKPF 337
    Length:337
    Mass (Da):37,238
    Last modified:March 18, 2008 - v2
    Checksum:i28E8A691659B4D67
    GO
    Isoform 2 (identifier: O43414-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-163: MATASPAADG...TCDKPQIHPQ → MFVMLQVPWL...MEVLAGQYGM

    Show »
    Length:222
    Mass (Da):25,009
    Checksum:i5DF6E20F9B256DC4
    GO
    Isoform 3 (identifier: O43414-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-209: Missing.

    Show »
    Length:128
    Mass (Da):14,542
    Checksum:i3DB7393DB221D90F
    GO

    Sequence cautioni

    The sequence AAC19158.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 209209Missing in isoform 3. 1 PublicationVSP_031104Add
    BLAST
    Alternative sequencei1 – 163163MATAS…QIHPQ → MFVMLQVPWLQSCANLVQIG APLPLLGCLGQYFEVLGSME VLAGQYGM in isoform 2. CuratedVSP_031103Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007157 mRNA. Translation: AAC19158.1. Different initiation.
    AK290567 mRNA. Translation: BAF83256.1.
    AL390776, AL035417 Genomic DNA. Translation: CAI12491.1.
    AL390776, AL035417 Genomic DNA. Translation: CAI12494.1.
    AL035417, AL390776 Genomic DNA. Translation: CAI23194.1.
    AL035417, AL390776 Genomic DNA. Translation: CAI23196.1.
    AC004254 Genomic DNA. Translation: AAC04618.1.
    BC001072 mRNA. Translation: AAH01072.1.
    BC004456 mRNA. Translation: AAH04456.1.
    CCDSiCCDS30696.1. [O43414-1]
    RefSeqiNP_076971.1. NM_024066.1. [O43414-1]
    UniGeneiHs.731413.

    Genome annotation databases

    EnsembliENST00000372257; ENSP00000361331; ENSG00000117419. [O43414-1]
    ENST00000372259; ENSP00000361333; ENSG00000117419. [O43414-2]
    GeneIDi79033.
    KEGGihsa:79033.
    UCSCiuc001clt.3. human. [O43414-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007157 mRNA. Translation: AAC19158.1 . Different initiation.
    AK290567 mRNA. Translation: BAF83256.1 .
    AL390776 , AL035417 Genomic DNA. Translation: CAI12491.1 .
    AL390776 , AL035417 Genomic DNA. Translation: CAI12494.1 .
    AL035417 , AL390776 Genomic DNA. Translation: CAI23194.1 .
    AL035417 , AL390776 Genomic DNA. Translation: CAI23196.1 .
    AC004254 Genomic DNA. Translation: AAC04618.1 .
    BC001072 mRNA. Translation: AAH01072.1 .
    BC004456 mRNA. Translation: AAH04456.1 .
    CCDSi CCDS30696.1. [O43414-1 ]
    RefSeqi NP_076971.1. NM_024066.1. [O43414-1 ]
    UniGenei Hs.731413.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2XRI X-ray 2.15 A 137-337 [» ]
    ProteinModelPortali O43414.
    SMRi O43414. Positions 136-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122498. 4 interactions.
    STRINGi 9606.ENSP00000361331.

    PTM databases

    PhosphoSitei O43414.

    Proteomic databases

    MaxQBi O43414.
    PaxDbi O43414.
    PRIDEi O43414.

    Protocols and materials databases

    DNASUi 79033.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372257 ; ENSP00000361331 ; ENSG00000117419 . [O43414-1 ]
    ENST00000372259 ; ENSP00000361333 ; ENSG00000117419 . [O43414-2 ]
    GeneIDi 79033.
    KEGGi hsa:79033.
    UCSCi uc001clt.3. human. [O43414-1 ]

    Organism-specific databases

    CTDi 79033.
    GeneCardsi GC01M044686.
    HGNCi HGNC:17276. ERI3.
    HPAi HPA027147.
    HPA029895.
    HPA056253.
    HPA058538.
    MIMi 609917. gene.
    neXtProti NX_O43414.
    PharmGKBi PA164719272.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5018.
    HOVERGENi HBG108293.
    PhylomeDBi O43414.
    TreeFami TF313449.

    Miscellaneous databases

    EvolutionaryTracei O43414.
    GenomeRNAii 79033.
    NextBioi 67747.
    PROi O43414.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43414.
    Bgeei O43414.
    CleanExi HS_ERI3.
    Genevestigatori O43414.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    InterProi IPR006055. Exonuclease.
    IPR013520. Exonuclease_RNaseT/DNA_pol3.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF00929. RNase_T. 1 hit.
    [Graphical view ]
    SMARTi SM00479. EXOIII. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Yu W., Sarginson J., Gibbs R.A.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Lung.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiERI3_HUMAN
    AccessioniPrimary (citable) accession number: O43414
    Secondary accession number(s): B1AK98
    , Q5T2T7, Q5T2T9, Q5TG35, Q9BQA0, Q9UEB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3