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O43414

- ERI3_HUMAN

UniProt

O43414 - ERI3_HUMAN

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Protein

ERI1 exoribonuclease 3

Gene
ERI3, PINT1, PRNPIP, PRNPIP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cofactori

Binds 2 magnesium ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi150 – 1501Magnesium 1 By similarity
Metal bindingi150 – 1501Magnesium 2 By similarity
Active sitei152 – 1521Proton acceptor Reviewed prediction
Metal bindingi152 – 1521Magnesium 1 By similarity
Binding sitei152 – 1521AMP By similarity
Metal bindingi249 – 2491Magnesium 2 By similarity
Active sitei307 – 3071Proton acceptor Reviewed prediction
Binding sitei307 – 3071AMP By similarity
Metal bindingi312 – 3121Magnesium 1 By similarity

GO - Molecular functioni

  1. exonuclease activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ERI1 exoribonuclease 3 (EC:3.1.-.-)
Alternative name(s):
Prion interactor 1
Prion protein-interacting protein
Gene namesi
Name:ERI3
Synonyms:PINT1, PRNPIP, PRNPIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:17276. ERI3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164719272.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337ERI1 exoribonuclease 3PRO_0000317626Add
BLAST

Proteomic databases

MaxQBiO43414.
PaxDbiO43414.
PRIDEiO43414.

PTM databases

PhosphoSiteiO43414.

Expressioni

Gene expression databases

ArrayExpressiO43414.
BgeeiO43414.
CleanExiHS_ERI3.
GenevestigatoriO43414.

Organism-specific databases

HPAiHPA027147.
HPA029895.
HPA056253.
HPA058538.

Interactioni

Subunit structurei

Interacts with PRNP By similarity.

Protein-protein interaction databases

BioGridi122498. 4 interactions.
STRINGi9606.ENSP00000361331.

Structurei

Secondary structure

1
337
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi144 – 1496
Beta strandi165 – 17410
Turni175 – 1773
Beta strandi180 – 1878
Beta strandi191 – 1933
Helixi198 – 2047
Helixi208 – 2114
Helixi217 – 23014
Turni231 – 2344
Beta strandi240 – 2478
Helixi248 – 2514
Helixi253 – 2619
Helixi267 – 2693
Beta strandi272 – 2743
Helixi275 – 2839
Turni288 – 2903
Helixi291 – 2977
Helixi309 – 32517

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XRIX-ray2.15A137-337[»]
ProteinModelPortaliO43414.
SMRiO43414. Positions 136-336.

Miscellaneous databases

EvolutionaryTraceiO43414.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 320175ExonucleaseAdd
BLAST

Sequence similaritiesi

Contains 1 exonuclease domain.

Phylogenomic databases

eggNOGiCOG5018.
HOVERGENiHBG108293.
PhylomeDBiO43414.
TreeFamiTF313449.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O43414-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATASPAADG GRGRPWEGGL VSWPPAPPLT LPWTWMGPSW GQHPGHWGFP    50
ALTEPSASPA AGLGIFEVRR VLDASGCSML APLQTGAARF SSYLLSRARK 100
VLGSHLFSPC GVPEFCSIST RKLAAHGFGA SMAAMVSFPP QRYHYFLVLD 150
FEATCDKPQI HPQEIIEFPI LKLNGRTMEI ESTFHMYVQP VVHPQLTPFC 200
TELTGIIQAM VDGQPSLQQV LERVDEWMAK EGLLDPNVKS IFVTCGDWDL 250
KVMLPGQCQY LGLPVADYFK QWINLKKAYS FAMGCWPKNG LLDMNKGLSL 300
QHIGRPHSGI DDCKNIANIM KTLAYRGFIF KQTSKPF 337
Length:337
Mass (Da):37,238
Last modified:March 18, 2008 - v2
Checksum:i28E8A691659B4D67
GO
Isoform 2 (identifier: O43414-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: MATASPAADG...TCDKPQIHPQ → MFVMLQVPWL...MEVLAGQYGM

Show »
Length:222
Mass (Da):25,009
Checksum:i5DF6E20F9B256DC4
GO
Isoform 3 (identifier: O43414-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Show »
Length:128
Mass (Da):14,542
Checksum:i3DB7393DB221D90F
GO

Sequence cautioni

The sequence AAC19158.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 209209Missing in isoform 3. VSP_031104Add
BLAST
Alternative sequencei1 – 163163MATAS…QIHPQ → MFVMLQVPWLQSCANLVQIG APLPLLGCLGQYFEVLGSME VLAGQYGM in isoform 2. VSP_031103Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007157 mRNA. Translation: AAC19158.1. Different initiation.
AK290567 mRNA. Translation: BAF83256.1.
AL390776, AL035417 Genomic DNA. Translation: CAI12491.1.
AL390776, AL035417 Genomic DNA. Translation: CAI12494.1.
AL035417, AL390776 Genomic DNA. Translation: CAI23194.1.
AL035417, AL390776 Genomic DNA. Translation: CAI23196.1.
AC004254 Genomic DNA. Translation: AAC04618.1.
BC001072 mRNA. Translation: AAH01072.1.
BC004456 mRNA. Translation: AAH04456.1.
CCDSiCCDS30696.1. [O43414-1]
RefSeqiNP_076971.1. NM_024066.1. [O43414-1]
UniGeneiHs.731413.

Genome annotation databases

EnsembliENST00000372257; ENSP00000361331; ENSG00000117419. [O43414-1]
ENST00000372259; ENSP00000361333; ENSG00000117419. [O43414-2]
GeneIDi79033.
KEGGihsa:79033.
UCSCiuc001clt.3. human. [O43414-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007157 mRNA. Translation: AAC19158.1 . Different initiation.
AK290567 mRNA. Translation: BAF83256.1 .
AL390776 , AL035417 Genomic DNA. Translation: CAI12491.1 .
AL390776 , AL035417 Genomic DNA. Translation: CAI12494.1 .
AL035417 , AL390776 Genomic DNA. Translation: CAI23194.1 .
AL035417 , AL390776 Genomic DNA. Translation: CAI23196.1 .
AC004254 Genomic DNA. Translation: AAC04618.1 .
BC001072 mRNA. Translation: AAH01072.1 .
BC004456 mRNA. Translation: AAH04456.1 .
CCDSi CCDS30696.1. [O43414-1 ]
RefSeqi NP_076971.1. NM_024066.1. [O43414-1 ]
UniGenei Hs.731413.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XRI X-ray 2.15 A 137-337 [» ]
ProteinModelPortali O43414.
SMRi O43414. Positions 136-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122498. 4 interactions.
STRINGi 9606.ENSP00000361331.

PTM databases

PhosphoSitei O43414.

Proteomic databases

MaxQBi O43414.
PaxDbi O43414.
PRIDEi O43414.

Protocols and materials databases

DNASUi 79033.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000372257 ; ENSP00000361331 ; ENSG00000117419 . [O43414-1 ]
ENST00000372259 ; ENSP00000361333 ; ENSG00000117419 . [O43414-2 ]
GeneIDi 79033.
KEGGi hsa:79033.
UCSCi uc001clt.3. human. [O43414-1 ]

Organism-specific databases

CTDi 79033.
GeneCardsi GC01M044686.
HGNCi HGNC:17276. ERI3.
HPAi HPA027147.
HPA029895.
HPA056253.
HPA058538.
MIMi 609917. gene.
neXtProti NX_O43414.
PharmGKBi PA164719272.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5018.
HOVERGENi HBG108293.
PhylomeDBi O43414.
TreeFami TF313449.

Miscellaneous databases

EvolutionaryTracei O43414.
GenomeRNAii 79033.
NextBioi 67747.
PROi O43414.
SOURCEi Search...

Gene expression databases

ArrayExpressi O43414.
Bgeei O43414.
CleanExi HS_ERI3.
Genevestigatori O43414.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
InterProi IPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00929. RNase_T. 1 hit.
[Graphical view ]
SMARTi SM00479. EXOIII. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Yu W., Sarginson J., Gibbs R.A.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 2).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Lung.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiERI3_HUMAN
AccessioniPrimary (citable) accession number: O43414
Secondary accession number(s): B1AK98
, Q5T2T7, Q5T2T9, Q5TG35, Q9BQA0, Q9UEB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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