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Protein

ERI1 exoribonuclease 3

Gene

ERI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi150Magnesium 1By similarity1
Metal bindingi150Magnesium 2By similarity1
Active sitei152Proton acceptorSequence analysis1
Metal bindingi152Magnesium 1By similarity1
Binding sitei152AMPBy similarity1
Metal bindingi249Magnesium 2By similarity1
Active sitei307Proton acceptorSequence analysis1
Binding sitei307AMPBy similarity1
Metal bindingi312Magnesium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ERI1 exoribonuclease 3 (EC:3.1.-.-)
Alternative name(s):
Prion interactor 1
Prion protein-interacting protein
Gene namesi
Name:ERI3
Synonyms:PINT1, PRNPIP, PRNPIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117419.14
HGNCiHGNC:17276 ERI3
MIMi609917 gene
neXtProtiNX_O43414

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000117419
PharmGKBiPA164719272

Polymorphism and mutation databases

BioMutaiERI3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176261 – 337ERI1 exoribonuclease 3Add BLAST337

Proteomic databases

EPDiO43414
MaxQBiO43414
PaxDbiO43414
PeptideAtlasiO43414
PRIDEiO43414

PTM databases

iPTMnetiO43414
PhosphoSitePlusiO43414

Expressioni

Gene expression databases

BgeeiENSG00000117419
CleanExiHS_ERI3
ExpressionAtlasiO43414 baseline and differential
GenevisibleiO43414 HS

Organism-specific databases

HPAiHPA027147
HPA029895

Interactioni

Subunit structurei

Interacts with PRNP.By similarity

Protein-protein interaction databases

BioGridi122498, 14 interactors
IntActiO43414, 8 interactors
MINTiO43414
STRINGi9606.ENSP00000361331

Structurei

Secondary structure

1337
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi144 – 149Combined sources6
Beta strandi165 – 174Combined sources10
Turni175 – 177Combined sources3
Beta strandi180 – 187Combined sources8
Beta strandi191 – 193Combined sources3
Helixi198 – 204Combined sources7
Helixi208 – 211Combined sources4
Helixi217 – 230Combined sources14
Turni231 – 234Combined sources4
Beta strandi240 – 247Combined sources8
Helixi248 – 251Combined sources4
Helixi253 – 261Combined sources9
Helixi267 – 269Combined sources3
Beta strandi272 – 274Combined sources3
Helixi275 – 283Combined sources9
Turni288 – 290Combined sources3
Helixi291 – 297Combined sources7
Helixi309 – 325Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XRIX-ray2.15A137-337[»]
ProteinModelPortaliO43414
SMRiO43414
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43414

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini146 – 320ExonucleaseAdd BLAST175

Phylogenomic databases

eggNOGiKOG0542 Eukaryota
COG5018 LUCA
GeneTreeiENSGT00530000063205
HOVERGENiHBG108293
InParanoidiO43414
KOiK18418
OrthoDBiEOG091G0IA2
PhylomeDBiO43414
TreeFamiTF313449

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR013520 Exonuclease_RNaseT/DNA_pol3
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00929 RNase_T, 1 hit
SMARTiView protein in SMART
SM00479 EXOIII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43414-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATASPAADG GRGRPWEGGL VSWPPAPPLT LPWTWMGPSW GQHPGHWGFP
60 70 80 90 100
ALTEPSASPA AGLGIFEVRR VLDASGCSML APLQTGAARF SSYLLSRARK
110 120 130 140 150
VLGSHLFSPC GVPEFCSIST RKLAAHGFGA SMAAMVSFPP QRYHYFLVLD
160 170 180 190 200
FEATCDKPQI HPQEIIEFPI LKLNGRTMEI ESTFHMYVQP VVHPQLTPFC
210 220 230 240 250
TELTGIIQAM VDGQPSLQQV LERVDEWMAK EGLLDPNVKS IFVTCGDWDL
260 270 280 290 300
KVMLPGQCQY LGLPVADYFK QWINLKKAYS FAMGCWPKNG LLDMNKGLSL
310 320 330
QHIGRPHSGI DDCKNIANIM KTLAYRGFIF KQTSKPF
Length:337
Mass (Da):37,238
Last modified:March 18, 2008 - v2
Checksum:i28E8A691659B4D67
GO
Isoform 2 (identifier: O43414-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-163: MATASPAADG...TCDKPQIHPQ → MFVMLQVPWL...MEVLAGQYGM

Show »
Length:222
Mass (Da):25,009
Checksum:i5DF6E20F9B256DC4
GO
Isoform 3 (identifier: O43414-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-209: Missing.

Show »
Length:128
Mass (Da):14,542
Checksum:i3DB7393DB221D90F
GO

Sequence cautioni

The sequence AAC19158 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0311041 – 209Missing in isoform 3. 1 PublicationAdd BLAST209
Alternative sequenceiVSP_0311031 – 163MATAS…QIHPQ → MFVMLQVPWLQSCANLVQIG APLPLLGCLGQYFEVLGSME VLAGQYGM in isoform 2. CuratedAdd BLAST163

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007157 mRNA Translation: AAC19158.1 Different initiation.
AK290567 mRNA Translation: BAF83256.1
AL035417 Genomic DNA No translation available.
AL390776 Genomic DNA No translation available.
AC004254 Genomic DNA Translation: AAC04618.1
BC001072 mRNA Translation: AAH01072.1
BC004456 mRNA Translation: AAH04456.1
CCDSiCCDS30696.1 [O43414-1]
RefSeqiNP_001288627.1, NM_001301698.1
NP_001288628.1, NM_001301699.1
NP_001288629.1, NM_001301700.1
NP_001288630.1, NM_001301701.1
NP_076971.1, NM_024066.2 [O43414-1]
UniGeneiHs.731413

Genome annotation databases

EnsembliENST00000372257; ENSP00000361331; ENSG00000117419 [O43414-1]
ENST00000372259; ENSP00000361333; ENSG00000117419 [O43414-2]
GeneIDi79033
KEGGihsa:79033
UCSCiuc001clt.4 human [O43414-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiERI3_HUMAN
AccessioniPrimary (citable) accession number: O43414
Secondary accession number(s): B1AK98
, Q5T2T7, Q5T2T9, Q5TG35, Q9BQA0, Q9UEB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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