Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ER membrane protein complex subunit 8

Gene

EMC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 8
Alternative name(s):
Neighbor of COX4
Protein FAM158B
Gene namesi
Name:EMC8
Synonyms:C16orf2, C16orf4, COX4AL, COX4NB, FAM158B, NOC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7864. EMC8.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • ER membrane protein complex Source: UniProtKB
  • membrane Source: UniProtKB
  • mitochondrion Source: ProtInc
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31668.

Polymorphism and mutation databases

BioMutaiEMC8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210ER membrane protein complex subunit 8PRO_0000221187Add
BLAST

Proteomic databases

EPDiO43402.
PaxDbiO43402.
PeptideAtlasiO43402.
PRIDEiO43402.

PTM databases

iPTMnetiO43402.
PhosphoSiteiO43402.

Expressioni

Tissue specificityi

Expressed in liver, pancreas, heart, lung, kidney, brain, skeletal muscle, and placenta. Expression levels are highest in pancreas and moderate in heart, skeletal muscle, and placenta.

Gene expression databases

BgeeiO43402.
CleanExiHS_COX4NB.
ExpressionAtlasiO43402. baseline and differential.
GenevisibleiO43402. HS.

Organism-specific databases

HPAiHPA049476.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).1 Publication

Protein-protein interaction databases

BioGridi115611. 33 interactions.
IntActiO43402. 12 interactions.
MINTiMINT-1449651.
STRINGi9606.ENSP00000253457.

Structurei

3D structure databases

ProteinModelPortaliO43402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMC8/EMC9 family.Curated

Phylogenomic databases

eggNOGiKOG3289. Eukaryota.
ENOG410Y8KS. LUCA.
GeneTreeiENSGT00390000006738.
HOGENOMiHOG000015340.
HOVERGENiHBG018182.
InParanoidiO43402.
OMAiMQIDAYA.
PhylomeDBiO43402.
TreeFamiTF313860.

Family and domain databases

InterProiIPR005366. UPF0172.
[Graphical view]
PANTHERiPTHR12941. PTHR12941. 1 hit.
PfamiPF03665. UPF0172. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43402-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGVKLTTQA YCKMVLHGAK YPHCAVNGLL VAEKQKPRKE HLPLGGPGAH
60 70 80 90 100
HTLFVDCIPL FHGTLALAPM LEVALTLIDS WCKDHSYVIA GYYQANERVK
110 120 130 140 150
DASPNQVAEK VASRIAEGFS DTALIMVDNT KFTMDCVAPT IHVYEHHENR
160 170 180 190 200
WRCRDPHHDY CEDWPEAQRI SASLLDSRSY ETLVDFDNHL DDIRNDWTNP
210
EINKAVLHLC
Length:210
Mass (Da):23,773
Last modified:June 1, 1998 - v1
Checksum:i41367FDD98769250
GO
Isoform 2 (identifier: O43402-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-210: Missing.

Note: No experimental confirmation available.
Show »
Length:126
Mass (Da):13,726
Checksum:i58A5B11E68AFD28C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei127 – 21084Missing in isoform 2. 1 PublicationVSP_045089Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005888 mRNA. Translation: AAB94489.1.
AF005889 Genomic DNA. Translation: AAB94820.1.
AC018695 Genomic DNA. No translation available.
BC005886 mRNA. Translation: AAH05886.1.
BC001472 mRNA. Translation: AAH01472.1.
BC007445 mRNA. Translation: AAH07445.1.
BC020250 mRNA. Translation: AAH20250.1.
BQ674834 mRNA. No translation available.
CCDSiCCDS10954.1. [O43402-1]
CCDS45541.1. [O43402-2]
RefSeqiNP_001135760.1. NM_001142288.1. [O43402-2]
NP_006058.1. NM_006067.4. [O43402-1]
UniGeneiHs.173162.

Genome annotation databases

EnsembliENST00000253457; ENSP00000253457; ENSG00000131148. [O43402-1]
ENST00000435200; ENSP00000391730; ENSG00000131148. [O43402-2]
GeneIDi10328.
KEGGihsa:10328.
UCSCiuc010vol.3. human. [O43402-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005888 mRNA. Translation: AAB94489.1.
AF005889 Genomic DNA. Translation: AAB94820.1.
AC018695 Genomic DNA. No translation available.
BC005886 mRNA. Translation: AAH05886.1.
BC001472 mRNA. Translation: AAH01472.1.
BC007445 mRNA. Translation: AAH07445.1.
BC020250 mRNA. Translation: AAH20250.1.
BQ674834 mRNA. No translation available.
CCDSiCCDS10954.1. [O43402-1]
CCDS45541.1. [O43402-2]
RefSeqiNP_001135760.1. NM_001142288.1. [O43402-2]
NP_006058.1. NM_006067.4. [O43402-1]
UniGeneiHs.173162.

3D structure databases

ProteinModelPortaliO43402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115611. 33 interactions.
IntActiO43402. 12 interactions.
MINTiMINT-1449651.
STRINGi9606.ENSP00000253457.

PTM databases

iPTMnetiO43402.
PhosphoSiteiO43402.

Polymorphism and mutation databases

BioMutaiEMC8.

Proteomic databases

EPDiO43402.
PaxDbiO43402.
PeptideAtlasiO43402.
PRIDEiO43402.

Protocols and materials databases

DNASUi10328.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253457; ENSP00000253457; ENSG00000131148. [O43402-1]
ENST00000435200; ENSP00000391730; ENSG00000131148. [O43402-2]
GeneIDi10328.
KEGGihsa:10328.
UCSCiuc010vol.3. human. [O43402-1]

Organism-specific databases

CTDi10328.
GeneCardsiEMC8.
HGNCiHGNC:7864. EMC8.
HPAiHPA049476.
MIMi604886. gene.
neXtProtiNX_O43402.
PharmGKBiPA31668.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3289. Eukaryota.
ENOG410Y8KS. LUCA.
GeneTreeiENSGT00390000006738.
HOGENOMiHOG000015340.
HOVERGENiHBG018182.
InParanoidiO43402.
OMAiMQIDAYA.
PhylomeDBiO43402.
TreeFamiTF313860.

Miscellaneous databases

GenomeRNAii10328.
NextBioi39157.
PROiO43402.
SOURCEiSearch...

Gene expression databases

BgeeiO43402.
CleanExiHS_COX4NB.
ExpressionAtlasiO43402. baseline and differential.
GenevisibleiO43402. HS.

Family and domain databases

InterProiIPR005366. UPF0172.
[Graphical view]
PANTHERiPTHR12941. PTHR12941. 1 hit.
PfamiPF03665. UPF0172. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The 5-prime region of the COX4 gene contains a novel overlapping gene, NOC4."
    Bachman N.J., Wu W., Schmidt T.R., Grossman L.I., Lomax M.I.
    Mamm. Genome 10:506-512(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    Tissue: Placenta and Retina.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Epidermal carcinoma, Muscle and Placenta.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION IN THE EMC COMPLEX, SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEMC8_HUMAN
AccessioniPrimary (citable) accession number: O43402
Secondary accession number(s): C9JB21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 1998
Last modified: May 11, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.