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Protein

ER membrane protein complex subunit 8

Gene

EMC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein family/group databases

TCDBi3.A.27.1.1 the c-terminal tail-anchored membrane protein biogenesis/ insertion complex-2 (tamp-b2) family

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 8
Alternative name(s):
Neighbor of COX4
Protein FAM158B
Gene namesi
Name:EMC8
Synonyms:C16orf2, C16orf4, COX4AL, COX4NB, FAM158B, NOC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000131148.8
HGNCiHGNC:7864 EMC8
MIMi604886 gene
neXtProtiNX_O43402

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10328
OpenTargetsiENSG00000131148
PharmGKBiPA31668

Polymorphism and mutation databases

BioMutaiEMC8

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211871 – 210ER membrane protein complex subunit 8Add BLAST210

Proteomic databases

EPDiO43402
PaxDbiO43402
PeptideAtlasiO43402
PRIDEiO43402

PTM databases

iPTMnetiO43402
PhosphoSitePlusiO43402
SwissPalmiO43402

Expressioni

Tissue specificityi

Expressed in liver, pancreas, heart, lung, kidney, brain, skeletal muscle, and placenta. Expression levels are highest in pancreas and moderate in heart, skeletal muscle, and placenta.

Gene expression databases

BgeeiENSG00000131148
CleanExiHS_COX4NB
ExpressionAtlasiO43402 baseline and differential
GenevisibleiO43402 HS

Organism-specific databases

HPAiHPA049476

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EMC2Q150064EBI-741841,EBI-359031

Protein-protein interaction databases

BioGridi115611, 45 interactors
IntActiO43402, 14 interactors
MINTiO43402
STRINGi9606.ENSP00000253457

Structurei

3D structure databases

ProteinModelPortaliO43402
SMRiO43402
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 150MPNPROSITE-ProRule annotationAdd BLAST147

Sequence similaritiesi

Belongs to the EMC8/EMC9 family.Curated

Phylogenomic databases

eggNOGiKOG3289 Eukaryota
ENOG410Y8KS LUCA
GeneTreeiENSGT00390000006738
HOGENOMiHOG000015340
HOVERGENiHBG018182
InParanoidiO43402
OMAiPENDWTN
OrthoDBiEOG091G0NV8
PhylomeDBiO43402
TreeFamiTF313860

Family and domain databases

CDDicd08060 MPN_UPF0172, 1 hit
InterProiView protein in InterPro
IPR005366 EMC8/9
IPR037518 MPN
PANTHERiPTHR12941 PTHR12941, 1 hit
PfamiView protein in Pfam
PF03665 UPF0172, 1 hit
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O43402-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGVKLTTQA YCKMVLHGAK YPHCAVNGLL VAEKQKPRKE HLPLGGPGAH
60 70 80 90 100
HTLFVDCIPL FHGTLALAPM LEVALTLIDS WCKDHSYVIA GYYQANERVK
110 120 130 140 150
DASPNQVAEK VASRIAEGFS DTALIMVDNT KFTMDCVAPT IHVYEHHENR
160 170 180 190 200
WRCRDPHHDY CEDWPEAQRI SASLLDSRSY ETLVDFDNHL DDIRNDWTNP
210
EINKAVLHLC
Length:210
Mass (Da):23,773
Last modified:June 1, 1998 - v1
Checksum:i41367FDD98769250
GO
Isoform 2 (identifier: O43402-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-210: Missing.

Note: No experimental confirmation available.
Show »
Length:126
Mass (Da):13,726
Checksum:i58A5B11E68AFD28C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045089127 – 210Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005888 mRNA Translation: AAB94489.1
AF005889 Genomic DNA Translation: AAB94820.1
AC018695 Genomic DNA No translation available.
BC005886 mRNA Translation: AAH05886.1
BC001472 mRNA Translation: AAH01472.1
BC007445 mRNA Translation: AAH07445.1
BC020250 mRNA Translation: AAH20250.1
BQ674834 mRNA No translation available.
CCDSiCCDS10954.1 [O43402-1]
CCDS45541.1 [O43402-2]
RefSeqiNP_001135760.1, NM_001142288.1 [O43402-2]
NP_006058.1, NM_006067.4 [O43402-1]
UniGeneiHs.173162

Genome annotation databases

EnsembliENST00000253457; ENSP00000253457; ENSG00000131148 [O43402-1]
ENST00000435200; ENSP00000391730; ENSG00000131148 [O43402-2]
GeneIDi10328
KEGGihsa:10328
UCSCiuc010vol.3 human [O43402-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEMC8_HUMAN
AccessioniPrimary (citable) accession number: O43402
Secondary accession number(s): C9JB21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 1998
Last modified: April 25, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health