O43399 (TPD54_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor protein D54
Short name=hD54

Alternative name(s):
Tumor protein D52-like 2

Gene names

Name:

TPD52L2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Forms a homodimer or heterodimer with other members of the family By similarity. Interacts with MAL2. Ref.7
Sequence similarities	Belongs to the TPD52 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of cell proliferation Traceable author statement PubMed 9484778PubMed 9484778. Source: UniProtKB
Cellular_component	perinuclear region of cytoplasm Inferred from direct assay PubMed 16112108PubMed 16112108. Source: UniProtKB
Molecular_function	protein homodimerization activity Inferred from direct assay PubMed 9484778. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Tpd52	Q62393	2	EBI-782616,EBI-782591	From a different organism.

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: O43399-1)

Also known as: HD54+ins2;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O43399-2)

Also known as: HD54-ins2;

The sequence of this isoform differs from the canonical sequence as follows:
     106-125: Missing.

Isoform 3 (identifier: O43399-3)

The sequence of this isoform differs from the canonical sequence as follows:
     106-125: Missing.
     159-159: R → RAHPFSHSFSSYSIRHSISMPAMR

Isoform 4 (identifier: O43399-4)

The sequence of this isoform differs from the canonical sequence as follows:
     106-125: Missing.
     157-157: D → DMSSYSIRHSISMPA

Isoform 5 (identifier: O43399-5)

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: D → DMSSYSIRHSISMPA

Note: No experimental confirmation available.

Isoform 6 (identifier: O43399-6)

The sequence of this isoform differs from the canonical sequence as follows:
     7-29: Missing.
     106-125: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Tumor protein D54		PRO_0000185744
Regions
	Coiled coil	38 – 82	45	Potential
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.13 Ref.15
	Modified residue	3	1	Phosphoserine Ref.11 Ref.15
	Modified residue	12	1	Phosphoserine Ref.8 Ref.10 Ref.11 Ref.13 Ref.15
	Modified residue	19	1	Phosphoserine Ref.13
	Modified residue	21	1	Phosphoserine Ref.13
	Modified residue	96	1	Phosphoserine Ref.11 Ref.12 Ref.13
	Modified residue	149	1	Phosphoserine Ref.12
	Modified residue	166	1	Phosphoserine Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.15
	Modified residue	192	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	7 – 29	23	Missing in isoform 6.		VSP_045154
	Alternative sequence	106 – 125	20	Missing in isoform 2, isoform 3, isoform 4 and isoform 6.		VSP_006547
	Alternative sequence	157	1	D → DMSSYSIRHSISMPA in isoform 4 and isoform 5.		VSP_038361
	Alternative sequence	159	1	R → RAHPFSHSFSSYSIRHSISM PAMR in isoform 3.		VSP_036756
Experimental info
	Sequence conflict	72	1	R → K in AAC98478. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (HD54+ins2) [UniParc]. Last modified January 23, 2002. Version 2. Checksum: 58F01BC67B1E3DE9	FASTA	206	22,238
	10 20 30 40 50 60 MDSAGQDINL NSPNKGLLSD SMTDVPVDTG VAARTPAVEG LTEAEEEELR AELTKVEEEI 70 80 90 100 110 120 VTLRQVLAAK ERHCGELKRR LGLSTLGELK QNLSRSWHDV QVSSAYVKTS EKLGEWNEKV 130 140 150 160 170 180 TQSDLYKKTQ ETLSQAGQKT SAALSTVGSA ISRKLGDMRN SATFKSFEDR VGTIKSKVVG 190 200 DRENGSDNLP SSAGSGDKPL SDPAPF
	Isoform 2 (HD54-ins2) [UniParc]. Checksum: 002CD68479D8250C	FASTA	186	19,901
	10 20 30 40 50 60 MDSAGQDINL NSPNKGLLSD SMTDVPVDTG VAARTPAVEG LTEAEEEELR AELTKVEEEI 70 80 90 100 110 120 VTLRQVLAAK ERHCGELKRR LGLSTLGELK QNLSRSWHDV QVSSAYKKTQ ETLSQAGQKT 130 140 150 160 170 180 SAALSTVGSA ISRKLGDMRN SATFKSFEDR VGTIKSKVVG DRENGSDNLP SSAGSGDKPL SDPAPF
	Isoform 3 [UniParc]. Checksum: 5087B635B9155443	FASTA	209	22,517
	10 20 30 40 50 60 MDSAGQDINL NSPNKGLLSD SMTDVPVDTG VAARTPAVEG LTEAEEEELR AELTKVEEEI 70 80 90 100 110 120 VTLRQVLAAK ERHCGELKRR LGLSTLGELK QNLSRSWHDV QVSSAYKKTQ ETLSQAGQKT 130 140 150 160 170 180 SAALSTVGSA ISRKLGDMRA HPFSHSFSSY SIRHSISMPA MRNSATFKSF EDRVGTIKSK 190 200 VVGDRENGSD NLPSSAGSGD KPLSDPAPF
	Isoform 4 [UniParc]. Checksum: 9BAD0A523C8F14DB	FASTA	200	21,450
	10 20 30 40 50 60 MDSAGQDINL NSPNKGLLSD SMTDVPVDTG VAARTPAVEG LTEAEEEELR AELTKVEEEI 70 80 90 100 110 120 VTLRQVLAAK ERHCGELKRR LGLSTLGELK QNLSRSWHDV QVSSAYKKTQ ETLSQAGQKT 130 140 150 160 170 180 SAALSTVGSA ISRKLGDMSS YSIRHSISMP AMRNSATFKS FEDRVGTIKS KVVGDRENGS 190 200 DNLPSSAGSG DKPLSDPAPF
	Isoform 5 [UniParc]. Checksum: 0A47C22C7C285FFF	FASTA	220	23,787
	10 20 30 40 50 60 MDSAGQDINL NSPNKGLLSD SMTDVPVDTG VAARTPAVEG LTEAEEEELR AELTKVEEEI 70 80 90 100 110 120 VTLRQVLAAK ERHCGELKRR LGLSTLGELK QNLSRSWHDV QVSSAYVKTS EKLGEWNEKV 130 140 150 160 170 180 TQSDLYKKTQ ETLSQAGQKT SAALSTVGSA ISRKLGDMSS YSIRHSISMP AMRNSATFKS 190 200 210 220 FEDRVGTIKS KVVGDRENGS DNLPSSAGSG DKPLSDPAPF
	Isoform 6 [UniParc]. Checksum: 1CF34D45DF97AABC	FASTA	163	17,473
	10 20 30 40 50 60 MDSAGQGVAA RTPAVEGLTE AEEEELRAEL TKVEEEIVTL RQVLAAKERH CGELKRRLGL 70 80 90 100 110 120 STLGELKQNL SRSWHDVQVS SAYKKTQETL SQAGQKTSAA LSTVGSAISR KLGDMRNSAT 130 140 150 160 FKSFEDRVGT IKSKVVGDRE NGSDNLPSSA GSGDKPLSDP APF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a third member of the D52 gene family indicates alternative coding sequence usage in D52-like transcripts." Nourse C.R., Mattei M.-G., Gunning P., Byrne J.A. Biochim. Biophys. Acta 1443:155-168(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING. Tissue: Mammary gland.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6). Tissue: Brain and Kidney.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
[7]	"Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system." Wilson S.H.D., Bailey A.M., Nourse C.R., Mattei M.-G., Byrne J.A. Genomics 76:81-88(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MAL2.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12 AND SER-166, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166, MASS SPECTROMETRY. Tissue: T-cell.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12 AND SER-166, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; SER-12; SER-96 AND SER-166, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96; SER-149 AND SER-166, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[13]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-19; SER-21; SER-96 AND SER-166, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; SER-12 AND SER-166, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF004429 mRNA. Translation: AAC98477.1. AF004430 mRNA. Translation: AAC98478.1. AK055068 mRNA. Translation: BAG51460.1. AK298366 mRNA. Translation: BAG60608.1. BT019631 mRNA. Translation: AAV38437.1. AL118506 Genomic DNA. Translation: CAC15492.1. AL118506 Genomic DNA. Translation: CAI21899.1. AL118506 Genomic DNA. Translation: CAI21900.1. AL118506 Genomic DNA. Translation: CAI21902.1. CH471077 Genomic DNA. Translation: EAW75195.1. CH471077 Genomic DNA. Translation: EAW75197.1. CH471077 Genomic DNA. Translation: EAW75198.1. CH471077 Genomic DNA. Translation: EAW75201.1. BC006804 mRNA. Translation: AAH06804.1.
IPI	IPI00221178. IPI00306825. IPI00399266. IPI00399267. IPI00399268.
RefSeq	NP_001230821.1. NM_001243892.1. NP_003279.2. NM_003288.3. NP_955393.1. NM_199361.2. NP_955394.1. NM_199362.2. NP_955395.1. NM_199363.2.
UniGene	Hs.473296.
3D structure databases
ProteinModelPortal	O43399.
ModBase	Search...
Protein-protein interaction databases
IntAct	O43399. 8 interactions.
STRING	9606.ENSP00000217121.
PTM databases
PhosphoSite	O43399.
2D gel databases
OGP	O43399.
Proteomic databases
PaxDb	O43399.
PRIDE	O43399.
Protocols and materials databases
DNASU	7165.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000346249; ENSP00000343547; ENSG00000101150. ENST00000348257; ENSP00000343554; ENSG00000101150. ENST00000351424; ENSP00000340006; ENSG00000101150. ENST00000352482; ENSP00000344647; ENSG00000101150. ENST00000358548; ENSP00000351350; ENSG00000101150. ENST00000369927; ENSP00000358943; ENSG00000101150.
GeneID	7165.
KEGG	hsa:7165.
UCSC	uc002ygz.3. human. uc002yha.3. human. uc002yhb.3. human. uc002yhc.3. human. uc011abl.2. human.
Organism-specific databases
CTD	7165.
GeneCards	GC20P062490.
HGNC	HGNC:12007. TPD52L2.
HPA	HPA047489.
MIM	603747. gene.
neXtProt	NX_O43399.
PharmGKB	PA36688.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG329468.
HOGENOM	HOG000231968.
HOVERGEN	HBG058643.
OrthoDB	EOG4BP1CV.
Enzyme and pathway databases
SignaLink	O43399.
Gene expression databases
ArrayExpress	O43399.
Bgee	O43399.
CleanEx	HS_TPD52L2.
Genevestigator	O43399.
GermOnline	ENSG00000101150. Homo sapiens.
Family and domain databases
InterPro	IPR007327. TPD52. [Graphical view]
PANTHER	PTHR19307. PTHR19307. 1 hit.
Pfam	PF04201. TPD52. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TPD52L2. human.
GenomeRNAi	7165.
NextBio	28048.
SOURCE	Search...

Entry information

Entry name

TPD54_HUMAN

Accession

Primary (citable) accession number: O43399
Secondary accession number(s): B4DPJ6 , E1P5G7, O43398, Q5JWU5, Q5JWU8, Q5U0E0, Q9H3Z6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2001
Last sequence update:	January 23, 2002
Last modified:	May 29, 2013
This is version 121 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.