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Protein

Tumor protein D54

Gene

TPD52L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101150-MONOMER.
SignaLinkiO43399.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein D54
Short name:
hD54
Alternative name(s):
Tumor protein D52-like 2
Gene namesi
Name:TPD52L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:12007. TPD52L2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi7165.
OpenTargetsiENSG00000101150.
PharmGKBiPA36688.

Polymorphism and mutation databases

BioMutaiTPD52L2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857441 – 206Tumor protein D54Add BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphoserineCombined sources1
Modified residuei12PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei163PhosphothreonineCombined sources1
Modified residuei166PhosphoserineCombined sources1
Modified residuei173PhosphothreonineCombined sources1
Modified residuei192PhosphoserineBy similarity1
Modified residuei195PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO43399.
PeptideAtlasiO43399.
PRIDEiO43399.
TopDownProteomicsiO43399-5. [O43399-5]

2D gel databases

OGPiO43399.

PTM databases

iPTMnetiO43399.
PhosphoSitePlusiO43399.
SwissPalmiO43399.

Expressioni

Gene expression databases

BgeeiENSG00000101150.
CleanExiHS_TPD52L2.
ExpressionAtlasiO43399. baseline and differential.
GenevisibleiO43399. HS.

Organism-specific databases

HPAiHPA047489.

Interactioni

Subunit structurei

Forms a homodimer or heterodimer with other members of the family (By similarity). Interacts with MAL2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Tpd52Q623932EBI-782616,EBI-782591From a different organism.

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi113018. 67 interactors.
IntActiO43399. 10 interactors.

Structurei

3D structure databases

ProteinModelPortaliO43399.
SMRiO43399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili38 – 82Sequence analysisAdd BLAST45

Sequence similaritiesi

Belongs to the TPD52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000015988.
HOGENOMiHOG000231968.
HOVERGENiHBG058643.
InParanoidiO43399.
OMAiRARPFSH.
OrthoDBiEOG091G0MLN.
PhylomeDBiO43399.
TreeFamiTF317562.

Family and domain databases

InterProiIPR007327. TPD52.
[Graphical view]
PANTHERiPTHR19307. PTHR19307. 1 hit.
PfamiPF04201. TPD52. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: O43399-1) [UniParc]FASTAAdd to basket
Also known as: HD54+ins2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSAGQDINL NSPNKGLLSD SMTDVPVDTG VAARTPAVEG LTEAEEEELR
60 70 80 90 100
AELTKVEEEI VTLRQVLAAK ERHCGELKRR LGLSTLGELK QNLSRSWHDV
110 120 130 140 150
QVSSAYVKTS EKLGEWNEKV TQSDLYKKTQ ETLSQAGQKT SAALSTVGSA
160 170 180 190 200
ISRKLGDMRN SATFKSFEDR VGTIKSKVVG DRENGSDNLP SSAGSGDKPL

SDPAPF
Length:206
Mass (Da):22,238
Last modified:January 23, 2002 - v2
Checksum:i58F01BC67B1E3DE9
GO
Isoform 2 (identifier: O43399-2) [UniParc]FASTAAdd to basket
Also known as: HD54-ins2

The sequence of this isoform differs from the canonical sequence as follows:
     106-125: Missing.

Show »
Length:186
Mass (Da):19,901
Checksum:i002CD68479D8250C
GO
Isoform 3 (identifier: O43399-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-125: Missing.
     159-159: R → RAHPFSHSFSSYSIRHSISMPAMR

Show »
Length:209
Mass (Da):22,517
Checksum:i5087B635B9155443
GO
Isoform 4 (identifier: O43399-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-125: Missing.
     157-157: D → DMSSYSIRHSISMPA

Show »
Length:200
Mass (Da):21,450
Checksum:i9BAD0A523C8F14DB
GO
Isoform 5 (identifier: O43399-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: D → DMSSYSIRHSISMPA

Note: No experimental confirmation available.
Show »
Length:220
Mass (Da):23,787
Checksum:i0A47C22C7C285FFF
GO
Isoform 6 (identifier: O43399-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     7-29: Missing.
     106-125: Missing.

Show »
Length:163
Mass (Da):17,473
Checksum:i1CF34D45DF97AABC
GO
Isoform 7 (identifier: O43399-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-157: D → DMRAHPFSHSFSSYSIRHSISMPA

Note: No experimental confirmation available.
Show »
Length:229
Mass (Da):24,854
Checksum:i0AF18A6C7059BE30
GO

Sequence cautioni

The sequence BU165202 differs from that shown. Reason: Frameshift at positions 155, 157, 173 and 188.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72R → K in AAC98478 (PubMed:9838088).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451547 – 29Missing in isoform 6. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_006547106 – 125Missing in isoform 2, isoform 3, isoform 4 and isoform 6. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_038361157D → DMSSYSIRHSISMPA in isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_047409157D → DMRAHPFSHSFSSYSIRHSI SMPA in isoform 7. 1 Publication1
Alternative sequenceiVSP_036756159R → RAHPFSHSFSSYSIRHSISM PAMR in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004429 mRNA. Translation: AAC98477.1.
AF004430 mRNA. Translation: AAC98478.1.
AK055068 mRNA. Translation: BAG51460.1.
AK298366 mRNA. Translation: BAG60608.1.
BT019631 mRNA. Translation: AAV38437.1.
AL118506 Genomic DNA. Translation: CAC15492.1.
AL118506 Genomic DNA. Translation: CAI21899.1.
AL118506 Genomic DNA. Translation: CAI21900.1.
AL118506 Genomic DNA. Translation: CAI21902.1.
CH471077 Genomic DNA. Translation: EAW75195.1.
CH471077 Genomic DNA. Translation: EAW75197.1.
CH471077 Genomic DNA. Translation: EAW75198.1.
CH471077 Genomic DNA. Translation: EAW75199.1.
CH471077 Genomic DNA. Translation: EAW75201.1.
BC006804 mRNA. Translation: AAH06804.1.
BU165202 mRNA. No translation available.
CCDSiCCDS13540.1. [O43399-1]
CCDS13541.1. [O43399-2]
CCDS13542.1. [O43399-7]
CCDS13543.1. [O43399-3]
CCDS13544.1. [O43399-5]
CCDS13545.1. [O43399-4]
CCDS58785.1. [O43399-6]
RefSeqiNP_001230821.1. NM_001243892.1. [O43399-6]
NP_003279.2. NM_003288.3. [O43399-1]
NP_955392.1. NM_199360.2. [O43399-7]
NP_955393.1. NM_199361.2. [O43399-3]
NP_955394.1. NM_199362.2. [O43399-5]
NP_955395.1. NM_199363.2. [O43399-4]
UniGeneiHs.473296.

Genome annotation databases

EnsembliENST00000217121; ENSP00000217121; ENSG00000101150. [O43399-7]
ENST00000346249; ENSP00000343547; ENSG00000101150. [O43399-1]
ENST00000348257; ENSP00000343554; ENSG00000101150. [O43399-2]
ENST00000351424; ENSP00000340006; ENSG00000101150. [O43399-3]
ENST00000352482; ENSP00000344647; ENSG00000101150. [O43399-5]
ENST00000358548; ENSP00000351350; ENSG00000101150. [O43399-4]
ENST00000369927; ENSP00000358943; ENSG00000101150. [O43399-6]
GeneIDi7165.
KEGGihsa:7165.
UCSCiuc002ygy.4. human. [O43399-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004429 mRNA. Translation: AAC98477.1.
AF004430 mRNA. Translation: AAC98478.1.
AK055068 mRNA. Translation: BAG51460.1.
AK298366 mRNA. Translation: BAG60608.1.
BT019631 mRNA. Translation: AAV38437.1.
AL118506 Genomic DNA. Translation: CAC15492.1.
AL118506 Genomic DNA. Translation: CAI21899.1.
AL118506 Genomic DNA. Translation: CAI21900.1.
AL118506 Genomic DNA. Translation: CAI21902.1.
CH471077 Genomic DNA. Translation: EAW75195.1.
CH471077 Genomic DNA. Translation: EAW75197.1.
CH471077 Genomic DNA. Translation: EAW75198.1.
CH471077 Genomic DNA. Translation: EAW75199.1.
CH471077 Genomic DNA. Translation: EAW75201.1.
BC006804 mRNA. Translation: AAH06804.1.
BU165202 mRNA. No translation available.
CCDSiCCDS13540.1. [O43399-1]
CCDS13541.1. [O43399-2]
CCDS13542.1. [O43399-7]
CCDS13543.1. [O43399-3]
CCDS13544.1. [O43399-5]
CCDS13545.1. [O43399-4]
CCDS58785.1. [O43399-6]
RefSeqiNP_001230821.1. NM_001243892.1. [O43399-6]
NP_003279.2. NM_003288.3. [O43399-1]
NP_955392.1. NM_199360.2. [O43399-7]
NP_955393.1. NM_199361.2. [O43399-3]
NP_955394.1. NM_199362.2. [O43399-5]
NP_955395.1. NM_199363.2. [O43399-4]
UniGeneiHs.473296.

3D structure databases

ProteinModelPortaliO43399.
SMRiO43399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113018. 67 interactors.
IntActiO43399. 10 interactors.

PTM databases

iPTMnetiO43399.
PhosphoSitePlusiO43399.
SwissPalmiO43399.

Polymorphism and mutation databases

BioMutaiTPD52L2.

2D gel databases

OGPiO43399.

Proteomic databases

EPDiO43399.
PeptideAtlasiO43399.
PRIDEiO43399.
TopDownProteomicsiO43399-5. [O43399-5]

Protocols and materials databases

DNASUi7165.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217121; ENSP00000217121; ENSG00000101150. [O43399-7]
ENST00000346249; ENSP00000343547; ENSG00000101150. [O43399-1]
ENST00000348257; ENSP00000343554; ENSG00000101150. [O43399-2]
ENST00000351424; ENSP00000340006; ENSG00000101150. [O43399-3]
ENST00000352482; ENSP00000344647; ENSG00000101150. [O43399-5]
ENST00000358548; ENSP00000351350; ENSG00000101150. [O43399-4]
ENST00000369927; ENSP00000358943; ENSG00000101150. [O43399-6]
GeneIDi7165.
KEGGihsa:7165.
UCSCiuc002ygy.4. human. [O43399-1]

Organism-specific databases

CTDi7165.
DisGeNETi7165.
GeneCardsiTPD52L2.
HGNCiHGNC:12007. TPD52L2.
HPAiHPA047489.
MIMi603747. gene.
neXtProtiNX_O43399.
OpenTargetsiENSG00000101150.
PharmGKBiPA36688.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000015988.
HOGENOMiHOG000231968.
HOVERGENiHBG058643.
InParanoidiO43399.
OMAiRARPFSH.
OrthoDBiEOG091G0MLN.
PhylomeDBiO43399.
TreeFamiTF317562.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101150-MONOMER.
SignaLinkiO43399.

Miscellaneous databases

ChiTaRSiTPD52L2. human.
GeneWikiiTPD52L2.
GenomeRNAii7165.
PROiO43399.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101150.
CleanExiHS_TPD52L2.
ExpressionAtlasiO43399. baseline and differential.
GenevisibleiO43399. HS.

Family and domain databases

InterProiIPR007327. TPD52.
[Graphical view]
PANTHERiPTHR19307. PTHR19307. 1 hit.
PfamiPF04201. TPD52. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPD54_HUMAN
AccessioniPrimary (citable) accession number: O43399
Secondary accession number(s): B4DPJ6
, E1P5G7, O43398, Q5JWU5, Q5JWU6, Q5JWU8, Q5U0E0, Q9H3Z6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 23, 2002
Last modified: November 30, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.