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Protein

Thioredoxin-like protein 1

Gene

TXNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Active thioredoxin with a redox potential of about -250 mV.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000091164-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 1
Alternative name(s):
32 kDa thioredoxin-related protein
Gene namesi
Name:TXNL1
Synonyms:TRP32, TXL, TXNL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:12436. TXNL1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • mitochondrion Source: GO_Central
  • nucleus Source: UniProtKB-SubCell
  • proteasome complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Organism-specific databases

DisGeNETi9352.
OpenTargetsiENSG00000091164.
PharmGKBiPA134967488.

Polymorphism and mutation databases

BioMutaiTXNL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001200162 – 289Thioredoxin-like protein 1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 37Redox-active1 Publication
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiO43396.
PaxDbiO43396.
PeptideAtlasiO43396.
PRIDEiO43396.
TopDownProteomicsiO43396.

2D gel databases

OGPiO43396.
REPRODUCTION-2DPAGEIPI00305692.

PTM databases

iPTMnetiO43396.
PhosphoSitePlusiO43396.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000091164.
CleanExiHS_TXNL1.
ExpressionAtlasiO43396. baseline and differential.
GenevisibleiO43396. HS.

Organism-specific databases

HPAiCAB016446.
HPA002828.
HPA002829.

Interactioni

Subunit structurei

Component of the 19S regulatory cap of the 26S proteasome. Interacts with PSMD14/RPN11. Interacts with, and reduces EEF1A1.1 Publication

Protein-protein interaction databases

BioGridi114755. 59 interactors.
IntActiO43396. 9 interactors.
MINTiMINT-5005836.
STRINGi9606.ENSP00000217515.

Structurei

Secondary structure

1289
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Helixi10 – 12Combined sources3
Helixi13 – 19Combined sources7
Turni20 – 22Combined sources3
Beta strandi25 – 30Combined sources6
Helixi35 – 50Combined sources16
Beta strandi54 – 60Combined sources7
Turni61 – 63Combined sources3
Helixi65 – 70Combined sources6
Beta strandi75 – 83Combined sources9
Beta strandi86 – 94Combined sources9
Helixi96 – 107Combined sources12
Helixi127 – 129Combined sources3
Turni132 – 134Combined sources3
Beta strandi136 – 139Combined sources4
Beta strandi142 – 144Combined sources3
Beta strandi150 – 154Combined sources5
Beta strandi166 – 182Combined sources17
Beta strandi186 – 188Combined sources3
Beta strandi193 – 199Combined sources7
Helixi208 – 211Combined sources4
Turni222 – 224Combined sources3
Turni235 – 237Combined sources3
Beta strandi241 – 248Combined sources8
Beta strandi263 – 271Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GH2X-ray2.22A2-108[»]
1WWYNMR-A122-279[»]
ProteinModelPortaliO43396.
SMRiO43396.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43396.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 109ThioredoxinAdd BLAST108
Domaini115 – 285PITHPROSITE-ProRule annotationAdd BLAST171

Sequence similaritiesi

Contains 1 PITH domain.PROSITE-ProRule annotation
Contains 1 thioredoxin domain.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0908. Eukaryota.
ENOG410YQ2G. LUCA.
GeneTreeiENSGT00530000063008.
HOGENOMiHOG000189802.
HOVERGENiHBG055982.
InParanoidiO43396.
OMAiPIFEMFP.
OrthoDBiEOG091G0G71.
PhylomeDBiO43396.
TreeFamiTF314399.

Family and domain databases

Gene3Di2.60.120.470. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR010400. PITH_dom.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF06201. PITH. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS51532. PITH. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGVKPVGSD PDFQPELSGA GSRLAVVKFT MRGCGPCLRI APAFSSMSNK
60 70 80 90 100
YPQAVFLEVD VHQCQGTAAT NNISATPTFL FFRNKVRIDQ YQGADAVGLE
110 120 130 140 150
EKIKQHLEND PGSNEDTDIP KGYMDLMPFI NKAGCECLNE SDEHGFDNCL
160 170 180 190 200
RKDTTFLESD CDEQLLITVA FNQPVKLYSM KFQGPDNGQG PKYVKIFINL
210 220 230 240 250
PRSMDFEEAE RSEPTQALEL TEDDIKEDGI VPLRYVKFQN VNSVTIFVQS
260 270 280
NQGEEETTRI SYFTFIGTPV QATNMNDFKR VVGKKGESH
Length:289
Mass (Da):32,251
Last modified:January 23, 2007 - v3
Checksum:iB2CC0BD8042225C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003938 mRNA. Translation: AAC39599.1.
AF052659 mRNA. Translation: AAC39898.1.
AF143897
, AF143890, AF143891, AF143892, AF143893, AF143894, AF143895, AF143896 Genomic DNA. Translation: AAF66676.1.
AF051896 mRNA. Translation: AAC05830.1.
BC001156 mRNA. Translation: AAH01156.1.
CCDSiCCDS11961.1.
PIRiJC5938.
RefSeqiNP_004777.1. NM_004786.2.
XP_016881582.1. XM_017026093.1.
UniGeneiHs.114412.

Genome annotation databases

EnsembliENST00000217515; ENSP00000217515; ENSG00000091164.
ENST00000590954; ENSP00000464918; ENSG00000091164.
GeneIDi9352.
KEGGihsa:9352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003938 mRNA. Translation: AAC39599.1.
AF052659 mRNA. Translation: AAC39898.1.
AF143897
, AF143890, AF143891, AF143892, AF143893, AF143894, AF143895, AF143896 Genomic DNA. Translation: AAF66676.1.
AF051896 mRNA. Translation: AAC05830.1.
BC001156 mRNA. Translation: AAH01156.1.
CCDSiCCDS11961.1.
PIRiJC5938.
RefSeqiNP_004777.1. NM_004786.2.
XP_016881582.1. XM_017026093.1.
UniGeneiHs.114412.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GH2X-ray2.22A2-108[»]
1WWYNMR-A122-279[»]
ProteinModelPortaliO43396.
SMRiO43396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114755. 59 interactors.
IntActiO43396. 9 interactors.
MINTiMINT-5005836.
STRINGi9606.ENSP00000217515.

PTM databases

iPTMnetiO43396.
PhosphoSitePlusiO43396.

Polymorphism and mutation databases

BioMutaiTXNL1.

2D gel databases

OGPiO43396.
REPRODUCTION-2DPAGEIPI00305692.

Proteomic databases

EPDiO43396.
PaxDbiO43396.
PeptideAtlasiO43396.
PRIDEiO43396.
TopDownProteomicsiO43396.

Protocols and materials databases

DNASUi9352.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217515; ENSP00000217515; ENSG00000091164.
ENST00000590954; ENSP00000464918; ENSG00000091164.
GeneIDi9352.
KEGGihsa:9352.

Organism-specific databases

CTDi9352.
DisGeNETi9352.
GeneCardsiTXNL1.
HGNCiHGNC:12436. TXNL1.
HPAiCAB016446.
HPA002828.
HPA002829.
MIMi603049. gene.
neXtProtiNX_O43396.
OpenTargetsiENSG00000091164.
PharmGKBiPA134967488.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0908. Eukaryota.
ENOG410YQ2G. LUCA.
GeneTreeiENSGT00530000063008.
HOGENOMiHOG000189802.
HOVERGENiHBG055982.
InParanoidiO43396.
OMAiPIFEMFP.
OrthoDBiEOG091G0G71.
PhylomeDBiO43396.
TreeFamiTF314399.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000091164-MONOMER.

Miscellaneous databases

ChiTaRSiTXNL1. human.
EvolutionaryTraceiO43396.
GeneWikiiTXNL1.
GenomeRNAii9352.
PROiO43396.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000091164.
CleanExiHS_TXNL1.
ExpressionAtlasiO43396. baseline and differential.
GenevisibleiO43396. HS.

Family and domain databases

Gene3Di2.60.120.470. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR010400. PITH_dom.
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF06201. PITH. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS51532. PITH. 1 hit.
PS00194. THIOREDOXIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXNL1_HUMAN
AccessioniPrimary (citable) accession number: O43396
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 163 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.