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Protein

Thioredoxin-like protein 1

Gene

TXNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Active thioredoxin with a redox potential of about -250 mV.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein 1
Alternative name(s):
32 kDa thioredoxin-related protein
Gene namesi
Name:TXNL1
Synonyms:TRP32, TXL, TXNL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000091164.12
HGNCiHGNC:12436 TXNL1
MIMi603049 gene
neXtProtiNX_O43396

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Organism-specific databases

DisGeNETi9352
OpenTargetsiENSG00000091164
PharmGKBiPA134967488

Polymorphism and mutation databases

BioMutaiTXNL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001200162 – 289Thioredoxin-like protein 1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 37Redox-active1 Publication
Modified residuei113PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiO43396
PaxDbiO43396
PeptideAtlasiO43396
PRIDEiO43396
TopDownProteomicsiO43396

2D gel databases

OGPiO43396
REPRODUCTION-2DPAGEiIPI00305692

PTM databases

iPTMnetiO43396
PhosphoSitePlusiO43396

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000091164
CleanExiHS_TXNL1
ExpressionAtlasiO43396 baseline and differential
GenevisibleiO43396 HS

Organism-specific databases

HPAiCAB016446
HPA002828
HPA002829

Interactioni

Subunit structurei

Component of the 19S regulatory cap of the 26S proteasome. Interacts with PSMD14/RPN11. Interacts with, and reduces EEF1A1.1 Publication

Protein-protein interaction databases

BioGridi114755, 63 interactors
IntActiO43396, 10 interactors
MINTiO43396
STRINGi9606.ENSP00000217515

Structurei

Secondary structure

1289
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Helixi10 – 12Combined sources3
Helixi13 – 19Combined sources7
Turni20 – 22Combined sources3
Beta strandi25 – 30Combined sources6
Helixi35 – 50Combined sources16
Beta strandi54 – 60Combined sources7
Turni61 – 63Combined sources3
Helixi65 – 70Combined sources6
Beta strandi75 – 83Combined sources9
Beta strandi86 – 94Combined sources9
Helixi96 – 107Combined sources12
Helixi127 – 129Combined sources3
Turni132 – 134Combined sources3
Beta strandi136 – 139Combined sources4
Beta strandi142 – 144Combined sources3
Beta strandi150 – 154Combined sources5
Beta strandi166 – 182Combined sources17
Beta strandi186 – 188Combined sources3
Beta strandi193 – 199Combined sources7
Helixi208 – 211Combined sources4
Turni222 – 224Combined sources3
Turni235 – 237Combined sources3
Beta strandi241 – 248Combined sources8
Beta strandi263 – 271Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GH2X-ray2.22A2-108[»]
1WWYNMR-A122-279[»]
ProteinModelPortaliO43396
SMRiO43396
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO43396

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 109ThioredoxinAdd BLAST108
Domaini115 – 285PITHPROSITE-ProRule annotationAdd BLAST171

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0908 Eukaryota
ENOG410YQ2G LUCA
GeneTreeiENSGT00530000063008
HOGENOMiHOG000189802
HOVERGENiHBG055982
InParanoidiO43396
OMAiPIFEMFP
OrthoDBiEOG091G0G71
PhylomeDBiO43396
TreeFamiTF314399

Family and domain databases

Gene3Di2.60.120.470, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR010400 PITH_dom
IPR037047 PITH_dom_sf
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF06201 PITH, 1 hit
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51532 PITH, 1 hit
PS00194 THIOREDOXIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O43396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGVKPVGSD PDFQPELSGA GSRLAVVKFT MRGCGPCLRI APAFSSMSNK
60 70 80 90 100
YPQAVFLEVD VHQCQGTAAT NNISATPTFL FFRNKVRIDQ YQGADAVGLE
110 120 130 140 150
EKIKQHLEND PGSNEDTDIP KGYMDLMPFI NKAGCECLNE SDEHGFDNCL
160 170 180 190 200
RKDTTFLESD CDEQLLITVA FNQPVKLYSM KFQGPDNGQG PKYVKIFINL
210 220 230 240 250
PRSMDFEEAE RSEPTQALEL TEDDIKEDGI VPLRYVKFQN VNSVTIFVQS
260 270 280
NQGEEETTRI SYFTFIGTPV QATNMNDFKR VVGKKGESH
Length:289
Mass (Da):32,251
Last modified:January 23, 2007 - v3
Checksum:iB2CC0BD8042225C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003938 mRNA Translation: AAC39599.1
AF052659 mRNA Translation: AAC39898.1
AF143897
, AF143890, AF143891, AF143892, AF143893, AF143894, AF143895, AF143896 Genomic DNA Translation: AAF66676.1
AF051896 mRNA Translation: AAC05830.1
BC001156 mRNA Translation: AAH01156.1
CCDSiCCDS11961.1
PIRiJC5938
RefSeqiNP_004777.1, NM_004786.2
XP_016881582.1, XM_017026093.1
UniGeneiHs.114412

Genome annotation databases

EnsembliENST00000217515; ENSP00000217515; ENSG00000091164
ENST00000590954; ENSP00000464918; ENSG00000091164
GeneIDi9352
KEGGihsa:9352

Similar proteinsi

Entry informationi

Entry nameiTXNL1_HUMAN
AccessioniPrimary (citable) accession number: O43396
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health