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O43395

- PRPF3_HUMAN

UniProt

O43395 - PRPF3_HUMAN

Protein

U4/U6 small nuclear ribonucleoprotein Prp3

Gene

PRPF3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (26 Sep 2003)
      Previous versions | rss
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    Functioni

    Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. poly(A) RNA binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. mRNA processing Source: ProtInc
    2. mRNA splicing, via spliceosome Source: UniProtKB
    3. RNA splicing Source: ProtInc
    4. RNA splicing, via transesterification reactions Source: UniProtKB

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U4/U6 small nuclear ribonucleoprotein Prp3
    Alternative name(s):
    Pre-mRNA-splicing factor 3
    Short name:
    hPrp3
    U4/U6 snRNP 90 kDa protein
    Gene namesi
    Name:PRPF3
    Synonyms:HPRP3, PRP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:17348. PRPF3.

    Subcellular locationi

    Nucleus speckle
    Note: Colocalizes with spliceosomal snRNPs.

    GO - Cellular componenti

    1. Cajal body Source: BHF-UCL
    2. cytoplasm Source: HPA
    3. nuclear speck Source: UniProtKB-SubCell
    4. nucleus Source: HPA
    5. spliceosomal complex Source: UniProtKB
    6. U4/U6 x U5 tri-snRNP complex Source: InterPro

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    Pathology & Biotechi

    Involvement in diseasei

    Retinitis pigmentosa 18 (RP18) [MIM:601414]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti493 – 4931P → S in RP18. 1 Publication
    VAR_046735
    Natural varianti494 – 4941T → M in RP18; reduces phosphorylation; impairs binding to PRPF4; impairs self-association; affects interaction with the U4/U5/U6 tri-snRNP complex; does not affect global pre-mRNA splicing. 2 Publications
    VAR_016877

    Keywords - Diseasei

    Disease mutation, Retinitis pigmentosa

    Organism-specific databases

    MIMi601414. phenotype.
    Orphaneti791. Retinitis pigmentosa.
    PharmGKBiPA134892509.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 683683U4/U6 small nuclear ribonucleoprotein Prp3PRO_0000097044Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei164 – 1641Phosphoserine2 Publications
    Modified residuei167 – 1671Phosphothreonine2 Publications
    Modified residuei619 – 6191Phosphoserine5 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiO43395.
    PaxDbiO43395.
    PRIDEiO43395.

    PTM databases

    PhosphoSiteiO43395.

    Miscellaneous databases

    PMAP-CutDBO43395.

    Expressioni

    Tissue specificityi

    Highly expressed in retina, liver, kidney and blood. Detected at lower levels in heart and brain.1 Publication

    Gene expression databases

    ArrayExpressiO43395.
    BgeeiO43395.
    CleanExiHS_PRPF3.
    GenevestigatoriO43395.

    Organism-specific databases

    HPAiHPA027226.

    Interactioni

    Subunit structurei

    Interacts directly with PRPF4. Part of a heteromeric complex containing PPIH, PRPF3 and PRPF4 that is stable in the absence of RNA. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-744322,EBI-744322
    DVL3Q929972EBI-744322,EBI-739789
    MFAP1P550812EBI-744322,EBI-1048159
    NKAPQ8N5F72EBI-744322,EBI-721539
    SF3B2Q134352EBI-744322,EBI-749111
    SLU7O953912EBI-744322,EBI-750559
    SMNDC1O759402EBI-744322,EBI-1052641
    U2AF2P263682EBI-744322,EBI-742339

    Protein-protein interaction databases

    BioGridi114577. 73 interactions.
    DIPiDIP-34508N.
    IntActiO43395. 29 interactions.
    MINTiMINT-1445186.
    STRINGi9606.ENSP00000315379.

    Structurei

    Secondary structure

    1
    683
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 2319
    Helixi28 – 3912
    Helixi44 – 518
    Turni52 – 554
    Helixi56 – 583
    Helixi60 – 7314

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1X4QNMR-A1-79[»]
    ProteinModelPortaliO43395.
    SMRiO43395. Positions 1-73.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO43395.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8787PWIPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi579 – 5846Poly-Val

    Sequence similaritiesi

    Contains 1 PWI domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG268901.
    HOGENOMiHOG000205412.
    HOVERGENiHBG053699.
    InParanoidiO43395.
    KOiK12843.
    OMAiPWVERTV.
    PhylomeDBiO43395.
    TreeFamiTF313082.

    Family and domain databases

    Gene3Di1.20.1390.10. 1 hit.
    InterProiIPR010541. DUF1115.
    IPR013881. Pre-mRNA_splic_Prp3.
    IPR027104. Prp3.
    IPR002483. PWI_dom.
    [Graphical view]
    PANTHERiPTHR14212. PTHR14212. 1 hit.
    PfamiPF06544. DUF1115. 1 hit.
    PF08572. PRP3. 1 hit.
    PF01480. PWI. 1 hit.
    [Graphical view]
    SMARTiSM00311. PWI. 1 hit.
    [Graphical view]
    SUPFAMiSSF101233. SSF101233. 1 hit.
    PROSITEiPS51025. PWI. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O43395-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALSKRELDE LKPWIEKTVK RVLGFSEPTV VTAALNCVGK GMDKKKAADH    50
    LKPFLDDSTL RFVDKLFEAV EEGRSSRHSK SSSDRSRKRE LKEVFGDDSE 100
    ISKESSGVKK RRIPRFEEVE EEPEVIPGPP SESPGMLTKL QIKQMMEAAT 150
    RQIEERKKQL SFISPPTPQP KTPSSSQPER LPIGNTIQPS QAATFMNDAI 200
    EKARKAAELQ ARIQAQLALK PGLIGNANMV GLANLHAMGI APPKVELKDQ 250
    TKPTPLILDE QGRTVDATGK EIELTHRMPT LKANIRAVKR EQFKQQLKEK 300
    PSEDMESNTF FDPRVSIAPS QRQRRTFKFH DKGKFEKIAQ RLRTKAQLEK 350
    LQAEISQAAR KTGIHTSTRL ALIAPKKELK EGDIPEIEWW DSYIIPNGFD 400
    LTEENPKRED YFGITNLVEH PAQLNPPVDN DTPVTLGVYL TKKEQKKLRR 450
    QTRREAQKEL QEKVRLGLMP PPEPKVRISN LMRVLGTEAV QDPTKVEAHV 500
    RAQMAKRQKA HEEANAARKL TAEQRKVKKI KKLKEDISQG VHISVYRVRN 550
    LSNPAKKFKI EANAGQLYLT GVVVLHKDVN VVVVEGGPKA QKKFKRLMLH 600
    RIKWDEQTSN TKGDDDEESD EEAVKKTNKC VLVWEGTAKD RSFGEMKFKQ 650
    CPTENMAREH FKKHGAEHYW DLALSESVLE STD 683
    Length:683
    Mass (Da):77,529
    Last modified:September 26, 2003 - v2
    Checksum:i4AA6AA4C99110284
    GO
    Isoform 2 (identifier: O43395-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-135: Missing.
         402-416: TEENPKREDYFGITN → GKSQERRLFWNHKSC
         417-683: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:281
    Mass (Da):31,889
    Checksum:i35DEDDAF71195A31
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421I → T in AAC09069. (PubMed:9328476)Curated
    Sequence conflicti273 – 2742EL → SV in AAC09069. (PubMed:9328476)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121K → N.
    Corresponds to variant rs12736964 [ dbSNP | Ensembl ].
    VAR_051286
    Natural varianti493 – 4931P → S in RP18. 1 Publication
    VAR_046735
    Natural varianti494 – 4941T → M in RP18; reduces phosphorylation; impairs binding to PRPF4; impairs self-association; affects interaction with the U4/U5/U6 tri-snRNP complex; does not affect global pre-mRNA splicing. 2 Publications
    VAR_016877

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 135135Missing in isoform 2. 1 PublicationVSP_056265Add
    BLAST
    Alternative sequencei402 – 41615TEENP…FGITN → GKSQERRLFWNHKSC in isoform 2. 1 PublicationVSP_056266Add
    BLAST
    Alternative sequencei417 – 683267Missing in isoform 2. 1 PublicationVSP_056267Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001947 mRNA. Translation: AAC09069.1.
    AF016370 mRNA. Translation: AAC51926.1.
    AK299980 mRNA. Translation: BAG61801.1.
    AL611942 Genomic DNA. Translation: CAH70312.1.
    CH471121 Genomic DNA. Translation: EAW53556.1.
    BC000184 mRNA. Translation: AAH00184.1.
    BC001954 mRNA. Translation: AAH01954.1.
    CCDSiCCDS951.1.
    PIRiT50839.
    T50840.
    RefSeqiNP_004689.1. NM_004698.2.
    UniGeneiHs.11776.

    Genome annotation databases

    EnsembliENST00000324862; ENSP00000315379; ENSG00000117360.
    ENST00000543398; ENSP00000445421; ENSG00000117360.
    GeneIDi9129.
    KEGGihsa:9129.
    UCSCiuc001eum.4. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF001947 mRNA. Translation: AAC09069.1 .
    AF016370 mRNA. Translation: AAC51926.1 .
    AK299980 mRNA. Translation: BAG61801.1 .
    AL611942 Genomic DNA. Translation: CAH70312.1 .
    CH471121 Genomic DNA. Translation: EAW53556.1 .
    BC000184 mRNA. Translation: AAH00184.1 .
    BC001954 mRNA. Translation: AAH01954.1 .
    CCDSi CCDS951.1.
    PIRi T50839.
    T50840.
    RefSeqi NP_004689.1. NM_004698.2.
    UniGenei Hs.11776.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1X4Q NMR - A 1-79 [» ]
    ProteinModelPortali O43395.
    SMRi O43395. Positions 1-73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114577. 73 interactions.
    DIPi DIP-34508N.
    IntActi O43395. 29 interactions.
    MINTi MINT-1445186.
    STRINGi 9606.ENSP00000315379.

    PTM databases

    PhosphoSitei O43395.

    Proteomic databases

    MaxQBi O43395.
    PaxDbi O43395.
    PRIDEi O43395.

    Protocols and materials databases

    DNASUi 9129.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324862 ; ENSP00000315379 ; ENSG00000117360 .
    ENST00000543398 ; ENSP00000445421 ; ENSG00000117360 .
    GeneIDi 9129.
    KEGGi hsa:9129.
    UCSCi uc001eum.4. human.

    Organism-specific databases

    CTDi 9129.
    GeneCardsi GC01P150293.
    GeneReviewsi PRPF3.
    HGNCi HGNC:17348. PRPF3.
    HPAi HPA027226.
    MIMi 601414. phenotype.
    607301. gene.
    neXtProti NX_O43395.
    Orphaneti 791. Retinitis pigmentosa.
    PharmGKBi PA134892509.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG268901.
    HOGENOMi HOG000205412.
    HOVERGENi HBG053699.
    InParanoidi O43395.
    KOi K12843.
    OMAi PWVERTV.
    PhylomeDBi O43395.
    TreeFami TF313082.

    Miscellaneous databases

    EvolutionaryTracei O43395.
    GeneWikii PRPF3.
    GenomeRNAii 9129.
    NextBioi 34221.
    PMAP-CutDB O43395.
    PROi O43395.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O43395.
    Bgeei O43395.
    CleanExi HS_PRPF3.
    Genevestigatori O43395.

    Family and domain databases

    Gene3Di 1.20.1390.10. 1 hit.
    InterProi IPR010541. DUF1115.
    IPR013881. Pre-mRNA_splic_Prp3.
    IPR027104. Prp3.
    IPR002483. PWI_dom.
    [Graphical view ]
    PANTHERi PTHR14212. PTHR14212. 1 hit.
    Pfami PF06544. DUF1115. 1 hit.
    PF08572. PRP3. 1 hit.
    PF01480. PWI. 1 hit.
    [Graphical view ]
    SMARTi SM00311. PWI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101233. SSF101233. 1 hit.
    PROSITEi PS51025. PWI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome."
      Wang A., Forman-Kay J., Luo Y., Luo M., Chow Y.-H., Plumb J., Friesen J.D., Tsui L.-C., Heng H.H.Q., Woolford J.L. Jr., Hu J.
      Hum. Mol. Genet. 6:2117-2126(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH PRPF4 AND U4/U5/U6 SNRNPS.
    2. "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs."
      Horowitz D.S., Kobayashi R., Krainer A.R.
      RNA 3:1374-1387(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 93-101; 253-267; 351-361; 409-428 AND 560-576, INTERACTION WITH PPIH; PRPF4 AND U4/U6 SNRNPS.
      Tissue: Neuroepithelium.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Skin.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-619, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."
      Liu S., Rauhut R., Vornlocher H.-P., Luehrmann R.
      RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164 AND THR-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
      Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-619, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-619, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; THR-167 AND SER-619, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-619, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Solution structure of PWI domain in U4/U6 small nuclear ribonucleoprotein PRP3(HPRP3)."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1-79.
    17. "Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa."
      Chakarova C.F., Hims M.M., Bolz H., Abu-Safieh L., Patel R.J., Papaioannou M.G., Inglehearn C.F., Keen T.J., Willis C., Moore A.T., Rosenberg T., Webster A.R., Bird A.C., Gal A., Hunt D., Vithana E.N., Bhattacharya S.S.
      Hum. Mol. Genet. 11:87-92(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS RP18 SER-493 AND MET-494, TISSUE SPECIFICITY.
    18. "Mutations in the pre-mRNA splicing-factor genes PRPF3, PRPF8, and PRPF31 in Spanish families with autosomal dominant retinitis pigmentosa."
      Martinez-Gimeno M., Gamundi M.J., Hernan I., Maseras M., Milla E., Ayuso C., Garcia-Sandoval B., Beneyto M., Vilela C., Baiget M., Antinolo G., Carballo M.
      Invest. Ophthalmol. Vis. Sci. 44:2171-2177(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT RP18 MET-494.
    19. "Mutation in the splicing factor Hprp3p linked to retinitis pigmentosa impairs interactions within the U4/U6 snRNP complex."
      Gonzalez-Santos J.M., Cao H., Duan R.C., Hu J.
      Hum. Mol. Genet. 17:225-239(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANT RP18 MET-494.

    Entry informationi

    Entry nameiPRPF3_HUMAN
    AccessioniPrimary (citable) accession number: O43395
    Secondary accession number(s): B4DSY9, O43446, Q5VT54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: September 26, 2003
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3