ARNT

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
protein dimerization activity Source: InterPro
transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processⁱ

positive regulation of transcription, DNA-templated
Source: MGI
Inferred from direct assayⁱ
- 11782478
transcription, DNA-templated Source: UniProtKB-KW

Keywordsⁱ

Molecular function	DNA-bindingSAAS annotation, ReceptorImported
Biological process	Transcription, Transcription regulationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Aryl hydrocarbon receptor nuclear translocatorImported
Gene namesⁱ	Name:ARNTImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

Nucleus
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00809239

GO - Cellular componentⁱ

cytoplasm Source: InterPro
nucleus Source: UniProtKB-SubCell
transcription factor complex Source: InterPro

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusSAAS annotation

PTM / Processingⁱ

Proteomic databases

PaxDbⁱ	O43392.
PeptideAtlas More...PeptideAtlasⁱ	O43392.

Interactionⁱ

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

Complete GO annotation...

Protein-protein interaction databases

Molecular INTeraction database More...MINTⁱ	MINT-7034501.

MINTⁱ

MINT-7034501.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O43392.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	89 – 142	BHLH (basic helix-loop-helix)InterPro annotationAdd BLAST		54
Domainⁱ	161 – 235	PAS (PER-ARNT-SIM)InterPro annotationAdd BLAST		75

Phylogenomic databases

eggNOGⁱ	ENOG410IQ5T. Eukaryota. ENOG410XVHF. LUCA.
HOGENOMⁱ	HOG000234379.
HOVERGENⁱ	HBG000164.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083. HLH. 1 hit. cd00130. PAS. 1 hit.
Gene3Dⁱ	4.10.280.10. 1 hit.
InterProⁱ	View protein in InterPro IPR011598. bHLH_dom. IPR001067. Nuc_translocat. IPR000014. PAS. IPR013767. PAS_fold.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010. HLH. 1 hit. PF00989. PAS. 1 hit.
PRINTSⁱ	PR00785. NCTRNSLOCATR.
SMARTⁱ	View protein in SMART SM00353. HLH. 1 hit. SM00091. PAS. 1 hit.
SUPFAMⁱ	SSF47459. SSF47459. 1 hit. SSF55785. SSF55785. 3 hits.
PROSITEⁱ	View protein in PROSITE PS50888. BHLH. 1 hit. PS50112. PAS. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

O43392-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAATTANPEM TSDVPSLGPA IASGNSGPGI QGGGAIVQRA IKRRPGLDFD 
        60         70         80         90        100
DDGEGNSKFL RCDDDQMSND KERFARSDDE QSSADKERLA RENHSEIERR 
       110        120        130        140        150
RRNKMTAYIT ELSDMVPTCS ALARKPDKLT ILRMAVSHMK SLRGTGNTST 
       160        170        180        190        200
DGSYKPSFLT DQELKHLILE AADGFLFIVS CETGRVVYVS DSVTPVLNQP 
       210        220        230        240        250
QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK TGTVKKEGQQ 
       260        270        280        290        300
SSMRMCMGSR RSFICRMRCG SSSVDPVSVN RLSFVRNRCR NGLGSVKDGE 
       310        320 
PHFVVVHCTG YIKAWPPAGV SLPDDDPA

Length:328

Mass (Da):36,012

Last modified:June 1, 1998 - v1

Checksum:ⁱ18F056368D984654

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF001307 mRNA. Translation: AAC03365.1.
UniGeneⁱ	Hs.632446.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF001307 mRNA. Translation: AAC03365.1.
UniGeneⁱ	Hs.632446.

3D structure databases

ProteinModelPortalⁱ	O43392.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

Molecular INTeraction database More...MINTⁱ	MINT-7034501.

MINTⁱ

MINT-7034501.

Proteomic databases

PaxDbⁱ	O43392.
PeptideAtlas More...PeptideAtlasⁱ	O43392.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IQ5T. Eukaryota. ENOG410XVHF. LUCA.
HOGENOMⁱ	HOG000234379.
HOVERGENⁱ	HBG000164.

Miscellaneous databases

ChiTaRSⁱ	ARNT. human.

ChiTaRSⁱ

ARNT. human.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083. HLH. 1 hit. cd00130. PAS. 1 hit.
Gene3Dⁱ	4.10.280.10. 1 hit.
InterProⁱ	View protein in InterPro IPR011598. bHLH_dom. IPR001067. Nuc_translocat. IPR000014. PAS. IPR013767. PAS_fold.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010. HLH. 1 hit. PF00989. PAS. 1 hit.
PRINTSⁱ	PR00785. NCTRNSLOCATR.
SMARTⁱ	View protein in SMART SM00353. HLH. 1 hit. SM00091. PAS. 1 hit.
SUPFAMⁱ	SSF47459. SSF47459. 1 hit. SSF55785. SSF55785. 3 hits.
PROSITEⁱ	View protein in PROSITE PS50888. BHLH. 1 hit. PS50112. PAS. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	O43392_HUMAN
Accessionⁱ	O43392Primary (citable) accession number: O43392
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 1, 1998
	Last sequence update:	June 1, 1998
	Last modified:	July 5, 2017
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - O43392 (O43392_HUMAN)

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Aryl hydrocarbon receptor nuclear translocator

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Interactionⁱ

GO - Molecular functionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O43392 (O43392_HUMAN)

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Aryl hydrocarbon receptor nuclear translocator

ARNT

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ