O43392 (O43392_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Aryl hydrocarbon receptor nuclear translocator EMBL AAC03365.1

Gene names

Name:

ARNT EMBL AAC03365.1

Organism

Homo sapiens (Human) EMBL AAC03365.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain. RuleBase RU000367 SAAS SAAS013767

Ontologies

Keywords
Biological process	Transcription Transcription regulation SAAS SAAS013767
Cellular component	Nucleus SAAS SAAS013767
Ligand	DNA-binding SAAS SAAS013767
Molecular function	Receptor EMBL AAC03365.1
Gene Ontology (GO)
Biological process	positive regulation of transcription, DNA-dependent Inferred from direct assay. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW receptor activity Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O43392 [UniParc]. Last modified June 1, 1998. Version 1. Checksum: 18F056368D984654	FASTA	328	36,012
	10 20 30 40 50 60 MAATTANPEM TSDVPSLGPA IASGNSGPGI QGGGAIVQRA IKRRPGLDFD DDGEGNSKFL 70 80 90 100 110 120 RCDDDQMSND KERFARSDDE QSSADKERLA RENHSEIERR RRNKMTAYIT ELSDMVPTCS 130 140 150 160 170 180 ALARKPDKLT ILRMAVSHMK SLRGTGNTST DGSYKPSFLT DQELKHLILE AADGFLFIVS 190 200 210 220 230 240 CETGRVVYVS DSVTPVLNQP QSEWFGSTLY DQVHPDDVDK LREQLSTSEN ALTGRILDLK 250 260 270 280 290 300 TGTVKKEGQQ SSMRMCMGSR RSFICRMRCG SSSVDPVSVN RLSFVRNRCR NGLGSVKDGE 310 320 PHFVVVHCTG YIKAWPPAGV SLPDDDPA

References

[1]	"Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein." Wilson C.L., Thomsen J., Hoivik D.J., Wormke M.T., Stanker L., Holtzapple C., Safe S.H. Arch. Biochem. Biophys. 346:65-73(1997) [PubMed: 9328285] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF001307 mRNA. Translation: AAC03365.1.
IPI	IPI00964540.
UniGene	Hs.632446.
3D structure databases
HSSP	HSSP built from PDB template 1AN4 based on UniProtKB P22415.
ProteinModelPortal	O43392.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-7034501.
STRING	O43392.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc001evt.1. human.
Phylogenomic databases
eggNOG	prNOG19308.
HOVERGEN	HBG000164.
Gene expression databases
ArrayExpress	O43392.
Family and domain databases
InterPro	IPR011598. HLH_DNA-bd. IPR001067. Nuc_translocat. IPR000014. PAS. IPR013767. PAS_fold. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
Pfam	PF00010. HLH. 1 hit. PF00989. PAS. 1 hit. [Graphical view]
PRINTS	PR00785. NCTRNSLOCATR.
SMART	SM00353. HLH. 1 hit. SM00091. PAS. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. HLH. 1 hit. PS50112. PAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	1693.

Entry information

Entry name

O43392_HUMAN

Accession

Primary (citable) accession number: O43392

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 1998
Last sequence update:	June 1, 1998
Last modified:	December 14, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.